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2.
Met Ions Life Sci ; 7: 111-51, 2010.
Article in English | MEDLINE | ID: mdl-20877806

ABSTRACT

The speciation of organotin(IV) cations in natural waters, in sewage or in biofluids is strongly influenced by the complex formation with the available metal-binding compounds, i.e., both high and low molecular weight ligands of biological and environmental interest. The primary intention of this chapter is to discuss the aquatic solution chemistry of organotin cations and their complexes formed with low and high molecular weight bioligands. Besides, some synthetic aspects, applications and sources of organotin pollution, their destinations in the environment, and toxicology will be also shortly discussed.


Subject(s)
Ecosystem , Organotin Compounds/metabolism , Water Pollutants, Chemical/metabolism , Animals , Environmental Exposure/adverse effects , Environmental Exposure/analysis , Humans , Kinetics , Methylation , Nerve Degeneration/chemically induced , Nerve Degeneration/metabolism , Organotin Compounds/chemistry , Organotin Compounds/poisoning , Pesticides/chemistry , Pesticides/metabolism , Pesticides/poisoning , Water Pollutants, Chemical/chemistry , Water Pollutants, Chemical/poisoning
7.
Mar Environ Res ; 59(5): 435-52, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15603768

ABSTRACT

An integrated biological-chemical survey of organotin compounds was carried out in Guanabara Bay, the second most important Brazilian harbor complex. The biological survey revealed high levels of imposex in Stramonita haemastoma populations. Inside the bay values of relative penis length index from 42.7 to 107.6 and vas deferens sequence index from III to VI were found, while organisms collected outside the bay had values ranging from <0.1 to 35.2 and from 0 to II. None of the females sampled inside the bay were normal and imposex was found in all stations. Surface sediments in the bay are contaminated by tributyltin (10-522 ng/g d.w.) and triphenyltin (<3.9-39.4 ng/g d.w.) with greater concentrations close to shipyards and marinas. The observed predominance of parent compounds (TBT and TPT) is commonly found when recent inputs occur, but may also indicate slow degradation processes in the anoxic conditions of these sediments. To our knowledge, this is the first report of a combined imposex-sediment approach to evaluate organotin contamination in marine environments of South America, and also the first report of TPT detection in environmental matrices in this region.


Subject(s)
Disorders of Sex Development/chemically induced , Disorders of Sex Development/veterinary , Organotin Compounds/poisoning , Snails/anatomy & histology , Trialkyltin Compounds/poisoning , Water Pollutants, Chemical/poisoning , Animals , Brazil , Environmental Monitoring , Female , Geologic Sediments/chemistry , Male , Snails/physiology
10.
Hum Exp Toxicol ; 17(7): 403-5, 1998 Jul.
Article in English | MEDLINE | ID: mdl-9726537

ABSTRACT

1. In animal studies, TPTA was found to be neurotoxic. In humans, variable CNS pictures have been described with or without significant EEG findings. Brain CT does not usually reveal any abnormalities. 2. Our patient presented with intermittent unique spontaneous involuntary movement of hands, facial twitching, silly smile and crying. Diplopia, drowsiness, giddiness, vertigo, bidirectional nystagmus, impairment of calculation ability, as well as disorientation to time, people and place also developed. EEG showed mild cortical dysfunction without seizures. MRI and Tc-99m HMPAO brain SPECT revealed no significant findings. TPTA may cause cellular dysfunction of brain without structural damage, which results in variable CNS clinical presentations. 3. Nadir of leucopenia was noted on the sixth day after consumption of TPTA. Liver impairment occurred on the ninth day. Borderline demyelinated neuropathy developed on the fifty-third day. CNS abnormalities, delayed peripheral neuropathy, hepatitis and leucopenia deserve monitoring for a prolonged period, even when the victim initially presents with GI upset only after consumption of TPTA.


