ABSTRACT
OBJECTIVE: To prepare Zhongjiefeng dispersible tablets. METHODS: The formulation of Zhongjiefeng dispersible tablets were optimized as index of disintegration time by orthogonal design test. RESULTS: The optimized Zhongjiefeng dispersible tablets, which were prepared by selecting 16% PVPP and 3% L-HPC as disintegrants, 40% MCC as filler, can disintegrate in 3 mins. CONCLUSIONS: The above formulation is reasonable and the disintegration time is suitable, so it can provide theoretic support for industrialization.
Subject(s)
Drugs, Chinese Herbal/administration & dosage , Magnoliopsida/chemistry , Pharmaceutic Aids/administration & dosage , Technology, Pharmaceutical/methods , Cellulose/administration & dosage , Cellulose/chemistry , Chemistry, Pharmaceutical , Drug Stability , Drugs, Chinese Herbal/chemistry , Pharmaceutic Aids/chemistry , Pharmaceutic Aids/classification , Plants, Medicinal/chemistry , Povidone/administration & dosage , Povidone/chemistry , Solubility , Tablets , Time FactorsABSTRACT
To prepare and optimize the gastrodin dispersible tablets by orthogonal design using the disintegration time as index. The quality of gastrodin dispersible tablets was evaluated by the initial stability test. The results showed that the disintegration time of optimized prescription formulation was 106s, i.e. L-HPC and CMS-Na was used by combining exterior and interior and the dissolution percent in vitro was obviously super to the conventional tablets. Moreover, the quality of the dispersible tablets was very well by stability test.
Subject(s)
Benzyl Alcohols/administration & dosage , Drugs, Chinese Herbal/administration & dosage , Glucosides/administration & dosage , Pharmaceutic Aids/administration & dosage , Plants, Medicinal/chemistry , Technology, Pharmaceutical/methods , Area Under Curve , Benzyl Alcohols/chemistry , Chemistry, Pharmaceutical , Drug Stability , Drugs, Chinese Herbal/chemistry , Glucosides/chemistry , Lactose/administration & dosage , Pharmaceutic Aids/chemistry , Pharmaceutic Aids/classification , Solubility , TabletsABSTRACT
Las bases dermatológicas son preparaciones semisólidas que están destinadas a la aplicación de medicamentos en forma externa. La prescripcón de recetas magistrales permite a los dermatológos individulaizar en forma adecuada las terapias de sus pacientes. Las bases pueden ser clasificadas según su composición en: bases oleaginosas, bases de absorción, emulsiones (aceite/agua, agua/aceite), bases hidrosolubles y geles. Por su bajo o nulo contenido en materia grasa, las bases más indicadas en acné o rosácea son las emulsiones de aceite en agua, las bases hidrosolubles, elaboradas con polietilenglicoles, y los geles. Es importante tener presente la posibilidad de interacciones o incompatibilidades entre diversos principios activos y las bases
Subject(s)
Humans , Basic Preparations , Drug Compounding , Pharmaceutic Aids/classification , Rosacea/drug therapy , Emulsions/analysis , Excipients/analysis , Gels/analysis , Hydrogen-Ion Concentration , Ointment Bases/analysis , Ointments/analysis , Sebum/metabolism , Skin AbsorptionABSTRACT
Different base types are necessary for dermatological preparations. The dominating part is played today and probably will also be played in the future by the hydrocarbon gels and the derivated cream systems. Possible interferences of the ingredients with the base components have to be watched by the dispensing of medical preparations for dermatological therapy. In regard to an optimal distribution of the ingredients solubility of the ingredients in the bases are important. Specific preservatives can be omitted if ethanol is added in concentrations of at least 15 per cent. There is a tendency to use mainly indifferent components.
