Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 13 de 13
Filter
2.
Probl Radiac Med Radiobiol ; 23: 510-516, 2018 Dec.
Article in English, Ukrainian | MEDLINE | ID: mdl-30582868

ABSTRACT

OBJECTIVE: To investigate the intensity of burdensome symptoms using self-assessment MPN-SAF TSS in patientswith radiation-associated and spontaneous myeloproiliferative neoplasms (MPNs). MATERIALS AND METHODS: The study included 89 patients with radiation-associated and spontaneous MPNs, the bur-densome symptoms of MPN were determined using MPN-SAF TSS. RESULTS: The average score for complaints in patients with radiation-associated MPNs was significantly higher thanin patients with spontaneous MPNs - 43.46 and 25.04 points, respectively (p = 0.003). MPN patients classified bysubtypes also showed differences regarding intensity of burdensome MPN symptoms, demonstrating significantlyhigher average score of complaints among primary myelofibrosis patients (35.60), compared to polycythemia vera(29.60) and essential thrombocythemia (18.05) patients, (p = 0.005). Our study did not reveal any influence of theJAK2 V617F mutation on MPN burdensome symptoms intensity in MPN patients. CONCLUSIONS: We demonstrated a higher intensity of the MPN burdensome symptoms determined by the optimizedself-assessment MPN-SAF TSS in patients with radiation-associated, and in primary myelofibrosis patients, indicat-ing increased severity of patient's general conditions at the stage of diagnosis verification. It is advisable to usethe optimized MPN-SAF TSS at the moment of molecular genetic testing during the diagnosis of MPN for selectionor modifying treatment strategies in order to achieve better quality of life for patients.


Subject(s)
Chernobyl Nuclear Accident , Environmental Exposure/adverse effects , Polycythemia Vera/physiopathology , Primary Myelofibrosis/physiopathology , Radiation Exposure/adverse effects , Thrombocythemia, Essential/physiopathology , Adult , Aged , Female , Gene Expression , Humans , Janus Kinase 2/genetics , Male , Middle Aged , Mutation , Polycythemia Vera/etiology , Polycythemia Vera/genetics , Polycythemia Vera/psychology , Primary Myelofibrosis/etiology , Primary Myelofibrosis/genetics , Primary Myelofibrosis/psychology , Quality of Life/psychology , Radiation Dosage , Radiation, Ionizing , Self-Assessment , Severity of Illness Index , Thrombocythemia, Essential/etiology , Thrombocythemia, Essential/genetics , Thrombocythemia, Essential/psychology , Ukraine
3.
Acta Derm Venereol ; 98(2): 185-190, 2018 Feb 07.
Article in English | MEDLINE | ID: mdl-28971208

ABSTRACT

Aquagenic pruritus (AP) has a significant influence on quality of life (QoL) in patients with polycythaemia vera. This study analysed the impact of AP on patient well-being in 102 patients with polycythaemia vera. Intensity of pruritus was evaluated using a visual analogue scale (VAS), verbal rating scale (VRS) and a 4-item Itch Questionnaire. Psychosocial aspects of AP were assessed with the Hospital Anxiety and Depression Scale (HADS), EQ-5D and itch-specific QoL questionnaire (ItchyQoL). AP of mean duration 6.6 ± 8.6 years and intensity 4.8 ± 1.9 points (VAS) was present in 42/102 individuals. The prevalence of depression and anxiety among patients with AP was 23.8% and 9.5%, respectively. Depression was more frequent in the AP group (vs. non-AP). Moreover, patients with AP had higher HADS-anxiety scoring than those without pruritus (p = 0.005). A negative correlation was found between duration of AP and EQ-5D-VAS. The ItchyQol score of 37.3 ± 12.3 points was influenced by the extent (p =0.01) and duration of episodes of AP (p = 0.02). In conclusion, AP places an additional burden on patients with polycy-thaemia vera, negatively influencing their QoL.


