ABSTRACT
OBJECTIVES: The effect of topical N-acetylcysteine (NAC) application was investigated on the healing of acute experimental tympanic membrane perforations. MATERIALS AND METHODS: Twenty guinea pigs were used in this study. Under intraperitoneal ketamine anesthesia, incisional myringotomies were performed in the posterosuperior quadrant of the tympanic membranes with a straight otologic hook. The diameter of the perforations was approximately 2 mm. Perforations in both ears were treated with freshly prepared sponges soaked in either 0.1 ml 0.9% NaCl solution (10 control animals) or 0.6 mg/0.1 ml NAC (10 animals) for three consecutive days. All the tympanic membranes were examined by otomicroscopy on the third, fifth, seventh, and ninth days. RESULTS: In the control group, all the perforations were completely closed at the end of nine days. During the same period, only 40% of the perforations were completely closed in the NAC group. The remaining ears exhibited otorrhea by the third day. CONCLUSION: N-acetylcysteine may cause severe otorrhea in the healing process of tympanic membrane perforations. Further studies including histopathological examinations are required to elucidate this condition.
Subject(s)
Acetylcysteine/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Otitis Media, Suppurative/chemically induced , Tympanic Membrane Perforation/drug therapy , Acetylcysteine/administration & dosage , Administration, Topical , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Guinea Pigs , Otitis Media, Suppurative/pathology , Severity of Illness Index , Tympanic Membrane Perforation/pathologyABSTRACT
The etiology of cholesteatoma is still enigmatic. Of the current theories, none has been confirmed with adequately convincing evidence. A completely suitable animal model has not hitherto been available and there is still a need for further experimental studies of this entity. As a possible experimental model we suggest dimethyl-benzanthracene induced cholesteatoma in the rat.
Subject(s)
9,10-Dimethyl-1,2-benzanthracene/adverse effects , Cholesteatoma, Middle Ear/chemically induced , Animals , Cholesteatoma, Middle Ear/pathology , Disease Models, Animal , Ear Canal/drug effects , Ear Canal/pathology , Ear, Middle/drug effects , Ear, Middle/pathology , Epithelium/drug effects , Epithelium/pathology , Eustachian Tube/drug effects , Eustachian Tube/pathology , Keratins/drug effects , Otitis Media, Suppurative/chemically induced , Otitis Media, Suppurative/pathology , Rats , Rats, Sprague-Dawley , Tympanic Membrane/drug effects , Tympanic Membrane/pathologySubject(s)
Aspirin/adverse effects , Otitis Media, Suppurative/chemically induced , Otitis Media/chemically induced , Acute Disease , Child , Child, Preschool , Drainage , Female , Humans , Infant , Infant, Newborn , Male , Otitis Media, Suppurative/drug therapy , Otitis Media, Suppurative/surgery , Penicillins/therapeutic useABSTRACT
In an attempt to find a causative factor for the increased incidence of otitis media with effusion, a detailed study of 50 cases was conducted. This study included 50 cases of nonpurulent otitis media with effusion requiring ventilating tubes without tonsilloadenoid pathology. A study of these cases revealed an interesting pattern which suggests that antihistamines and decongestants may be causative or precipitating factors in the etiology of otitis media with effusion. A pilot study on the effects of these drugs on mucociliary activity was conducted and revealed further evidence that antihistamines and decongestants interfere with normal mucociliary activity which probably is a factor in abnormal Eustachian tube physiology.
