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1.
Fiziol Zh (1994) ; 58(5): 3-13, 2012.
Article in Ukrainian | MEDLINE | ID: mdl-23233941

ABSTRACT

The study was conducted in normotensive and spontaneously hypertensive rats anesthetized with urethane (1600 mg/kg of animal weight, intraperitoneally). It has been shown that in normotensive rats, injections of a specific inhibitor of Na+, K(+)-ATPase ouabain (10(-8)-10(-5) mol/l) in the populations of the neurons within nucleus of the solitary tract (NTS), paramedian reticular nucleus (PMn) and lateral reticular nucleus (LRN) were accompanied by the development of the hypertensive responses in a dose-dependent fashion. These data suggest that Na+, K(+)-ATPase of the neuron somatic membranes in the medullary cardiovascular nuclei is involved in neural control of the cardiovascular function, and its inhibition by microinjections of ouabain promotes the development of hypertension. In contrast to normotensive rats, ouabain injected in the medullary nuclei of spontaneously hypertensive animals induced either enhanced hypertensive or hypotensive responses. Biochemical analysis revealed that the activity of Na+, K(+)-ATPase in the microsomal fraction of the medulla oblongata of spontaneously hypertensive rats significantly exceeded its activity in the medulla oblongata of normotensive animals. Possible mechanisms of ouabain effects in spontaneously hypertensive rats have being discussed. Activation of Na+, K(+)-ATPase activity of the cardiovascular neurons with asparkam injections in the medullary nuclei resulted in hypotensive responses in both normotensive and spontaneously hypertensive rats.


Subject(s)
Hypertension/enzymology , Neurons/drug effects , Olivary Nucleus/drug effects , Reticular Formation/drug effects , Sodium-Potassium-Exchanging ATPase/metabolism , Solitary Nucleus/drug effects , Animals , Blood Pressure/drug effects , Cardiotonic Agents/administration & dosage , Enzyme Activation/drug effects , Hemodynamics/drug effects , Hypertension/physiopathology , Injections, Intraventricular , Microinjections , Neurons/enzymology , Olivary Nucleus/enzymology , Ouabain/administration & dosage , Potassium Magnesium Aspartate/administration & dosage , Potassium Magnesium Aspartate/analogs & derivatives , Rats , Rats, Inbred SHR , Reticular Formation/enzymology , Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors , Solitary Nucleus/enzymology
2.
Anesteziol Reanimatol ; (3): 8-13, 2011.
Article in Russian | MEDLINE | ID: mdl-21853612

ABSTRACT

UNLABELLED: The purpose of the study is to examine the relationship between the concentration of magnesium in plasma and vascular reactions during cardiac surgery. MATERIALS AND METHODS: The study included 77 patients with coronary artery disease who underwent myocardial revascularization surgery. In the first group (n = 44) during the entire operation infusion solution "potassium and magnesium asparginate" (Berlin-Chemie) was carried out at a rate of 1.5-2 ml/kg/h, in the second group (n = 33) patients were injected magnesium free crystalloid solutions. An analysis of central hemodynamics (PiCCO Plus) and microcirculation (laser Doppler flowmetry LASMA) was carried out. CONCLUSION: Maintenance of normal concentrations of magnesium in blood plasma reduces the incidence of episodes of intraoperative hypertension and improves peripheral microcirculation.


Subject(s)
Anesthesia, General , Cardiotonic Agents/blood , Hemodynamics/drug effects , Magnesium/blood , Myocardial Revascularization/methods , Adult , Aged , Cardiotonic Agents/administration & dosage , Cardiotonic Agents/therapeutic use , Crystalloid Solutions , Extracorporeal Circulation , Female , Humans , Hypertension/prevention & control , Intraoperative Complications/prevention & control , Isotonic Solutions , Magnesium/administration & dosage , Magnesium/therapeutic use , Male , Microcirculation/drug effects , Middle Aged , Potassium Magnesium Aspartate/administration & dosage , Potassium Magnesium Aspartate/blood , Potassium Magnesium Aspartate/therapeutic use , Treatment Outcome
3.
Anesteziol Reanimatol ; (5): 17-21, 2008.
Article in Russian | MEDLINE | ID: mdl-19105253

