Persecutee in the Third Reich, full professor in the GDR: The communist physician Carl Coutelle (1908-1993) and his post-war career as pathologist.

As an avowed communist, Carl Coutelle was one of the few (future) pathologists persecuted for purely political reasons in the Third Reich. Despite this peculiarity, his life has received little attention. The present article takes the existing research desideratum as an opportunity to elaborate on Coutelle's fate during the Nazi era, but also on his academic rise to the position of full professor at the University of Halle (GDR). The analysis is based on extensive files from various German archives. The article pursues a twofold question: On the one hand, it seems necessary to clarify how Coutelle's life between 1933 and 1945 can be characterized and classified, and on the other hand, it is of interest whether he owed his career in the GDR primarily to scientific merit or to state support. It can be shown that Coutelle's career path reflects the prevailing political power relations: With the beginning of the Third Reich, Coutelle was completely disenfranchised because of his political views; he was forced to emigrate, interrupted his nascent scientific career, and became actively involved in the international anti-fascist resistance. After the war, Coutelle became one of the protagonists of the socialist transformation and denazification of the health care system in the Soviet Occupation Zone. Now his career took the opposite course: Although his research performance was below average compared to other pathologists from the GDR, the avowed communist was appointed full professor - due to state intervention and against the declared will of the faculty in Halle.

Nazi, collaborator or opponent? The role of the pathologist Robert Rössle in the Third Reich.

For many, Robert Rössle is one of the most important pathologists of the first half of the 20th century. His research in the fields of inflammation, constitution, growth and age, and immunity gave him the status of a pioneer. Because he was not a nominal member of the Nazi Party (NSDAP), Rössle did not have to undergo denazification proceedings and was able to continue his academic career seamlessly after 1945. Only recently, the question of Rössle's actual role in the Third Reich has been raised - in connection with a possible renaming of the Robert-Rössle-Straße in Berlin. Our paper takes this issue as an opportunity to critically examine Rössle's involvement in National Socialism. For this study, all available literature and extensive primary material on Rössle from various archives was reviewed and evaluated with regard to the question posed. The investigations show that Rössle held a number of offices in the administrative apparatus of the Nazi state even though not being a party member. They gave him access to high-ranking representatives and most likely also knowledge about medical crimes. Rössle researched and published on hereditary biology and racial hygiene issues, thus supporting the ideology of the Nazi State. Robert Rössle must be regarded as an early proponent of racial hygiene, political collaborator and profiteer of the Third Reich. However, it remains unclear whether he was directly involved in human experiments. There is no evidence that he critically distanced himself from his role in the Third Reich after 1945.

From unskilled worker to full professor: The eventful life and career of the Jewish pathologist Herman Medak (1914-1991).

The Jewish pathologist Herman Medak (1914-1991) went down in medical history as a pioneer in the early detection of oral carcinomas. As a longtime full professor of oral pathology at the University of Illinois, he influenced several generations of students and young researchers. His many experimental studies attracted special attention, as did his "Atlas of Oral Cytology" (1970). Largely unknown, however, is the fact that the Viennese-born scientist had to flee from the Nazi regime immediately before his medical state examination and thus arrived in the United States without a qualifying professional degree. This article attempts to fill the existing research gaps and to reconstruct Medak's life and work. It sheds light on Medak's years of study in Vienna, his forced emigration from Austria, his restart in the U.S. and his path to becoming a full professor of oral pathology. It also addresses the question of why Medak remained in Chicago until the end of his life and how the University of Vienna later dealt with its expelled students. The analysis is based on a large number of documents from archives in Austria and the U.S., but also on transcripts and other material from the private collection of the Medak family. These documents were supplemented and compared with the relevant secondary literature. It can be shown that Medak had to overcome considerable setbacks not only in Vienna, but also in the U.S., before he got on the road to professional success. Five factors ultimately proved to be career-enhancing: the Nimbus of the "Vienna School", Medak's unconditional striving for education, his deliberate specialization in oral pathology, his early international contacts and his willingness to adapt and acculturate. Like most other displaced scholars, Medak was widely ignored in postwar Austria. Today, the University of Vienna maintains an online memorial book that also provides information about Medak - albeit still rudimentary.

[The pathologist Hans Klein (1912-1984) : Autopsy of his role in the "Third Reich"]. / Der Pathologe Hans Klein (1912­1984) : Obduktion seiner Rolle im "Dritten Reich".

