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1.
Am J Surg ; 231: 18-23, 2024 May.
Article in English | MEDLINE | ID: mdl-38641371

ABSTRACT

BACKGROUND: Surgical management for Paget's disease (PD) of the breast is controversial. This study aims to assess outcomes of PD patients based on procedure type and determine the reliability of imaging in estimating disease extent. METHODS: A retrospective review analyzed clinicopathologic data of PD patients between 2009 and 2022. Pre-operative imaging size (PIS) was compared to post-operative pathology size (PPS) looking at concordance. RESULTS: Thirty patients had PD, 21 underwent total mastectomy (TM) and 9 breast conserving surgery (BCS). Seventeen patients (56.7 â€‹%) had a final diagnosis of invasive cancer (14 â€‹TM, 3 BCS), with no local recurrences. Only 6/19 (31.6 â€‹%) patients with positive findings on ultrasound/mammogram had concordance between PIS and PPS. There were no breast/chest wall recurrences with a median follow up of 35.9 months. CONCLUSION: Ultrasound and mammogram had poor concordance with pathological size. BCS is feasible in select patients. MRI may help guide management.


Subject(s)
Adenocarcinoma , Breast Neoplasms , Paget's Disease, Mammary , Humans , Female , Paget's Disease, Mammary/diagnostic imaging , Paget's Disease, Mammary/surgery , Mastectomy , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/surgery , Reproducibility of Results , Breast/pathology , Retrospective Studies , Adenocarcinoma/surgery
3.
Pathol Res Pract ; 253: 155058, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38181578

ABSTRACT

Primary melanoma of the nipple (PMN) is exceedingly rare, with only single cases reported to date. We identified 10 patients with PMN: 5 females, 5 males, median age 55.5 years (range 29-66) at diagnosis of melanoma in situ (4 cases) or invasive melanoma (6 cases, Breslow depth 0.2 mm to 3.5 mm). Follow-up was available for all 10 patients (median 19 months, range 1-183). Nine patients had no evidence of disease; one patient died of disease (13.5 months) after presenting with a nodal metastasis. One case was exceptional, because the patient presented with a pigmented lesion that histopathologically exhibited co-existence of melanoma in situ and Paget disease, a challenging differential diagnosis due to immunohistochemical pitfalls in distinction between melanoma in situ and the pigmented variant of mammary Paget disease. Here we report the second largest series of PMN including a case of PMN colliding with mammary Paget disease, to raise awareness of these rare malignancies.


Subject(s)
Adenocarcinoma , Breast Neoplasms , Melanoma , Paget's Disease, Mammary , Skin Neoplasms , Male , Female , Humans , Adult , Middle Aged , Aged , Melanoma/complications , Melanoma/diagnosis , Melanoma/pathology , Paget's Disease, Mammary/diagnosis , Nipples/pathology , Skin Neoplasms/pathology , Adenocarcinoma/pathology , Breast Neoplasms/complications , Breast Neoplasms/pathology
7.
Am J Dermatopathol ; 46(3): 175-178, 2024 Mar 01.
Article in English | MEDLINE | ID: mdl-38153267

ABSTRACT

ABSTRACT: Mammary Paget disease is a rare form of breast cancer, which typically presents as an eczematous plaque on the nipple or surrounding skin. It is often a clinical diagnosis that is confirmed with skin biopsy. Histologic hallmarks of mammary Paget disease include large, pleomorphic, malignant, ductal epithelial cells within the epidermis. Chronic lichenoid inflammation may be seen in the papillary dermis but is not diagnostic. Because mammary Paget disease often overlies ductal carcinoma in situ or invasive carcinoma of the breast, prompt bilateral mammography is warranted. We report a case of Paget disease of the nipple with negative breast imaging that was originally misdiagnosed due to a dense lichenoid infiltrate obscuring the neoplasm.


Subject(s)
Adenocarcinoma , Breast Neoplasms , Carcinoma , Paget's Disease, Mammary , Humans , Female , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/pathology , Breast Neoplasms/pathology , Carcinoma/pathology , Skin/pathology , Adenocarcinoma/pathology , Nipples/pathology , Inflammation/pathology
8.
J Cutan Pathol ; 51(4): 280-283, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38114301

ABSTRACT

Pigmented mammary Paget disease is a rare variant of mammary Paget disease that is often clinically misdiagnosed as a melanocytic lesion of the skin or nipple-areolar complex. Careful morphological assessment, along with the performance of adequate immunohistochemical stains, will help in achieving the right diagnosis and avoiding misdiagnosis of the entity as malignant melanoma. We report a rare case of pigmented mammary Paget disease with concomitant colonization of the underlying invasive ductal carcinoma by melanocytes mimicking melanoma.


