Exostose cartilaginosa múltipla em um canino pediátrico / Multiple cartilaginous exostoses in a pediatric dog

Background: Multiple cartilaginous exostosis (MCE) is a rare neoplastic disease in dogs that is characterized by the presence of osteochondromas in multiple bones. MCE is a disorder of development during growth and maturation, the realetiology of which has yet to be elucidated, but is believed to have a genetic basis. Usually affected animals have a historyof a palpable mass on the bone surface, causing anatomical deformities and compression of adjacent structures. SinceMCE is a rare neoplastic disease in dogs it may be difficult to recognize in the clinic. The aim of this study was to reporta case of MCE in a pediatric dog.Case: A female 4-month-old Rottweiler dog with a history of bone neoformation on the left hind limb, anorexia, weightloss, and difficulty walking received clinical care. The disease had its initial onset 2 months prior. At physical examination, the animal showed paresis of the hind limbs and a bony tumor on the lateral part of the left tibia. A complete bloodcell count and serum biochemical profile were obtained. The only abnormality diagnosed was hyperproteinemia due tohyperglobulinemia. Other diagnostic tests were not authorized and the animal was euthanized. At the necropsy, an intrathoracic neoformation was observed from the sixth to the eighth rib on the right antimer. Some tumors were also observedon the fourth lumbar vertebra and between the first and the second sacral vertebra, and a left tibial tumor, which had beenobserved at physical examination. The sagittal section of the spine revealed the presence of extradural compression of thespinal cord due to vertebral proliferations with compression of the nerve roots. All of the proliferations had macroscopicsimilarities, being firm, sessile, irregular, and with complete adherence to deep planes. Tumor samples were submitted tohistopathological analysis and the tissue morphology was compatible with osteochondroma...(AU)

Exostose cartilaginosa múltipla em um canino pediátrico / Multiple cartilaginous exostoses in a pediatric dog

Background: Multiple cartilaginous exostosis (MCE) is a rare neoplastic disease in dogs that is characterized by the presence of osteochondromas in multiple bones. MCE is a disorder of development during growth and maturation, the realetiology of which has yet to be elucidated, but is believed to have a genetic basis. Usually affected animals have a historyof a palpable mass on the bone surface, causing anatomical deformities and compression of adjacent structures. SinceMCE is a rare neoplastic disease in dogs it may be difficult to recognize in the clinic. The aim of this study was to reporta case of MCE in a pediatric dog.Case: A female 4-month-old Rottweiler dog with a history of bone neoformation on the left hind limb, anorexia, weightloss, and difficulty walking received clinical care. The disease had its initial onset 2 months prior. At physical examination, the animal showed paresis of the hind limbs and a bony tumor on the lateral part of the left tibia. A complete bloodcell count and serum biochemical profile were obtained. The only abnormality diagnosed was hyperproteinemia due tohyperglobulinemia. Other diagnostic tests were not authorized and the animal was euthanized. At the necropsy, an intrathoracic neoformation was observed from the sixth to the eighth rib on the right antimer. Some tumors were also observedon the fourth lumbar vertebra and between the first and the second sacral vertebra, and a left tibial tumor, which had beenobserved at physical examination. The sagittal section of the spine revealed the presence of extradural compression of thespinal cord due to vertebral proliferations with compression of the nerve roots. All of the proliferations had macroscopicsimilarities, being firm, sessile, irregular, and with complete adherence to deep planes. Tumor samples were submitted tohistopathological analysis and the tissue morphology was compatible with osteochondroma...

