Revisión histórica de la fisiología de las glándulas paratiroides / Historical review of the physiology of parathyroid glands

Las glándulas paratiroides fueron identificadas por primera vez en humanos, por Ivan Sãndstrom (1880). Von Recklinghausen en 1891 describe un "linfonódulo marrón rojizo" bajo la tiroides de un paciente con fibrosis quística ósea. Ese mismo año Gley asocio la pérdida en la función de las paratiroides con la tetania. Vassale y Generali publicaron un trabajo en 1897 realizado tras tiroidectomías en perros y concluyen que una de las funciones de las paratiroides era la remoción de toxinas, concordando con la "teoría de detoxificación". G. Moussu (1898) clamó haber tratado satisfactoriamente a un paciente con tetania administrándole extracto acuoso de paratiroides equinas. En 1903 Askanazy establece que los tumores de la glándula tiroides u otras glándulas endocrinas y afecciones descalcificantes esqueléticas podrían relacionarse al describir el primer caso de asociación entre un tumor paratiroideo y la enfermedad de Von Recklinghausen. MacCallum y Voegtlin (1924), tras numerosos estudios, dedujeron que la paratiroides actuaba como moduladora del metabolismo del calcio. Collip (1925) confirmó el rol protagónico de las paratiroides en la regulación del calcio mediante experimentos basados en que la "paratirina" podía aliviar la tetania post-paratiroidectomía Barnicot en 1948 concluye que la hormona paratiroidea estimula la resorción osteoclásica de forma directa; ese nismo año, Jahan y Pitts demostraron que esta hormona incrementa la reabsorción renal tubular de calcio y magnesio. En 1973, Aurbach purifica cierta cantidad de hormona paratiroidea, caracterizándose su estructura proteica y molecular. La clonación de su receptor por Jüppner y Abou-Samra (1991) permitió estudiar con mayor énfasis sus acciones celulares.

Parathyroid glands were identified by the first time in human beings by Ivan Sãndstrom (1880). Von Recklinghausen in 1891 describes "lymph node reddish brown" low thyroid of patients with fibrosis cystic in bones. The same year Gley associated the loss in the function of the parathyroids with tetania. Vassale and Generali published a review in 1897 realized after thyroidectomies in dogs and they concluded that one of the parathyroid functions was the renoval of toxins, agreeing with "theory of detoxification". G. Moussu (1898) cried out to have treated satisfactorily a patient with tetania administering watery extract of equine parathyroids. In 1903 Askanazy establishes that the tumors of the thyroid gland or other endocrines glands and decalcifying affections of the skeleton might be related on having described the first case of association between a parathyroid tumor and Von Recklinghausen's disease. Mac callum and Voegtlin (1924), alter numerous studies, deduced that parathyroid was actuating like modulating of the metabolism of the calcium. Collip (1925) confirmed the leading role of the parathyroid glands in the regulation of calcium by means of experiments based on which the "parathyrina" could relieve the postparathyroidectomy tetania. Barnicot in 1948 concludes that the parathyroid hormone stimulates the osteoclastic resorption directly, the same year, Jahan and Pitts demonstrated that this hormone increases the renal tubular reabsorption of calcium and magnesium. In 1973, Aurbach purifies certain quatity of parathyroid hormone, its multifaceted and molecular structure being characterized. The cloning of its receptor for Jüppner and Abou-Samra(1991) allowed to study with bigger emphasis its cellular actions.

History of parathyroid gland surgery: an historical case series.