ABSTRACT

The study included 42 patients with coronary heart disease operated on the coronary arteries. A potassium and magnesium asparaginate (PMA) solution, 450-1000 ml, was injected in 30 patients for 5-7 hours; other crystalloid solutions was used in a control group (n = 12). The concentrations of potassium and magnesium were measured prior to surgery, following initial anesthesia, before and after extracorporeal circulation (EC). The measurements suggested a significant potassium and magnesium intake at surgery under EC. The use of PMA solution showed its advantage in stabilizing the study electrolytes at the main surgical stages. Inclusion of PMA into infusion therapy considerably reduced a need for an additional use of concentrated KCl solution to maintain potassium at the preoperative level. Of particular importance was the use of PMA to maintain magnesium that was held in the upper normal range throughout the operation, as shown by both the median values and an individual analysis. When PLA was not administered, the mean concentration of magnesium was consistent with that in the lower normal electrolyte range and 50% patients developed hypomagnesemia. The comparative analysis of the clinical course after EC in both groups of patients with different levels of magnesium was indicative of the better status of some hemostatic parameters with the level of magnesium being maintained in the upper normal range.


Subject(s)
Cardiotonic Agents/therapeutic use , Extracorporeal Circulation , Magnesium/blood , Myocardial Revascularization/methods , Potassium Magnesium Aspartate/therapeutic use , Potassium/blood , Water-Electrolyte Balance/drug effects , Adult , Aged , Cardiotonic Agents/administration & dosage , Coronary Disease/blood , Coronary Disease/surgery , Female , Humans , Male , Middle Aged , Potassium Magnesium Aspartate/administration & dosage , Prospective Studies , Retrospective Studies , Treatment Outcome
4.
Eksp Klin Farmakol ; 70(1): 17-21, 2007.
Article in Russian | MEDLINE | ID: mdl-17402586

ABSTRACT

Injection forms of potassium (K) and magnesium (Mg) aspartate (Asp) were compared in preventing cardiac disorders caused by electrolytic disturbances, primarily low K and Mg levels (e.g. caused by the treatment with cardiac glycosides and diuretic drugs). Widely used K- and Mg-Asp preparations (asparkam, panangin, pamaton) are synthesized from aspartic acid representing a racemic mixture of L- and D-stereoisomers. Differences in metabolism and utilization of D- and L-amino acids probably influence the pharmacological properties of K and Mg L- and D-aspartates. Moreover, the pharmacologically effective doses of Mg and K salts can induce toxicity, which depends on the nature of anions. The aim of this study was to compare of antiarrhythmic action of K and Mg L-, D-, and DL-Asp stereoisomers using calcium chloride (CaCl2) and aconitine induced arrhythmia models in rats and strophanthin-K induced arrhythmia model in guinea pigs. It was found that intravenously administered K- and Mg-L-Asp exhibited higher activity compared to K- and Mg-D- and DL-Asp on the strophanthin-K, CaCl2, and aconitine induced arrhythmia models. Indeed, K- and Mg-L-Asp more effectively decreased the incidence of arrhythmias, increased the time to onset of the first arrhythmia, decreased percentage loss of rats, and increased the survival life of animals after the first arrhythmia onset in rats with arrhythmias induced by strophanthin-K and CaCl2 as compared to K and Mg-D- and DL-Asp. At the same time K- and Mg-L-Asp was better than D- and DL-Asp with respect to acute toxicity (LD50), effective dose (ED50) and antiarrhythmic (therapeutic) ratio (LD50/ED50) in rats with aconitine-induced arrhythmia model.


Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Arrhythmias, Cardiac/drug therapy , Potassium Magnesium Aspartate/therapeutic use , Aconitine/toxicity , Animals , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/chemistry , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/prevention & control , Calcium Chloride/toxicity , Disease Models, Animal , Guinea Pigs , Heart Rate/drug effects , Injections , Potassium Magnesium Aspartate/administration & dosage , Potassium Magnesium Aspartate/chemistry , Rats , Stereoisomerism , Strophanthins/toxicity
5.
Klin Med (Mosk) ; 80(9): 60-2, 2002.
Article in Russian | MEDLINE | ID: mdl-12416230

ABSTRACT

According to estimates of WHO experts cases with diagnosed cardiomyopathy account for 40-60 per 100,000. Restrictive cardiopathy (RCP) is encountered in 5% of all the diagnosed cases of cardiomyopathy. Two patients (a mother and her daughter) with suspected of family RCP were examined using ECG, Holter ECG monitoring, echo-CG, histological tests, x-ray, blood biochemical tests. Echo-CG was most informative for verification of RCP diagnosis. The daughter had edema, enlarged liver, arterial hypertension, cardiac arrhythmia. The mother had arrhythmia, dyslipidemia. Based on the above symptoms, the patients received combined drug therapy with positive results.