Excisão cirúrgica de um osteocondroma de raiz nervosa da cauda equina de cão / Surgical excision of an osteochondroma in a nerve root of the cauda equina of a dog

Background: Spinal neoplasms are classified into extradural, intradural/extramedullary or intramedullary. Intradural/extramedullary tumors include meningiomas and nerve sheath tumors, which arise from meninges or peripheral nerves around the spinal cord. Clinical signs are related to dysfunction of the involved nerve and include pain, nerve root signature and atrophy. Osteochondromas are benign tumors located within the bone, on its surface or in extra-osseous regions, when they are classified as soft tissue osteochondoma. The aim of this study is to describe a case of an osteochondroma in a nervous root of the cauda equina in a dog, whose surgical resection allowed the resolution of the clinical signs.Case: A 12-year-old, male, Labrador Retriever dog, was presented with a 40-day history of progressive, painful, pelvic limb paresis, with no improvement when treated with analgesics and acupuncture. Neurological abnormalities included paraparesis, sometimes worse in the left pelvic limb, that was carried flexed at the level of the stifle, hindlimb atrophy, decreased interdigital reflexes and pain in the lumbar spinal region, mainly over L6 vertebra. Results of blood count and serum biochemical analysis were unremarkable. Computed tomography (CT) of the lumbosacral area was performed and the evaluation of images in transverse and reconstructed dorsal and sagittal planes allowed the visualization of a hyperattenuating and calcified round structure with 8 mm x 6 mm, in the left side of vertebral canal, at the level of caudal epiphysis of L6. Lumbosacral (L7-S1) CT abnormalities, as subchondral sclerosis, mild disc margin bulging, spondylosis deformans and foraminal proliferation were also observed but were considered clinically insignificant.[...](AU)

Excisão cirúrgica de um osteocondroma de raiz nervosa da cauda equina de cão / Surgical excision of an osteochondroma in a nerve root of the cauda equina of a dog

Background: Spinal neoplasms are classified into extradural, intradural/extramedullary or intramedullary. Intradural/extramedullary tumors include meningiomas and nerve sheath tumors, which arise from meninges or peripheral nerves around the spinal cord. Clinical signs are related to dysfunction of the involved nerve and include pain, nerve root signature and atrophy. Osteochondromas are benign tumors located within the bone, on its surface or in extra-osseous regions, when they are classified as soft tissue osteochondoma. The aim of this study is to describe a case of an osteochondroma in a nervous root of the cauda equina in a dog, whose surgical resection allowed the resolution of the clinical signs.Case: A 12-year-old, male, Labrador Retriever dog, was presented with a 40-day history of progressive, painful, pelvic limb paresis, with no improvement when treated with analgesics and acupuncture. Neurological abnormalities included paraparesis, sometimes worse in the left pelvic limb, that was carried flexed at the level of the stifle, hindlimb atrophy, decreased interdigital reflexes and pain in the lumbar spinal region, mainly over L6 vertebra. Results of blood count and serum biochemical analysis were unremarkable. Computed tomography (CT) of the lumbosacral area was performed and the evaluation of images in transverse and reconstructed dorsal and sagittal planes allowed the visualization of a hyperattenuating and calcified round structure with 8 mm x 6 mm, in the left side of vertebral canal, at the level of caudal epiphysis of L6. Lumbosacral (L7-S1) CT abnormalities, as subchondral sclerosis, mild disc margin bulging, spondylosis deformans and foraminal proliferation were also observed but were considered clinically insignificant.[...]

Osteochondroma in a young cat infected by feline leukemia virus / Ostecondroma em um felino jovem infectado pelo vírus da leucemia felina

Osteochondromas are primary bone tumors characterized by cartilage-covered bone projections involving single or multiple masses (osteochondromatosis). This study reports the clinical and pathological findings from a young domestic cat with osteochondroma in the humerus. During the clinical evaluation, the animal had pronounced right forelimb musculature atrophy and an increased distal humeral volume. Histopathological examination of the neoplasm revealed a proliferative lesion characterized mostly by endochondral ossification and peripheral foci of proliferating cartilage tissue. Further testing using immunohistochemical staining and polymerase chain reaction revealed the presence of feline leukemia virus antigens in the hematopoietic cells of the bone marrow and FeLV proviral DNA in the peripheral blood lymphocytes. Clinical and pathological findings are consistent with osteochondroma. This neoplasm occurred in an eight-month-old feline with humeral enlargement that had been present since two months old.(AU)

