ABSTRACT
Eccrine poroma presents as a single, symptomless erythematous papule in areas with a high density of eccrine sweat glands. Although rare, eccrine poromas can present as multiple lesions, otherwise known as eccrine poromatosis. The etiology of eccrine poromatosis is unclear. We present two cases of eccrine poromatosis in patients who had undergone chemotherapy, radiation therapy, and stem cell transplant. This case report serves to raise awareness of this condition and highlight its association with malignancies and their treatment.
Subject(s)
Antineoplastic Agents/adverse effects , Poroma/etiology , Radiotherapy/adverse effects , Sweat Gland Neoplasms/etiology , Aged , Drug-Related Side Effects and Adverse Reactions , Humans , Lymphoma, Large B-Cell, Diffuse/complications , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Mantle-Cell/complications , Lymphoma, Mantle-Cell/drug therapy , Male , Middle Aged , Poroma/pathology , Prostatic Neoplasms/complications , Prostatic Neoplasms/radiotherapy , Sweat Gland Neoplasms/pathologySubject(s)
Leukemia, Myeloid, Acute/therapy , Merkel cell polyomavirus/isolation & purification , Papillomaviridae/isolation & purification , Poroma/virology , Stem Cell Transplantation/adverse effects , Sweat Gland Neoplasms/virology , Allografts , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy, Needle , Follow-Up Studies , Humans , Immunohistochemistry , In Situ Hybridization/methods , Leukemia, Myeloid, Acute/diagnosis , Male , Polymerase Chain Reaction/methods , Poroma/etiology , Poroma/therapy , Rare Diseases , Risk Assessment , Stem Cell Transplantation/methods , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/therapySubject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Peripheral Blood Stem Cell Transplantation/adverse effects , Poroma/etiology , Sweat Gland Neoplasms/etiology , Female , Humans , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/therapy , Middle Aged , Poroma/pathology , Sweat Gland Neoplasms/pathology , Transplantation, AutologousABSTRACT
Eccrine poromas are rare, benign adnexal tumors that often occur as solitary papules. Rarely, eccrine poromas can present as multiple lesions, which is referred to as eccrine poromatosis. We report a case of eccrine poromatosis occuring on the palms and soles occuring after chemotherapy in a patient with a history of acute myeloid leukemia.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Leukemia, Myeloid, Acute/complications , Poroma/etiology , Poroma/pathology , Sweat Gland Neoplasms/complications , Cytarabine/administration & dosage , Daunorubicin/administration & dosage , Etoposide/administration & dosage , Humans , Leukemia, Myeloid, Acute/therapy , Male , Middle Aged , Stem Cell Transplantation , Sweat Gland Neoplasms/pathologySubject(s)
Adenocarcinoma/radiotherapy , Eye Neoplasms/radiotherapy , Lacrimal Apparatus Diseases/radiotherapy , Neoplasms, Radiation-Induced/etiology , Poroma/etiology , Sweat Gland Neoplasms/etiology , Adenocarcinoma/surgery , Aged , Biopsy , Eye Neoplasms/surgery , Female , Humans , Lacrimal Apparatus Diseases/surgery , Poroma/pathology , Radiotherapy, Adjuvant/adverse effects , Risk Factors , Sweat Gland Neoplasms/pathologyABSTRACT
A poroma is a benign epithelial neoplasm that most commonly presents as a solitary papule on the palm or sole. We report the case of a 25-year-old male, with a history of acute myelogenous leukemia, who developed multiple poromas on the feet. Poromatosis - the occurrence of multiple poromas - has been described in six adults and one child; it appears to be more prevalent in patients with a history of lymphoproliferative disorder or radiation exposure.
Subject(s)
Foot Diseases/diagnosis , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Second Primary/diagnosis , Poroma/diagnosis , Sweat Gland Neoplasms/diagnosis , Adult , Bone Marrow Transplantation/adverse effects , Foot Diseases/etiology , Foot Diseases/pathology , Humans , Leukemia, Myeloid, Acute/complications , Male , Neoplasms, Multiple Primary/etiology , Neoplasms, Multiple Primary/pathology , Neoplasms, Second Primary/etiology , Neoplasms, Second Primary/pathology , Poroma/etiology , Poroma/pathology , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/pathologyABSTRACT
The poroid family of neoplasms includes hidroacanthoma simplex, eccrine poroma, dermal duct tumor, and poroid hidradenoma. These benign adnexal neoplasms are derived from the eccrine or apocrine sweat ducts or glands. Poroid neoplasms, including poromas, have been reported during pregnancy and have been hypothesized to be hormonally influenced. Poromatosis, the occurrence of multiple poromas, rarely has been reported in association with hidrotic ectodermal dysplasia, prior radiation therapy, and non-Hodgkin lymphoma occurring after chemotherapy. We report a case of eruptive poromatosis in pregnancy with 8 poromas occurring in the third trimester, further supporting the hypothesis of a hormonal association in the etiology of this neoplasm.
Subject(s)
Poroma/pathology , Sweat Gland Neoplasms/pathology , Adult , Female , Humans , Poroma/diagnosis , Poroma/etiology , Pregnancy , Pregnancy Trimester, Third , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/etiologyABSTRACT
We describe a patient with previous solid-organ (testicular, oesophageal) and haematological (acute myeloid leukaemia) malignancies, in whom chronic cutaneous graft-versus-host disease was complicated by poromas and porokeratosis. Chemotherapy, total body irradiation, longstanding immunosuppression and ultraviolet radiation may all have played a part in the pathogenesis of the skin tumours.
