1.
J Cutan Pathol
; 39(3): 377-81, 2012 Mar.
Article
in English
| MEDLINE
| ID: mdl-22236092
ABSTRACT
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer was recently described as a clinicopathologic entity occurring secondary to iatrogenic or age-related immune suppression. The histopathology of EBV-positive mucocutaneous ulcer reveals a polymorphous infiltrate including atypical large B-cells and Reed-Sternberg-like cells which are CD20-positive, CD30-positive and EBV-positive. The disorder follows an indolent and self-limited course. We report a case of EBV-positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists.
Subject(s)
Antimetabolites, Antineoplastic/adverse effects , Azathioprine/adverse effects , Epstein-Barr Virus Infections/chemically induced , Epstein-Barr Virus Infections/pathology , Herpesvirus 4, Human , Skin Ulcer/chemically induced , Skin Ulcer/virology , Aged , Antigens, CD20/metabolism , Antimetabolites, Antineoplastic/administration & dosage , Azathioprine/administration & dosage , B-Lymphocytes/metabolism , B-Lymphocytes/pathology , B-Lymphocytes/virology , Female , Humans , Ki-1 Antigen/metabolism , Pemphigoid, Benign Mucous Membrane/drug therapy , Pemphigoid, Benign Mucous Membrane/metabolism , Pemphigoid, Benign Mucous Membrane/pathology , Pemphigoid, Benign Mucous Membrane/virology , Reed-Sternberg Cells/metabolism , Reed-Sternberg Cells/pathology , Reed-Sternberg Cells/virology , Skin Ulcer/metabolism , Skin Ulcer/pathology
2.
Hautarzt
; 58(5): 388-90, 2007 May.
Article
in German
| MEDLINE
| ID: mdl-17450343
