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1.
Vet Surg ; 49(2): 304-309, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31738445

ABSTRACT

OBJECTIVE: To describe the location of the dorsal perineal artery in cats and identify landmarks for axial pattern flaps based on this vessel. STUDY DESIGN: Anatomic study. ANIMALS: Twelve feline cadavers. METHODS: Nonselective barium sulfate angiography was performed via injection of the descending aorta. Skin excised from the perineum and thighs was evaluated via gross inspection and radiography to identify angiosomes. RESULTS: The dorsal perineal artery had a robust angiosome on the caudal thigh in 10 of 12 cadavers. The artery exited the ischiorectal fossa along the muscular furrow between the biceps femoris and semitendinosus muscles and passed sagittally toward the popliteal fossa in those 10 specimens. All cadavers had a consistent angiosome based on the ventral perineal artery, which was located on the caudomedial thigh. All cadavers also had a consistent angiosome from a cutaneous branch of the popliteal artery, which traveled in a distal to proximal direction starting at the popliteal fossa. CONCLUSION: The dorsal perineal artery had a large cutaneous angiosome on the caudal thigh, which was consistent in most cats. The ventral perineal artery and cutaneous branch of the popliteal artery had consistent but smaller cutaneous angiosomes. CLINICAL SIGNIFICANCE: The axial pattern flaps of the cutaneous branches of the dorsal and ventral perineal arteries and the popliteal artery provide a robust arterial blood supply to the skin of the perineum and the caudal thigh. These three flaps may therefore have adequate vascular supply to consistently survive in most cats.


Subject(s)
Arteries/anatomy & histology , Cats/anatomy & histology , Hindlimb/blood supply , Perineum/blood supply , Skin/blood supply , Surgical Flaps/veterinary , Angiography , Animals , Cadaver
2.
Eur J Obstet Gynecol Reprod Biol ; 243: 83-86, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31675634

ABSTRACT

OBJECTIVE: The study was aimed at assessing the influence of pelvic congestion syndrome (PCS) on the clinical manifestations of chronic venous disease (CVD) of the lower extremities in patients with concomitant varicose veins of the pelvis and lower extremities. STUDY DESIGN: We examined clinically and with duplex ultrasound 30 women with varicose veins of the lower extremity only (VVLE) and another 45 women with VVLE and concomitant varicose veins of the pelvis (VVP) causing symptoms of the pelvic congestion syndrome (PCS). All patients had chronic venous disease (CVD) of class C2 (n = 47) or C3 (n = 28) according to the CEAP classification. All patients underwent duplex ultrasound (DUS) of the lower extremities and pelvis. Based on the clinical examination and DUS findings, the patients were allocated into two groups: group 1 (n = 30 patients with isolated VVLE without the signs of PCS and pelvic veins lesions) and group 2 (n = 45 patients with concomitant PCS, VVP and VVLE). The rates and severity of varicose, pain, and edema syndromes, and leg heaviness were assessed. RESULTS: The patients of the group 2 had significantly more severe clinical manifestations of CVD, 4 times higher risk of leg pain (odds ratio [OR] 4.23; 95% CI 1.57-11.39), 7 times higher risk of leg edema (OR 7.42; 95% CI 2.23-24.78), 5 times higher risk of leg heaviness (OR 5.3; 95% CI 1.85-15.07), and in general 2 times more severe varicose veins, compared with the group 1. CONCLUSION: The PCS is associated with an increase in the incidence and severity of the CVD symptoms.


Subject(s)
Hyperemia/physiopathology , Lower Extremity/blood supply , Pelvic Pain/physiopathology , Pelvis/blood supply , Varicose Veins/physiopathology , Adult , Case-Control Studies , Edema/etiology , Edema/physiopathology , Female , Humans , Hyperemia/complications , Pain/etiology , Pain/physiopathology , Pelvic Pain/etiology , Perineum/blood supply , Saphenous Vein , Ultrasonography , Varicose Veins/complications , Vulva/blood supply
3.
Curr Med Res Opin ; 35(1): 27-31, 2019 01.
Article in English | MEDLINE | ID: mdl-29985674

ABSTRACT

Aim: The aim of study was to investigate the opportunities of local phlebectomy in the elimination of isolated pelvic-perineal reflux (PPR), as well as to determine the feasibility of endovascular embolization of the tributaries of internal iliac veins in PPR. Clinical trial no. NCT01598051.Materials and methods: The work is based on the results of examination and treatment of 43 female patients with varicose veins of the pelvis, perineum, and lower extremities. Patients had no signs of pelvic congestion syndrome (PCS). All patients underwent duplex ultrasound scanning (DUS) and ovariography with pelvic phlebography (OPP). For the elimination of PPR, local phlebectomy was performed in the major labia and perineal area, with maximal possible mobilization of the vessel within the operative wound (33 patients). In 10 patients with isolated varicose transformation of the superficial veins on the posterior thigh, mini-phlebectomy was performed using the Varady phlebectomy extractors.Results and discussion: The varicose syndrome of the external genitalia, perineum, and posterior thigh was successfully treated in 100% of patients. Findings suggest that thorough mobilization and excision of the veins of the pudendal labia, perineum, and subcutaneous veins of the thigh is a reliable method for eliminating the pathological reflux from the intrapelvic veins to the superficial veins of the perineum and lower extremities. No recurrences of vulvar, perineal varices or dilation of the veins of the lower extremities were observed in 100% of patients over the 3-year follow-up period.Conclusion: Local phlebectomy is an effective technique for eliminating the isolated PPR in patients with varicose transformation of intrapelvic, vulvar, or perineal veins. Endovascular embolization of the tributaries of the internal iliac veins is not an essential component in the treatment of PPR. The present study has a limitation due to the absence of patients with PCS. The effectiveness of phlebectomy in the treatment of isolated PPR was studied.


