Activity of Antioxidant Enzymes in the Regional Blood Flow during Pelvic Venous Disorders in Women.

Activity of some antioxidant enzymes (superoxide dismutase, catalase, and glutathionedependent enzymes), as well as the level of LPO products in the region regional blood flow (collateral branches of the main trunks of ovarian veins) in women with pelvic venous disorders were studied. A compensatory increase in activity of superoxide dismutase, catalase, and glutathione peroxidase during stage I of the disease was found; during stage II, superoxide dismutase activity decreased and glutathione peroxidase increased, while during stage III, pronounced decrease in activities of all studied enzymes was observed. The level of lipid peroxidation products in the regional blood flow increased as the disease progressed, with maximum values in the third stage.

[Effect of tribenol on the activity of certain redox enzymes in inflamed venous walls]. / Vliianie tribenola n aktivnost' nekotorykh okislitel'no-vosstanovitel'nykh fermentov v venoznoi stenke pri ee vospalenii.

A study was made on the mechanism of action of the antivaricose agent tribenol (ethyl-3,5,6-tri-O-benzyl-D-glucofuranozide; glivenol) on the activity of hydroxyreductase on the Krebs cycle and glycolysis during occlusion of the femoral vein and its inflammation in rats. It was shown histochemically that on the 5th day of traumatic phlebitis after ligation of the vein, its wall shows a substantial rise in the activity of succinate- and malate dehydrogenase (SDH and MDH), a slight increase in the activity of lactate dehydrogenase (LDH) and a pronounced lowering of the activity of alpha-glycerophosphate dehydrogenase (alpha-GPDH). The treatment with tribenol in a dose of 25 mg/kg for 5 days makes the activity of SDH and alpha-GPDH return to normal, drastically increases the activity of LDH and produces no significant effect on MDH. In a dose of 250 mg/kg tribenol makes the activity of all hydroxyreductases studied return to normal or reduces it.