ABSTRACT
People with diabetes have been experimenting with and modifying their own diabetes devices and technologies for many decades in order to achieve the best possible quality of life and improving their long-term outcomes, including do-it-yourself (DIY) closed loop systems. Thousands of individuals use DIY closed loop systems globally, which work similarly to commercial systems by automatically adjusting and controlling insulin dosing, but are different in terms of transparency, access, customization, and usability. Initial outcomes seen by the DIY artificial pancreas system community are positive, and randomized controlled trials are forthcoming on various elements of DIYAPS technology.
Subject(s)
Diabetes Mellitus/therapy , Glycemic Control/instrumentation , Pancreas, Artificial , Self-Management , Automation/instrumentation , Automation/methods , Blood Glucose Self-Monitoring/history , Blood Glucose Self-Monitoring/instrumentation , Blood Glucose Self-Monitoring/trends , Community Networks/history , Community Networks/trends , Diabetes Mellitus/blood , Diabetes Mellitus/drug therapy , Glycemic Control/history , Glycemic Control/methods , Glycemic Control/trends , History, 20th Century , History, 21st Century , Humans , Insulin/administration & dosage , Insulin Infusion Systems/history , Insulin Infusion Systems/trends , Pancreas, Artificial/history , Pancreas, Artificial/supply & distribution , Pancreas, Artificial/trends , Patient Advocacy/history , Patient Advocacy/trends , Self Efficacy , Self-Management/history , Self-Management/methods , Self-Management/psychology , Self-Management/trendsABSTRACT
In past decades, a rapid evolution of diabetes technology led to increased popularity and use of continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) in the ambulatory setting for diabetes management, and recently, the artificial pancreas became available. Efforts to translate this technology to the hospital setting have shown accuracy and reliability of CGM, safety of CSII in appropriate populations, improvement of inpatient glycemic control with computerized glycemic management systems, and feasibility of inpatient CGM-CSII closed-loop systems. Several ongoing studies are focusing on continued translation of this technology to improve glycemic control and outcomes in hospitalized patients.
Subject(s)
Diabetes Mellitus/therapy , Hospitalization , Hyperglycemia/therapy , Inventions , Blood Glucose/analysis , Blood Glucose Self-Monitoring/history , Blood Glucose Self-Monitoring/instrumentation , Blood Glucose Self-Monitoring/trends , Diabetes Mellitus/blood , Diabetes Mellitus/drug therapy , Diabetes Mellitus/history , History, 20th Century , History, 21st Century , Hospitalization/trends , Humans , Hyperglycemia/blood , Hyperglycemia/drug therapy , Hyperglycemia/history , Inpatients , Insulin/administration & dosage , Insulin Infusion Systems/history , Insulin Infusion Systems/supply & distribution , Insulin Infusion Systems/trends , Inventions/history , Inventions/trends , Pancreas, Artificial/history , Pancreas, Artificial/supply & distributionSubject(s)
Diabetes Mellitus , Inventions/trends , Adult , Blood Glucose Self-Monitoring/history , Blood Glucose Self-Monitoring/instrumentation , Blood Glucose Self-Monitoring/trends , Child , Diabetes Mellitus/blood , Diabetes Mellitus/drug therapy , History, 21st Century , Humans , Insulin/administration & dosage , Insulin Infusion Systems/history , Insulin Infusion Systems/supply & distribution , Insulin Infusion Systems/trends , Inventions/history , Pancreas, Artificial/history , Pancreas, Artificial/supply & distribution , Pancreas, Artificial/trendsABSTRACT
Intensive insulin therapy (IIT) has been shown to reduce micro- and macrovascular complications in patients with type 1 diabetes mellitus (T1DM). However, IIT is associated with a significant increase in severe hypoglycemic events, resulting in increased morbidity and mortality. Optimization of glycemic control without hypoglycemia (especially nocturnal) should be the next major goal for subjects on insulin treatment. The use of insulin pumps along with continuous glucose monitors (CGMs) has made it easier but requires significant resources and patient education. Research is ongoing to close the loop by integrating the pump and the CGM using different algorithms. The currently available closed-loop system is the threshold suspend. Steps needed to achieve a near-perfect closed-loop are (1) a control-to-range system that will reduce the incidence and/or severity of hyper- and/or hypoglycemia by adjusting the insulin dose and (2) a control-to-target system, a fully automated or hybrid system that sets target glucose levels to individual needs and maintains glucose levels throughout the day using insulin (unihormonal) alone or with other hormones such as glucagon or possibly pramlintide (bihormonal). Future research is also focusing on better insulin delivery devices (pumps), more accurate CGMs, better predictive algorithms, and ultra-rapid-acting insulin analogs to make the closed-loop system as physiological as possible.