ABSTRACT
Granular parakeratosis (GP) is a rare, idiopathic, and benign skin condition that presents classically as erythematous to brown hyperkeratotic papules that can coalesce into plaques. Axillary GP was initially observed by Northcutt and colleagues and has since been described in various other areas of the body including other intertriginous and non-intertriginous sites. The term "granular parakeratosis" is now used to describe not only the skin condition, but also a distinctive histological reactive pattern on biopsy specimens that are either regarded as the disease itself, or merely as an incidental finding. Upon review of the current findings, opinions, and associations of this entity, we propose the reappraisal of GP as a reactive pattern, rather than a distinct entity.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Dermatologic Agents/therapeutic use , Parakeratosis/drug therapy , Parakeratosis/pathology , Axilla/pathology , Biopsy, Needle , Female , Humans , Immunohistochemistry , Incidence , Male , Parakeratosis/classification , Parakeratosis/epidemiology , Prognosis , Rare Diseases , Risk Assessment , Severity of Illness Index , Treatment OutcomeABSTRACT
Introducción: en 1978, Ackerman añadió a los tradicionales términos de hiperqueratosis ortoqueratósica y paraqueratósica tres variedades de la primera: laxa, compacta y laminar. Método: en este artículo redefinimos y matizamos tales términos llamando la atención sobre un aspecto no estudiado anteriormente: la apetencia tintorial de cada una de esas variedades de capa córnea. Resultados: la capa córnea laxa, normal o hiperqueratósica es siempre basófila. La córnea compacta, normal, hiperqueratósica o heterotópica muestra dos variantes, una basófila y otra eosinófila. La córnea laminar es siempre eosinófila igual que la córnea paraqueratósica. Conclusiones: tomando como base la apetencia tintorial de la capa córnea (basófila o eosinófila) y su estructura (laxa, compacta, laminar o paraqueratósica), se propone un algoritmo con el que efectuar una descripción objetiva de la capa córnea epidérmica de cada biopsia. Se discute la significación de cada una de esas variedades atendiendo a la localización del proceso biopsiado (AU)
Subject(s)
Humans , Epidermis/pathology , Parakeratosis/diagnosis , Keratoderma, Palmoplantar/diagnosis , Epidermis/cytology , Parakeratosis/pathology , Parakeratosis/classification , Keratoderma, Palmoplantar/pathology , Basophils/pathologyABSTRACT
A study of dermatopathological specimens exhibiting parakeratosis has been made and the parakeratosis classified on morphological and topographical criteria. Twelve patterns of parakeratosis have been identified and their association with particular pathological conditions described.