Subject(s)
Cardiomyopathy, Restrictive/genetics , Adult , Aged , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/therapeutic use , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/therapeutic use , Aspirin/administration & dosage , Aspirin/therapeutic use , Atenolol/administration & dosage , Atenolol/therapeutic use , Atrial Fibrillation/complications , Atrial Fibrillation/drug therapy , Cardiomyopathy, Restrictive/complications , Cardiomyopathy, Restrictive/diagnosis , Cardiomyopathy, Restrictive/drug therapy , Cardiotonic Agents/administration & dosage , Cardiotonic Agents/therapeutic use , Echocardiography , Electrocardiography, Ambulatory , Female , Follow-Up Studies , Hemodynamics , Humans , Hypertension/complications , Hypertension/drug therapy , Niacin/administration & dosage , Niacin/therapeutic use , Platelet Aggregation Inhibitors/administration & dosage , Platelet Aggregation Inhibitors/therapeutic use , Potassium Magnesium Aspartate/administration & dosage , Potassium Magnesium Aspartate/therapeutic use , Propranolol/administration & dosage , Propranolol/therapeutic use , Time Factors , Vasodilator Agents/administration & dosage , Vasodilator Agents/therapeutic use
6.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 16(4): 210-2, 1996 Apr.
Article in Chinese | MEDLINE | ID: mdl-9206242

ABSTRACT

Sixty chronic active hepatitis patients complicated with hyperbilirubinemia (total bilirubin > 171 mumol/L) were treated with combined treatment of Ganyan IV and Western medicine. The curative effect was compared with that treated with Western medicine alone as control (56 cases). Result showed that the effect of combined therapy group was much better than that of the control in eliminating the jaundice, descending the alanine transaminase (ALT) and improving the reversed A/G ratio (P < 0.05-0.001). In experimental studies, Ganyan IV was applied to the mice with acute liver damage formed by CCl4. It also showed significant effect on reducing total bilirubin and elevating the serum albumin statistically as compared with control (P < 0.05 = 0.01). In addition Ganyan IV could accellerating the bile excretion of normal as well as of liver damaged rats significantly. It was concluded that the Ganyan IV has the effects of treating jaundice, descending transaminase, elevating serum albumin and improving A/G ratio.


Subject(s)
Drugs, Chinese Herbal/administration & dosage , Hepatitis, Chronic/drug therapy , Hyperbilirubinemia/drug therapy , Adolescent , Adult , Animals , Carbon Tetrachloride , Chemical and Drug Induced Liver Injury , Drug Therapy, Combination , Female , Hepatitis, Chronic/complications , Humans , Hyperbilirubinemia/etiology , Magnesium Sulfate/administration & dosage , Male , Mice , Middle Aged , Potassium Magnesium Aspartate/administration & dosage , Random Allocation , Rats , Rats, Wistar
7.
Int J Sport Nutr ; 5(2): 102-9, 1995 Jun.
Article in English | MEDLINE | ID: mdl-7670449

ABSTRACT

This study examined the effects of aspartate supplementation (ASP) on plasma ammonia concentrations ([NH4+]) during and after a resistance training workout (RTW). Twelve male weight trainers were randomly administered ASP or vitamin C in a crossover, double blind protocol, each trial separated by 1 wk. ASP and vitamin C were given over a 2-hr period beginning 5 hr prior to the RTW. The RTW consisted of bench, incline, shoulder, and triceps presses, and biceps curls at 70% of one repetition maximum (1-RM). After the RTW a bench press test (BPT) to failure at 65% of 1-RM was used to assess performance. [NH4+] was determined preexercise, 20 and 40 min midworkout, immediately postexercise, and 15 min postexercise. Treatment-by-time ANOVAs, paired t tests, and contrast comparisons were used to identify mean differences. No significant differences were observed between treatments for [NH4+] or BPT. [NH4+] increased significantly from Pre to immediately postexercise for both the ASP and vitamin C trials. Acute ASP supplementation does not reduce [NH4+] during and after a high intensity RTW in weight trained subjects.