Subject(s)
Embolization, Therapeutic/methods , Iliac Vein , Varicose Veins/therapy , Adult , Female , Humans , Middle Aged , Pelvis/blood supply , Perineum/blood supply , Phlebography , Treatment Outcome
4.
Angiol Sosud Khir ; 24(3): 86-90, 2018.
Article in Russian | MEDLINE | ID: mdl-30321151

ABSTRACT

The work was based on the results of examination and treatment of 43 female patients presenting with varicose transformation of pelvic, perineal, and lower-limb veins. The inclusion criteria were as follows: the presence of visually determined varicose transformation of the veins of the external genital organs, perineum, posterior surface of the thighs, as well as valvular insufficiency of the mentioned veins by the findings of ultrasonographic angioscanning (USAS). The following exclusion criteria were applied: the presence of pregnancy, symptoms of pelvic venous plethora (PVP), and varicothrombophlebitis. In 33 women correction of the pelvioperineal reflux (PPR) was performed with the help of local phlebectomy on the large pudendal lips and perineum, with the maximally possible mobilization of the vessel within the limits of the operative wound. Miniphlebectomy with the use of Varady phleboextractors was performed in 10 women presenting with isolated varicose transformation of the subcutaneous veins of the posterior femoral surface. The duration of follow up of patients amounted to 3 years. The criteria for efficiency of the carried out treatment were as follows: freedom from varicose syndrome both in the perineum and on the lower extremities, as well as no PVP symptoms during the whole term of follow up. Varicose syndrome of the external genital organs, perineum and posterior surface of the femurs was successfully eliminated in 100% of patients. Meticulous mobilization and removal of the veins of the labia majora, perineum and subcutaneous femoral veins is a reliable method of removing pathological reflux of blood from the intrapelvic to superficial veins of the perineum and lower limbs. 100% of our patients were found to be free from relapses of either vulvar or perineal varicosity, with no evidence of lower limb varicose veins. Local phlebectomy is an efficient method of elimination of varicose syndrome induced by PVP in patients with dilatation of intrapelvic, vulvar and perineal veins.


Subject(s)
Femoral Vein , Genitalia, Female/blood supply , Lower Extremity/blood supply , Pelvis/blood supply , Perineum/blood supply , Varicose Veins , Venous Insufficiency , Adult , Female , Femoral Vein/pathology , Femoral Vein/physiopathology , Femoral Vein/surgery , Follow-Up Studies , Humans , Middle Aged , Outcome and Process Assessment, Health Care , Reproducibility of Results , Varicose Veins/complications , Varicose Veins/physiopathology , Varicose Veins/surgery , Vascular Surgical Procedures/adverse effects , Vascular Surgical Procedures/methods , Venous Insufficiency/etiology , Venous Insufficiency/physiopathology , Venous Insufficiency/surgery , Venous Valves/physiopathology
5.
Surg Radiol Anat ; 40(7): 729-734, 2018 Jul.
Article in English | MEDLINE | ID: mdl-29589145

ABSTRACT

OBJECTIVE: In radical cystectomy, the surgeon generally ligates the umbilical artery at its origin. This artery may give rise to several arteries that supply the sexual organs. Our aim was to evaluate pelvic and perineal devascularisation in women after total cystectomy. PATIENTS AND METHODS: We carried out a prospective anatomical and radiological study. We performed bilateral pelvic dissections of fresh adult female cadavers to identify the dividing branches of the umbilical artery. In parallel, we examined and compared the pre- and postoperative imaging investigations [magnetic resonance imaging (MRI) angiography] in patients undergoing cystectomy for benign disease to quantify the loss of pelvic vascularisation on the postoperative images by identifying the occluded arteries. RESULTS: The anatomical study together with the radiological study visualised 35 umbilical arteries (n = 70) with their branching patterns and collateral arteries. The uterine artery originated from the umbilical artery in more than 75% of cases (n = 54) of the internal pudendal artery in 34% (n = 24) and the vaginal artery in 43% (n = 30). The postoperative MRI angiograms showed pelvic devascularisation in four patients. Devascularisation was dependent on the level of surgical ligation. In the four patients with loss of pelvic vascular supply, the umbilical artery had been ligated at its origin. CONCLUSION: The umbilical artery gives rise to various branches that supply the pelvis and perineum. If the surgeon ligates the umbilical artery at its origin during total cystectomy, there is a significant risk of pelvic and perineal devascularisation.