The role of pathologist Hans Klein during the National Socialist era and his career in post-war Germany have hardly received systematic attention. During World War II, Hans Klein worked in two medical institutions, where he collaborated with individuals who were significantly involved in Nazi crimes. Klein's participation initially extended mainly to his work as an employed pathologist at the Rudolf Virchow Hospital in Berlin. There he was introduced to autopsy practices in the context of the children's euthanasia programme and autopsies of victims of medical experiments. Later, a shift in his activities is noticeable at the Hohenlychen Sanatorium. Klein's activities there increasingly involved independent research or voluntary collaboration in the projects of other scientists that were closely connected to the SS and experiments on human beings in concentration camps. He never had to face justice. His role was not further investigated by the Allies - probably due to his non-existent Nazi party and SS membership.

Political pragmatist or man of conviction? Heinrich Bredt (1906-1989) and his involvement in the Third Reich.

Heinrich Bredt (1906-1989) has to be considered one of the most prominent German pathologists of the past century. While his scientific oeuvre - especially his research on pathology of the cardiovascular system - received widespread attention, his actual connection to National Socialism remains largely concealed. This paper takes this need for clarification as an occasion for a detailed investigation of Bredt's political role in the Third Reich, based on source material from Federal, State and University Archives. The analysis shows that Heinrich Bredt had already joined the anti-Semitic and anti-democratic Association of German Students in the 1920s, and from 1933 onward he entered various Nazi organizations - including the Nazi Party. Unlike in later statements, Bredt was not just a nominal member of the Party, he held various offices in National Socialist organizations and was accordingly classified as loyal to the regime by the Nazi authorities. In contrast, during his time in the socialist dictatorship of East Germany, Bredt remained aloof from the ruling Socialist Unity Party of Germany and its political organizations - unlike many former Nazi Party members who behaved in a political opportune manner in East Germany as well. Bredt demonstrated a distance from the socialist system which suggests that his political actions were guided not by pragmatic but by ideological considerations.

Just "one of so many"? The pathologist Theodor Fahr (1877-1945) and his ambivalent relationship to National Socialism.

Theodor Fahr is well known as a pioneer in renal pathology and the eponym of "Fahr's disease". While his professional merits are undisputed, his relationship to National Socialism remains unclear. On the one hand, he signed the public "oath of allegiance" of German professors to Adolf Hitler, on the other hand, he appeared as a mentor to his Jewish colleague Paul Kimmelstiel. In 1945, Fahr committed suicide after being dismissed by the Allied military government for political reasons. However, he left behind memoirs in which he outlined himself as a determined opponent of National Socialism. It is precisely these ambiguities that form the starting point of this study. The aim is to reconstruct Fahr's personal and professional career and to outline his political stance in the Third Reich. In addition, it will be clarified how Fahr's life and work were received after 1945 and whether (or how) his relationship to National Socialism was addressed. This study is based on different types of sources: Various archival documents on Fahr and Kimmelstiel are compared and contrasted with Fahr's unpublished autobiography and the available secondary literature on Fahr and his work. The analysis shows that Fahr's relationship to National Socialism became more distanced over time. However, he did not emerge as a critic of Nazi ideology during the Third Reich - even though he claimed in his memoirs that he had consistently despised Hitler. While Fahr is not to be considered an ardent National Socialist, he held to the stereotype of the "unscrupulous" Jew. The study concludes that Fahr was a politically ambivalent character with a distinctly anti-Semitic disposition, which he tried to soften by emphasizing his relationships with individual Jewish colleagues such as Kimmelstiel.

Hans Joachim Scherer: an under-recognized pioneer of glioma research in Belgium.

Hans Joachim Scherer (1906-1946) was a German pathologist who fled Germany to Belgium to work on glioma genesis, growth and progression. Despite being seldom cited, and due to the contributions discussed in this article, Hans Joachim Scherer, can be considered a founding father of contemporary neuropathology and glioma research. We discuss Scherer's achievements in glioma classification, glomerular structures of glioma, primary and secondary glioblastoma, glioma growth patterns, non-resectability of glioma, pseudopalisadic necrosis and the late occurrence of symptoms in glioma.

From emigration to remigration: The Jewish pathologist Fritz Meyer (1875-1953) and his extraordinary life course.

