Subject(s)
Breast Neoplasms/complications , Paraneoplastic Syndromes, Ocular/etiology , Vitelliform Macular Dystrophy/etiology , Fatal Outcome , Female , Fluorescein Angiography , Humans , Middle Aged , Neoplasm Metastasis , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Tomography, Optical Coherence , Vitelliform Macular Dystrophy/diagnostic imagingABSTRACT
PURPOSE: To report a case of bilateral diffuse uveal melanocytic proliferation associated with renal carcinoma and to illustrate the importance of ancillary examinations to early diagnosis and treatment. DESIGN: Clinical case report. METHODS: A 56-year-old man reported a 3-day history of visual impairment and scotoma in the right eye. An ophthalmoscopic examination, visual field test, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, optical coherence tomography, and systemic evaluation were performed. RESULTS: Fundus examination showed multiple nevus-like uveal pigmented lesions bilaterally. Optical coherence tomography showed a subfoveal serous retinal detachment and focal loss of the retinal pigment epithelium with adjacent areas of retinal pigment epithelial thickening in the right eye, explaining the scotoma on the visual field examination. Indocyanine green angiography showed multiple round areas of hypofluorescence corresponding to the nevus-like pigmented tumors seen on funduscopy, and retinal pigment epithelium damage corresponding to hypoautofluorescence on fundus autofluorescence imaging and window defects points seen on fluorescein angiography bilaterally. After bilateral diffuse uveal melanocytic proliferation diagnosis, a systemic workup showed clear cell carcinoma in the left kidney. Owing to the tumoral size, chemotherapy was administered. CONCLUSION: Renal carcinoma associated with bilateral diffuse uveal melanocytic proliferation is rare, and the patterns observed in the ancillary examinations, including indocyanine green angiography, are useful for early-stage diagnosis and immediate referral for systemic investigation and treatment.
Subject(s)
Coloring Agents , Early Detection of Cancer/methods , Indocyanine Green , Kidney Neoplasms/complications , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Uveal Neoplasms/diagnostic imaging , Fluorescein Angiography/methods , Humans , Male , Middle AgedSubject(s)
Autoantibodies/blood , Brain Neoplasms/pathology , Germinoma/pathology , Nerve Tissue Proteins/immunology , Optic Nerve Diseases/pathology , Paraneoplastic Syndromes, Ocular/pathology , Pinealoma/pathology , Adolescent , Biomarkers, Tumor/metabolism , Blotting, Western , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/immunology , Brain Neoplasms/surgery , Germinoma/diagnostic imaging , Germinoma/immunology , Germinoma/surgery , Humans , Hydrolases , Immunohistochemistry , Magnetic Resonance Imaging , Male , Microtubule-Associated Proteins , Optic Nerve Diseases/diagnostic imaging , Optic Nerve Diseases/immunology , Optic Nerve Diseases/surgery , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Paraneoplastic Syndromes, Ocular/immunology , Paraneoplastic Syndromes, Ocular/surgery , Pineal Gland/pathology , Pinealoma/diagnostic imaging , Pinealoma/immunology , Pinealoma/surgeryABSTRACT
PURPOSE: To report a case of paraneoplastic vitelliform maculopathy in a patient with metastatic melanoma of unknown primary site. METHODS: Case report. Main outcome measures include funduscopic examination, fluorescein angiography, fundus autofluorescence, and spectral domain optical coherence tomography. RESULTS: A 44-year-old man with a known history of metastatic melanoma was referred for ophthalmic evaluation because of bilateral vision loss. Funduscopic examination was remarkable for vitelliform maculopathy that was confirmed with fundus autofluorescence and spectral domain optical coherence tomography. CONCLUSION: We describe a rare case of paraneoplastic vitelliform maculopathy. There are many etiologies of acquired vitelliform retinal lesions in the retina. Multimodal retinal imaging, including fundus autofluorescence and spectral domain optical coherence tomography, can be best used to identify these lesions. A history of systemic metastatic melanoma should be ruled out in patients with vitelliform maculopathy.
Subject(s)
Melanoma/secondary , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Vitelliform Macular Dystrophy/diagnostic imaging , Adult , Humans , MaleABSTRACT
Paraneoplastic retinopathy is a rare cause of painless vision loss, associated with an underlying (and often occult) systemic malignancy. Ocular examination findings are subtle, and the diagnosis is often made on the basis of electrophysiology findings. This report describes the case of a 48-year-old Caucasian man with paraneoplastic retinopathy presenting as visual disturbance, central scotomata and abnormal electrophysiology. He was subsequently diagnosed with papillary thyroid malignancy.