Subject(s)
Cystectomy , Magnetic Resonance Angiography , Umbilical Arteries/anatomy & histology , Umbilical Arteries/surgery , Uterine Artery/anatomy & histology , Cadaver , Collateral Circulation , Contrast Media , Female , Humans , Ligation , Middle Aged , Organometallic Compounds , Pelvis/blood supply , Perineum/blood supply , Prospective Studies
6.
Ostomy Wound Manage ; 64(2): 10-29, 2018 02.
Article in English | MEDLINE | ID: mdl-29481324

ABSTRACT

The use of electrical stimulation (ES) should be considered for treating nonhealing pressure ulcers (PUs), but optimal ES wound treatment protocols have yet to be established. A randomized, controlled, double-blind clinical study was conducted to evaluate the effects of cathodal and anodal high-voltage monophasic pulsed current (HVMPC) on periwound skin blood flow (PSBF) and size reduction of Stage 2 to Stage 4 PUs of at least 4 weeks' duration. Persons >18 years of age, hospitalized with neurological injuries, at high risk for PU development (Norton scale <14 points; Waterlow scale >15 points), and with at least 1 Stage 2 to Stage 4 PU were eligible to participate in the study. Persons with necrotic wounds, osteomyelitis, electronic or metal implants in the PU area, PUs in need of surgical intervention, acute wound inflammation, diabetes (HBA1c >7%), diabetic neuropathy, cancer, and/or allergies to standard wound treatments were excluded. Patients were randomly assigned to 1 of 3 groups: anodal (AG), cathodal (CG), or placebo (PG) ES. All groups received individualized PU prevention and standard wound care. In the PG, sham ES was applied; the AG and CG were treated with anodal and cathodal HVMPC, respectively (154 µs 100 Hz; 360 µC/second; 1.08 C/day), 50 minutes per day, 5 days per week, for a maximum of 8 weeks. PSBF was measured using laser Doppler flowmetry at baseline, week 2, and week 4, and wound surface area measurements were obtained and analyzed using a digitizer connected to a personal computer. Data analysis utilized the maximum-likelihood chi-squared test, the analysis of variance Kruskal-Wallis test, the Kruskal-Wallis post-hoc test, and Spearman's rank order correlation. Nonlinear approximation based on exponential function was used to calculate treatment time needed to reduce the wound area by 50%. In all tests, the level of significance was set at P ≤.05. Of the 61 participating patients, 20 were in the AG (mean age 53.2 ± 13.82 years), 21 in the CG (mean age 55.67 ± 17.83 years), and 20 in the PG (mean age 52.5 ± 13.18 years). PUs (baseline size range 1.01 cm2 to 59.57 cm2; duration 4 to 48 weeks) were most frequently located in the sacral region (73.77%) and classified as Stage 3 (62.29%). PSBF at week 2 was significantly higher in the AG and CG than in the PG (P <.05). Week 4 differences were not statistically significant. Wound percentage area reduction calculated at week 8 for the AG (64.10% ± 29.22%) and CG (74.06% ± 23.23%) were significantly different from PG ulcers (41.42% ± 27.88%; P = .0391 and P = .0024, respectively). In both ES groups, PSBF at week 4 and percent wound surface area reductions between weeks 4 and 8 were positively correlated, but only the AG correlation was statistically significant (P = .049). In this study, both ES modalities improved blood flow and wound area reduction rate. Studies examining optimal ES treatment times for healing to occur, the effect of comorbidities and baseline wound variables on ES outcomes, and the nature of the relationship between blood flow and healing are necessary.


Subject(s)
Electric Stimulation Therapy/standards , Perineum/blood supply , Pressure Ulcer/therapy , Wound Healing/physiology , Adult , Aged , Double-Blind Method , Electric Stimulation Therapy/methods , Female , Humans , Male , Middle Aged , Perineum/injuries , Perineum/physiopathology , Skin Care/methods
7.
Dis Colon Rectum ; 60(9): 945-953, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28796733

