1.
Oligonucleotides
; 15(2): xiii, 2005.
Article
in English
| MEDLINE
| ID: mdl-15989420
Subject(s)
Oligonucleotides/history , Plants/virology , Greece , History, 20th Century , History, 21st Century
2.
Nature
; 431(7010): 755, 2004 Oct 14.
Article
in English
| MEDLINE
| ID: mdl-15483592
Subject(s)
Chemistry, Organic/history , Oligonucleotides/chemical synthesis , History, 20th Century , History, 21st Century , Netherlands , Oligonucleotides/chemistry , Oligonucleotides/genetics , Oligonucleotides/history , Oligosaccharides/chemical synthesis , Oligosaccharides/history , United States , Vaccines, Synthetic/history
3.
Curr Protoc Nucleic Acid Chem
; Chapter 4: Unit 4.1, 2001 May.
Article
in English
| MEDLINE
| ID: mdl-18428848
ABSTRACT
The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of modified oligonucleotides that are complementary to specific nucleotide sequences in mRNA targets. Such modified oligonucleotides can be used to disrupt the flow of genetic information from transcribed mRNAs to proteins. This antisense strategy has been used to develop therapeutic oligonucleotides against cancer and various infectious diseases in humans. This overview reports recent advances in the application of oligonucleotides as drug candidates, describes the relationship between oligonucleotide modifications and their therapeutic profiles, and provides general guidelines for enhancing oligonucleotide drug properties.
