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1.
J Surg Res ; 298: 81-87, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38581766

ABSTRACT

INTRODUCTION: Enhanced Recovery Programs (ERPs) mitigate racial disparities in postoperative length of stay (LOS) for colorectal populations. It is unclear, however, if these effects exist in the bariatric surgery population. Therefore, this study aimed to evaluate the racial disparities in LOS before and after implementation of bariatric surgery ERP. METHODS: A retrospective cohort study was performed using data from a single institution. Patients undergoing minimally invasive sleeve gastrectomy or Roux-en-Y gastric bypass from 2017 to 2019 (pre-ERP) or 2020-2022 (ERP) were included. Chi-square, Kruskal-Wallis, and analysis of variance were used to compare groups, and estimated LOS (eLOS) was assessed via multivariable regression. RESULTS: Seven hundred sixty four patients were identified, including 363 pre-ERPs and 401 ERPs. Pre-ERP and ERP cohorts were similar in age (median 44.3 years versus 43.8 years, P = 0.80), race (53.4% Black versus 56.4% Black, P = 0.42), and preoperative body mass index (median 48.3 versus 49.4, P = 0.14). Overall median LOS following bariatric surgery decreased from 2 days pre-ERP to 1 day following ERP (P < 0.001). Average LOS for Black and White patients decreased by 0.5 and 0.48 days, respectively. However, overall eLOS remained greater for Black patients compared with White patients despite ERP implementation (eLOS 0.21 days, P = 0.01). CONCLUSIONS: Implementation of a bariatric surgery ERP was associated with decreased LOS for both Black and White patients. However, Black patients did have slightly longer LOS than White patients in both pre-ERP and ERP eras. More work is needed to understand the driving mechanism(s) of these disparities to eliminate them.


Subject(s)
Bariatric Surgery , Enhanced Recovery After Surgery , Length of Stay , Humans , Male , Female , Length of Stay/statistics & numerical data , Retrospective Studies , Adult , Middle Aged , Bariatric Surgery/statistics & numerical data , Black or African American/statistics & numerical data , Healthcare Disparities/statistics & numerical data , Healthcare Disparities/ethnology , Obesity, Morbid/surgery , Obesity, Morbid/ethnology , White People/statistics & numerical data
2.
Surg Obes Relat Dis ; 20(5): 454-461, 2024 May.
Article in English | MEDLINE | ID: mdl-38326184

ABSTRACT

BACKGROUND: The rates of postoperative complications can vary among specific patient populations. OBJECTIVES: The aim of this study is to examine how gender, race, and ethnicity can affect short-term postoperative complications in bariatric surgery patients. SETTING: United States. METHODS: Patients who underwent bariatric surgery between the years 2016 and 2021 were included and stratified based on gender, race/ethnicity, and procedure type. The 30-day outcomes were assessed using Clavien-Dindo (CD) classification of III-V. Wilcoxon rank-sum test was performed to compare continuous variables among groups and Chi-squared test for categorical variables. Logistic regression was performed to examine the effects of gender, race/ethnicity on CD classification ≥ III complications by the procedure type. RESULTS: A total of 975,642 bariatric surgery patients were included. Descriptive univariate analysis showed that CD ≥ III complications were higher among non-Hispanic blacks (NHB) and lowest in Hispanic patients, regardless of their gender, except in the duodenal switch DS group, where non-Hispanic whites (NHW) had the lowest complication rate. There was no difference between male and female patients with regards to postoperative complications, except in the sleeve gastrectomy (SG) group, where NHW males had more complications than NHW females. Sleeve gastrectomy showed the lowest complication rates followed by gastric bypass and DS in all groups. In multivariate logistic regression model, for both females and males NHBs had higher odds of postoperative complications compared to NHWs in sleeve gastrectomy (Female aOR:1.31, 95% CI: [1.23-1.40]; Male aOR:1.24, 95% CI: [1.08-1.43], P < .001) and gastric bypass (Female aOR:1.24, 95% CI: [1.16-1.33]; Male aOR:1.25, 95% CI: [1.06-1.48], P < .01). CONCLUSIONS: Non-Hispanic Black patients are at a higher rate of developing CD ≥ III complications compared to non-Hispanic Whites after bariatric surgery. The male gender was not a significant risk factor for serious postoperative complications. Among the different types of bariatric procedures, sleeve gastrectomy has the lowest rates of severe complications, followed by gastric bypass and duodenal switch. These results highlight the significance of considering gender, race, ethnicity, and procedure type during preoperative evaluation, surgical planning, and postoperative care.