ABSTRACT

BACKGROUND: There are many previous reports for using the internal pudendal artery perforator flap in vulvovaginal reconstruction; however, reports of this flap for perineal reconstruction after abdominoperineal excision of the rectum are scarce. OBJECTIVE: The purpose of this study was to evaluate the outcomes of immediate internal pudendal artery perforator flap reconstruction for irradiated abdominoperineal resection defects. DESIGN: This was a prospective case series. SETTINGS: This flap could represent a step forward over other perineal flap approaches or primary closure. PATIENTS: A total of 73 consecutive patients with anorectal tumors were included. INTERVENTIONS: The study included immediate perineal reconstruction using 122 internal pudendal artery perforator flaps after abdominoperineal excision of the rectum. MAIN OUTCOME MEASURES: Dimensions of the perineal defect (in centimeters squared), hospital stay (days), healing time (days), and postoperative complications (Clavien-Dindo grades) were measured. RESULTS: The means of the perineal defect, hospital stay, and healing time were 51.62 cm, 15.94 days, and 38.52 days. The higher the patient BMI, the longer healing time (p = 0.02); Clavien-Dindo complications grades III to IV were greater in patients with perineal defect ≥60 cm (p = 0.03; OR = 10.56); postoperative complications were higher both in patients with anal squamous cell carcinoma (p = 0.005; OR = 6.09) and in patients with comorbidities (p = 0.04; OR = 2.78); hospital stay (p= 0.001) and healing time (p < 0.001) were higher in patients who had postoperative complications. The complete perineal wound healing at 12 weeks was achieved by 95% of patients, and our 30-day mortality rate was 4%. LIMITATIONS: As a nonrandomized study, our results have to be interpreted with caution. CONCLUSIONS: Multiple previously described advantages associated with internal pudendal artery perforator flap were also observed here, reinforcing the idea that it is reliable, versatile, and a useful option for perineal reconstruction after abdominoperineal excision of the rectum. Therefore, we propose that this flap could be considered as the first choice for perineal reconstruction in selected patients with moderate and some large defects after abdominoperineal excision of the rectum. See Video Abstract at http://links.lww.com/DCR/A367.


Subject(s)
Anus Neoplasms , Carcinoma, Squamous Cell , Colectomy/methods , Perforator Flap , Perineum , Plastic Surgery Procedures , Postoperative Complications , Rectal Neoplasms , Abdomen/pathology , Abdomen/surgery , Anus Neoplasms/pathology , Anus Neoplasms/surgery , Arteries/surgery , Brazil , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Female , Humans , Male , Middle Aged , Outcome and Process Assessment, Health Care , Perineum/blood supply , Perineum/pathology , Perineum/surgery , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Postoperative Complications/prevention & control , Prospective Studies , Plastic Surgery Procedures/adverse effects , Plastic Surgery Procedures/methods , Rectal Neoplasms/pathology , Rectal Neoplasms/surgery
8.
J Vasc Surg Venous Lymphat Disord ; 5(4): 493-499, 2017 07.
Article in English | MEDLINE | ID: mdl-28623983

ABSTRACT

OBJECTIVE: Pelvic venous incompetence can cause symptomatic varicose veins in the perineum, buttock, and thigh. Presentation, symptom severity, and response to treatment of pelvic source varicose veins are not well defined. Currently available tools to measure the severity of lower extremity venous disease and its effects on quality of life may be inadequate to assess disease severity in these patients. The purpose of this study was to evaluate the histories, demographics, and clinical presentations of women with pelvic source varicose veins and to compare these data to a population of women with nonpelvic source varicose veins. METHODS: A total of 72 female patients with symptomatic pelvic source varicose veins were prospectively followed up. Age, weight, height, parity, and birth weights of offspring were recorded. Both pelvic source varicose veins and saphenous incompetence were identified by duplex ultrasound. Patients were queried as to their primary symptoms, activities that made their symptoms worse, and time when their symptoms were most prominent. Severity of disease was objectively evaluated using the revised Venous Clinical Severity Score (rVCSS) and 10-point numeric pain rating scale (NPRS). RESULTS: Compared with women without a pelvic source of varicose veins (N = 1163), patients with pelvic source varicose veins were younger (mean, 44.6 ± 8.6 vs 52.6 ± 12.9 years; P < .001), had lower body mass index (mean, 21.9 ± 2.8 vs 25.8 ± 6.2; P < .001), and had larger babies than the U.S. population mean (mean, 3656 ± 450 g vs 3389 ± 466 g; P < .001). The most common symptoms were aching (68%), throbbing (47%), and heaviness (35%). In premenopausal patients, 70% noted that symptoms were worst during menses. NPRS score varied from 0 to 8 (mean, 4.9). The correlation between rVCSS (mean 5.6 ± 1.9) and NPRS was small (r = 0.26; P = .03). There was a modest correlation between older age and lower NPRS scores (r = -0.39; P < .001). CONCLUSIONS: Women with pelvic source varicose veins are a unique subset of patients. They are younger and thinner than those with nonpelvic source varicose veins, have larger infants than the general U.S. population, and have an inverse correlation between age and pain. As the majority of premenopausal patients have increased symptoms during menses, this may be due to hormonal influence. As it is poorly associated with patient-reported discomfort, the rVCSS is a poor tool for evaluating pelvic source varicose veins. A disease-specific tool for the evaluation of pelvic source varicose veins is critically needed, and this study is a first step in that endeavor.


