ABSTRACT
B-, H- and L-catepsine-like activity regarding Na-benzoyl-D,L-arginine-4-nitroanilide, L-leucine-4-nitroanilide and azocasein was studied in the blood plasma of patients with different diseases of thyroid, parathyroid and adrenal glands. It has been shown that the high H- catepsine-like activity confirming the activation of blood catepsin H secretion accompanied by the tissue growth under any pathology took place in the blood plasma of patients with all the above diseases. High B- catepsine-like activity in the blood plasma of patients with thyroid diseases was exceptionally fixed under the nodular forms of thyroid pathology, while the character of changes in L catepsine-like activity under these diseases was not so natural. In diaseses of the adrenal glands the changes in the B- and L-catepsine-like activity were only shown in the blood plasma of patients with cerebral layer tumors but not the gland cortex: B-catepsine-like activity increased in the blood plasma of patients with benign or malignant tumors, and L-catepsine-like activity decreased under benign tumor from chromaffin tissue. The established picture of changes in enzymatic activity in the blood plasma of patients does not allow to think that the determination of blood B- and L- catepsine-like activity can be recommended for obtaining additional information at diagnosis thyroid diseases.
Subject(s)
Adrenal Gland Diseases/blood , Cathepsin B/blood , Cathepsin H/blood , Cathepsin L/blood , Parathyroid Diseases/blood , Thyroid Diseases/blood , Adrenal Gland Diseases/enzymology , Adult , Female , Humans , Male , Parathyroid Diseases/enzymology , Thyroid Diseases/enzymologyABSTRACT
No disponible
Subject(s)
Humans , Magnesium/metabolism , Ion Channels/physiology , Parathyroid Diseases/enzymology , Risk Factors , Magnesium Deficiency/physiopathology , Chondrocalcinosis/physiopathology , Tetany/physiopathologyABSTRACT
Acid-phosphatase-rich granules, separate from the parathyroid-hormone-containing secretory granules, have been demonstrated in the normal, adenomatous and primary hyperplastic human parathyroid glands. These granules are thought to represent lysosomes which are derived from the Golgi region. In the normal glands these granules are postulated to be associated with involution of the cell organelles during the normal secretory cycle. In the adenomatous and hyperplastic glands evidence is presented that these lysosomes are associated with the destruction of secretary granules and parthyroid hormone.