Subject(s)
Breast Neoplasms , Melanoma , Paget's Disease, Mammary , Pigmentation Disorders , Humans , Female , Paget's Disease, Mammary/pathology , Diagnosis, Differential , Breast Neoplasms/pathology , Melanocytes/pathology , Melanoma/diagnosis , Melanoma/pathology , Pigmentation Disorders/pathology , Pigmentation
9.
Am J Dermatopathol ; 46(1): 46-49, 2024 Jan 01.
Article in English | MEDLINE | ID: mdl-37982495

ABSTRACT

ABSTRACT: Male breast cancer comprises less than 1% of all breast cancer cases. Mammary Paget disease (MPD) represents a subset of breast cancer that presents with skin changes of the nipple and areola, and is frequently misdiagnosed clinically due to similarities with other disease states, leading to an average delay in diagnosis of 1 month to 2 years. Pigmented mammary Paget disease (PMPD) is an uncommon variant of MPD that clinically and histologically resembles malignant melanoma. Due to variable immunohistochemical staining patterns, analysis can be challenging and often requires interpretation of panels for accurate diagnosis. We present a rare case of PMPD in a male, originally diagnosed both clinically and histologically as malignant melanoma, to highlight the diagnostic challenges that this entity presents, and to review staining patterns which may be useful in its diagnosis.


Subject(s)
Breast Neoplasms, Male , Breast Neoplasms , Melanoma , Paget's Disease, Mammary , Skin Neoplasms , Humans , Male , Breast Neoplasms/pathology , Breast Neoplasms, Male/diagnosis , Breast Neoplasms, Male/pathology , Diagnosis, Differential , Melanoma/diagnosis , Melanoma/pathology , Nipples/pathology , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology
10.
Zhonghua Bing Li Xue Za Zhi ; 52(8): 832-837, 2023 Aug 08.
Article in Chinese | MEDLINE | ID: mdl-37527989

ABSTRACT

Objective: To investigate the expression of MSI1 and HER2 in mammary Paget's disease, and the correlation between the expression levels of MSI1 and HER2 and the clinicopathologic characteristics and prognosis of the patients. Methods: Clinical data and paraffin-embedded specimens of 34 pairs of mammary Paget's disease and underlying breast cancer were collected at the Department of Pathology, Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University from March 2011 to December 2019. Immunohistochemistry was used to detect the expression of MSI1 and HER2 in mammary Paget's disease and the accompanying breast cancer, and to analyze the correlation between the expression levels of MSI1 and HER2 and their clinicopathologic features, as well as their influence on prognosis. Results: In mammary Paget's disease, the positive rate of MSI1 was 91.2% (31/34) and the positive rate of HER2 was 88.2% (30/34); the expression of MSI1 and HER2 was positively correlated (P=0.001, r=0.530). The expression of MSI1 was positively correlated with menopausal status (r=0.372, P=0.030) and lymph node metastasis (r=0.450, P=0.008). HER2 expression was positively correlated with menopausal status (r=0.436, P=0.010), and negatively correlated with ER expression (r=-0.365, P=0.034). The co-expression of MSI1 and HER2 was positively correlated with age (r=0.347, P=0.044) and menopausal status (r=0.496, P=0.003), and negatively correlated with ER expression (r=-0.461, P=0.006). Conclusions: MSI1 and HER2 are highly expressed in mammary Paget's disease and their expression levels are positively correlated. The correlation analysis between clinicopathological features and prognosis suggests that both of them may be involved in the occurrence and development of mammary Paget's disease and are potential therapeutic targets for mammary Paget's disease.


Subject(s)
Breast Neoplasms , Paget's Disease, Mammary , Humans , Female , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/metabolism , Paget's Disease, Mammary/pathology , Breast Neoplasms/pathology , Prognosis , Lymphatic Metastasis , Nerve Tissue Proteins/metabolism , RNA-Binding Proteins
12.
Cancer Med ; 12(13): 14104-14111, 2023 07.
Article in English | MEDLINE | ID: mdl-37170681