Subject(s)
Ammonia/blood , Exercise/physiology , Potassium Magnesium Aspartate/pharmacology , Adolescent , Adult , Analysis of Variance , Ascorbic Acid/administration & dosage , Ascorbic Acid/pharmacology , Cross-Over Studies , Double-Blind Method , Food, Fortified , Humans , Lactates/blood , Male , Potassium Magnesium Aspartate/administration & dosage
8.
Vestn Otorinolaringol ; (5): 47-9, 1991.
Article in Russian | MEDLINE | ID: mdl-1661458

ABSTRACT

Virological and cytochemical parameters of blood leukocytes during acute stenosing laryngotracheitis in 53 children were measured, viz. succinate dehydrogenase, mitochondrial alpha-glycerophosphate dehydrogenase, acid and alkaline phosphatase, myeloperoxidase. The patients were subjected to a combined treatment which included metabolites and their cofactors. The treatment gave good results, shortening the duration and reducing the number of relapses of the disease.


Subject(s)
Laryngostenosis/blood , Leukocytes/enzymology , Tracheal Stenosis/blood , Tracheitis/blood , Acid Phosphatase/blood , Acute Disease , Alkaline Phosphatase/blood , Enzyme Activation/drug effects , Glycerolphosphate Dehydrogenase/blood , Glycerolphosphate Dehydrogenase/deficiency , Humans , Infant , Laryngostenosis/complications , Peroxidase/blood , Peroxidase/deficiency , Potassium Magnesium Aspartate/administration & dosage , Potassium Magnesium Aspartate/pharmacology , Riboflavin/administration & dosage , Riboflavin/pharmacology , Succinate Dehydrogenase/blood , Tracheal Stenosis/complications , Tracheitis/complications
9.
Wien Med Wochenschr ; 141(3): 64-5, 1991.
Article in German | MEDLINE | ID: mdl-1711738

ABSTRACT

In 21 patients with ventricular arrhythmias we analysed the effect of an intravenous infusion of potassium-magnesium-aspartate. It could be demonstrated that the frequency of ventricular ectopic beats significantly declined 1 hour after starting the medication. The maximum effect occurred at the 6th and 7th hour and continued until the 10th hour after starting the medication.


Subject(s)
Anti-Arrhythmia Agents , Cardiac Complexes, Premature/drug therapy , Electrocardiography, Ambulatory/drug effects , Potassium Magnesium Aspartate/administration & dosage , Electrocardiography, Ambulatory/instrumentation , Female , Humans , Infusions, Intravenous , Male , Microcomputers , Middle Aged , Signal Processing, Computer-Assisted/instrumentation
10.
J Cardiothorac Anesth ; 3(2): 176-80, 1989 Apr.
Article in English | MEDLINE | ID: mdl-2519943

ABSTRACT

In a prospective randomized double-blind study, the peripheral vascular effects of potassium chloride (KCl) and potassium-magnesium-aspartate (KMA) were compared. Twenty patients undergoing coronary artery bypass graft surgery received either 12 mmol of KCl (n = 10) or 12 mmol of KMA (n = 10) into the oxygenator of the heart-lung machine during extracorporeal circulation (ECC). The most striking difference between these two solutions was vasoconstriction following KCl administration and vasodilation after KMA injection. In the KMA group, decreases of perfusion pressure (MAP) and systemic vascular resistance (SVR), as well as changes in the oxygenator volume (dV), were significant (P less than 0.01) between the first and the fifth minutes. Maximal changes of MAP, from 72 +/- 13 to 59 +/- 12 mmHg (mean +/- SD), and SVR were recorded in the first and second minutes. Oxygenator volume changes reached their maximum (285 +/- 163 mL) in the tenth minute. In the KCl group, maximal increases in MAP, from 70 +/- 16 to 81 +/- 20 mmHg (mean +/- SD), and SVR were found in the fourth minute. Maximal changes in dV (300 +/- 315 mL) were measured in the tenth minute. Plasma epinephrine levels, which were already elevated during ECC, showed further increases in all cases in the KCl group and in most of the cases in the KMA group. The change in plasma epinephrine concentration following KCl injection was significant (P less than 0.01). No characteristic change in plasma norepinephrine was found in either of the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Epinephrine/blood , Extracorporeal Circulation , Hemodynamics/drug effects , Norepinephrine/blood , Potassium Chloride/pharmacology , Potassium Magnesium Aspartate/pharmacology , Potassium/blood , Aged , Analysis of Variance , Blood Pressure/drug effects , Blood Volume/drug effects , Double-Blind Method , Humans , Middle Aged , Oxygenators , Potassium Chloride/administration & dosage , Potassium Magnesium Aspartate/administration & dosage , Prospective Studies , Vascular Resistance/drug effects
12.
Kardiologiia ; 24(3): 35-9, 1984 Mar.
Article in Russian | MEDLINE | ID: mdl-6727091