Subject(s)
Cost of Illness , Pruritus/epidemiology , Quality of Life , Water/adverse effects , Adult , Aged , Aged, 80 and over , Anxiety/diagnosis , Anxiety/epidemiology , Anxiety/psychology , Depression/diagnosis , Depression/epidemiology , Depression/psychology , Female , Humans , Male , Mental Health , Middle Aged , Poland/epidemiology , Polycythemia Vera/diagnosis , Polycythemia Vera/epidemiology , Polycythemia Vera/psychology , Polycythemia Vera/therapy , Prevalence , Pruritus/diagnosis , Pruritus/psychology , Pruritus/therapy , Risk Factors , Surveys and Questionnaires
4.
J Natl Compr Canc Netw ; 14(12): 1563-1570, 2016 12.
Article in English | MEDLINE | ID: mdl-27956541

ABSTRACT

BACKGROUND: BCR-ABL-negative myeloproliferative neoplasms (MPNs) represent a heterogeneous group of diseases, including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). Psychological manifestations among these diseases have not been adequately described. METHODS: Cross-sectional surveys measuring distress, anxiety, and depression were collected from patients with BCR-ABL-negative MPNs from May 2015 to October 2015. Participants provided demographic information and completed the Distress Thermometer and Problem List (DT&PL) to assess distress and the Hospital Anxiety and Depression Scale (HADS) to assess distress, anxiety, and depression. They provided information on how their MPN affected their lives. RESULTS: Of the 117 participants, 31.2% had PV, 28.4% had ET, 28.4% had MF, and 11.9% had another type of MPN. Time with MPN varied from less than 1 year (7.5%), 1 to 3 years (19.8%), 3 to 5 years (23.6%), 5 to 10 years (19.8%), and more than 10 years (29.2%). Distress averaged 3.14 (SD, 2.83; DT&PL), with 40.4% meeting NCCN criteria for distress, and averaged 8.97 (SD, 7.44; HADS), with 38.5% meeting HADS criteria for distress. Anxiety averaged 5.54 (SD, 4.37), with 31.3% meeting HADS criteria for anxiety. Depression averaged 3.4 (SD, 3.4), with 12.5% meeting HADS criteria for depression. Distress was higher for PV (3.86), MF (3.12), and "other" MPN (4.33) than it was for ET (1.81; P=.016). Distress was more common in non-white patients (P=.015) and those with either PV or MF but not ET (DT&PL ≥4; P=.038). Patients' comments described coping strategies or symptom burden. CONCLUSIONS: Distress and anxiety are highly prevalent with BCR-ABL-negative MPNs and may correspond to disease-related symptom burden. These findings deserve further study.


Subject(s)
Anxiety/epidemiology , Depression/epidemiology , Fusion Proteins, bcr-abl/metabolism , Polycythemia Vera/psychology , Primary Myelofibrosis/psychology , Stress, Psychological/epidemiology , Thrombocythemia, Essential/psychology , Adult , Age Factors , Aged , Antidepressive Agents/therapeutic use , Anxiety/drug therapy , Cross-Sectional Studies , Depression/drug therapy , Female , Humans , Male , Middle Aged , Polycythemia Vera/metabolism , Prevalence , Primary Myelofibrosis/metabolism , Sex Factors , Stress, Psychological/drug therapy , Thrombocythemia, Essential/metabolism , Time Factors
5.
Cancer ; 122(12): 1888-96, 2016 Jun 15.
Article in English | MEDLINE | ID: mdl-27070130

ABSTRACT

BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODS: A total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTS: Overall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P<.001), with 64% of patients with MPN describing some degree of sexual dysfunction and 43% experiencing severe symptoms. The presence of sexual symptoms correlated closely with all domains of patient functionality (physical, social, cognitive, emotional, and role functioning) and were associated with a reduced quality of life. Sexual problems also were found to be associated with other MPN symptoms, particularly depression and nocturnal and microvascular-related symptoms. Sexual dysfunction was more severe in patients aged >65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. CONCLUSIONS: The results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management. Cancer 2016;122:1888-96. © 2016 American Cancer Society.