Fritz Meyer (1875-1953) is undoubtedly one of the most enigmatic pathologists and internists of his time: He emerged early as a major researcher in the field of infectious diseases. Later, he also focused on heart and lung diseases and became a celebrity doctor who treated ambassadors and prominent contemporaries of the United States. The course of his life was as unusual as his professional activities: At the beginning of the Third Reich, Meyer experienced far-reaching repression due to his Jewish ancestry, which led to forced emigration to the USA. Although he achieved professional success in his new homeland, he returned to Germany in 1948 - as one of very few Jewish emigrants from the Third Reich. This article takes these peculiarities as an opportunity to take a closer look at Fritz Meyer: It recapitulates the biography and scientific merits of the Jewish pathologist and pays special attention to the background of his emigration to the USA and his later remigration to Germany. The central basis of the study are contemporary newspaper articles and various archival sources evaluated for the first time. These sources are compared with the sparse secondary literature on Meyer and other persecuted pathologists. The results of the study can be summarized in five points: (1) Meyer's research on infectious diseases - especially diphtheria, tuberculosis and serum therapy - was considered leading-edge at the time. (2) Meyer suffered widespread repression after 1933, which led him to emigrate to the United States in 1935. (3) Thanks to influential contacts, he was able to continue his professional career in the U.S. almost seamlessly. (4) In the postwar period, he decided to return to Germany, mainly out of attachment to Europe. (5) His reintegration in Germany seemed to be successful - however, he died only a few years after his remigration. The analysis leads to the conclusion that Meyer's social reintegration in postwar Germany was significantly facilitated by his professional reputation and his largely apolitical demeanor in public; nevertheless, it can be shown that he secretly lamented the lack of consciousness of guilt of the German postwar population. Several indications cast doubt on his intention to remain permanently in Germany. This includes the fact that he held on to his U.S. citizenship until the end of his life and that his wife remained in the United States.

Facts and fiction: The pathologist Gerhard Seifert (1921-2014) and his dealings with National Socialism.

Gerhard Seifert is considered one of the leading German pathologists of his time. He was not only an outstanding scientist but also shaped the politics of university pathology like hardly anyone else. In the context of a national research project on the role of German pathologists in the Third Reich, it was recently discovered that Seifert had joined the Nazi Party. The present study takes this hitherto unknown fact as an occasion for a closer analysis of Seifert's life and work - with a special focus on the Third Reich; the aim is to clarify (1) when and how Seifert's membership came about and (2) how he dealt with the Nazi era and his own political role in the period after 1945. The present study is based on various archival documents. Furthermore, Seifert's autobiography "A Saxon in Hamburg - A Doctor's Life from East to West" was evaluated and cross-referenced with the archival sources. Last not least a systematic re-analysis of the literature on Seifert was conducted, including eulogies and obituaries on his life and work. It can be shown that Gerhard Seifert was an outstanding scientist - with special merits in the fields of oral pathology (including salivary glands), the pathology of the pancreas, endocrine pathology and osteopathology -, an extensive networker and an enigmatic personality. However, it is also demonstrable that Seifert joined the Nazi Party at the age of 17, remained a member until its abolition at the end of the Second World War, and concealed his party membership after 1945. In this respect, he built his career in postwar Germany on a false statement.

"I have had an exceedingly beautiful life" The Jewish gynecopathologist Robert Meyer (1864-1947) and his extraordinary response to Nazi repression.

The Jewish scientist Robert Meyer received worldwide professional recognition as a pioneer gynecopathologist. Before his death, he wrote a memoir in which he gave an entirely positive assessment of his life. The latter, however, is at odds with the fact that he was disenfranchised by the National Socialists and driven into emigration. But even before Hitler's seizure of power, he had to cope with several strokes in private as well as in professional life. This article takes these apparent inconsistencies as an occasion for a fundamental analysis of Robert Meyer's life and work. Special attention is paid to his scientific achievements, but also to repressive experiences in the Third Reich, the background of his emigration and his specific handling of these adversities. Various archival documents, Meyer's memoirs, and other contemporary writings by and about Robert Meyer and about the development of the field of gynecopathology serve as central sources. The study concludes that Meyer made fundamental contributions to the embryology of the vagina, ovarian tumors, cancer diagnosis, endometriosis, and genital and fetal abnormalities. Despite his scientific merits, he was never granted a regular professorship - mainly, because he was professionally caught between two stools (gynecology and pathology), but also due to low career ambition. Nevertheless, thanks to influential supporters, he was able to hold out in Germany until 1939, when he emigrated to the United States. Meyer considered his life "beautiful" despite many misfortunes because he defined happiness in life primarily in terms of fulfilling personal relationships and was willing to accept life as it comes. In addition, he found distraction and fulfillment in his scientific work.

William Hunter's aristocratic post mortems.

