1.
Arterioscler Thromb Vasc Biol
; 31(11): 2397-401, 2011 Nov.
Article
in English
| MEDLINE
| ID: mdl-22011752
ABSTRACT
A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the different challenges we faced 3 decades ago in this undertaking and describes how our path was influenced by our focus on a disease process and by the evolving general understanding of the molecular effectors of cell proliferation.