ABSTRACT
OBJECTIVE: To evaluate the diagnostic value of anti-microbial peptide (cathelicidin), LL-37, in congenital pneumonia and its relation to 25 hydroxycholecalciferol [(25 OH)D] status. METHODS: The study included 30 neonates with congenital pneumonia and culture proven sepsis admitted to neonatal intensive care unit of Ain Shams University and 30 healthy neonates as control group. All neonates were subjected to history taking, clinical examination and measurement of serum 25(OH)D and cathelicidin. RESULTS: Neonates with congenital pneumonia had significantly higher serum cathelicidin and lower serum 25(OH)D compared to controls. Serum cathelicidin was negatively correlated with Apgar score at 1 and 5 min and positively correlated with length of stay among patient group. CONCLUSION: Cut-off value of cathelicidin to diagnose congenital pneumonia was 17 pg/mmol with 93% sensitivity and 86% specificity. Neonates with congenital pneumonia had significantly high cathelicidin and low 25(OH)D suggesting a possible role of fetal 25(OH)D deficiency as predisposing factor for congenital pneumonia.
Subject(s)
Antimicrobial Cationic Peptides/blood , Pneumonia, Bacterial/diagnosis , Vitamin D Deficiency/complications , Biomarkers/blood , Calcifediol/blood , Case-Control Studies , Escherichia coli Infections/blood , Escherichia coli Infections/congenital , Escherichia coli Infections/diagnosis , Female , Humans , Infant, Newborn , Klebsiella Infections/blood , Klebsiella Infections/congenital , Klebsiella Infections/diagnosis , Klebsiella pneumoniae/isolation & purification , Male , Pneumonia, Bacterial/blood , Pneumonia, Bacterial/congenital , Pneumonia, Pneumococcal/blood , Pneumonia, Pneumococcal/congenital , Pneumonia, Pneumococcal/diagnosis , Pseudomonas Infections/blood , Pseudomonas Infections/congenital , Pseudomonas Infections/diagnosis , Risk Factors , Sensitivity and Specificity , Staphylococcal Infections/blood , Staphylococcal Infections/congenital , Staphylococcal Infections/diagnosis , Vitamin D Deficiency/blood , Vitamin D Deficiency/congenital , Vitamin D Deficiency/diagnosis , CathelicidinsSubject(s)
Gonorrhea/transmission , Infectious Disease Transmission, Vertical , Neisseria gonorrhoeae/isolation & purification , Pneumonia, Bacterial/congenital , Pneumonia, Bacterial/microbiology , Adult , Anti-Bacterial Agents/therapeutic use , Cefotaxime/therapeutic use , Female , Humans , Infant, Newborn , Pneumonia, Bacterial/drug therapy , Pregnancy , Premature BirthABSTRACT
We present an autopsy case of intrauterine pneumonia in a term newborn in whom Ureaplasma parvum was confirmed by PCR examinations, including a novel diagnostic tool for detecting pathogens that caused neonatal infections using multiplex PCR. This is the first report of U. parvum being implicated in the pathogenesis of congenital pneumonia with sepsis in a term newborn.
Subject(s)
Chorioamnionitis/microbiology , Pneumonia, Bacterial/congenital , Pregnancy Complications, Infectious/microbiology , Sepsis/congenital , Ureaplasma Infections/congenital , Ureaplasma , Fatal Outcome , Female , Humans , Infant, Newborn , Male , Pneumonia, Bacterial/diagnosis , Pneumonia, Bacterial/therapy , Pregnancy , Sepsis/diagnosis , Sepsis/therapy , Ureaplasma Infections/diagnosis , Ureaplasma Infections/therapySubject(s)
Campylobacter Infections/complications , Infant, Extremely Low Birth Weight , Infant, Premature, Diseases/microbiology , Pregnancy Complications, Infectious/microbiology , Female , Humans , Infant, Newborn , Infant, Premature , Infant, Premature, Diseases/diagnosis , Infant, Premature, Diseases/therapy , Intensive Care, Neonatal , Pneumonia, Bacterial/congenital , Pneumonia, Bacterial/microbiology , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/therapyABSTRACT
A 25-day-old boy was admitted to hospital because of pneumonia and additionally developed symptoms of encephalitis. The immune fluorescence test for Chlamydia trachomatis in tracheal fluids was positive. Furthermore, ligase chain reaction for C trachomatis was positive in the cerebrospinal fluid. The antibiotic regimen was changed to erythromycin intravenously. C trachomatis encephalitis is rare in neonates and may result from a defect in the alternative pathway of complement activation which was the case in this patient.