Subject(s)
Brain/drug effects , Central Nervous System/drug effects , Fungicides, Industrial/poisoning , Organotin Compounds/poisoning , Adult , Brain/pathology , Cognition/drug effects , Electroencephalography/drug effects , Female , Humans , Motor Activity/drug effects , Suicide, Attempted
13.
Am J Nephrol ; 13(2): 124-8, 1993.
Article in English | MEDLINE | ID: mdl-8342577

ABSTRACT

Three patients who developed acute nephropathy following ingestion of triphenyltin acetate (TPTA) are described. All of them had significant proteinuria, azotemia, and polyuria. Mild neurological manifestations in all patients were also noted. Hematuria and pyuria were noted in 1 severely poisoned patient. Evidence for hepatitis was present in 2 patients, and for pancreatitis in 1. Renal biopsy showed focal fusion of glomerular cell processes and proximal tubular damage with cellular necrosis. Two patients survived with complete recovery of renal functions. One old patient died of aspiration pneumonia. Acute nephropathy following organotin intoxication appears to result mainly from proximal renal tubular damage with a benign and reversible clinical course.


Subject(s)
Fungicides, Industrial/poisoning , Kidney Tubular Necrosis, Acute/chemically induced , Organotin Compounds/poisoning , Adult , Aged , Chemical and Drug Induced Liver Injury/etiology , Humans , Kidney/pathology , Kidney Tubular Necrosis, Acute/pathology , Male , Nervous System Diseases/chemically induced , Pancreatitis/chemically induced
14.
Br J Ind Med ; 48(2): 136-9, 1991 Feb.
Article in English | MEDLINE | ID: mdl-1825604

ABSTRACT

A case of triphenyltin acetate (TPTA) poisoning is described. The patient, who had been exposed mainly to cutaneous absorption, showed acute stages of an urticarial eruption, signs of hepatic injury, slight glucose intolerance, and electroencephalographic abnormalities. Concomitant with the highest concentrations of tin in plasma and the peak of tin excretion in urine, neutrophils did not show the normal increase in actin polymerisation after stimulation with a chemotactic peptide (100 nM fMLP). The peak of urinary excretion of tin occurred between the fifth and the sixth day after poisoning; subsequently, the rate of excretion became slow, suggesting biphasic kinetics with the possibility of a cumulative trend.


Subject(s)
Dermatitis, Occupational/chemically induced , Fungicides, Industrial/poisoning , Organotin Compounds/poisoning , Urticaria/chemically induced , Adult , Dermatitis, Occupational/pathology , Dermatitis, Occupational/urine , Electroencephalography/drug effects , Humans , Liver/drug effects , Male , Neutrophils/drug effects , Skin/pathology , Skin Absorption , Tin/urine , Urticaria/pathology , Urticaria/urine
15.
J Neurol Neurosurg Psychiatry ; 53(4): 356-7, 1990 Apr.
Article in English | MEDLINE | ID: mdl-2160519

ABSTRACT

A 23 year old male developed abdominal pain, diarrhoea, and vomiting several hours after poisoning with acute triphenyltin intoxication in a suicide attempt. Severe ataxia, dysmetria, nystagmus, and blurring of vision soon supervened. Disturbance of consciousness and confusion developed 12 days later and lasted for two months. A delayed sensorimotor polyneuropathy was shown by electrophysiological studies to be due to axonal degeneration and demyelination. The neuropathy rapidly recovered after consciousness was regained.


Subject(s)
Organotin Compounds/poisoning , Adult , Brain Diseases/chemically induced , Consciousness , Humans , Male , Peripheral Nervous System Diseases/chemically induced
16.
Pol J Pharmacol Pharm ; 41(1): 7-14, 1989.
Article in English | MEDLINE | ID: mdl-2587439

ABSTRACT

The effects of organotin fungicide Brestan 60 and SnCl4 on rat brain and adrenal catecholamines (CA) were examined. Rats were treated with 0.5 LD50 of Brestan 60 (acute experiment) or 0.05 LD50 (subchronic experiment) and SnCl4 in equal dose of inorganic tin. Brestan 60 in both experiments decreased CA concentrations in the brain and adrenals. In contrast, SnCl4 did not alter brain CA but had greater effect on adrenal CA than Brestan 60 had. Effects of organotin fungicide may be related with inhibition of oxidative phosphorylation and membrane-bound ATP-ases.


