Trastorno límite de la personalidad (TLP): características, etiología y tratamiento / Borderline personality disorder (BPD): features, etiology and treatment

El trastorno límite de personalidad (TLP) se ha considerado como el paradigma de trastorno severo de la personalidad. Los principales síntomas son el comportamiento suicida, la autolesión no suicida, el comportamiento agresivo y la reactividad emocional. El inicio del TLP depende de la combinación de factores genéticos y ambientales, especialmente de la vulnerabilidad biológica y la exposición a experiencias traumáticas durante la infancia. Entre sus características destacan las alteraciones en la percepción de posibles amenazas y rechazo social, las interacciones emoción-cognición y alteraciones de la cognición social, la importancia del estrés social y la mentalización. En el aspecto neurobiológico destacan alteraciones del volumen de diversas estructuras cerebrales, metabolismo cerebral, alteraciones funcionales y de la conectividad funcional. Los trastornos psiquiátricos comórbidos más frecuentes en los pacientes con TLP son ansiedad, trastornos afectivos, trastorno por déficit de atención e hiperactividad, trastorno de estrés postraumático y abuso de sustancias. En lo que se refiere al tratamiento, destacan las técnicas psicológicas, como la terapia conductual dialéctica y la EMDR, pero es frecuente la utilización de fármacos eficaces para síntomas específicos, como agresividad/hostilidad o falta de control de los impulsos

Borderline personality disorder (BPD) is considered the most severe personality disorder. Principal symptoms are suicidal behavior, non-suicidal injuries, aggressive behavior and emotional hyperreactivity. BPD onset depends of the combination of genetics and environmental factors, specially on biological vulnerability and exposition to traumatic experiences during childhood. The main features are threatened feelings, social rejection, interactions emotion-cognition and social cognition disorders, social stress and mentalization difficulties. About neurobiological aspects, we can highlight disorders in brain structures, brain metabolism, functional and functional connectivity. The most common comobird deseases in pacients with BPD are anxiety, affective disorders, attention deficit and hiperactivity disorder (ADHD), post traumatic stress disorder (PTSD) and substance abuse. According to treatment, psychological techniques are employed such as dialectical behavioral technique, EMDR. Usually, we can also associate drugs for controlling specific symptoms such as aggressivity o impulse control disabilities

Accurate phenotyping: Reconciling approaches through Bayesian model averaging.

Genetic research into complex diseases is frequently hindered by a lack of clear biomarkers for phenotype ascertainment. Phenotypes for such diseases are often identified on the basis of clinically defined criteria; however such criteria may not be suitable for understanding the genetic composition of the diseases. Various statistical approaches have been proposed for phenotype definition; however our previous studies have shown that differences in phenotypes estimated using different approaches have substantial impact on subsequent analyses. Instead of obtaining results based upon a single model, we propose a new method, using Bayesian model averaging to overcome problems associated with phenotype definition. Although Bayesian model averaging has been used in other fields of research, this is the first study that uses Bayesian model averaging to reconcile phenotypes obtained using multiple models. We illustrate the new method by applying it to simulated genetic and phenotypic data for Kofendred personality disorder-an imaginary disease with several sub-types. Two separate statistical methods were used to identify clusters of individuals with distinct phenotypes: latent class analysis and grade of membership. Bayesian model averaging was then used to combine the two clusterings for the purpose of subsequent linkage analyses. We found that causative genetic loci for the disease produced higher LOD scores using model averaging than under either individual model separately. We attribute this improvement to consolidation of the cores of phenotype clusters identified using each individual method.