The history of the parathyroid glands is a fascinating one full of famous medical names. The discovery of the glands was followed by laborious research into their anatomy, embryology and pathology and into the physiology of calcium metabolism; this led to the manufacture of hormone substitutes and, finally, to the refinement of surgical techniques. The glands were first identified in 1850 by Sir Richard Owen, conservator of the Hunterian Museum, but it was not until 1880 that the term 'glandulae parathyroideae' was first used. The physiology of parathyroid hormone and calcium metabolism eluded physicians and the forefathers of thyroid surgery alike for several decades more. Patients were treated as curiosities and were documented as untreatable medical patients or as inexplicable thyroid surgery complications. Halsted noticed the 'disastrous results from the loss of the glands' and the resulting tetany, as did Billroth. It is the patients, however, who best illustrate the journey of discovery. In this review, we discuss three cases, highlighting their contributions.

A historical perspective on surgery of the thyroid and parathyroid glands.

The history of thyroid and parathyroid surgery dates back thousands of years, but the developments leading to the contemporary era began just over a century ago. Pioneers in the field include Billroth, Kocher, Mayo, and Halsted. This article examines the historical progress of operating on the thyroid and parathyroid and the impact of physiology on surgery, surgery on physiology, and recent advances in technologies.

First parathyroid surgeon: Sir John Bland-Sutton and the parathyroids.

Felix Mandl from Vienna has long been acclaimed as having carried out the first parathyroidectomy for primary hyperparathyroidism in 1925. He was not, however, the first surgeon to have seen the parathyroid glands, either at surgery or in the pathology laboratory. There is evidence that the first intentional removal of a parathyroid tumour was probably carried out at the Middlesex Hospital, London, UK, by Sir John Bland-Sutton at least a decade earlier. Indeed, Sir John Bland-Sutton appeared to have been very much aware of the parathyroid gland and the pathology associated with it for many years, even before this first parathyroid operation. He described a post-mortem specimen of a parathyroid tumour in 1886; he surgically removed a parathyroid cyst in 1909; and then carried out an intentional parathyroidectomy for a parathyroid tumour some time before 1917.

[History of surgery of the parathyroid glands]. / Histoire de la chirurgie des glandes parathyroïdes.

In 1850 Sir Richard Owen discovered the parathyroid glands in rhinoceros. After they have been discovered in man in 1880 their history spread all along the 20th century. The history started from the descriptive anatomy and the clinical pictures of their illness to the trouble of their functioning. The hormone was studied while the surgeons began to cure adenoma, hyperplasia and cancers.

Historical perspective of parathyroid disease.

This article highlights key historical developments in the understanding of parathyroid function and disease, a story that involves many clinical investigators and classic scientific debate. The current medical community is certainly indebted to the innate curiosity and perseverance of these historical figures.

The glandulae parathyroideae of Ivar Sandström. Contributions from two continents.

The parathyroid glands, the last major organ to be recognized in man, were discovered in 1880 by Ivar Sandström, a Swedish medical student. Initially, the discovery attracted little attention; later, with the uncovering of the relationship of the glands to severe bone disease, interest quickened. In the early 1900's, Jacob Erdheim demonstrated that the four parathyroid glands were enlarged in osteomalacia and in rickets; he concluded correctly that this was a compensatory phenomenon. Subsequently, occasional cases of bone disease (von Recklinghausen's disease of bone) were encountered in which only a single gland was enlarged. In 1915, Friedrich Schlaugenhaufer suggested that enlargement of a single parathyroid gland might be the cause of the bone disease, not its result. The first parathyroidectomy for von Recklinghausen's disease of bone was performed by Felix Mandl in 1925 in Vienna. Subsequently, the parathyroid glands were shown to be affected by a number of primary pathological processes-neoplasia (adenoma and carcinoma) and hyperplasia (wasserhelle-cell and chief-cell types)-that resulted in overactivity and required surgical removal of one or more of them.

[Landmarks in the history of parathyroid research]. / Markierungspunkte in der Geschichte der Parathyreoideaforschung.

The history of parathyroid research begins in the middle of the 19th century with the identification of the glands, the importance of which remained for a long time unexplored. Marking points of investigations (role in calcium metabolism) are demonstrated. Special problems of hypo- and hyperparathyroidism remained of interest up to the present day.