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1.
JAMA Netw Open ; 7(5): e2410763, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38739390

ABSTRACT

Importance: Individuals with congenital heart disease (CHD) are increasingly reaching childbearing age, are more prone to adverse pregnancy events, and uncommonly undergo recommended cardiac evaluations. Data to better understand resource allocation and financial planning are lacking. Objective: To examine health care use and costs for patients with CHD during pregnancy. Design, Setting, and Participants: This retrospective cohort study was performed from January 1, 2010, to December 31, 2016, using Merative MarketScan commercial insurance data. Participants included patients with CHD and those without CHD matched 1:1 by age, sex, and insurance enrollment year. Pregnancy claims were identified for all participants. Data were analyzed from September 2022 to March 2024. Exposures: Baseline characteristics (age, US region, delivery year, insurance type) and pregnancy-related events (obstetric, cardiac, and noncardiac conditions; birth outcomes; and cesarean delivery). Main Outcomes and Measures: Health service use (outpatient physician, nonphysician, emergency department, prescription drugs, and admissions) and costs (total and out-of-pocket costs adjusted for inflation to represent 2024 US dollars). Results: A total of 11 703 pregnancies (mean [SD] maternal age, 31.5 [5.4] years) were studied, with 2267 pregnancies in 1785 patients with CHD (492 pregnancies in patients with severe CHD and 1775 in patients with nonsevere CHD) and 9436 pregnancies in 7720 patients without CHD. Compared with patients without CHD, pregnancies in patients with CHD were associated with significantly higher health care use (standardized mean difference [SMD] range, 0.16-1.46) and cost (SMD range, 0.14-0.55) except for out-of-pocket inpatient and ED costs. After adjustment for covariates, having CHD was independently associated with higher total (adjusted cost ratio, 1.70; 95% CI, 1.57-1.84) and out-of-pocket (adjusted cost ratio, 1.40; 95% CI, 1.22-1.58) costs. The adjusted mean total costs per pregnancy were $15 971 (95% CI, $15 480-$16 461) for patients without CHD, $24 290 (95% CI, $22 773-$25 806) for patients with any CHD, $26 308 (95% CI, $22 788-$29 828) for patients with severe CHD, and $23 750 (95% CI, $22 110-$25 390) for patients with nonsevere CHD. Patients with vs without CHD incurred $8319 and $700 higher total and out-of-pocket costs per pregnancy, respectively. Conclusions and Relevance: This study provides novel, clinically relevant estimates for the cardio-obstetric team, patients with CHD, payers, and policymakers regarding health care and financial planning. These estimates can be used to carefully plan for and advocate for the comprehensive resources needed to care for patients with CHD.


Subject(s)
Health Care Costs , Heart Defects, Congenital , Insurance, Health , Humans , Female , Pregnancy , Heart Defects, Congenital/economics , Adult , Retrospective Studies , Insurance, Health/statistics & numerical data , Insurance, Health/economics , United States , Health Care Costs/statistics & numerical data , Health Expenditures/statistics & numerical data , Patient Acceptance of Health Care/statistics & numerical data , Young Adult , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/therapy
2.
J Am Heart Assoc ; 10(15): e022040, 2021 08 03.
Article in English | MEDLINE | ID: mdl-34323114

ABSTRACT

Maternal mortality has been increasing in the United States over the past 3 decades, while decreasing in all other high-income countries during the same period. Cardiovascular conditions account for over one fourth of maternal deaths, with two thirds of deaths occurring in the postpartum period. There are also significant healthcare disparities that have been identified in women experiencing maternal morbidity and mortality, with Black women at 3 to 4 times the risk of death as their White counterparts and women in rural areas at heightened risk for cardiovascular morbidity and maternal morbidity. However, many maternal deaths have been shown to be preventable, and improving access to care may be a key solution to addressing maternal cardiovascular mortality. Medicaid currently finances almost half of all births in the United States and is mandated to provide coverage for women with incomes up to 138% of the federal poverty level, for up to 60 days postpartum. In states that have not expanded coverage, new mothers become uninsured after 60 days. Medicaid expansion has been shown to reduce maternal mortality, particularly benefiting racial and ethnic minorities, likely through reduced insurance churn, improved postpartum access to care, and improved interpregnancy care. However, even among states with Medicaid expansion, significant care gaps exist. An additional proposed intervention to improve access to care in these high-risk populations is extension of Medicaid coverage for 1 year after delivery, which would provide the most benefit to women in Medicaid nonexpanded states, but also improve care to women in Medicaid expanded states.