William Hunter's writings, lectures and his collection of circa 1,400 pathological specimens at the University of Glasgow show that, within the scientific limitations of the 18th Century, he had a sound grasp of the significance of morbid anatomical appearances. Unlike John Hunter's collection at the Royal College of Surgeons of England, few of the Hunterian specimens at Glasgow have an accompanying case history. Within the Special Collections at the Glasgow University Library are a small number of post mortem reports, including four involving William Hunter's aristocratic patients. This article explores these patient cases, and also the only instance recorded by John Hunter of William working with him on a post mortem of an aristocrat, that of the Marquis of Rockingham, Prime Minister, who died in 1782. The study aims to better understand William Hunter's medical practice and his professional connections with other practitioners. The post mortem examinations were carried out by a surgeon/anatomist and observed by the patient's physician(s). For aristocratic post mortems, those attending were senior and well-established practitioners. The notes made were not particularly detailed. The reports show clearly that William Hunter's practice, in the 1760s at least, was not confined to midwifery.

Aldred Scott Warthin: Ann Arbor's Erudite, Outspoken, and Academically Transformative Early 20th Century Pathologist.

CONTEXT.­: Aldred Scott Warthin, MD, PhD, was professor of pathology and director of the pathological laboratory at the University of Michigan during the first third of the 20th century. OBJECTIVE.­: To explore the life and accomplishments of Dr. Warthin and his impact on academic anatomic and clinical pathology. DESIGN.­: Available primary and secondary historic sources were reviewed. RESULTS.­: After studying music, biology, and botany, Warthin attended medical school at the University of Michigan, graduating in 1891; he remained in Ann Arbor for 40 years, almost single-handedly transforming a rundown department into a top academic department. He was a dedicated teacher who produced 2 important pathology textbooks. His research interests were diverse. In 1913, he published one of the first papers unambiguously documenting heritability of cancers; subsequent research on one of his cancer families resulted in the description of Lynch Syndrome. He published extensively in the fields of surgical pathology and experimental pathology. He was a recognized expert on syphilis and pathology of aging. CONCLUSIONS.­: Warthin's name is eponymously associated with Warthin-Finkeldey giant cells in measles, Warthin's tumor of the parotid, and Warthin-Starry stain for the diagnosis of syphilis as well as Warthin's sign in the clinical diagnosis of pericarditis.

The Accidental Pathologist: A Curiosity-Driven Journey from Plant Evolution to Innate Immunity.

I have had the singular opportunity to perform research and to participate in medical education. Not unexpectedly, people have asked me which of the two was more important to me. My answer has always been and remains that I am equally passionate about research and teaching. My research has been curiosity driven and not purposeful; hence, I was willing to take risks. That my research led to the discovery of natural killer cells and the unraveling of the molecular basis of a human disease was an unexpected reward. By contrast, my interest in medical education was purposeful, with the goal of improving healthcare by teaching pathology as the scientific foundation of medicine. It started with participation in Robbins pathology texts but progressed toward development of technology-based tools for medical education. This was driven by the belief that technology, by providing equal access to knowledge across the world, can be a powerful democratizing force.

Success or failure? Pathologists persecuted under National Socialism and their careers after emigrating to the United States.

This study examines the biographies of pathologists persecuted by the National Socialists after their emigration from the German Reich to the USA. The work is based on primary sources from various archives and a systematic evaluation of secondary literature on the persons concerned. The study yields five central results: (1) Out of 118 identified persecuted pathologists, a total of 91 persons left the German Reich, 60 of them demonstrably to the USA. (2) The majority of the pathologists immigrated to the USA between 1938 and 1941. (3) A good two thirds of the pathologists were (again) employed in the USA as university teachers, the majority in the leading position of Full Professor. (4) The preferred area of employment was the East Coast of the USA. (5) The labor market situation was particularly favorable for specialized pathologists. It can be concluded that the majority of the emigrated pathologists studied succeeded in continuing or even expanding their professional careers in the USA, with existing academic networks playing a noticeable role. Pathology thus occupies a special position in the context of the migration history of persecuted physicians under National Socialism.

Morton E Hall: Conservator of the Canadian War Museum in London, England during the Great War and Alberta's Second Pathologist.

