ABSTRACT
OBJECTIVE: To estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The Serum Neopterin and Interleukin-2 (IL-2) were measured. METHODS: Sixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups: (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared. RESULTS: In group A, Serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both Serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, Serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation. CONCLUSION: Autologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.
Subject(s)
Blood Transfusion, Autologous/adverse effects , Interleukin-2/immunology , Neopterin/immunology , Perioperative Care/adverse effects , Postgastrectomy Syndromes/etiology , Postgastrectomy Syndromes/immunology , Stomach Neoplasms/immunology , Stomach Neoplasms/surgery , Adult , Aged , Blood Transfusion, Autologous/methods , Female , Humans , Interleukin-2/blood , Male , Middle Aged , Neopterin/blood , Perioperative Care/methods , Postgastrectomy Syndromes/blood , Stomach Neoplasms/blood , Treatment OutcomeABSTRACT
The method of dynamic endoscopic observation was used in examination of 288 patients after resections of the stomach. Four types of the inflammatory reaction of the gastric stump mucosa and of the anastomosed intestine were found out depending on the degree and spread of the inflammatory alterations during the postoperative period. A correlation was established between the type of inflammatory and immunomorphological changes and the probability of the appearance of peptic ulcer of the anastomosis.
Subject(s)
Gastrectomy , Gastric Mucosa/pathology , Gastroscopy , Adult , Biopsy , Female , Follow-Up Studies , Gastric Mucosa/immunology , Humans , Male , Middle Aged , Postgastrectomy Syndromes/immunology , Postgastrectomy Syndromes/pathology , Prognosis , Stomach Diseases/immunology , Stomach Diseases/pathology , Stomach Diseases/surgeryABSTRACT
Patients with stomach cancer, primary chronic gastritis (with intestine-type metaplasia of mucosa), old-age gastritis, post-resection gastritis, B12-deficiency-induced gastritis, stomach ulcer and chronic non-specific diseases of the lungs revealed a high sensitization to stomach cancer antigens matched by a low one to antigens of unaltered mucosa of the stomach. Patients with malignancies at sites other than the stomach, morphological patterns of gastritis as well as cases of primary chronic gastritis unaccompanied by intestinal metaplasia showed a reverse correlation: a high activity of T-lymphocytes with respect to unaltered gastric mucosa antigens and a low one--to stomach cancer antigens. An immunologic test using stomach and tumor antigens for screening of those at high risk for stomach cancer is suggested.