ABSTRACT

PURPOSE: To classify the molecular subtypes of Paget's disease of the breast, and then compare them with general breast cancer to get deeper understanding of this disease and offer better management of associate patients in clinical decisions. METHODS: We used immunohistochemistry to examine 42 cases of this disease by antibodies against estrogen and progesterone receptors, Ki-67, as well as human epidermal growth factor receptor 2 (HER-2). Due to damage and loss of specimens, etc., we obtained 36 pathological specimens from the 42 patients. For 30 of 36 pathological specimens (83.3%), we obtained a complete molecular subtype. Cause the other 6 pathological specimens have missing immunohistochemistry items. For patients with bilateral breast cancer, only information on the side with PDB is listed. For patients with recurrence, only information on the first onset was included. We finally compared and studied the molecular subtype of 26 samples. We calculated the relative frequencies of molecular subtypes including luminal A, luminal B, HER-2-enriched, and basal-like and compared them between PDB and general breast carcinomas in other studies. RESULTS: The luminal A and B subtype were found, respectively, in 3 (11.5%) and 6 (23.1%) of all patients, and 15 cases of HER-2-enriched subtype was detected (57.7%). In addition, 2 (7.7%) showed a basal-like subtype. CONCLUSION: The molecular subtypes of common breast cancer and PDB-associated breast cancer differ. Luminal subtypes are the most common in the former, while within our samples HER-2 positive subtype was the highest in PDB-associated breast carcinoma. With further understanding of this disease, rational therapies will be applied in different patients and cures for PDB and PDB-associated carcinoma will be achieved.


Subject(s)
Adenocarcinoma , Breast Neoplasms , Carcinoma , Paget's Disease, Mammary , Humans , Female , Paget's Disease, Mammary/pathology , Immunohistochemistry , Breast Neoplasms/pathology , Carcinoma/complications , Adenocarcinoma/complications
13.
Int J STD AIDS ; 34(10): 735-739, 2023 09.
Article in English | MEDLINE | ID: mdl-37097071

ABSTRACT

Paget's disease was first described in 1874 as an eczematoid changes of the nipple associated with underlying breast carcinoma. Extra-mammary Paget's disease (EMPD) is rare with involvement of the male genitalia described in small case series and management options varying according to location and extent. The diagnosis of EMPD requires a high index of clinical suspicion and close liaison with the multidisciplinary team, particularly histopathology. We present two cases of EMPD affecting the male external genitalia that highlight important learnings in the presentation, diagnosis, and management of EMPD.


Subject(s)
Adenocarcinoma , Breast Neoplasms , Paget Disease, Extramammary , Paget's Disease, Mammary , Male , Humans , Paget Disease, Extramammary/diagnosis , Paget Disease, Extramammary/surgery , Paget Disease, Extramammary/pathology , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/surgery , Paget's Disease, Mammary/pathology , Breast Neoplasms/diagnosis , Breast Neoplasms/pathology , Penis/pathology
14.
Arkh Patol ; 85(2): 32-39, 2023.
Article in Russian | MEDLINE | ID: mdl-37053351

ABSTRACT

Paget's disease of the breast is a rare type of cancer that affects the skin of the nipple and usually the areola. At the same time, most patients also have one or more tumors in the immediate vicinity of the focus of mammary Paget's disease. This tumor must be distinguished from normal or atypical Toker cells, and also differentiated from diseases such as Bowen's disease of the nipple and melanocytic lesions of the nipple and areola region, including nipple melanoma and BAP1-inactivated nevus (Wiesner nevus). Currently, there is no routine pathological diagnostic algorithm for these conditions. The aim of the work is to formulate a clear clinical and morphological algorithm for diagnosing Paget's disease of the breast and Toker cells, Bowen's disease of the nipple and areola, as well as melanoma and BAP1-inactivated nevi of the above localizations. Surgical material obtained from patients with Paget's disease of the breast (18), Toker cells of the nipple (2), Bowen's disease of the nipple (6), melanoma of the nipple (1), BAP1-inactivated nevus (1) was studied. The material was examined histologically with hematoxylin and eosin staining, Alcian blue and PAS reaction, as well as immunohistochemically with the following panel of antibodies: CD138, p53, CK8, CK7, HER2/neu, EMA, HMB-45, Melan A, S-100, p63, p16 and BAP1. An easy-to-learn pathoanatomical algorithm for diagnosing Paget's cancer has been developed, which will be especially useful for pathologists who encounter pathology of the nipple and areola in their work.