Subject(s)
Bariatric Surgery , Obesity, Morbid , Postoperative Complications , Humans , Male , Female , Bariatric Surgery/statistics & numerical data , Bariatric Surgery/methods , Postoperative Complications/ethnology , Postoperative Complications/etiology , Postoperative Complications/epidemiology , Adult , Middle Aged , Sex Factors , United States/epidemiology , Obesity, Morbid/surgery , Obesity, Morbid/ethnology , Ethnicity/statistics & numerical data , Retrospective Studies , Treatment Outcome , Racial Groups/statistics & numerical data
3.
Obes Surg ; 33(4): 1297-1299, 2023 04.
Article in English | MEDLINE | ID: mdl-36811749

ABSTRACT

Despite the greater prevalence of obesity, African American (AA) adults represent a minority of bariatric surgery patients. The aim of this study was to determine variables associated with attrition among AA patients seeking bariatric surgery. We performed a retrospective analysis of a consecutive series of AA patients with obesity referred for surgery and who initiated the preoperative work-up as per insurance requirements. The sample was then divided between those undergoing surgery and those who did not receive surgery. The multivariable logistic regression analysis showed that male patients (OR 0.53 95% CI 0.28-0.98) and those with public insurance (OR 0.56, 95% CI 0.37 - 0.83) were significantly less likely to undergo surgery. The use of telehealth was strongly associated with receiving surgery (OR 3.53, 95% CI 2.36 - 5.29). Our results might help developing targeted strategies to reduce attrition rates among AA patients with obesity seeking bariatric surgery.


Subject(s)
Bariatric Surgery , Black or African American , Obesity , Patient Acceptance of Health Care , Adult , Humans , Male , Bariatric Surgery/statistics & numerical data , Black or African American/statistics & numerical data , Obesity/epidemiology , Obesity/ethnology , Obesity/surgery , Obesity, Morbid/epidemiology , Obesity, Morbid/ethnology , Obesity, Morbid/surgery , Retrospective Studies , Patient Acceptance of Health Care/ethnology , Patient Acceptance of Health Care/statistics & numerical data , Female , Insurance, Health/statistics & numerical data
4.
Am J Surg ; 221(4): 741-748, 2021 04.
Article in English | MEDLINE | ID: mdl-32279831

ABSTRACT

INTRODUCTION: Bariatric surgery is associated with 20-30% weight recidivism. As a result, revisional bariatric operation is increasingly performed. Disparity in bariatric outcomes remains controversial and very little is known about revisional bariatric surgery outcomes in ethnic cohorts. METHODS: Revisional bariatric cases were identified from the 2015 and 2016 Bariatric Surgery Accreditation and Quality Improvement Program Participant Use Data File. 1:1 case-control matching was performed and perioperative outcomes compared between racial cohorts. RESULTS: 24,197 cases were analyzed, including 20.78% Black patients. At baseline, there were differences in demographics and pre-existing conditions between racial cohorts. Matched analysis compared 7,286 Black and White patients. Operative duration (p = 0.008) and length of stay (p = 0.0003) were longer in Black patients. Readmission (6.8% vs. 5.4%, p = 0.009) was higher in Black patients. Bleeding (0.82% vs. 0.38%, p = 0.02) and surgical site infection (SSI) (2.6% vs. 1.8%, p = 0.01) were higher in White patients. CONCLUSION: Revisional bariatric surgery is safe. Apart from a higher rate of bleeding, SSI and readmission, outcomes were not mediated by race.


Subject(s)
Bariatric Surgery , Black or African American , Obesity, Morbid/ethnology , Obesity, Morbid/surgery , Reoperation/statistics & numerical data , White People , Case-Control Studies , Female , Humans , Male , Middle Aged
7.
J Clin Endocrinol Metab ; 106(4): e1868-e1879, 2021 03 25.
Article in English | MEDLINE | ID: mdl-33098299

ABSTRACT

CONTEXT: The prevalence of obesity is burgeoning among African American and Latina women; however, few studies investigating the skeletal effects of bariatric surgery have focused on these groups. OBJECTIVE: To investigate long-term skeletal changes following Roux-en-Y gastric bypass (RYGB) in African American and Latina women. DESIGN: Four-year prospective cohort study. PATIENTS: African American and Latina women presenting for RYGB (n = 17, mean age 44, body mass index 44 kg/m2) were followed annually for 4 years postoperatively. MAIN OUTCOME MEASURES: Dual-energy x-ray absorptiometry (DXA) measured areal bone mineral density (aBMD) at the spine, hip, and forearm, and body composition. High-resolution peripheral quantitative computed tomography measured volumetric bone mineral density (vBMD) and microarchitecture. Individual trabecula segmentation-based morphological analysis assessed trabecular morphology and connectivity. RESULTS: Baseline DXA Z-Scores were normal. Weight decreased ~30% at Year 1, then stabilized. Parathyroid hormone (PTH) increased by 50% and 25-hydroxyvitamin D was stable. By Year 4, aBMD had declined at all sites, most substantially in the hip. There was significant, progressive loss of cortical and trabecular vBMD, deterioration of microarchitecture, and increased cortical porosity at both the radius and tibia over 4 years. There was loss of trabecular plates, loss of axially aligned trabeculae, and decreased trabecular connectivity. Whole bone stiffness and failure load declined. Risk factors for bone loss included greater weight loss, rise in PTH, and older age. CONCLUSIONS: African American and Latina women had substantial and progressive bone loss, deterioration of microarchitecture, and trabecular morphology following RYGB. Further studies are critical to understand the long-term skeletal consequences of bariatric surgery in this population.