Subject(s)
Adrenal Glands/metabolism , Brain Chemistry/drug effects , Catecholamines/metabolism , Organotin Compounds/poisoning , Adrenal Glands/drug effects , Animals , Dopamine/metabolism , Lethal Dose 50 , Male , Norepinephrine/metabolism , Rats , Rats, Inbred Strains
17.
Vet Hum Toxicol ; 26(2): 121-2, 1984 Apr.
Article in English | MEDLINE | ID: mdl-6730297

ABSTRACT

Neurologic and psychiatric symptoms such as headache, tinnitus, defective hearing, changing desorientation and aggressiveness are initial symptoms of methyltin chloride intoxication. Some patients also developed epileptic equivalents, such as dreamy attacks and central ventilation transaminases. Laboratory findings included low levels of serum potassium, leucocytosis and elevated transaminases. The excretion rate of tin in the urine correlated with the severity of the intoxication. There was no measurable effect of plasma separation or d-penicillamine therapy on tin excretion in the urine or on the clinical picture. The long-term prognosis of severely intoxicated persons is poor. Neurohistopathologic findings confirm the animal studies by Brown et al and the severe damage and cell necrosis in the hippocampus area. To prevent such events workers need to be warned of the risk and dangers of working with organo-metallic compounds. The effectiveness of protective clothes and gas masks should be checked. In exposed workers regular testing is advised of tin concentrations in the urine.


Subject(s)
Accidents, Occupational , Organotin Compounds/poisoning , Chemical Industry , Humans , Male , Nervous System Diseases/chemically induced , Tin/urine
18.
Neurotoxicology ; 5(2): 141-58, 1984.
Article in English | MEDLINE | ID: mdl-6542185

ABSTRACT

Current uses of organotins include heat stabilizers for polyvinyl chloride (PVC), catalysts for polyurethane foam and silicone rubber, biocides, and animal health products. Domestic production consumption in 1982 is about 28 million pounds, and overall growth is estimated at 7 percent per year. Physical properties of organotins, including solubility in water, octanol-water partition coefficients, and Freundlich adsorption isotherm constants, are not well characterized. Analytical methods for tin in environmental and biological matrices involve concentration, separation, and identification by chromatography, spectrometry, and spectroscopy. Environmental fate and effects of organotins are not well understood. Degradation reactions may yield a complex set of products, including inorganic tin oxide. The effects of exposure of workers and release of organotins to the environment at point sources have been documented. Nonpoint sources of environmental exposure include discard and sanitary landfill disposal of plastics and direct release of biocides to aquatic or marine environments. Other dissipative uses of organotins which pose potential human risk include PVC food wrapping and bottles and rigid potable water pipe. The long term health effects of low level exposure to organotins are not known. Toxic metal cycling in the environment, including biomethylation of inorganic tin by naturally occurring bacteria, is of rising concern.


Subject(s)
Organotin Compounds , Chemical Phenomena , Chemistry , Chromatography, Gas , Economics , Environmental Exposure , Environmental Pollution , Humans , Kinetics , Occupational Diseases/chemically induced , Organotin Compounds/analysis , Organotin Compounds/poisoning , Refuse Disposal
19.
Acta Psychiatr Scand Suppl ; 303: 100-4, 1983.
Article in English | MEDLINE | ID: mdl-6575580

ABSTRACT

Previous impressions of specificity of psychiatric manifestations in relation to particular chemical intoxications have been confirmed by comparisons of the symptoms and signs of two groups of individuals. Nine persons exposed to inorganic mercury had "erethism" and xenophobia in addition to non-specific features of central nervous system poisoning. Twelve men with heavy exposure to organotins, in contrast to ten men with light or no exposure, more frequently presented an unique alternation between outbursts of range and deep depression, the later lasting from a few hours to a few days. The more heavily exposed men also had a greater number of nonspecific symptoms from neurotoxins.


Subject(s)
Mercury Poisoning/psychology , Occupational Diseases/chemically induced , Organotin Compounds/poisoning , Substance-Related Disorders/psychology , Adult , Brain/drug effects , Depressive Disorder/chemically induced , Female , Humans , Male , Occupational Diseases/psychology
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