ABSTRACT
On the basis of studies aimed at the substantiation of MAC for cyclophos in soil it was established, that subthreshold amounts of cyclophos according to the water-migration and air-migration indexes of harmfulness equal 0.03 mg per 1 kg of absolutely dry soil, according to the general sanitary index--0.1 mg/kg. Since cyclophos destruction period in plants is relatively short (8 days), there is no danger of translocation of the pesticide from soil in amounts exceeding the maximum allowable level for cyclophos in food stuffs. The pesticide migration in the system soil-plant was not determined. The water migration and air-migration indexes are the limiting indexes of harmfulness for cyclophos. 0.03 mg/kg is recommended as the maximum allowable concentration of cyclophos in soil.
Subject(s)
Air Pollutants/toxicity , Polyphosphates/toxicity , Soil Microbiology , Soil Pollutants/toxicity , Water Pollutants, Chemical/toxicity , Air Pollutants/analysis , Drug Resistance, Microbial , Drug Stability , Maximum Allowable Concentration , Moldova , Polyphosphates/analysis , Polyphosphates/pharmacokinetics , Polyphosphates/standards , Soil Pollutants/analysis , Ukraine , Water Pollutants, Chemical/analysisABSTRACT
The results of analysis of 99mTc-Pyrophosphate (99mPyP), taken as a representative of the group of compounds having an organic P-O-P bond, and of the three diphosphonate compounds: methylene diphosphonate (MDP), 2,3-dicarboxy propane diphosphonate (DPD) and ethane-1-hydroxy-1, 1-diphosphonate (EHDP), which differ in their chemical structure, are shown. Also, some physicochemical parameters such as chloroform-water apparent partition coefficient, the osmotic pressure and pH values in final preparations were studied. The radiochemical purity of these radiopharmaceuticals was determined by the two methods: Sephadex chromatography for separation of 99mTc-hydrolysate and TLC on silica gel with 85% methanol for the determination of free 99mTcO-4. The yield of labelling for both methods was over 90%. Also, pharmacokinetic parameters such as binding to the plasma proteins and to erythrocytes were determined. 99mTc-PyP binding to plasma proteins was higher than the binding of diphosphonate compounds. The quantitative distribution of preparations was determined in experimental animals.