Subject(s)
Bone Diseases, Metabolic/ethnology , Bone Diseases, Metabolic/etiology , Gastric Bypass/adverse effects , Absorptiometry, Photon , Adult , Black or African American/statistics & numerical data , Body Composition , Bone Density/physiology , Bone Diseases, Metabolic/diagnosis , Cohort Studies , Female , Follow-Up Studies , Gastric Bypass/statistics & numerical data , Hispanic or Latino/statistics & numerical data , Humans , Middle Aged , New York/epidemiology , Obesity, Morbid/diagnosis , Obesity, Morbid/ethnology , Obesity, Morbid/surgery , Time Factors , Tomography, X-Ray Computed
8.
NCHS Data Brief ; (360): 1-8, 2020 Feb.
Article in English | MEDLINE | ID: mdl-32487284

ABSTRACT

Obesity is associated with serious health risks (1). Severe obesity further increases the risk of obesity-related complications, such as coronary heart disease and end-stage renal disease (2,3). From 1999-2000 through 2015-2016, a significantly increasing trend in obesity was observed (4). This report provides the most recent national data for 2017-2018 on obesity and severe obesity prevalence among adults by sex, age, and race and Hispanic origin. Trends from 1999-2000 through 2017-2018 for adults aged 20 and over are also presented.


Subject(s)
Obesity, Morbid/epidemiology , Adult , Age Factors , Ethnicity , Female , Humans , Male , Middle Aged , Obesity/epidemiology , Obesity/etiology , Obesity, Morbid/ethnology , Obesity, Morbid/etiology , Prevalence , Risk Factors , Sex Factors , United States/epidemiology , Young Adult
9.
Obes Surg ; 30(3): 931-940, 2020 03.
Article in English | MEDLINE | ID: mdl-31916133

ABSTRACT

OBJECTIVE: The role of liver fatty acid-binding protein (FABP1) in obesity is presently unclear. We investigated the association of FABP1 with obesity and the changes noted after laparoscopic sleeve gastrectomy (LSG) in a Chinese population. METHODS: The cross-sectional analysis included 187 individuals: 65 had normal weight (18.5 ≤ body mass index (BMI) < 24 kg/m2), 59 were overweight (24 ≤ BMI < 28 kg/m2), and 63 were obese (BMI ≥ 28 kg/m2). We also assessed 25 severely obese patients (BMI, 38.58 ± 4.59 kg/m2) at baseline and at 3, 6, and 12 months after LSG to observe FABP1 levels. RESULTS: FABP1 levels in the obese (30.33 ± 23.59 ng/ml, **P < 0.01, ***P < 0.001) and overweight (18.96 ± 18.75 ng/ml, P = 0.471) individuals were significantly higher than those in normal weight individuals (14.30 ± 9.37 ng/ml). Linear regression analysis revealed that the FABP1 levels were positively correlated with BMI (R2 = 0.201, ***P < 0.001), ALT (R2 = 0.324, ***P < 0.001), AST (R2 = 0.387, ***P < 0.001), m-AST (R2 = 0.160, ***P < 0.001), γ-GT (R2 = 0.106, ***P < 0.001), DBil (R2 = 0.078, ***P < 0.001), UA (R2 = 0.111, ***P < 0.001), FBG (R2 = 0.066, ***P < 0.001), LDL (R2 = 0.042, **P = 0.005), and were negatively correlated with HDL (R2 = 0.051, **P = 0.002). After adjusting for age, sex, ALT, AST, TC, TG, HDL, LDL, FBG, and UA, FABP1 was independently correlated with BMI (*P < 0.05). With decreasing BMI after LSG, the FABP1 levels (29.46 ± 21.19 ng/ml, P = 0.463, P = 0.06, *P < 0.05) also decreased at 3 (23.00 ± 22.77 ng/ml), 6 (14.41 ± 15.48 ng/ml), and 12 months (11.55 ± 3.27 ng/ml). CONCLUSION: Serum FABP1 levels are closely correlated with obesity and many metabolic factors, and we found that with the decrease in BMI after LSG, the FABP1 levels also progressively decreased postoperatively. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: ChiCTR-OCS-12002381.