Subject(s)
Adenocarcinoma , Bowen's Disease , Breast Neoplasms , Melanoma , Nevus , Paget's Disease, Mammary , Skin Neoplasms , Humans , Female , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/pathology , Bowen's Disease/diagnosis , Bowen's Disease/pathology , Diagnosis, Differential , Melanoma/diagnosis , Adenocarcinoma/diagnosis , Skin Neoplasms/diagnosis , Breast Neoplasms/diagnosis , Nevus/diagnosis
16.
Tidsskr Nor Laegeforen ; 143(5)2023 03 28.
Article in Norwegian | MEDLINE | ID: mdl-36987906

ABSTRACT

BACKGROUND: Paget's disease of the nipple comprises approximately 1 % of all breast cancers, and presents with unilateral eczematoid changes to the nipple, areola or surrounding skin. Symptoms can be pain, itching or stinging in the area. CASE PRESENTATION: A female patient in her sixties presented to the skin clinic 18 months after initial detection of a rash surrounding her left nipple. Earlier ultrasound and mammography had not indicated pathology. Clinical suspicion and punch biopsies revealed a ductal carcinoma in situ. Surgical excision had to be repeated three times before the underlying malignancy was totally removed. INTERPRETATION: Eczematoid changes in the nipple area are associated with underlying ductal carcinoma or a carcinoma in situ, and biopsies should be taken.


Subject(s)
Breast Neoplasms , Eczema , Paget's Disease, Mammary , Humans , Female , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/pathology , Paget's Disease, Mammary/surgery , Nipples/pathology , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/surgery , Eczema/pathology , Mammography , Pain
17.
J Cutan Pathol ; 50(5): 434-440, 2023 May.
Article in English | MEDLINE | ID: mdl-36808637

ABSTRACT

BACKGROUND: Trichorhinophalangeal syndrome type 1 (TPRS1) expression has been found to be highly sensitive and specific for breast carcinomas. The frequency of TRPS1 expression in cutaneous neoplasms such as mammary Paget disease (MPD) and extramammary PD (EMPD) is currently unknown. We assessed the utility of TRPS1 immunohistochemistry (IHC) in the evaluation of MPD, EMPD, and their histopathologic mimics, squamous cell carcinoma in situ (SCCIS) and melanoma in situ (MIS). METHODS: Twenty-four MPDs, 19 EMPDs, 13 SCCISs, and 9 MISs were subjected to immunohistochemical analysis using anti-TRPS1 antibody. The intensity (none, 0; weak, 1+ ; moderate, 2+ ; strong, 3+ ) and proportion (<1%, absent; 1%-25%, focal; 26%-75%, patchy; >75%, diffuse) of TRPS1 expression were recorded. Relevant clinical data were documented. RESULTS: TPRS1 expression was present in 100% (24/24) of MPDs, with 88% (21/24) of MPDs exhibiting strong, diffuse immunoreactivity. Sixty-eight percent (13/19) of EMPDs showed TRPS1 expression. Intriguingly, EMPDs lacking TRPS1 expression were consistently of perianal origin. TRPS1 expression was seen in 92% (12/13) of SCCISs but was absent in all MISs. CONCLUSIONS: TRPS1 may be useful to distinguish MPDs/EMPDs from MISs, but its utility is limited in distinguishing them from other pagetoid intraepidermal neoplasms such as SCCISs.


Subject(s)
Paget Disease, Extramammary , Paget's Disease, Mammary , Repressor Proteins , Female , Humans , Biomarkers, Tumor/metabolism , Breast Neoplasms/pathology , Immunohistochemistry , Paget Disease, Extramammary/diagnosis , Paget Disease, Extramammary/metabolism , Paget Disease, Extramammary/pathology , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/metabolism , Paget's Disease, Mammary/pathology , Repressor Proteins/metabolism , Skin Neoplasms/metabolism , Skin Neoplasms/pathology
18.
Br J Hosp Med (Lond) ; 84(1): 1-8, 2023 Jan 02.
Article in English | MEDLINE | ID: mdl-36708338

ABSTRACT

Paget's disease of the breast typically affects postmenopausal women and is associated with an underlying malignancy. Skin changes are a common presenting symptom, as well as a lump, nipple discharge, pain and changes to the nipple shape. Imaging options include ultrasound for women under the age of 35 years or mammogram and ultrasound for women over the age of 40 years. The definitive diagnostic investigation is a tissue core biopsy. Cases are discussed by a multidisciplinary team to decide on the optimal management strategy. Management options are typically surgical and include breast-conserving surgery or mastectomy in addition to oncoplastic techniques. Sentinel lymph node biopsy is performed in all patients undergoing surgery. Adjuvant chemotherapy, radiotherapy or endocrine therapy can be used to treat concomitant invasive disease or ductal carcinoma in situ.


