1.
Cephalalgia
; 5(1): 25-9, 1985 Mar.
Article
in English
| MEDLINE
| ID: mdl-2985264
ABSTRACT
Adrenoceptors have been measured in the platelets from migrainous children, using (3H) yohimbine. Maximum binding (Bmax) was not significantly different in migrainous children and controls, 259 +/- 21 and 265 +/- 19 f moles per mg of protein respectively. Dissociation constants (KD) were significantly higher in the migraine group than in the controls 2.62 +/- 0.18 and 2.17 +/- 0.07 respectively (p less than 0.02). Bmax values were lower in 6 out of 9 cases following treatment with pizotifen. In 8 out of 9 cases KD values were lower following pizotifen treatment; in one case there was no change.
Subject(s)
Blood Platelets/metabolism , Migraine Disorders/blood , Pizotyline/therapeutic use , Receptors, Adrenergic, beta/metabolism , Thiophenes/therapeutic use , Adolescent , Child , Child, Preschool , Female , Humans , Male , Migraine Disorders/drug therapy , Pizotyline/blood , Yohimbine/blood
2.
Headache
; 16(3): 96-104, 1976 Jul.
Article
in English
| MEDLINE
| ID: mdl-965227