Subject(s)
Fatty Acid-Binding Proteins/blood , Gastrectomy , Obesity, Morbid/blood , Obesity, Morbid/surgery , Obesity/blood , Adult , Asian People , Body Mass Index , China/epidemiology , Cross-Sectional Studies , Female , Follow-Up Studies , Gastrectomy/methods , Gastrectomy/statistics & numerical data , Humans , Laparoscopy/methods , Laparoscopy/statistics & numerical data , Male , Middle Aged , Obesity/diagnosis , Obesity/ethnology , Obesity, Morbid/diagnosis , Obesity, Morbid/ethnology , Postoperative Period
10.
Obes Surg ; 30(2): 587-594, 2020 02.
Article in English | MEDLINE | ID: mdl-31617114

ABSTRACT

INTRODUCTION: Bariatric surgery-induced weight loss may reduce resting energy expenditure (REE) and fat-free mass (FFM) disproportionately thereby predisposing patients to weight regain and sarcopenia. METHODS: We compared REE and body composition of African-American and Caucasian Roux-en-Y gastric bypass (RYGB) patients after surgery with a group of non-operated controls (CON). REE by indirect calorimetry; skeletal muscle (SM), trunk organs, and brain volumes by MRI; and FFM by DXA were measured at post-surgery visits and compared with CON (N = 84) using linear regression models that adjusted for relevant covariates. Ns in RYGB were 50, 42, and 30 for anthropometry and 39, 27, 17 for MRI body composition at years 1, 2, and 5 after surgery, respectively. RESULTS: Regression models adjusted for age, weight, height, ethnicity, and sex showed REE differences (RYGB minus CON; mean ± s.e.): year 1 (43.2 ± 34 kcal/day, p = 0.20); year 2 (- 27.9 ± 37.3 kcal/day, p = 0.46); year 5 (114.6 ± 42.3 kcal/day, p = 0.008). Analysis of FFM components showed that RYGB had greater trunk organ mass (~ 0.4 kg) and less SM (~ 1.34 kg) than CON at each visit. REE models adjusted for FFM, SM, trunk organs, and brain mass showed no between-group differences in REE (- 15.9 ± 54.8 kcal/day, p = 0.8; - 46.9 ± 64.9 kcal/day, p = 0.47; 47.7 ± 83.0 kcal/day, p = 0.57, at years 1, 2, and 5, respectively). CONCLUSIONS: Post bariatric surgery patients maintain a larger mass of high-metabolic rate trunk organs than non-operated controls of similar anthropometrics. Interpreting REE changes after weight loss requires an accurate understanding of fat-free mass composition at both the organ and tissue levels. CLINICAL TRIAL REGISTRATION: Long-term Effects of Bariatric Surgery (LABS-2) NCT00465829.


Subject(s)
Bariatric Surgery , Basal Metabolism/physiology , Body Composition/physiology , Energy Metabolism/physiology , Obesity, Morbid/surgery , Adiposity/physiology , Adult , Aged , Bariatric Surgery/rehabilitation , Calorimetry, Indirect , Case-Control Studies , Female , Follow-Up Studies , Gastric Bypass , Humans , Male , Middle Aged , Obesity, Morbid/ethnology , Obesity, Morbid/metabolism , Rest/physiology , Time Factors , Weight Loss/physiology
11.
Obes Surg ; 30(3): 975-981, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31848986

ABSTRACT

BACKGROUND: Metabolic surgery is the most effective method for weight loss in the long-term treatment of morbid obesity and its comorbidities. The primary aim of this study was to examine factors associated with percent total weight loss (%TWL) after metabolic surgery among an ethnically diverse sample of patients. METHODS: A retrospective review was performed on 1012 patients who underwent either a sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) at our institution between January 2008 and June 2015. RESULTS: African Americans had a lower %TWL than non-Hispanic/Latino Whites at 6, 9, 12, 18, and 48 months. At all timeframes, there was a negative association between pre-surgery TWL and %TWL after surgery. Female sex was negatively associated with %TWL at 3 months only. Higher initial BMI was also associated with greater post-operative %TWL at 18, 24 and 36 months. Older patients had lower %TWL at 6, 9, 12 and 24 months post-surgery. Patients who received RYGB had greater %TWL than those who received SG at 3, 6, 9, 12, 24 and 36 months. CONCLUSIONS: African Americans had a lower %TWL than non-Hispanic/Latino Whites at most time points; there were no other significant race/ethnicity or sex differences. BMI (greater initial BMI), age (lower) and RYGB were associated with a greater post-operative %TWL at certain post-surgery follow-up time points. A limitation of this study is that there was missing data at a number of time points due to lack of attendance at certain follow-up visits.


Subject(s)
Bariatric Surgery , Obesity, Morbid/ethnology , Obesity, Morbid/surgery , Weight Loss/physiology , Adult , Black or African American/statistics & numerical data , Comorbidity , Female , Hispanic or Latino/statistics & numerical data , Humans , Male , Middle Aged , Obesity, Morbid/diagnosis , Obesity, Morbid/epidemiology , Prognosis , Retrospective Studies , Time Factors , Treatment Outcome , White People/statistics & numerical data
12.
Obes Surg ; 30(3): 1011-1020, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31745861

