[Lactoferrin and its role in the pathogenesis of tick-borne encephalitis]. / Laktoferrin i ego diagnosticheskaia rol' pri kleshchevom éntsefalite.

The content of lactoferrin (LF) was studied in the liquor and blood of patients with tick-borne encephalitis (TBE) of the meningeal and focal types; additionally, the information density of the discussed parameter was assessed for evaluating the severity and degree of the inflammation process in the central nervous system (CNS). The LF level was determined in liquor of 37 samples obtained from TBE patients (main group) and of 10 persons with osteochondrosis (controls); it was also determined in the serum taken from 21 TBE patients and from 40 healthy donors by using the immune-enzyme analysis. The LF concentration in TBE patients was found to exceed the normal value by 1.5-3 times during the whole observation period. As for the liquor, it was high, by the onset of the disease, by more than 20 times, however, after the 7th day it was higher 6-fold. A direct dependence of a concentration of the studied protein on a form and severity of the disease was established. The LF level in the liquor of TBE patients alongside with clinical signs can be an objective indicator of a severity and activity of the inflammation process in the CNS; it can also be a criteria of how much the conducted therapy effective is.

[The possible role of alpha 2-macroglobulin in regulating the immune components of the brain in tick-borne encephalitis]. / Vozmozhnaia rol' al'fa 2-makroglobulina v reguliatsii immunnykh komponentov mozga pri kleshchevom éntsefalite.

In tick-borne encephalitis certain immunopathological reactions develop in the tissues of the central nervous system; alpha 2-macroglobulin may serve as the marker of the activity of these reactions. The dynamic study of liquor taken from 16 patients with the meningeal and focal forms of tick-borne encephalitis (TBE), 8 patients with severe craniocerebral traumas accompanied by meningitis and 10 patients with osteochondrosis was made. As revealed in this study, in TBE patients the level of alpha 2-macroglobulin increases 3.5-fold and remains stable during the acute period of the disease.

[The permeability of the hemato-encephalic barrier in neurological cancer patients in the postoperative period]. / Pronitsaemost' gematoéntsefalicheskogo bar'era u neiroonkologicheskikh bol'nykh v posleoperatsionnom periode.

The permeability of the blood-brain barrier was studied in 48 patients by examining the protein indices of cerebrospinal fluid. The types of changes in the indices were identified, which reflected the level of the permeability and correlate with good and poor postoperative outcomes. Possible ways of correcting hypertransudation across the barrier were defined.

[Peroxide chemiluminescence of the cerebrospinal fluid in spinal cord tumors]. / Issledovanie perekisnoi khemiliuminestsentsii tserebrospinal'noi zhidkosti pri opukholiakh spinnogo mozga.

Spontaneous and initiated by hydrogen peroxide chemiluminescence was evaluated before and after freezing of the CSF from 20 patients with various spinal tumors and 10 controls with intervertebral lumbar osteochondrosis. The intensity of the above chemiluminescence was found significantly different in tumors and osteochondrosis. Cryotreatment induced marked changes in CSF chemiluminescence, especially in extramedullary spinal tumors. CSF treatment with hydrogen peroxide entailed alterations in free radical oxidation which can serve an additional criterion in combined diagnosis of spinal cord tumors.

[The intrathecal synthesis of G-class immunoglobulins in neurological cancer patients]. / Sostoianie intratekal'nogo sinteza immunoglobulinov klassa G u neiroonkologicheskikh bol'nykh.

The authors show that brain tumors onset and relevant recurrences are closely related to enhanced synthesis of IgG in the liquor and of circulating immune complexes as well as to blocking factors registered in the liquor. The above facts illustrate autoimmune reactions involved in pathogenesis and recurrent growth of brain tumors. Surgical removal of the latter inhibits the intensity of IgG intrathecal synthesis.

[Changes in the immunobiochemical composition of the cerebrospinal fluid and the antitumor reactions of the local immune system in astrocytic brain tumors]. / Izmeneniia immunobiokhimicheskogo sostava tserebrospinal'noi zhidkosti i protivoopukholevye reaktsii mestnoi immunnoi sistemy pri opukholiakh golovnogo mozga astrotsitarnogo riada.

Pre- and postoperative immunochemical indices of cerebrospinal fluid (CSF) were investigated in 10 patients with fibrillary-protoplasmic astrocytoma and 10 patients with glioblastoma multiforme. Malignant neoplastic developments in the brain are associated with appearance of marked humoral reaction. Tumor-specific CSF changes observed comprise registration of ceruloplasmin immunomodulating proteins and alpha 2-macroglobulin. It is emphasized that biochemical antioxidant, antiprotease, energy-supplying systems are related directly to humoral immune reactions in the process of relevant postoperative rehabilitation.

[Chemoluminescence of the cerebrospinal fluid in spinal cord tumors]. / Khemoliuminestsentsiia tserebrospinal'noi zhidkosti pri opukholiakh spinnogo mozga.

The article discusses a new method for recognising tumors of the spinal cord--spontaneous and photoinduced chemoluminescence of the cerebrospinal fluid. Twenty-seven patients with tumors of the spinal cord of various localization and histological structure and 15 individuals of the control group were examined. Statistically significant differences in chemoluminescence in extra- and intramedullary tumors and in the control group were revealed. The effect of intensified luminescence of the cerebrospinal fluid in exposure to ultraviolet radiation was demonstrated, especially in cases with extramedullary tumors. The described method is an auxiliary criterion in c.s.f. diagnosis of spinal tumors.