Subject(s)
Health Services Accessibility , Maternal Mortality , Medicaid , Pregnancy Complications, Cardiovascular , Adult , Ethnicity , Female , Health Policy/trends , Health Services Accessibility/organization & administration , Health Services Accessibility/standards , Healthcare Disparities/ethnology , Healthcare Disparities/statistics & numerical data , Humans , Maternal Mortality/ethnology , Maternal Mortality/trends , Medicaid/economics , Medicaid/standards , Policy Making , Postpartum Period , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/mortality , United States/epidemiology
3.
JAMA Netw Open ; 4(4): e217491, 2021 04 01.
Article in English | MEDLINE | ID: mdl-33885772

ABSTRACT

Importance: Women and families constitute the fastest-growing segments of the homeless population. However, there is limited evidence on whether women experiencing homelessness have poorer childbirth delivery outcomes and higher costs of care compared with women not experiencing homelessness. Objective: To compare childbirth delivery outcomes and costs of care between pregnant women experiencing homelessness vs those not experiencing homelessness. Design, Setting, and Participants: This cross-sectional study included 15 029 pregnant women experiencing homelessness and 308 242 pregnant women not experiencing homelessness who had a delivery hospitalization in 2014. The study used statewide databases that included all hospital admissions in 3 states (ie, Florida, Massachusetts, and New York). Delivery outcomes and delivery-associated costs were compared between pregnant women experiencing homelessness and those not experiencing homelessness cared for at the same hospital (analyzed using the overlap propensity-score weighting method and multivariable regression models with hospital fixed effects). The Benjamini-Hochberg false discovery rate procedure was used to account for multiple comparisons. Data were analyzed from January 2020 through May 2020. Exposure: Housing status at delivery hospitalization. Main Outcomes and Measures: Outcome variables included obstetric complications (ie, antepartum hemorrhage, placental abnormalities, premature rupture of the membranes, preterm labor, and postpartum hemorrhage), neonatal complications (ie, fetal distress, fetal growth restriction, and stillbirth), delivery method (ie, cesarean delivery), and delivery-associated costs. Results: Among 15 029 pregnant women experiencing homelessness (mean [SD] age, 28.5 [5.9] years) compared with 308 242 pregnant women not experiencing homelessness (mean [SD] age, 29.4 [5.8] years) within the same hospital, those experiencing homelessness were more likely to experience preterm labor (adjusted probability, 10.5% vs 6.7%; adjusted risk difference [aRD], 3.8%; 95% CI, 1.2%-6.5%; adjusted P = .03) and had higher delivery-associated costs (adjusted costs, $6306 vs $5888; aRD, $417; 95% CI, $156-$680; adjusted P = .02) compared with women not experiencing homelessness. Those experiencing homelessness also had a higher probability of placental abnormalities (adjusted probability, 4.0% vs 2.0%; aRD, 1.9%; 95% CI, 0.4%-3.5%; adjusted P = .053), although this difference was not statistically significant. Conclusions and Relevance: This study found that women experiencing homelessness, compared with those not experiencing homelessness, who had a delivery and were admitted to the same hospital were more likely to experience preterm labor and incurred higher delivery-associated costs. These findings suggest wide disparities in delivery-associated outcomes between women experiencing homelessness and those not experiencing homelessness in the US. The findings highlight the importance for health care professionals to actively screen pregnant women for homelessness during prenatal care visits and coordinate their care with community health programs and social housing programs to make sure their health care needs are met.