ABSTRACT

BACKGROUND: There is evidence of racial disparity in the long-term weight loss outcomes of bariatric surgery. However, there has been a more limited evaluation of the impact of race on immediate perioperative outcomes. The aim of this study was to compare 30-day postoperative outcomes among different races. STUDY DESIGN: The 2016 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database was queried to identify patients aged ≥ 18 and body mass index ≥ 35 who underwent primary laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) with known information on race. We then evaluated the effect of five different races on four different 30-day outcomes. RESULTS: Of the total 106,932 patients (79.5% White, 19.3% African American (AA), 0.5% Asian, 0.4% American Indian or Alaska Native, 0.3% Native Hawaiian or other Pacific Islander), 30-day rates of postoperative complication, readmission, re-intervention, and reoperation were 6, 3.8, 1.3, and 1.2%, respectively. After controlling for other covariates in multivariate logistic regression and selecting White as reference, AA was the only race associated with a higher risk of postoperative complications (odds ratio [OR] 1.13; confidence interval [CI] 1.06-1.2) and readmissions (OR 1.47; CI 1.3-1.6). AA and American Indian or Alaska Native were also associated with higher re-interventions (OR 1.31; CI 1.15-1.51 and OR 2.11; CI 1.03-4.34). Furthermore, AA was associated with lower 30-day reoperations (OR 0.83; CI 0.7-0.9). CONCLUSION: This study found significant racial differences in short-term outcomes following bariatric surgery. Factors underlying these disparities are unclear and warrant further investigation.


Subject(s)
Bariatric Surgery , Health Status Disparities , Obesity, Morbid/ethnology , Obesity, Morbid/surgery , Postoperative Complications/ethnology , Adolescent , Adult , Black or African American/statistics & numerical data , Aged , Bariatric Surgery/adverse effects , Bariatric Surgery/statistics & numerical data , Databases, Factual , Female , Humans , Laparoscopy/adverse effects , Laparoscopy/statistics & numerical data , Male , Middle Aged , Obesity, Morbid/diagnosis , Patient Readmission/statistics & numerical data , Postoperative Complications/etiology , Postoperative Complications/therapy , Prognosis , Racial Groups/statistics & numerical data , Reoperation/adverse effects , Reoperation/statistics & numerical data , Treatment Outcome , United States/epidemiology , Weight Loss/physiology , Young Adult
13.
N Engl J Med ; 381(25): 2440-2450, 2019 12 19.
Article in English | MEDLINE | ID: mdl-31851800

ABSTRACT

BACKGROUND: Although the national obesity epidemic has been well documented, less is known about obesity at the U.S. state level. Current estimates are based on body measures reported by persons themselves that underestimate the prevalence of obesity, especially severe obesity. METHODS: We developed methods to correct for self-reporting bias and to estimate state-specific and demographic subgroup-specific trends and projections of the prevalence of categories of body-mass index (BMI). BMI data reported by 6,264,226 adults (18 years of age or older) who participated in the Behavioral Risk Factor Surveillance System Survey (1993-1994 and 1999-2016) were obtained and corrected for quantile-specific self-reporting bias with the use of measured data from 57,131 adults who participated in the National Health and Nutrition Examination Survey. We fitted multinomial regressions for each state and subgroup to estimate the prevalence of four BMI categories from 1990 through 2030: underweight or normal weight (BMI [the weight in kilograms divided by the square of the height in meters], <25), overweight (25 to <30), moderate obesity (30 to <35), and severe obesity (≥35). We evaluated the accuracy of our approach using data from 1990 through 2010 to predict 2016 outcomes. RESULTS: The findings from our approach suggest with high predictive accuracy that by 2030 nearly 1 in 2 adults will have obesity (48.9%; 95% confidence interval [CI], 47.7 to 50.1), and the prevalence will be higher than 50% in 29 states and not below 35% in any state. Nearly 1 in 4 adults is projected to have severe obesity by 2030 (24.2%; 95% CI, 22.9 to 25.5), and the prevalence will be higher than 25% in 25 states. We predict that, nationally, severe obesity is likely to become the most common BMI category among women (27.6%; 95% CI, 26.1 to 29.2), non-Hispanic black adults (31.7%; 95% CI, 29.9 to 33.4), and low-income adults (31.7%; 95% CI, 30.2 to 33.2). CONCLUSIONS: Our analysis indicates that the prevalence of adult obesity and severe obesity will continue to increase nationwide, with large disparities across states and demographic subgroups. (Funded by the JPB Foundation.).


Subject(s)
Obesity, Morbid/epidemiology , Obesity/epidemiology , Adult , Body Mass Index , Female , Forecasting , Humans , Income , Male , Obesity/ethnology , Obesity, Morbid/ethnology , Prevalence , Self Report , Sex Distribution , United States/epidemiology
14.
BMC Genet ; 20(1): 97, 2019 12 18.
Article in English | MEDLINE | ID: mdl-31852448