Subject(s)
Chlamydia Infections/congenital , Chlamydia trachomatis , Encephalitis/congenital , Infant, Newborn, Diseases/diagnosis , Chlamydia Infections/diagnosis , Chlamydia Infections/immunology , Complement Pathway, Alternative/immunology , Diagnosis, Differential , Electroencephalography , Encephalitis/diagnosis , Encephalitis/immunology , Humans , Infant, Newborn , Infant, Newborn, Diseases/immunology , Male , Pneumonia, Bacterial/congenital , Pneumonia, Bacterial/diagnosis , Pneumonia, Bacterial/immunologySubject(s)
Chlamydia Infections , Chlamydia trachomatis , Chlamydophila Infections , Chlamydophila pneumoniae , Adolescent , Anti-Bacterial Agents/therapeutic use , Child , Chlamydia Infections/diagnosis , Chlamydia Infections/epidemiology , Chlamydia Infections/therapy , Chlamydia trachomatis/growth & development , Chlamydia trachomatis/isolation & purification , Chlamydophila Infections/congenital , Chlamydophila Infections/diagnosis , Chlamydophila Infections/epidemiology , Chlamydophila Infections/therapy , Chlamydophila pneumoniae/growth & development , Chlamydophila pneumoniae/isolation & purification , Female , Humans , Infant , Infant, Newborn , Male , Pneumonia, Bacterial/congenital , TrachomaABSTRACT
In the course of a connatal pneumonia, a 7-day-old female newborn developed symmetrical subcutaneous nodules on her back, shoulders, and upper arms. These skin lesions were accompanied by hypercalcemia. Histological examination confirmed the putative clinical diagnosis of subcutaneous fat necrosis of the newborn. We discuss the differential diagnoses, therapeutic strategies, and prognosis of this uncommon disorder of the fat tissue.
Subject(s)
Fat Necrosis/congenital , Pneumonia, Bacterial/congenital , Sclerema Neonatorum/diagnosis , Sepsis/congenital , Biopsy , Diagnosis, Differential , Failure to Thrive/diagnosis , Failure to Thrive/pathology , Fat Necrosis/diagnosis , Fat Necrosis/pathology , Female , Follow-Up Studies , Humans , Hypercalcemia/diagnosis , Hypercalcemia/pathology , Infant, Newborn , Panniculitis, Nodular Nonsuppurative/congenital , Panniculitis, Nodular Nonsuppurative/diagnosis , Panniculitis, Nodular Nonsuppurative/pathology , Pneumonia, Bacterial/diagnosis , Pneumonia, Bacterial/pathology , Sclerema Neonatorum/pathology , Sepsis/diagnosis , Sepsis/pathology , Skin/pathologyABSTRACT
The predisposition of the newborns to contract infections diseases is dependent upon the limited efficiency of their immune mechanisms. Congenital infections amount to 5.7% in the research material, and the acquired infections 1.15%. The isolation of the microorganism is the basis for treating infections-the profiles of the pathogenic bacterial in flora were subjected to analysis. Im generalised infections Stafphylococcus epidermidis makes 56.6% and E. Coli accounts for 87.5 of the infections of the urinary system. In our research the late sepsis and pneumonia are more frequently the result of the hospital infection (14.2%) in the cases of congenital infections-pneumonia and the infection of the urinary system (72%). Hematologic indicators such as: leucopenia, thormbocytopenia, I/T are distinct infection markers (those were found in 31% of the cases). The CRP protein shows the lowest values in congenital infections, still monitoring its level is useful for assessing the effectiveness of the undertaken antybacterial treatment. The newborns of male sex (58%) more often prone to infection. Pneumonia is the manifestation pertaining to an organ in 70% of congenital infections, the infection of urinary system amounts to 17.1%.