Subject(s)
Cesarean Section/statistics & numerical data , Health Care Costs/statistics & numerical data , Ill-Housed Persons/statistics & numerical data , Obstetric Labor, Premature/epidemiology , Adult , Case-Control Studies , Cesarean Section/economics , Delivery, Obstetric/economics , Female , Fetal Distress/economics , Fetal Distress/epidemiology , Fetal Growth Retardation/economics , Fetal Growth Retardation/epidemiology , Fetal Membranes, Premature Rupture/economics , Fetal Membranes, Premature Rupture/epidemiology , Humans , Infant, Newborn , Obstetric Labor Complications/economics , Obstetric Labor Complications/epidemiology , Obstetric Labor, Premature/economics , Parturition , Placenta Diseases/economics , Placenta Diseases/epidemiology , Postpartum Hemorrhage/economics , Postpartum Hemorrhage/epidemiology , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/epidemiology , Stillbirth/economics , Stillbirth/epidemiology , Uterine Hemorrhage/economics , Uterine Hemorrhage/epidemiology , Young Adult
4.
Pregnancy Hypertens ; 17: 82-88, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31487662

ABSTRACT

BACKGROUND: Peripartum cardiomyopathy (PPCM) and preeclampsia are strongly associated, yet a description of risk factors for PPCM among women with preeclampsia is currently lacking. Additionally, the effect of preeclampsia on PPCM-related outcomes is not well known. METHODS: We constructed a cohort of delivery admissions from 2011 to 2014 using a large US administrative database (Marketscan). We assessed risk factors for the development of PPCM among women with preeclampsia. We compared the risks of major adverse cardiovascular events (MACE) at 6 months between PPCM with co-incident preeclampsia (pePPCM) and PPCM without preeclampsia (npePPCM). RESULTS: We included 1,024,035 pregnancies, of which 64,503 (6.3%) had preeclampsia. A total of 874 had PPCM (283 with preeclampsia and 591 without preeclampsia). Among women with preeclampsia, clinical risk factors for PPCM consisted in chronic kidney disease (OR 3.18, 95% CI [1.51, 6.69]), multiple pregnancy (OR 2.11, 95% CI [1.49, 2.98]), chronic hypertension (OR 1.88, 95% CI [1.43, 2.47]), advanced maternal age (OR 1.82, 95% CI [1.42, 2.33]), and type 2 diabetes (OR 1.58, 95% CI [1.00, 2.48]). Women with pePPCM had a higher risk of MACE than women with npePPCM (adjusted RR 1.29, 95% CI [1.06, 1.57]) due to increased rates of clinical heart failure and pulmonary embolism in the pePPCM group. Mortality did not differ between groups. CONCLUSION: Preeclamptic women with risk factors for PPCM and women with pePPCM at increased risk of MACE should be followed closely. Further studies are required to determine whether preeclampsia affects the long-term prognosis of women with PPCM.


Subject(s)
Cardiomyopathies/epidemiology , Insurance, Health , Outcome Assessment, Health Care , Pre-Eclampsia/epidemiology , Pregnancy Complications, Cardiovascular/epidemiology , Prenatal Care , Adult , Cardiomyopathies/complications , Cardiomyopathies/economics , Cohort Studies , Databases, Factual , Delivery, Obstetric , Female , Humans , Peripartum Period , Pre-Eclampsia/economics , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Risk Factors , United States/epidemiology
5.
Eur J Heart Fail ; 19(9): 1131-1141, 2017 09.
Article in English | MEDLINE | ID: mdl-28271625