ABSTRACT

BACKGROUND: As obesity is becoming pandemic, morbid obesity (MO), an extreme type of obesity, is an emerging issue worldwide. It is imperative to understand the factors responsible for huge weight gain in certain populations in the modern society. Very few genome-wide association studies (GWAS) have been conducted on MO patients. This study is the first MO-GWAS study in the Han-Chinese population in Asia. METHODS: We conducted a two-stage GWAS with 1110 MO bariatric patients (body mass index [BMI] ≥ 35 kg/m2) from Min-Sheng General Hospital, Taiwan. The first stage involved 575 patients, and 1729 sex- and age-matched controls from the Taiwan Han Chinese Cell and Genome Bank. In the second stage, another 535 patients from the same hospital were genotyped for 52 single nucleotide polymorphisms (SNPs) discovered in the first stage, and 9145 matched controls from Taiwan Biobank were matched for confirmation analysis. RESULTS: The results of the joint analysis for the second stage revealed six top ranking SNPs, including rs8050136 (p-value = 7.80 × 10- 10), rs9939609 (p-value = 1.32 × 10- 9), rs1421085 (p-value = 1.54 × 10- 8), rs9941349 (p-value = 9.05 × 10- 8), rs1121980 (p-value = 7.27 × 10- 7), and rs9937354 (p-value = 6.65 × 10- 7), which were all located in FTO gene. Significant associations were also observed between MO and RBFOX1, RP11-638 L3.1, TMTC1, CBLN4, CSMD3, and ERBB4, respectively, using the Bonferroni correction criteria for 52 SNPs (p < 9.6 × 10- 4). CONCLUSION: The most significantly associated locus of MO in the Han-Chinese population was the well-known FTO gene. These SNPs located in intron 1, may include the leptin receptor modulator. Other significant loci, showing weak associations with MO, also suggested the potential mechanism underlying the disorders with eating behaviors or brain/neural development.


Subject(s)
Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics , Asian People/genetics , Genome-Wide Association Study/methods , Obesity, Morbid/genetics , Polymorphism, Single Nucleotide , Adult , Asian People/ethnology , Carrier Proteins/genetics , Case-Control Studies , Female , Genetic Predisposition to Disease , Humans , Male , Membrane Proteins/genetics , Middle Aged , Obesity, Morbid/ethnology , RNA Splicing Factors/genetics , Receptor, ErbB-4/genetics , Taiwan/ethnology , Young Adult
15.
Surg Obes Relat Dis ; 15(11): 1943-1948, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31629668

ABSTRACT

BACKGROUND: Several studies have demonstrated that minorities and Hispanic ethnicities have disproportionally greater burden of morbid obesity in the United States. However, the majority of bariatric procedures are performed in the non-Hispanic white population. OBJECTIVES: The objective of this study was to investigate the weight loss and remission of obesity-related co-morbidities based on race and ethnicity. SETTING: The Longitudinal Assessment of Bariatric Surgery prospective, multicenter, observational study was used to collect patients from 10 different health centers across the United States. METHODS: Retrospective analysis of a prospective, multicenter, observational study over a 5-year follow-up. RESULTS: All patients who underwent primary gastric bypass and provided racial/ethnic information were included in the study (n = 1695). Regardless of race or ethnicity, total weight loss was maintained over a 5-year follow-up, which included 87% of the original cohort. However, whites had on average 1.94% higher adjusted total weight loss compared with blacks (P < .0001). After adjusting for confounders there were no significant differences in resolution of co-morbidities, including diabetes. CONCLUSION: All patients regardless of race or ethnicity have significant and sustained total weight loss and resolution of co-morbidities after gastric bypass at 5-year follow-up.


Subject(s)
Comorbidity , Ethnicity , Gastric Bypass/methods , Obesity, Morbid/surgery , Racial Groups/ethnology , Weight Loss/ethnology , Adult , Body Mass Index , Female , Follow-Up Studies , Humans , Longitudinal Studies , Male , Middle Aged , Obesity, Morbid/ethnology , Prospective Studies , Retrospective Studies , Time Factors , Treatment Outcome , United States
16.
Obes Surg ; 29(12): 3954-3965, 2019 12.
Article in English | MEDLINE | ID: mdl-31292885

ABSTRACT

OBJECTIVE: Bariatric surgery has a significant impact on levels of thyroid hormones and various inflammatory markers in obesity. The relationship between changes in thyroid hormones and inflammatory markers after bariatric surgery is unknown. We aimed to investigate the changes in thyroid hormones and their relations to inflammatory changes after laparoscopic sleeve gastrectomy (LSG) in Chinese patients with morbid obesity. METHODS: Eighty-eight patients with morbid obesity (56.8% female; age 30.9 ± 9.5 years; BMI 39.9 ± 5.7 kg/m2) submitted to LSG were selected. Patients were subdivided into euthyroid group and subclinical hypothyroidism (SH) group. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), inflammatory markers, and related metabolic indexes were analyzed pre- and 12 months post-LSG. RESULTS: SH patients presented significantly higher interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) than euthyroid patients. Twelve-month post-surgery, the SH incidence decreased from 31.8 to 2.3% (P < 0.001). TSH levels were declined significantly in both groups but were more pronounced in SH group (P < 0.001), whereas no change in FT4 in either group. Additionally, we observed marked reduction of IL-6, TNF-α, and CRP in SH group, as well as TNF-α and CRP in euthyroid group. After adjusting for age, baseline BMI, and changes in BMI, decrease in TSH correlated significantly with decreased HOMA-IR and TNF-α in euthyroid group and decreased fasting insulin (FINS), IL-6, TNF-α, and CRP in SH group. CONCLUSION: LSG promotes TSH reduction in patients with morbid obesity that is more pronounced in patients with SH and correlated with improved inflammatory state after surgery.