Subject(s)
Pelvis/blood supply , Saphenous Vein/diagnostic imaging , Ultrasonography, Doppler, Duplex/methods , Varicose Veins/diagnostic imaging , Venous Insufficiency/diagnosis , Adult , Female , Follow-Up Studies , Humans , Middle Aged , Perineum/blood supply , Predictive Value of Tests , Prospective Studies , Risk Assessment , Sensitivity and Specificity , Severity of Illness Index , Varicose Veins/complications , Venous Insufficiency/complications , Venous Insufficiency/diagnostic imaging
9.
J Pharmacol Exp Ther ; 356(3): 673-80, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26718241

ABSTRACT

Activation of adenosine receptors (ARs) has been implicated in the modulation of renal and cardiovascular systems, as well as erectile functions. Recent studies suggest that adenosine-mediated regulation of erectile function is mainly mediated through A2BAR activation. However, no studies have been conducted to determine the contribution of AR subtype in the regulation of the vascular tone of the pudendal artery (PA), the major artery supplying and controlling blood flow to the penis. Our aim was to characterize the contribution of AR subtypes and identify signaling mechanisms involved in adenosine-mediated vascular tone regulation in the PA. We used a DMT wire myograph for muscle tension measurements in isolated PAs from wild-type, A2AAR knockout, A2BAR knockout, and A2A/A2BAR double-knockout mice. Real-time reverse transcription-polymerase chain reaction was used to determine the expression of the AR subtypes. Data from our pharmacologic and genetic approaches suggest that AR activation-mediated vasodilation in the PA is mediated by both the A2AAR and A2BAR, whereas neither the A1AR nor A3AR play a role in vascular tone regulation of the PA. In addition, we showed that A2AAR- and A2BAR-mediated vasorelaxation requires activation of nitric oxide and potassium channels; however, only the A2AAR-mediated response requires protein kinase A activation. Our data are complemented by mRNA expression showing the expression of all AR subtypes with the exception of the A3AR. AR signaling in the PA may play an important role in mediating erection and represent a promising therapeutic option for the treatment of erectile dysfunction.


Subject(s)
Arteries/physiology , Receptor, Adenosine A2B/physiology , Vasodilation/physiology , Adenosine A2 Receptor Agonists/pharmacology , Animals , Arteries/drug effects , Dose-Response Relationship, Drug , Male , Mice , Mice, Inbred C57BL , Mice, Knockout , Organ Culture Techniques , Perineum/blood supply , Vasodilation/drug effects
10.
Anat Histol Embryol ; 45(2): 88-99, 2016 Apr.
Article in English | MEDLINE | ID: mdl-25702925

ABSTRACT

The aim of this study was to investigate the variability of the internal pudendal artery. Two hundred and thirty-two pelvic halves from 116 adult dogs were examined. Twenty-six anatomical variations were found, thirteen occurring in more than 5% of the dogs. Anatomical variations were grouped in relation to the origin of the prostatic/vaginal arteries, middle rectal artery, urethral artery, ventral perineal and caudal rectal arteries. The chi-squared test was used to analyse differences in sex, side of the body, profile and size, and the results were considered statistically significant when P ≤ 0.05. An identical vascular pattern in both hemipelvises was found for most of the anatomical variations described.


Subject(s)
Dogs/anatomy & histology , Iliac Artery/anatomy & histology , Animals , Aorta, Abdominal/anatomy & histology , Buttocks/blood supply , Chi-Square Distribution , Dogs/classification , Female , Ischium/blood supply , Lumbosacral Region/blood supply , Male , Perineum/blood supply , Prostate/blood supply , Rectum/blood supply , Tail/blood supply , Umbilical Arteries/anatomy & histology , Urethra/blood supply , Uterus/blood supply , Vagina/blood supply , Vas Deferens/blood supply
11.
Zhonghua Nan Ke Xue ; 22(10): 902-905, 2016 Oct.
Article in Chinese | MEDLINE | ID: mdl-29278472

ABSTRACT

OBJECTIVE: To explore the clinical effect of testicular artery-sparing microscopic varicocelectomy (MV) in combination with Qilin Pills (QL) in the treatment of bilateral varicocele-induced oligoasthenospermia. METHODS: Sixty patients with bilateral varicocele-induced oligoasthenospermia were randomly assigned to receive MV (n=30) or MV+QL (n=30), those in the latter group treated with oral QL for 12 weeks postoperatively. At 4, 8, and 12 weeks after operation, we compared the semen volume, sperm concentration, sperm motility, the levels of serum Inh B, luteinizing hormone (LH) and total testosterone (TT), and the testosterone secretion index (TSI) between the two groups. RESULTS: After surgery, all the patients showed disappearance of varicocele symptoms, remarkably improved semen volume, sperm concentration, sperm motility, serum Inh B and TT levels, TSI, decreased LH and FSH (P<0.01). At 12 weeks after treatment, statistically significant differences were found between the MV and MV+QL groups in Inh B (138.96±22.26 vs 129.54±22.23) ng/L, LH (3.17±0.12 vs 3.59±0.11) IU/L, TT (13.98±3.02 vs 12.68±3.12) nmol/L, and TSI (4.41±0.53 vs 3.53±0.51) nmol/ IU (P<0.05). The pregnancy rate was significantly higher in the MV+QL than in the MV group (73.4% vs 36.6%, P<0.05). CONCLUSIONS: Testicular artery-sparing microscopic varicocelectomy combined with Qilin Pills is an effective strategy for the treatment of bilateral varicocele-induced oligoasthenospermia by significantly improving the semen quality of the patient.