ABSTRACT

AIMS: The purpose of this study is to describe disease presentation, co-morbidities, diagnosis and initial therapeutic management of patients with peripartum cardiomyopathy (PPCM) living in countries belonging to the European Society of Cardiology (ESC) vs. non-ESC countries. METHODS AND RESULTS: Out of 500 patients with PPCM entered by 31 March 2016, we report on data of the first 411 patients with completed case record forms (from 43 countries) entered into this ongoing registry. There were marked differences in socio-demographic parameters such as Human Development Index, GINI index on inequality, and Health Expenditure in PPCM patients from ESC vs. non-ESC countries (P < 0.001 each). Ethnicity was Caucasian (34%), Black African (25.8%), Asian (21.8%), and Middle Eastern backgrounds (16.4%). Despite the huge disparities in socio-demographic factors and ethnic backgrounds, baseline characteristics are remarkably similar. Drug therapy initiated post-partum included ACE inhibitors/ARBs and mineralocorticoid receptor antagonists with identical frequencies in ESC vs. non-ESC countries. However, in non-ESC countries, there was significantly less use of beta-blockers (70.3% vs. 91.9%) and ivabradine (1.4% vs. 17.1%), but more use of diuretics (91.3% vs. 68.8%), digoxin (37.0% vs. 18.0%), and bromocriptine (32.6% vs. 7.1%) (P < 0.001). More patients in non-ESC vs. ESC countries continued to have symptomatic heart failure after 1 month (92.3% vs. 81.3%, P < 0.001). Venous thrombo-embolic events, arterial embolizations, and cerebrovascular accidents were documented in 28 of 411 patients (6.8%). Neonatal death rate was 3.1%. CONCLUSION: PPCM occurs in women from different ethnic backgrounds globally. Despite marked differences in socio-economic background, mode of presentation was largely similar. Embolic events and persistent heart failure were common within 1 month post-diagnosis and required intensive, multidisciplinary management.


Subject(s)
Cardiomyopathies , Cardiovascular Agents/therapeutic use , Heart Failure , Peripartum Period , Pregnancy Complications, Cardiovascular , Puerperal Disorders , Adult , Cardiomyopathies/complications , Cardiomyopathies/diagnosis , Cardiomyopathies/economics , Cardiomyopathies/therapy , Comorbidity , Demography , Disease Management , Ethnicity , Europe/epidemiology , Female , Health Expenditures/statistics & numerical data , Heart Failure/diagnosis , Heart Failure/economics , Heart Failure/epidemiology , Heart Failure/etiology , Humans , Peripartum Period/ethnology , Peripartum Period/physiology , Pregnancy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/epidemiology , Pregnancy Complications, Cardiovascular/therapy , Puerperal Disorders/diagnosis , Puerperal Disorders/economics , Puerperal Disorders/epidemiology , Puerperal Disorders/etiology , Registries/statistics & numerical data , Socioeconomic Factors
6.
BJOG ; 123(1): 40-7, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26113232

ABSTRACT

BACKGROUND: Oral nifedipine is recommended along with labetalol and hydralazine for treatment of severe hypertension during pregnancy by most authorities. Although nifedipine is cheap and easily administered, the usage pattern among health care providers suggests a strong preference for labetalol despite lack of evidence for the same. OBJECTIVES: To determine the efficacy and safety of oral nifedipine for treatment of severe hypertension of pregnancy compared with intravenous labetalol. SEARCH STRATEGY: We systematically searched for articles comparing oral nifedipine with intravenous labetalol for the treatment of severe hypertension during pregnancy in any language, over Medline, Cochrane Central Register of Clinical Trials and Google Scholar from inception till February 2014. SELECTION CRITERIA: We included all RCTs that compared intravenous labetalol with oral nifedipine for treatment of severe hypertension during pregnancy, addressing relevant efficacy and safety outcomes. DATA COLLECTION AND ANALYSIS: Eligible studies were reviewed, and data were extracted onto a standard form. We used Cochrane review manager software for quantitative analysis. Data were analysed using a fixed effect model. MAIN RESULTS: The pooled analysis of seven trials (four from developing countries) consisting of 363 woman-infant pairs showed that oral nifedipine was associated with less risk of persistent hypertension (RR 0.42, 95% CI 0.18-0.96) and reported maternal side effects (RR 0.57, 95% CI 0.35-0.94). However, on sensitivity analysis the outcome 'persistent hypertension' was no longer significant. Other outcomes did not reach statistical significance. CONCLUSION: Oral nifedipine is as efficacious and safe as intravenous labetalol and may have an edge in low resource settings. TWEETABLE ABSTRACT: Although studies to date are few in number and small, nifedipine shows promise for severe hypertension in pregnancy.