Subject(s)
C-Reactive Protein/metabolism , Cytokines/blood , Gastrectomy , Inflammation/blood , Obesity, Morbid/surgery , Thyrotropin/blood , Thyroxine/blood , Adult , Asian People , Biomarkers/blood , Female , Follow-Up Studies , Gastrectomy/methods , Humans , Hypothyroidism/blood , Hypothyroidism/complications , Hypothyroidism/diagnosis , Hypothyroidism/ethnology , Inflammation/diagnosis , Inflammation/ethnology , Inflammation/etiology , Laparoscopy , Male , Obesity, Morbid/blood , Obesity, Morbid/complications , Obesity, Morbid/ethnology , Retrospective Studies , Treatment Outcome
17.
Obes Surg ; 29(11): 3646-3652, 2019 11.
Article in English | MEDLINE | ID: mdl-31264174

ABSTRACT

INTRODUCTION/PURPOSE: Bariatric surgery (BS) has emerged as a cornerstone procedure to prevent and treat obesity-related comorbidities. As the Hispanic population continues to grow in the USA, their importance to the healthcare system cannot be understated. We aimed to assess the use of BS and related healthcare outcomes in Hispanics using a national database. MATERIALS AND METHODS: Case-control study using the 2010 to 2014 National Inpatient Sample datasets. BS use in Hispanics compared to non-Hispanics was the primary outcome. Secondary outcomes included inpatient mortality, morbidity, resource use, length of hospital stay, hospital costs, and total hospitalization charges. Propensity scores were used to match Hispanic patients with BS with non-Hispanic patients with BS using sex, age, and Charlson Comorbidity Index as covariates. A multivariate model was then used to adjust for additional confounding factors. RESULTS: From the 105,435 patients who underwent BS, a propensity-matched cohort of 20,440 was created (10,945 Hispanics). Mean (SD) age was 45 (17.2) years, and 73,594 (69.8%) were women. The prevalence of BS in Hispanics was 21/100,000 persons (281/100,000 admissions) compared to 36/100,000 persons (337/100,000 admissions) for non-Hispanics. On multivariate analysis, Hispanics displayed adjusted propensity-matched odds of 0.88 of having BS (P < 0.01). No differences were seen in the surgical approach performed. Hispanics and non-Hispanics had similar mortality, morbidity, hospital length of stay, and costs. CONCLUSION: Despite higher obesity rates, the use of BS is lower in Hispanics. For those who underwent BS, no difference in clinical outcomes and minor differences in resource use were observed.


Subject(s)
Bariatric Surgery , Hispanic or Latino/statistics & numerical data , Obesity, Morbid/ethnology , Obesity, Morbid/surgery , Adult , Case-Control Studies , Databases, Factual , Female , Hospitalization , Humans , Male , Middle Aged , Propensity Score , Treatment Outcome , United States , Weight Loss
18.
Obes Surg ; 29(11): 3577-3580, 2019 11.
Article in English | MEDLINE | ID: mdl-31201695

ABSTRACT

Ethnicity has been shown to affect weight loss outcome and attrition after bariatric surgery. We analyze data from a multiethnic urban cohort of patients (n = 570) followed up to 12 months after either gastric bypass (RYGB) or gastric banding (AGB) surgery. Percent total weight loss was greater at 1 year after RYGB (35%) compared with that of AGB (13%), regardless of ethnicity. Hispanics were more likely to undergo RYGB (77.3% vs. 61.2% of African-Americans and 50.4% of Caucasians). Ethnicity had no effect on attrition after RYGB, but Hispanics had better follow-up rate after AGB. Our data do not support an effect of ethnicity on surgical weight loss at 1 year.


Subject(s)
Bariatric Surgery , Black or African American , Hispanic or Latino , Obesity, Morbid/ethnology , Weight Loss/ethnology , White People , Adult , Cohort Studies , Female , Humans , Male , Middle Aged , Obesity, Morbid/surgery
19.
JAMA Surg ; 154(5): e190029, 2019 05 01.
Article in English | MEDLINE | ID: mdl-30840063

