ABSTRACT
Pituitary tumour apoplexy is a rare but potentially life threatening clinical syndrome that mostly results from haemorrhage in the pre-existent tumour. Pure ischaemic subtype of apoplexy is even rarer. The presentation can be hard to differentiate clinically from bacterial meningitis. Moreover, the presence of one does not necessarily exclude the other and early diagnosis of both conditions is imperative for timely management. We report a case of ischaemic pituitary tumour apoplexy that may have precipitated in the setting of bacterial meningitis.
Subject(s)
Meningitis, Bacterial/complications , Pituitary Apoplexy/complications , Pituitary Neoplasms/complications , Adult , Diagnosis, Differential , Female , Humans , Meningitis, Bacterial/diagnosis , Pituitary Apoplexy/diagnosis , Pituitary Apoplexy/microbiology , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/microbiologyABSTRACT
PURPOSE: There is a high incidence of abnormal sphenoid sinus changes in patients with pituitary apoplexy (PA). Their pathophysiology is currently unexplored and may reflect an inflammatory or infective process. In this preliminary study, we characterised the microbiota of sphenoid sinus mucosa in patients with PA and compared findings to a control group of surgically treated non-functioning pituitary adenomas (NFPAs). METHODS: In this prospective observational study of patients undergoing trans-sphenoidal surgery for PA or NFPA, sphenoid sinus mucosal specimens were microbiologically profiled through PCR-cloning of the 16S rRNA gene. RESULTS: Ten patients (five with PA and five with NFPAs) with a mean age of 51 years (range 23-71) were included. Differences in the sphenoid sinus microbiota of the PA and NFPA groups were observed. Four PA patients harboured Enterobacteriaceae (Enterobacter spp., N = 3; Escherichia coli, N = 1). In contrast, patients with NFPAs had a sinus microbiota more representative of health, including Staphylococcus epidermidis (N = 2) or Corynebacterium spp. (N = 2). CONCLUSIONS: PA may be associated with an abnormal sphenoid sinus microbiota that is similar to that seen in patients with sphenoid sinusitis.
Subject(s)
Pituitary Apoplexy/microbiology , Sphenoid Sinus/microbiology , Adult , Aged , Female , Humans , Male , Microbiota , Middle Aged , Pituitary Neoplasms/microbiology , Pituitary Neoplasms/surgery , Prospective Studies , Young AdultSubject(s)
Pituitary Apoplexy/microbiology , Pituitary Diseases/complications , Pituitary Gland/pathology , Tuberculoma, Intracranial/complications , Adult , Antitubercular Agents/therapeutic use , Female , Humans , Magnetic Resonance Imaging , Pituitary Diseases/diagnosis , Pituitary Diseases/drug therapy , Pituitary Diseases/pathology , Tomography, X-Ray Computed , Tuberculoma, Intracranial/diagnosis , Tuberculoma, Intracranial/drug therapy , Tuberculoma, Intracranial/pathologyABSTRACT
The combination of apoplectic symptoms and a sellar mass most often points to a diagnosis of a pituitary adenoma. Sellar tuberculomas are not considered as a cause of 'pituitary apoplexy' and there has been no radiological documentation of haemorrhage associated with them. We report a 27 years old man who presented with 3 previous episodes of pituitary apoplexy. CT scan showed evidence of a sellar mass with haemorrhage. Transsphenoidal biopsy of the intrasellar mass was reported as 'tuberculoma'. The patient had marked reduction in the size of the lesion following antituberculous therapy with no recurrence of symptoms. Intrasellar tuberculomas must be considered as one of the differential diagnosis when patients present with a pituitary apoplexy.