O osteocondroma é um tumor ósseo primário que se caracteriza por apresentar uma projeção óssea recoberta por cartilagem que pode ser formado por uma única ou por múltiplas massas (osteocondromatose). O objetivo deste trabalho é descrever os achados clínicos e patológicos de um felino jovem com osteocondroma no úmero. Na avaliação clínica, o felino apresentava atrofia acentuada da musculatura do membro torácico direito além de um aumento de volume em região distal do úmero. No exame histopatológico, observou-se uma lesão proliferativa composta em sua maior parte por ossificação endocondral com focos periféricos de tecido cartilaginoso proliferado. Testes de imuno-histoquímica e reação em cadeia da polimerase revelaram a presença de antígenos de FeLV em células da linhagem hematopoiética da medula óssea e DNA proviral em linfócitos do sangue periférico, respectivamente. Os achados clínicos e patológicos foram consistentes com um osteocondroma em um felino jovem, com oito meses de idade, com lesão em úmero desde os dois meses de idade.(AU)

Osteochondroma in a young cat infected by feline leukemia virus / Ostecondroma em um felino jovem infectado pelo vírus da leucemia felina

Osteochondromas are primary bone tumors characterized by cartilage-covered bone projections involving single or multiple masses (osteochondromatosis). This study reports the clinical and pathological findings from a young domestic cat with osteochondroma in the humerus. During the clinical evaluation, the animal had pronounced right forelimb musculature atrophy and an increased distal humeral volume. Histopathological examination of the neoplasm revealed a proliferative lesion characterized mostly by endochondral ossification and peripheral foci of proliferating cartilage tissue. Further testing using immunohistochemical staining and polymerase chain reaction revealed the presence of feline leukemia virus antigens in the hematopoietic cells of the bone marrow and FeLV proviral DNA in the peripheral blood lymphocytes. Clinical and pathological findings are consistent with osteochondroma. This neoplasm occurred in an eight-month-old feline with humeral enlargement that had been present since two months old.

O osteocondroma é um tumor ósseo primário que se caracteriza por apresentar uma projeção óssea recoberta por cartilagem que pode ser formado por uma única ou por múltiplas massas (osteocondromatose). O objetivo deste trabalho é descrever os achados clínicos e patológicos de um felino jovem com osteocondroma no úmero. Na avaliação clínica, o felino apresentava atrofia acentuada da musculatura do membro torácico direito além de um aumento de volume em região distal do úmero. No exame histopatológico, observou-se uma lesão proliferativa composta em sua maior parte por ossificação endocondral com focos periféricos de tecido cartilaginoso proliferado. Testes de imuno-histoquímica e reação em cadeia da polimerase revelaram a presença de antígenos de FeLV em células da linhagem hematopoiética da medula óssea e DNA proviral em linfócitos do sangue periférico, respectivamente. Os achados clínicos e patológicos foram consistentes com um osteocondroma em um felino jovem, com oito meses de idade, com lesão em úmero desde os dois meses de idade.

Osteocondroma intratraqueal em um cão idoso relato de caso / Intratracheal osteochondroma in an old dog a case report / Osteocondroma intratraqueal en un perro viejo relato de caso

Neoplasias traqueais primárias são incomuns em cães e gatos. Os animais acometidos são geralmente de meia-idade a idosos, exceto aqueles que desenvolvem osteocondromas. As manifestações clínicas são consistentes com a obstrução das vias aéreas superiores, incluindo mais comumente tosse, intolerância ao exercício, dificuldade respiratória e cianose. O diagnóstico normalmente é feito por meio do exame radiográfico simples; a realização de traqueoscopia possibilita a identificação e a biópsia das lesões. Lesões neoplásicas devem ser diferenciadas de corpos estranhos e pólipos. Uma cadela da raça pastor alemão, de quinze anos de idade, apresentava histórico de dificuldade respiratória e tosse havia um ano, com piora progressiva. A identificação da formação foi realizada a partir do exame radiográfico simples, e o diagnóstico definitivo foi obtido pela traqueoscopia, seguida da biópsia e do exame histopatológico da formação. (AU)

