ABSTRACT
The synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions of 3-aryl-2,3-epoxy-1-phenyl-1-propanone with phenylhydrazine was carried out in 69-99% yields at room temperature under ultrasound irradiation. This method provides several advantages such as operational simplicity, higher yield and environment friendly.
Subject(s)
Hydrochloric Acid/chemistry , Phenylhydrazines/chemistry , Phenylhydrazines/radiation effects , Propane/chemistry , Propane/radiation effects , Pyrazoles/chemical synthesis , Pyrazoles/radiation effects , Sonication/methods , Catalysis , Hydrochloric Acid/radiation effects , Radiation DosageABSTRACT
Fresh mushrooms ( Agaricus bisporus ) were irradiated at doses of 1, 3, and 5 kGy to assess the effect of gamma-irradiation on the major aromatic compounds agaritine (beta-N-(gamma-L-(+)-glutamyl)-4-(hydroxymethyl)phenylhydrazine) and GHB (gamma-glutaminyl-4-hydroxybenzene) as well as on the total phenolic content and antioxidant capacity. Up to 3 kGy, agaritine was not affected. At 5 kGy, a significant reduction (p = 0.05) from 1.54 (0 kGy) to 1.35 g/kg dry weight (DW) was observed. gamma-Glutaminyl-4-hydroxybenzene decreased by 22% at 1 kGy and by 31% at 5 kGy. Additionally, agaritine standard solutions at concentrations of 10(-4) and 5 x 10(-5) mol/L were irradiated to compare the effect on agaritine content in aqueous solutions and in the sample matrix. A rapid decay was observed, 50% at 750 Gy (10(-4) mol/L) and 400 Gy (5 x 10(-5) mol/L). The total phenolic content and antioxidant capacity were not significantly (p = 0.05) influenced by irradiation.