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Oligospermia/etiology , Oligospermia/therapy , Varicocele/surgery , Vascular Surgical Procedures , Arteries , Female , Humans , Inhibin-beta Subunits/blood , Luteinizing Hormone/blood , Male , Organ Sparing Treatments , Perineum/blood supply , Pregnancy , Pregnancy Rate , Semen Analysis , Sperm Count , Sperm Motility , Spermatic Cord , Testosterone/blood , Varicocele/complications
12.
Microsurgery ; 35(8): 627-33, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26461172

ABSTRACT

OBJECTIVE: Extensive defects of the perineal or inguinal area require well vascularized free flap coverage. This area has an abundance of perforating arteries and veins based on vessels from the femoral artery and internal iliac artery. We present our experience on the use of perforators as recipient vessels in reconstructing soft tissue defects of the perineal and inguinal area with free flaps. PATIENTS AND METHODS: From March 2012 to August 2014, 13 patients underwent free flap reconstruction for soft tissue defects of the inguinal or perineal area. Perforating arteries with diameters ranging from 0.7 to 1.2 mm were used as recipient arteries. Accompanying veins or neighboring superficial veins were secured as recipient veins. RESULTS: All flaps survived attached to a recipient perforator with a diameter ranging from 0.7 to 1.2 mm. These vessels were found in the inguinal or perineal areas, regions that are supplied by the superficial circumflex iliac vessels, superficial inferior epigastric vessels, superficial and deep external pudendal vessels, lateral and medial circumflex femoral vessels, and internal pudendal vessels. There were no cases of arterial insufficiency or venous congestion, flap necrosis, or infection. A single case of hematoma beneath the flap was treated by simple evacuation. There were no donor complications. CONCLUSION: Using perforators as the recipient during free flap reconstruction of the inguinal and perinea area allows the surgeon to choose from a wider choice of vessels, and yields acceptable flap survival.


Subject(s)
Free Tissue Flaps/transplantation , Groin/blood supply , Perineum/blood supply , Plastic Surgery Procedures/methods , Soft Tissue Injuries/surgery , Adult , Aged , Anastomosis, Surgical , Arteries/surgery , Female , Free Tissue Flaps/blood supply , Graft Survival , Groin/injuries , Groin/surgery , Humans , Male , Middle Aged , Perineum/injuries , Perineum/surgery , Treatment Outcome , Veins/surgery
13.
Ann R Coll Surg Engl ; 97(7): e108-11, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26414373

ABSTRACT

The low incidence of partial segmental thrombosis of the corpus cavernosum (PSTCC) means its management is guided by isolated case reports. Erectile function is an important outcome that has not been described quantitatively in the literature. We present two cases of PSTCC managed conservatively. Although both patients reported resolution of local symptoms, formal analysis of sexual function at follow-up review has revealed that only one achieved complete recovery.


Subject(s)
Fibrinolytic Agents/therapeutic use , Heparin, Low-Molecular-Weight/therapeutic use , Impotence, Vasculogenic/etiology , Perineum/blood supply , Thrombosis/drug therapy , Adult , Humans , Male , Thrombosis/complications , Thrombosis/diagnosis , Young Adult
14.
J Pediatr Urol ; 11(4): 227.e1-6, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26163459

ABSTRACT

AIMS: We sought to evaluate the initial presentation and diagnosis, to compare presenting symptoms of these anomalies with respect to location, and describe the management course and review the treatment outcomes of vascular anomalies (VA) in genitourinary and perineal area. We described changes in the evaluation and management approach over time. METHODS: After IRB approval, we reviewed the Vascular Anomalies Program 3,780 patient database from 1998-2013, identifying 85 patients with GUP VA. Demographics, presentation, anatomic location, imaging modalities and treatments were reviewed. For the 76 patients that were managed at our institution, we analyzed data for management approach change over time, duration of follow-up, complications, and treatment outcomes. Using Chi-squared test, we analyzed the treatment eras for any difference in presenting symptoms, or management approach. RESULTS: From the VAP database, we identified 85 patients with GUP VA. Vascular tumors (VT) were more common than vascular malformations (VM) (62/85, 72.9% vs. 23/85, 27.1%). The 62 patients with VT were subdivided into infantile hemangioma (IH) (49, 79%) and congenital hemangioma (CH) (13, 20.9%). The 23 patients with VM were subdivided into simple (18, 78.2%) and complex (2, 8.7%), and one patient had Klippel-Trenaunay syndrome. Overall, genital VA were more common than perineal (43/85, 54.2% vs. 24/85, 28.2%). None of our patients had urinary involvement. Ultrasound was used in 34% (29/85) of VA patients, the majority were VM (18/23, 78%). Majority of patients were symptomatic with ulceration, pain and bleeding (54/85, 63.5%). Malformations were more complex, presenting as extensive lesions (6/23, 26.1%), which included pelvic extension in 5 (21.7%). Seventy-six patients were managed at our institution. Treatment was utilized more frequently than observation overall (46/76, 60% vs. 30/76, 40%), and more frequently for VM than VT (12/18, 63% vs. 34/58, 57%). After introduction of oral propranolol for treatment of IH in 2010, fewer patients presented with ulceration (p = 0.213), and more were treated with propranolol over procedural therapy (p = 0.157). Overall, complete treatment of these lesions was achieved in 82.9% (63/76), with low complication rate (6/76, 7.9%). CONCLUSIONS: Evaluation and management of VA is best performed with expert multidisciplinary team at tertiary care center. Imaging studies are mostly used in evaluation of VM. Symptomatic VA involving the perineum and genitalia require therapeutic management. With the introduction of propranolol for treatment of IH, oral therapies were used more often with excellent outcomes. A multidisciplinary approach is essential to treatment innovation, patient-centered therapies and improving therapeutic outcomes.