Primary tracheal neoplasms are uncommon in dogs and cats. Affected animals are generally middle-aged or older, except those that develop osteochondromas. Clinical signs are consistent with upper airway obstruction, most often including cough, intolerance to exercise, breathing difficulty and cyanosis. Diagnosis is usually achieved with a simple radiographic evaluation, while the tracheoscopy allows direct visualization and sampling of the lesion. Neoplastic lesions should be differentiated from other structures such as foreign bodies and polyps. This article reports the case of a 15-year-old female German Shepherd that had a one-year history of progressive dyspnea and cough. Survey radiography helped disclose a mass, but the definite diagnosis was achieved by means of a tracheoscopy followed by biopsy and histopathological exam of the tumor.(AU)

Las neoplasias traqueales primarias son poco comunes en perros y gatos. Los animales afectados son generalmente de edad media a viejos, excepto los que desarrollan osteocondromas. Las manifestaciones clínicas son consistentes con obstrucción de las vías aéreas superiores, frecuentemente tos, intolerancia al ejercicio, dificultad respiratoria y cianosis. El diagnóstico se alcanza normalmente a través de exámen radiográfico simple; la traqueoscopía permite la identificación y biopsia delas lesiones. Las lesiones neoplásicas deben ser diferenciadas de cuerpos extraños y pólipos. Una perra Ovejero alemán de quince años presentó un histórico de dificultad respiratoria y tos desde hacía un año, con agravamiento progresivo. La identificación dela formación se consiguió a través de radiografías simples, y el diagnóstico definitivos e obtuvo por traqueoscopia, biopsia y examen histopatológico de la formación.(AU)

Osteocondroma intratraqueal em um cão idoso – relato de caso / Intratracheal osteochondroma in an old dog – a case report / Osteocondroma intratraqueal en un perro viejo – relato de caso

Neoplasias traqueais primárias são incomuns em cães e gatos. Os animais acometidos são geralmente de meia-idade a idosos, exceto aqueles que desenvolvem osteocondromas. As manifestações clínicas são consistentes com a obstrução das vias aéreas superiores, incluindo mais comumente tosse, intolerância ao exercício, dificuldade respiratória e cianose. O diagnóstico normalmente é feito por meio do exame radiográfico simples; a realização de traqueoscopia possibilita a identificação e a biópsia das lesões. Lesões neoplásicas devem ser diferenciadas de corpos estranhos e pólipos. Uma cadela da raça pastor alemão, de quinze anos de idade, apresentava histórico de dificuldade respiratória e tosse havia um ano, com piora progressiva. A identificação da formação foi realizada a partir do exame radiográfico simples, e o diagnóstico definitivo foi obtido pela traqueoscopia, seguida da biópsia e do exame histopatológico da formação.

Primary tracheal neoplasms are uncommon in dogs and cats. Affected animals are generally middle-aged or older, except those that develop osteochondromas. Clinical signs are consistent with upper airway obstruction, most often including cough, intolerance to exercise, breathing difficulty and cyanosis. Diagnosis is usually achieved with a simple radiographic evaluation, while the tracheoscopy allows direct visualization and sampling of the lesion. Neoplastic lesions should be differentiated from other structures such as foreign bodies and polyps. This article reports the case of a 15-year-old female German Shepherd that had a one-year history of progressive dyspnea and cough. Survey radiography helped disclose a mass, but the definite diagnosis was achieved by means of a tracheoscopy followed by biopsy and histopathological exam of the tumor.

Las neoplasias traqueales primarias son poco comunes en perros y gatos. Los animales afectados son generalmente de edad media a viejos, excepto los que desarrollan osteocondromas. Las manifestaciones clínicas son consistentes con obstrucción de las vías aéreas superiores, frecuentemente tos, intolerancia al ejercicio, dificultad respiratoria y cianosis. El diagnóstico se alcanza normalmente a través de exámen radiográfico simple; la traqueoscopía permite la identificación y biopsia delas lesiones. Las lesiones neoplásicas deben ser diferenciadas de cuerpos extraños y pólipos. Una perra Ovejero alemán de quince años presentó un histórico de dificultad respiratoria y tos desde hacía un año, con agravamiento progresivo. La identificación dela formación se consiguió a través de radiografías simples, y el diagnóstico definitivos e obtuvo por traqueoscopia, biopsia y examen histopatológico de la formación.