Subject(s)
Infusion Pumps , Poisoning/etiology , Adult , Drug Overdose , Equipment Failure , Female , Humans , Infant, Newborn , Magnesium Sulfate/poisoning , Oxytocin/poisoning , Poisoning/mortality , PregnancySubject(s)
Oxytocin/poisoning , Water Intoxication/chemically induced , Acute Disease , Adult , Female , Humans , PregnancyABSTRACT
The use of oxytocin in labor has the inherent danger of producing uterine hyperstimulation with resultant fetal distress. When produced by gradual titration of intravenous oxytocin, discontinuation of the medication is usually sufficient to reverse the process. However, the rapid administration of a large intravenous dose of oxytocin, as occurred in this patient, may result in hypertonic uterine contractions and fetal distress unresponsive to traditional measures. The rationale for using a tocolytic drug to reverse the uterine hypertonus, produce intrauterine fetal resuscitation, and prevent cesarean section is discussed in this report.
Subject(s)
Adrenergic beta-Agonists/therapeutic use , Fetal Distress/drug therapy , Muscle Hypertonia/drug therapy , Oxytocin/antagonists & inhibitors , Uterine Contraction/drug effects , Adult , Female , Fetal Distress/chemically induced , Humans , Muscle Hypertonia/chemically induced , Oxytocin/poisoning , Pregnancy , Ritodrine/therapeutic useSubject(s)
Ergonovine/poisoning , Infant, Newborn, Diseases/chemically induced , Oxytocin/poisoning , Pulmonary Edema/chemically induced , Accidents , Humans , Infant, Newborn , Infant, Newborn, Diseases/mortality , Infant, Newborn, Diseases/pathology , Lung/pathology , Male , Pulmonary Edema/mortality , Pulmonary Edema/pathologyABSTRACT
The clinical course is described of an infant who accidentally received an adult dose of Syntometrine (synthetic oxytocin + ergometrine) at delivery. The infant soon became ill with convulsions and ventilatory failure, and later with water intoxication. Similar reported cases are reviewed and recommendations are given for the management of future cases.
