Subject(s)
Herpes Zoster Ophthalmicus/virology , Herpesvirus 3, Human/isolation & purification , Phlebitis/virology , Retinal Diseases/virology , Retinal Vein/virology , Acyclovir/therapeutic use , Adult , Antiviral Agents/therapeutic use , DNA, Viral/analysis , Female , Fluorescein Angiography , Genome, Viral , Herpes Zoster Ophthalmicus/diagnosis , Herpes Zoster Ophthalmicus/drug therapy , Herpesvirus 3, Human/genetics , Humans , Intraocular Pressure , Iridocyclitis/diagnosis , Iridocyclitis/drug therapy , Iridocyclitis/virology , Male , Phlebitis/diagnosis , Phlebitis/drug therapy , Polymerase Chain Reaction , Prednisolone/therapeutic use , Retinal Diseases/diagnosis , Retinal Diseases/drug therapy , Retinal Vein/drug effects , Retinal Vein/pathology , Visual AcuityABSTRACT
Lichen sclerosus (LS) is a chronic inflammatory disease of unknown etiology that may affect the genital and/or extragenital skin of individuals of either sex at all ages. In boys, the prepuce is the most common site of involvement. The diagnostic criteria of LS include the presence of inflammatory infiltrates mainly composed of T lymphocytes. We report on two cases of LS of the prepuce because of the unusual feature of lymphocytic (CD45RO+ and CD20+), histiocytic (CD68+), and granulomatous phlebitis. This lesion was not present in a group of another 18 cases of childhood penile LS. We have not been able to find any references describing and illustrating inflammatory involvement of the dermal vein walls in LS. Unlike the data reported in the literature, the dermal inflammatory infiltrates of these two cases showed a similar proportion of B and T lymphocytes in addition to frequent CD68+ histiocytes.