Subject(s)
Blindness/etiology , Carcinoma/complications , Paraneoplastic Syndromes, Ocular/complications , Retinal Diseases/etiology , Thyroid Neoplasms/complications , Carcinoma/surgery , Carcinoma, Papillary , Humans , Male , Middle Aged , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Retinal Diseases/diagnostic imaging , Thyroid Cancer, Papillary , Thyroid Neoplasms/surgery , Thyroidectomy , Tomography, Optical CoherenceSubject(s)
Melanoma/complications , Paraneoplastic Syndromes, Ocular/pathology , Skin Neoplasms/complications , Aged, 80 and over , Humans , Lymphatic Metastasis , Male , Melanoma/diagnostic imaging , Melanoma/pathology , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Radiography, Thoracic , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/pathology , Tomography, Optical CoherenceABSTRACT
CLINICAL CASE: A 33-year-old male diagnosed with Parinaud's syndrome, exotropia and post-papillary oedema optic atrophy in his left eye. A pineal germinoma was diagnosed after performing neuroimaging scans and a stereotactic biopsy. He was treated with chemotherapy and radiotherapy, showing a complete pathological response. The Parinaud's syndrome persists one year after diagnosis and the patient has refused to have strabismus surgery. DISCUSSION: Parinaud's syndrome consists of a supranuclear vertical gaze palsy resulting from damage to the midbrain tectum. The involvement of adjacent structures leads to the «Parinaud-plus¼ syndrome. When a Parinaud's syndrome is accompanied by diplopia («Parinaud-plus¼ syndrome), extension of the injury into adjacent areas must be considered.
Subject(s)
Diplopia/etiology , Germinoma/complications , Ocular Motility Disorders/etiology , Paraneoplastic Syndromes, Ocular/etiology , Pinealoma/complications , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cisplatin/administration & dosage , Combined Modality Therapy , Cranial Irradiation , Diplopia/diagnostic imaging , Etoposide/administration & dosage , Germinoma/drug therapy , Germinoma/radiotherapy , Humans , Male , Ocular Motility Disorders/diagnostic imaging , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Pinealoma/drug therapy , Pinealoma/radiotherapy , Remission Induction , Urinary Incontinence/etiology , Ventriculoperitoneal ShuntSubject(s)
Antirheumatic Agents/adverse effects , Hydroxychloroquine/adverse effects , Paraneoplastic Syndromes, Ocular/chemically induced , Retinal Diseases/chemically induced , Antirheumatic Agents/administration & dosage , Female , Fluorescein Angiography , Humans , Hydroxychloroquine/administration & dosage , Lupus Erythematosus, Systemic/drug therapy , Middle Aged , Optical Imaging , Paraneoplastic Syndromes, Ocular/diagnosis , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Retinal Diseases/diagnosis , Retinal Diseases/diagnostic imaging , Tomography, Optical CoherenceABSTRACT
Neuromyelitis optica spectrum disorders (NMOSD) occasionally develop in patients with tumor in relation to aquaporin-4 IgG (AQP4-IgG), representing a new paraneoplastic phenomenon. We reported three patients with paraneoplastic NMOSD and provided a comprehensive review of the literature. A total of 34 cases with paraneoplastic NMOSD were identified from our own case database (n = 3) and the previous literature (n = 31). The median age at NMOSD-related symptom onset was 50.5 years, and 91% of the cases were female. 11 (32%) cases had breast carcinoma. In 15 (44%) cases, NMOSD-related symptoms preceded tumor detection [median, 4 (range 1-180) months], and in 19 (56%) cases, symptoms followed tumor detection [median, 12 (range 3-180) months]. 5/14 (36%) cases had hiccups and vomiting as the initial symptoms, with the involvement of medulla oblongata. In 10/14 (71%) cases, cervical spinal cord was involved. In contrast to idiopathic NMO, NMOSD is more likely to be paraneoplastic than in patients aged over 50 years at the onset of symptoms, especially for female patients. Breast carcinoma is the most common tumor associated with paraneoplastic NMOSD, accounting for nearly a third of all types of tumors. Paraneoplastic NMOSD usually involves medulla oblongata and cervical spinal cord. We recommend adding AQP4-IgG as an onconeural antibody, but its clinical utility warrants further investigations.
Subject(s)
Neuromyelitis Optica , Paraneoplastic Syndromes, Ocular , Adolescent , Adult , Age of Onset , Female , Humans , Male , Neuromyelitis Optica/diagnostic imaging , Neuromyelitis Optica/epidemiology , Neuromyelitis Optica/physiopathology , Paraneoplastic Syndromes, Ocular/diagnostic imaging , Paraneoplastic Syndromes, Ocular/epidemiology , Paraneoplastic Syndromes, Ocular/physiopathologyABSTRACT
We present an interesting [18F]fluoro-2-deoxyglucose positron emission tomography (FDG-PET) imaging finding in a patient with ocular flutter and cerebellar ataxia as part of anti-Ma 1/2 antibody-mediated paraneoplastic syndrome associated with a testicular seminoma. He had a typical anterior mesial temporal hyperintensity on magnetic resonance imaging (MRI) without gadolinium enhancement. In addition, his FDG-PET images showed increased deep cerebellar and inferior rectus and superior oblique ocular muscles FDG uptake. This case is the first to visualize in vivo the possible underlying neuropathological mechanism of ocular flutter associated with cerebellar nuclei on functional imaging.