Subject(s)
Myeloproliferative Disorders/physiopathology , Myeloproliferative Disorders/psychology , Sexual Dysfunction, Physiological/etiology , Sexual Dysfunctions, Psychological/etiology , Case-Control Studies , Female , Humans , Male , Middle Aged , Polycythemia Vera/physiopathology , Polycythemia Vera/psychology , Primary Myelofibrosis/physiopathology , Primary Myelofibrosis/psychology , Quality of Life , Sexual Behavior , Sexuality , Surveys and Questionnaires , Thrombocythemia, Essential/physiopathology , Thrombocythemia, Essential/psychology
6.
Leuk Lymphoma ; 54(10): 2226-30, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23398206

ABSTRACT

The quality of life (QoL) at the time of diagnosis of myeloproliferative neoplasm (MPN) has, to date, not been studied. One hundred and seventy-nine patients with MPN: 80 with essential thrombocythemia (ET), 73 with polycythemia vera (PV), 22 with primary myelofibrosis (PMF) and four with MPN undifferentiated, were included in this study. European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQC30) and the MPN-Symptom Assessment Form (MPN-SAF) were used to evaluate QoL. Fatigue was the most reported symptom in these patients. Patients with PV reported significantly higher mean scores for inactivity, dizziness, cough, itching, depression and lower total QoL compared to patients with ET. Patients with PV had significantly more headache and itching compared to patients with PMF. When the newly diagnosed patients with MPN were compared with a cohort of patients with MPN with mean disease duration of 7.8 years, the differences were most striking for patients with PMF, with significantly more fatigue, abdominal discomfort, concentration problems, insomnia, fever, weight loss and lower overall QoL developed over time.


Subject(s)
Myeloproliferative Disorders/psychology , Polycythemia Vera/psychology , Quality of Life , Adult , Aged , Aged, 80 and over , Female , Health Surveys , Humans , Male , Middle Aged , Myeloproliferative Disorders/diagnosis , Polycythemia Vera/diagnosis , Surveys and Questionnaires
8.
Br J Clin Pract ; 49(2): 97-9, 1995.
Article in English | MEDLINE | ID: mdl-7779654

ABSTRACT

A patient with polycythaemia rubra vera is described, presenting primarily with symptoms attributed to depression. While in the ward she developed a stroke, confirmed on CT scan of the head. Venesection alone produced marked improvement in her neurological and psychiatric symptoms. The clinical picture corresponds most accurately to the neurological syndrome of abulia, which is an important differential diagnosis of depression with psychomotor retardation. The pathophysiology of impaired cerebral blood flow causing neuropsychiatric symptoms in polycythaemia is discussed.


Subject(s)
Depression/etiology , Polycythemia Vera/psychology , Volition , Adult , Bloodletting , Female , Humans , Syndrome
9.
Br J Psychiatry ; 162: 833-5, 1993 Jun.
Article in English | MEDLINE | ID: mdl-8330115

ABSTRACT

The case is described of a 65-year-old woman who initially presented with delirium caused by polycythaemia rubra vera. Following venesection she was discharged home recovered, but presented again shortly after with an episode of mania associated with relapse of her polycythaemia.


Subject(s)
Bipolar Disorder/etiology , Delirium/etiology , Neurocognitive Disorders/etiology , Polycythemia Vera/complications , Aged , Bipolar Disorder/psychology , Blood Cell Count , Bloodletting , Delirium/psychology , Female , Humans , Neurocognitive Disorders/psychology , Neurologic Examination , Neuropsychological Tests , Polycythemia Vera/psychology , Recurrence
11.
Br J Psychiatry ; 158: 842-4, 1991 Jun.
Article in English | MEDLINE | ID: mdl-1873637

ABSTRACT

A patient with polycythaemia rubra vera complicated by severe psychotic depression is described. There have been no previous reports of polycythaemia rubra vera associated with psychiatric morbidity.


Subject(s)
Depressive Disorder/psychology , Ischemic Attack, Transient/psychology , Neurocognitive Disorders/psychology , Polycythemia Vera/psychology , Aged , Anxiety Disorders/psychology , Delusions/psychology , Electroconvulsive Therapy , Follow-Up Studies , Hallucinations/psychology , Humans , Male , Neuropsychological Tests , Psychiatric Status Rating Scales
SELECTION OF CITATIONS
SEARCH DETAIL
...