ABSTRACT

The effect of a series of drugs (retabolil, strophanthin, retabolil with strophanthin, retabolil with panangin , methyluracil with panangin ) on protein metabolism was investigated in 246 patients with acute myocardial infarction. Retabolil both alone and combined with panangin , and a methyluracil-- panangin combination were found to have anticatabolic and protein synthesizing effects. Strophanthin, when used in the acute period of myocardial infarction, contributes to an increase in the protein decay rate and a decrease in protein synthesis. When it is employed in combination with metabolism corrective agents (retabolil), the adverse effects of strophanthin mentioned above are eliminated.


Subject(s)
Anabolic Agents/administration & dosage , Myocardial Infarction/drug therapy , Serum Albumin, Radio-Iodinated/metabolism , Adult , Aged , Drug Therapy, Combination , Humans , Middle Aged , Myocardial Infarction/metabolism , Nandrolone/administration & dosage , Nandrolone/analogs & derivatives , Nandrolone Decanoate , Potassium Magnesium Aspartate/administration & dosage , Strophanthins/administration & dosage , Uracil/administration & dosage , Uracil/analogs & derivatives
13.
Farmakol Toksikol ; 45(6): 41-5, 1982.
Article in Russian | MEDLINE | ID: mdl-7151998

ABSTRACT

The effects of isoptin and panangin on the collateral coronary blood flow have been examined in dogs during acute occlusion of the left coronary artery. It has been established that panangin (1 and 6 mg/kg) and isoptin (0.005 mg/kg) increase the collateral blood inflow to the ischemic zone, raise the cardiac output, and reduce the peripheral resistance. The raising of the isoptin dose up to 0.01 mg/kg inhibits the blood supply of the affected area, decreases the systolic and minute heart volumes.


Subject(s)
Aspartic Acid/analogs & derivatives , Calcium Channel Blockers/administration & dosage , Collateral Circulation/drug effects , Coronary Circulation/drug effects , Coronary Disease/drug therapy , Potassium Magnesium Aspartate/administration & dosage , Verapamil/administration & dosage , Animals , Coronary Disease/physiopathology , Dogs , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Hemodynamics/drug effects , Male
15.
Kardiologiia ; 16(12): 81-7, 1976 Dec.
Article in Russian | MEDLINE | ID: mdl-64640

ABSTRACT

The antiarrhythmic effect of Panangine and Strophantin was studied by way of rhythmography in patients with extrasystole of different etiology. The strophantin (0.25 mg) an Panangine (2 vials intravenously) tests, and therapeutic courses of Panagine (2 coated tablets 3 times a day for 5--7 days) or of Strophantin (0.25 mg) with Panagine (2 vials intravenously) for 7--10 days were conducted. A course of Strophantin with Panangine was given only to those patient who did not increase the number of their extrasystoles after the Strophantin test. Such a course resulted in the most striking antiarrhythmic effect (60.3% of the patients).


Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Aspartic Acid/analogs & derivatives , Cardiac Complexes, Premature/drug therapy , Potassium Magnesium Aspartate/administration & dosage , Strophanthins/administration & dosage , Administration, Oral , Cardiac Complexes, Premature/etiology , Clinical Trials as Topic , Drug Therapy, Combination , Heart Function Tests , Humans , Injections, Intravenous , Potassium Magnesium Aspartate/therapeutic use , Strophanthins/therapeutic use
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