Subject(s)
Disease Management , Perineum/blood supply , Urogenital Abnormalities/epidemiology , Vascular Malformations/epidemiology , Child, Preschool , Female , Humans , Incidence , Infant , Infant, Newborn , Male , Prognosis , Retrospective Studies , Urogenital Abnormalities/therapy , Vascular Malformations/therapy , Washington/epidemiology
15.
Microsurgery ; 35(1): 64-7, 2015 Jan.
Article in English | MEDLINE | ID: mdl-24848991

ABSTRACT

Gluteal artery perforator flaps are a good option to reconstruct perineal and posterior vaginal wall defects after abdominoperineal resection. The bulkiness of the folded flap may compromise the results by obliterating the introitus and vaginal cavity. In this report, we present a case of the use of a superior gluteal artery dual perforator-pedicled propeller flap to reconstruct the posterior vaginal wall and perineum in a 60-year-old female who had an abdominoperineal resection of a locally progressive anal squamous cell carcinoma. Two perforators were completely skeletonized through gluteus maximus muscle fibers. The vascularization of the skin flap was based on the first perforator, whereas the aponeurotic flap was vascularized by the second perforator. The vaginal defect was reconstructed with a gluteus maximus aponeurotic flap, and the perineal reconstruction was based on a superior gluteal artery perforator skin flap. No postoperative infection or necrosis occurred. Skin healing was completed in 3 weeks. Vaginal opening was controlled using lubricant and graduated vaginal dilators during 6 weeks. The patient began sexual intercourse 2 months postoperatively. No revision was needed. Perineal and posterior vaginal wall defects may be reconstructed with a gluteal artery perforator flap. The thickness of the flap allows a complete filling of the full perineal cavity. The gluteus maximus aponeurosis may be suitable for the reconstruction of the posterior vaginal wall.


Subject(s)
Anus Neoplasms/surgery , Buttocks/blood supply , Carcinoma, Squamous Cell/surgery , Microsurgery/methods , Perforator Flap/blood supply , Perforator Flap/surgery , Perineum/blood supply , Perineum/surgery , Plastic Surgery Procedures/methods , Surgical Flaps/blood supply , Surgical Flaps/surgery , Vagina/blood supply , Vagina/surgery , Chemoradiotherapy , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Middle Aged , Postoperative Care/methods , Wound Healing/physiology
16.
Abdom Imaging ; 38(3): 588-97, 2013 Jun.
Article in English | MEDLINE | ID: mdl-22923172

ABSTRACT

PURPOSE: High-flow priapism is often a sequela of perineal trauma resulting in an arteriocavernosal fistula (ACF) between a cavernosal artery and lacunar spaces of the penis. We report our experience utilizing magnetic resonance angiography (MRA) in addition to color Doppler Sonography (CDS) in the workup and treatment planning of 4 patients with high-flow priapism. METHODS: All patients had suspected high-flow priapism diagnosed by clinical exam and CDS and underwent MRA of the penis prior to sub-selective arterial embolization (SSAE) of the feeding vessel(s). RESULTS: While CDS is valuable in diagnosing and lateralizing high-flow priapism, it does not provide clear anatomic delineation of the number and origin of feeding vessels. MRA provided demonstration of the fistula, demonstrated bilateral ACF supply in 2 patients, and afforded three-dimensional display of the feeding vessels which facilitated pre-embolization planning. CONCLUSIONS: In all four cases, MRA was an effective tool for displaying arterial and venous anatomy, localizing the ACF, and planning subsequent SSAE. MRA influenced management in two out of 4 patients by demonstrating bilateral feeding vessels to their ACFs that required bilateral SSAE.


