[Synthesis and pharmacological properties of des-9-glycine analogs of [Orn8]vasopressin]. / Sintez i farmakologicheskie svoistva dez-9-glitsinovykh analogov [Orn8]vazopressina.

Three new analogues of vasopressin, viz. des-Gly9-[Phe2, Orn8]vasopressin, diglycyl-des-Gly9-[Phe2, Orn8]vasopressin, and diglycyl-des-Gly9-[Val4, Orn8]vasopressin, were synthesized to investigate the structure-function relationship. Hormonal (vasopressor, antidiuretic, uterotonic, galactogogic) activities of the new compounds were determined, their effect on elaboration and retention of the active avoidance behaviour in rats was studied.