ABSTRACT
Secondary malignancies are an important cause of morbidity and mortality in childhood cancer survivors. Salivary gland tumors account for about 6% of the second cancers. The majority of these are mucoepidermoid carcinomas (MEC) of the parotid gland. We report the clinical and pathological features of a rarer histological type, acinic cell carcinoma (ACC), in a childhood acute lymphoblastic leukemia (ALL) survivor. The behavior of secondary ACC appears similar to primary tumor and similar treatment may be adopted. Early recognition and complete resection is important for achieving a good outcome. Careful monitoring for recurrence or a third malignancy is needed.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Carcinoma, Acinar Cell/etiology , Neoplasms, Radiation-Induced/etiology , Neoplasms, Second Primary/etiology , Parotid Neoplasms/etiology , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Whole-Body Irradiation/adverse effects , Adenoma, Sweat Gland/etiology , Adenoma, Sweat Gland/surgery , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Asparaginase/administration & dosage , Asparaginase/adverse effects , Carcinoma, Acinar Cell/chemically induced , Carcinoma, Acinar Cell/radiotherapy , Carcinoma, Acinar Cell/surgery , Child, Preschool , Combined Modality Therapy/adverse effects , Cyclophosphamide/administration & dosage , Cyclophosphamide/adverse effects , Cytarabine/administration & dosage , Cytarabine/adverse effects , Daunorubicin/administration & dosage , Daunorubicin/adverse effects , Epirubicin/administration & dosage , Epirubicin/adverse effects , Etoposide/administration & dosage , Etoposide/adverse effects , Follow-Up Studies , Humans , Male , Mercaptopurine/administration & dosage , Mercaptopurine/adverse effects , Methotrexate/administration & dosage , Methotrexate/adverse effects , Neoplasms, Radiation-Induced/radiotherapy , Neoplasms, Radiation-Induced/surgery , Neoplasms, Second Primary/chemically induced , Neoplasms, Second Primary/radiotherapy , Neoplasms, Second Primary/surgery , Parotid Neoplasms/chemically induced , Parotid Neoplasms/radiotherapy , Parotid Neoplasms/surgery , Prednisolone/administration & dosage , Prednisolone/adverse effects , Recurrence , Remission Induction , Survivors , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/surgery , Vincristine/administration & dosage , Vincristine/adverse effectsABSTRACT
Primary parotid gland tumors are rare during childhood; however, these tumors are more common as second malignant neoplasms following radiation therapy. The authors report a case of secondary parotid mucoepidermoid carcinoma after chemotherapy for childhood acute lymphoblastic leukemia.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Carcinoma, Mucoepidermoid/chemically induced , Neoplasms, Second Primary/chemically induced , Parotid Neoplasms/chemically induced , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Asparaginase/administration & dosage , Brain Neoplasms/prevention & control , Carcinoma, Mucoepidermoid/radiotherapy , Carcinoma, Mucoepidermoid/surgery , Child, Preschool , Cyclophosphamide/administration & dosage , Cytarabine/administration & dosage , Daunorubicin/administration & dosage , Disease-Free Survival , Humans , Male , Methotrexate/administration & dosage , Parotid Neoplasms/radiotherapy , Parotid Neoplasms/surgery , Prednisone/administration & dosage , Vincristine/administration & dosageSubject(s)
Areca , Parotid Neoplasms/chemically induced , Plant Extracts , Plants, Medicinal , Tannins , Animals , Female , Male , Mice , Parotid Neoplasms/pathologyABSTRACT
Two cases are presented of malignant tumour of the parotid gland following sialography with Thorotrast, 28 and 45 years previously. Both cases were histologically established as squamous cell carcinoma and the presence of Thorotrast in the tumours was confirmed by autohistoradiography. It is suggested that the tumours may have developed from metaplastic ductal epithelium after many years of exposure to the alpha radiation from Thorotrast deposits in the gland.
Subject(s)
Carcinoma, Squamous Cell/chemically induced , Parotid Neoplasms/chemically induced , Sialography , Thorium Dioxide/adverse effects , Autoradiography , Carcinoma, Squamous Cell/diagnostic imaging , Carcinoma, Squamous Cell/pathology , Contrast Media , Female , Humans , Middle Aged , Parotid Gland/pathology , Parotid Neoplasms/diagnostic imaging , Parotid Neoplasms/pathologyABSTRACT
Pretreatment of rats with isoprenaline sulphate (IPR) stimulated DNA synthesis in both salivary and mammary gland tissues. Salivary gland tumours induced by N-methyl-N-nitrosourea (MNU) were observed for the first time in rats, but occurred only in IPR-pretreated animals given MNU during the period of IPR-stimulated DNA synthesis. The cumulative index of MNU-induced mammary tumours and the number of tumours per tumour-bearing rat were increased by IPR-pretreament only if the animals received MNU during the period of IPR-stimulated DNA synthesis.