Subject(s)
Embolization, Therapeutic , Magnetic Resonance Angiography , Priapism/diagnosis , Adolescent , Embolization, Therapeutic/methods , Humans , Male , Middle Aged , Penis/blood supply , Penis/diagnostic imaging , Penis/injuries , Perineum/blood supply , Priapism/diagnostic imaging , Priapism/etiology , Priapism/physiopathology , Regional Blood Flow , Skating/injuries , Ultrasonography, Doppler, Color , Young Adult
17.
Urology ; 79(6): 1390-4, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22656416

ABSTRACT

OBJECTIVE: Extensive defects of the perineal area, with exposure of the testes, are difficult to reconstruct. For the reconstruction of these defects, we applied gracilis muscle flap combined with pudendal artery perforator fasciocutaneous flap, which provided us a reliable cutaneous flap and allowed us to cover exposed testes with sufficient muscular volume. METHODS: We retrospectively analyzed 7 patients from 2004-2011 whose penoscrotal defects had been reconstructed using gracilis muscle flap and an internal pudendal artery perforator flap. Six had Fournier's gangrene and 1 had extramammary Paget's disease. We examined characteristics of the patients, preoperative management, operative procedure, and their clinical courses. RESULTS: All flaps survived during the entire follow-up periods. The mean width of the defects was 10.14 cm and the mean length was 9.29 cm. The width of the fasciocutaneous flap was approximately 6-10 cm, whereas the length ranged from 10-15 cm. The reconstructed areas were in good functional and esthetic conditions. CONCLUSION: The combination of the gracilis muscle flap and the internal pudendal artery perforator fasciocutaneous flap provides pliable and reliable soft tissue coverage for extensive penoscrotal defects with adequate bulkiness and minimal donor site morbidity.


Subject(s)
Fournier Gangrene/surgery , Genital Diseases, Male/surgery , Penis/surgery , Plastic Surgery Procedures/methods , Scrotum/surgery , Surgical Flaps , Adult , Genital Neoplasms, Male/surgery , Humans , Laser-Doppler Flowmetry , Male , Paget Disease, Extramammary/surgery , Perineum/blood supply , Retrospective Studies , Surgical Flaps/blood supply
18.
Clin Anat ; 25(8): 983-5, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22730067

ABSTRACT

This study investigated the frequency of an accessory pudendal artery in 15 adult cadavers fixed with formaldehyde solution. The prevalence of accessory pudendal artery varies between 7 and 75% according to the method of identification (imaging studies, microstereoscopic cadaveric dissection, and open and laparoscopic surgeries). Currently, under discussion is the role of this artery in postprostatectomy erectile dysfunction. Accordingly, it is important to know the true prevalence to appreciate its clinical significance. The internal pudendal system was examined through direct dissection, and findings were compared with the different methods of identification published.


Subject(s)
Arteries/abnormalities , Genitalia, Male/blood supply , Pelvis/blood supply , Perineum/blood supply , Adult , Cadaver , Dissection , Humans , Male , Prevalence
20.
Urology ; 78(1): 159-63, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21256552

ABSTRACT

OBJECTIVES: To report the surgical anatomy of the muscles of the urogenital diaphragm and the pattern of its vessels in the classic exstrophy bladder and incontinent epispadias. METHODS: A total of 11 patients, 9 with unoperated classic exstrophy and 2 with incontinent epispadias, who were >5 years old at presentation, were selected for the present study. Magnetic resonance imaging of the pelvis was performed using a 3.0 T magnetic resonance imaging scanner and an 8-channel coil. Computed tomography was performed for 5 patients using a multidetector row helical computed tomography scanner. Angiograms of the vessels of the urogenital diaphragm were also obtained using magnetic resonance imaging and computed tomography. RESULTS: A central perineal body was seen in all the patients, with attachment of the bulbospongiosus anteriorly, superficial transverse perinei laterally, and anal sphincter posteriorly. At the root of corpora, the ischiocavernosus muscle was also seen. The triangle among the ischiocavernosus, bulbospongiosus, and superficial transverse perinei muscle was accentuated and contained the perineal artery, indirectly indicating the course of the perineal nerve. The dorsal penile artery was nearer to the posterior edge of the ischiopubic ramus, before coursing on the lateral aspect of the anterior segment of the corpora. The deep transverse perinei muscle and laid open external urethral sphincter were also seen in the proximal planes of the urogenital diaphragm. CONCLUSIONS: First, all the muscles of the urogenital diaphragm, including the external urethral sphincter, were present in the exstrophy bladder. Second, the perineal artery and its sphincteric branches were in the triangular space between the ischiocavernosus, bulbospongiosus, and superficial transverse perinei muscle. Finally, the dorsal penile artery ran along the inner edge of the ischiopubic ramus before lying on lateral aspect of the corpora.


Subject(s)
Bladder Exstrophy/pathology , Epispadias/pathology , Urogenital System/anatomy & histology , Child , Child, Preschool , Humans , Imaging, Three-Dimensional , Magnetic Resonance Angiography , Male , Pelvic Floor/anatomy & histology , Pelvic Floor/blood supply , Perineum/anatomy & histology , Perineum/blood supply , Tomography, X-Ray Computed , Urogenital System/blood supply
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