ABSTRACT

Importance: The outcomes of bariatric surgery vary considerably across patients, but the association of race with these measures remains unclear. Objective: To examine the association of race on perioperative and 1-year outcomes of bariatric surgery. Design, Setting, and Participants: Propensity score matching was used to assemble cohorts of black and white patients from the Michigan Bariatric Surgery Collaborative who underwent a primary bariatric operation (Roux-en-Y gastric bypass, sleeve gastrectomy, or adjustable gastric banding) between June 2006 and January 2017. Cohorts were balanced on baseline characteristics and procedure. Conditional fixed-effects models were used to evaluate the association of race on outcomes within hospitals and surgeons. Data analysis occurred from June 2006 through August 2018. Main Outcomes and Measures: Thirty-day complications and health care resource utilization measures, as well as 1-year weight loss, comorbidity remission, quality of life, and satisfaction. Results: In each group, 7105 patients were included. Black patients had a higher rate of any complication (628 [8.8%] vs 481 [6.8%]; adjusted odds ratio, 1.33 [95% CI, 1.17-1.51]; P = .02), but there were no significant differences in the rates of serious complications (178 [2.5%] vs 135 [1.9%]; adjusted odds ratio, 1.32 [95% CI, 1.05-1.66]; P = .29) or mortality (5 [0.10%] vs 7 [0.10%]; adjusted odds ratio, 0.73 [95% CI, 0.23-2.31]; P = .54). Black patients had a greater length of stay (mean [SD], 2.2 [3.0] days vs 1.9 [1.7] days; adjusted odds ratio, 0.30 [95% CI, 0.20-0.40]; P < .001), as well as a higher rate of emergency department visits (541 [11.6%] vs 826 [7.6%]; adjusted odds ratio, 1.60 [95% CI, 1.43-1.79]; P < .001) and readmissions (414 [5.8%] vs 245 [3.5%]; adjusted odds ratio, 1.73 [95% CI, 1.47-2.03]; P < .001). At 1 year, black patients had lower mean total body weight loss and as a percentage of weight (32.0 kg [26%]; vs 38.3 kg [29%]; P < .001) and this held true across procedures. Remission of hypertension was lower for black patients (564 [40.0%] vs 1096 [56.0%]; P < .001), but the rate of sleep apnea remission (467 [62.6%] vs 615 [56.1%]; P = .005) and gastroesophageal reflux disease (309 [78.6%] vs 453 [75.4%]; P = .049) were higher. There were no significant differences in remission of diabetes with insulin dependence, diabetes without insulin dependence,or hyperlipidemia hyperlipidemia. Fewer black patients than white patients reported a good or very good quality of life (1379 [87.2%] vs 2133 [90.4%]; P = .002) and being very satisfied with surgery (1908 [78.4%] vs 2895 [84.2%]; P < .001) at 1 year. Conclusions and Relevance: Black patients undergoing bariatric surgery in Michigan had significantly higher rates of 30-day complications and resource utilization and experienced lower weight loss at 1 year than a matched cohort of white patients. While sleep apnea and gastroesophageal reflux disease remission were higher and hypertension remission lower in black patients, comorbidity remission was otherwise similar between matched cohorts. Racial and cultural differences among patients should be considered when designing strategies to optimize outcomes with bariatric surgery.


Subject(s)
Bariatric Surgery/methods , Laparoscopy/methods , Obesity, Morbid/surgery , Postoperative Complications/ethnology , Propensity Score , Racial Groups , Weight Loss/physiology , Adult , Body Mass Index , Female , Follow-Up Studies , Humans , Incidence , Male , Michigan/epidemiology , Obesity, Morbid/ethnology , Retrospective Studies
20.
Obes Surg ; 29(7): 2151-2157, 2019 07.
Article in English | MEDLINE | ID: mdl-30830531

ABSTRACT

OBJECTIVE: This study examined food addiction (FA) and acculturation among a Hispanic bariatric surgery-seeking sample. SETTING: University hospital. METHOD: Four hundred forty-four (n = 215 English-speaking; n = 229 Spanish-speaking) Hispanic adults seeking bariatric surgery completed established self-report measures examining food addiction and acculturation. RESULTS: 35.8% met criteria for FA, which was significantly associated with acculturation level to the USA. Participants who endorsed greater acculturation also endorsed a significantly higher level of FA symptoms compared with those who endorsed less acculturation. Acculturation level was significantly associated with FA and BMI. CONCLUSIONS: FA rate in this bariatric surgery-seeking Hispanic patient group is similar to rates reported among bariatric candidates of varying ethnic backgrounds. Our results suggest a relationship between FA symptom expression and acculturation to the USA. Improving understanding of the onset and progression of severity of FA symptoms may have clinical implications for Hispanic patients seeking bariatric surgery.


Subject(s)
Acculturation , Bariatric Surgery , Food Addiction/ethnology , Hispanic or Latino , Obesity, Morbid/surgery , Patient Acceptance of Health Care , Adolescent , Adult , Aged , Bariatric Surgery/statistics & numerical data , Comorbidity , Female , Food Addiction/complications , Health Behavior/ethnology , Hispanic or Latino/psychology , Hispanic or Latino/statistics & numerical data , Humans , Male , Middle Aged , Obesity, Morbid/ethnology , Patient Acceptance of Health Care/ethnology , Patient Acceptance of Health Care/psychology , Patient Acceptance of Health Care/statistics & numerical data , Surveys and Questionnaires , United States/epidemiology , Young Adult
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