Subject(s)
Breast Neoplasms , Carcinoma, Intraductal, Noninfiltrating , Paget's Disease, Mammary , Humans , Female , Adult , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/therapy , Paget's Disease, Mammary/pathology , Mastectomy , Breast Neoplasms/diagnosis , Breast Neoplasms/therapy , Breast Neoplasms/pathology , Carcinoma, Intraductal, Noninfiltrating/pathology , Carcinoma, Intraductal, Noninfiltrating/surgery , Nipples/pathology
19.
J Cancer Res Clin Oncol ; 149(3): 1175-1184, 2023 Mar.
Article in English | MEDLINE | ID: mdl-35364707

ABSTRACT

PURPOSE: Little is known about the prognostic value of androgen receptor (AR) status in mammary Paget's disease (MPD). The purpose of this study was to explore AR status and the distribution of molecular subtypes in MPD as well as the relationship between AR expression and clinicopathological factors and to evaluate its prognostic value. METHODS: We analyzed 170 MPD patients of varying subtypes. AR expression was verified by immunohistochemical staining, and the correlations between AR expression and clinicopathological characteristics and survival status were analyzed. We further investigated 91 MPD patients with invasive ductal carcinoma (MPD-IDC). RESULTS: AR was expressed in 55.3% of overall MPD patients, and 78.2% had the human epidermal growth factor receptor 2 (HER2) overexpression subtype. AR positivity was significantly correlated with BMI (P = 0.037) and pathological N stage (P = 0.023). Multivariate analysis indicated that pathological T stage and pathological N stage were independent prognostic factors for overall survival (OS). The positive AR group was significantly associated with better OS (P = 0.014). Among 91 MPD-IDC patients, AR was expressed in 56.0%, and 80.0% had the HER2 overexpression subtype. AR positivity was significantly correlated with pathological N stage (P = 0.033). Multivariate analysis indicated that AR and pathological T stage were independent prognostic factors for OS. Furthermore, AR positivity was significantly related to better OS (P = 0.005) in MPD-IDC patients as well as in patients with the HER2 overexpression subtype (P = 0.029). CONCLUSION: Our results confirmed that AR is a potential biomarker for evaluating the prognosis of patients.


Subject(s)
Breast Neoplasms , Carcinoma, Ductal, Breast , Paget's Disease, Mammary , Humans , Female , Paget's Disease, Mammary/complications , Paget's Disease, Mammary/metabolism , Paget's Disease, Mammary/pathology , Receptors, Androgen , Prognosis , Gene Expression , Breast Neoplasms/complications , Carcinoma, Ductal, Breast/pathology
20.
Surgery ; 173(3): 619-625, 2023 03.
Article in English | MEDLINE | ID: mdl-36273972

ABSTRACT

BACKGROUND: The objective of this study was to evaluate racial differences in treatment (ie, surgery, chemotherapy, and radiation) and survival among patients with Paget's disease of the breast in the Surveillance, Epidemiology and End Result program. METHODS: Women >18 years old diagnosed with localized or regional Paget's disease between January 1, 2010 to December 31, 2016 in the Surveillance, Epidemiology and End Result program were included. The cohort was divided into Black and White patients. Univariable analysis compared the groups. Using propensity score matching, Black and White patients were nearest matched (1:2) on age at diagnosis; Surveillance, Epidemiology and End Result summary stage; surgery; chemotherapy; and year of diagnosis. The log-rank test evaluated the matched sample's overall survival and disease-specific survival. RESULTS: Of the 1,181 patients, the racial distribution was 1,049 (88.8%) White and 132 (11.2%) Black. A higher percentage of Black women were Medicaid insured (Black 25.8% vs White 11.1%), lived in neighborhoods with low socioeconomic status (Black 53.0% vs White 25.4%), and had regional disease than White women (Black 41.7% vs White 29%). There were no racial differences in receipt of radiation therapy (P = .90), breast surgery (P = .23), or axillary surgery (P = .25). Black patients were more likely to receive chemotherapy (Black 34.8% vs White 26.3% P = .038). In the propensity matched cohort, Black patients had a worse overall survival (P < .005) and disease-specific survival (P = .05) than White patients. CONCLUSION: In this cohort of patients with Paget's disease, despite differences in sociodemographic factors, there were no disparities in locoregional treatment. However, on matched analysis, Black patients had a worse overall survival and disease-specific survival than their White counterparts.


Subject(s)
Adenocarcinoma , Breast Neoplasms , Paget's Disease, Mammary , United States/epidemiology , Humans , Female , Adolescent , Paget's Disease, Mammary/therapy , White People , Breast , Black People , Breast Neoplasms/therapy , Healthcare Disparities
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