Morton Eldred Hall (1887-1975), a little known pioneer pathologist in Western Canada who had trained at Belleview Hospital in New York City, arrived at the newly forming medical school at the University of Alberta in Edmonton in 1914. Shortly after this, First World War broke out and Hall enlisted. He was eventually posted at the Royal College of Surgeons in London where he assisted Sir Arthur Keith, the conservator of the Hunterian Museum and the Army Medical Collection, pathological specimens derived from fallen Dominion soldiers which were to be preserved as teaching specimens to help train military surgeons. Keith and Morton published important papers documenting the types of wounds generated by modern warfare. These papers are all that remain of the British War Collection as the museum was bombed by the Germans during Second World War. Specimens derived from Canadian casualties had been repatriated to Canada. Hall briefly served as the conservator for the Canadian Medical War Museum, the name given to Canadian specimens. After safely getting these precious war relics home in 1919, Hall returned to Edmonton where he was head of pathology at the Royal Alexandra Hospital, associate professor of pathology, and developed unique insights into university politics.

[Walter Büngeler (1900-1987) : Nazi victim or political influencer in Brazil?] / Walter Büngeler (1900­1987) : Opfer der NS-Zeit oder nationalsozialistischer Kontaktmann in Brasilien?

Walter Büngeler is one of the best known German pathologists of the 20th century. He became internationally known for his basic research on leukaemia and the pathology of tumours. In 1936 he left Europe for Brazil but returned in 1942. After 1945, he staged himself as a political victim who had been expelled first by the National Socialists and later from Brazil. In fact, with this portrayal he succeeded in passing the denazification procedure without any damage and in continuing and considerably expanding his university career. Until the recent past, Büngeler was described in the relevant literature as a Nazi critic or victim. But does the presentation handed down by Büngeler stand up to a critical examination of the facts?On the basis of contemporary sources, the article reveals serious differences between Büngeler's statements and historical facts. It can be shown that Büngeler's allegations in denazification were incorrect in all relevant aspects.

What the early pathologists got wrong, and right, about the pathology of Crohn's disease: a historical perspective.

Surgeons, who documented what they had seen and felt in the abdomen of the patient, made the earliest descriptions of Crohn's disease (CD). Dalziel wrote the first pathology description in 1913. Crohn and his coworkers reinvented what Dalziel had written about and called it by a different name, 'regional enteritis'. Later others elaborated on the histologic features, at first the lymphoid follicles, later the granulomas. Some thought the latter were comprised of lymphatic endothelial cells and that endothelial plugs obstructed the lymphatics. Tonelli and others recognized that lymphedema was important and caused by obstructions to lymphatic vasculature. Some lymphatics they described contained lymphocyte plugs and others granulomas. Immunohistochemistry (IHC) has now shown that endothelial cells are not the cause of lymphatic obstruction, but rather CD68-positive macrophages, concluding that the 'lymphocyte thrombi' are passive, caught upstream of granuloma-obstructed lymphatics. Numerous authors recognized that transmural edema was the most significant change in Crohn's disease and that this was later followed by fibrosis and contracture of the diseased segment. Key descriptive papers spoke of the segmental lymphedema. Most recently, attention has been given to attachments of the intralymphatic CD68+ granulomas to a focal point where endothelial damage occurred, damage suggesting infectious penetration of the mucosa, necrosis of lymphatic endothelium and then granulomatous response, both inside and outside the lymphatics, of submucosa, muscularis, and subserosa. D2-40 IHC outlines the endothelium, and anti-CD68 shows the granulomas. IHC adds a valuable perspective when reviewing CD resections.

German pathologist Walter Büngeler (1900-1987)-Nazi victim or political influencer in Brazil?

One of the most wellknown German pathologists of the twentieth century, Walter Büngeler became internationally known for his elemental research on leukemia and the pathology of tumors. In 1936, Büngeler left Nazi Germany for Brazil, but returned to Germany in 1942. After the war ended in 1945, Büngeler portrayed himself as a political victim who had been expelled first by the National Socialists and later by the Brazilian government, and in fact, he was able to successfully perpetuate this image and emerged unscathed from his de-Nazification procedure, continuing on to a successful university career with stations in Kiel and Munich as both professor and dean, as well as a term as DGP president. Up until very recently, Büngeler was portrayed in literature as a victim and critic of Nazism. Does this self-portrayal stand up to a critical examination of the facts? It is precisely this question that is the focus of this article. The analysis draws upon primary sources; namely, Büngeler's own claims from a curriculum vitae filled out in 1943 as well as his de-Nazification file from the post-war period. This article exposes significant contradictions between these two sources. The statements Büngeler made in his de-Nazification file can be verified as false in all relevant aspects. Nevertheless, Büngeler managed to create a wide-reaching and successful version of himself; a picture which persisted until only very recently.