Subject(s)
Antihypertensive Agents/administration & dosage , Hypertension, Pregnancy-Induced/drug therapy , Labetalol/administration & dosage , Nifedipine/administration & dosage , Practice Patterns, Physicians'/statistics & numerical data , Pregnancy Complications, Cardiovascular/drug therapy , Administration, Intravenous , Administration, Oral , Adult , Antihypertensive Agents/economics , Cost-Benefit Analysis , Evidence-Based Medicine , Female , Humans , Hypertension, Pregnancy-Induced/economics , Hypertension, Pregnancy-Induced/prevention & control , Labetalol/economics , Nifedipine/economics , Practice Patterns, Physicians'/economics , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/prevention & control , Treatment Outcome
7.
Int J Gynaecol Obstet ; 132(1): 4-10, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26489486

ABSTRACT

BACKGROUND: Pregnancy-related venous thromboembolism (VTE) is one of the leading causes of maternal morbidity and mortality. OBJECTIVES: To review the epidemiology, and humanistic and economic burden of pregnancy-related VTE. SEARCH STRATEGY: Medline, the Cochrane Central Register of Controlled Trials, Econlit, Science Direct, JSTOR, Oxford Journals, and Cambridge Journals were searched for reports published between January 2000 and December 2012. Keywords related to VTE, pregnancy, and epidemiology and the humanistic and economic burdens were combined. SELECTION CRITERIA: Eligible studies evaluated the incidence, mortality, recurrence, complications, quality-of-life, and economic burden of VTE among pregnant women, and had been published in English. DATA COLLECTION AND ANALYSIS: Background information of the study, participants' characteristics, and study outcomes were collected. Meta-analyses of data were performed. MAIN RESULTS: Twenty studies were included, none of which investigated the economic burden. The pooled overall incidence of pregnancy-related VTE was 1.2 per 1000 deliveries. The pooled VTE case fatality rate was 0.68% and the recurrence rate was 4.27%. The pooled risk of major bleeding was 1.05%. Post-thrombotic syndrome seemed to have a negative effect on quality of life. CONCLUSIONS: Although the incidence of VTE was found to be relatively low during pregnancy and the postpartum period, the clinical burden is high. Further research is required to assess the economic burden of pregnancy-relate VTE.


Subject(s)
Pregnancy Complications, Cardiovascular/epidemiology , Venous Thromboembolism/epidemiology , Adult , Cost of Illness , Female , Humans , Incidence , Postpartum Period , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/psychology , Quality of Life , Recurrence , Venous Thromboembolism/economics , Venous Thromboembolism/psychology
8.
Diabetes Metab Res Rev ; 31(7): 707-16, 2015 Oct.
Article in English | MEDLINE | ID: mdl-25899622

ABSTRACT

BACKGROUND: Increasing diabetes prevalence affects a substantial number of pregnant women in the United States. Our aims were to evaluate health outcomes, medical costs, risks and types of complications associated with diabetes in pregnancy for mothers and newborns. METHODS: In this retrospective claims analysis, patients were identified from the Truven Health MarketScan(®) database (2004-2011 inclusive). Participants were aged 18-45 years, with ascertainable diabetes status [Yes/No], date of birth event >2005 and continuous health plan enrolment ≥21 months before and 3 months after the birth. RESULTS: In total, 839 792 pregnancies were identified, and 66 041 (7.86%) were associated with diabetes mellitus [type 1 (T1DM), 0.13%; type 2 (T2DM), 1.21%; gestational (GDM), 6.29%; and GDM progressing to T2DM (patients without prior diabetes who had a T2DM diagnosis after the birth event), 0.23%]. Relative risk (RR) of stillbirth (2.51), miscarriage (1.28) and Caesarean section (C-section) (1.77) was significantly greater with T2DM versus non-diabetes. Risk of C-section was also significantly greater for other diabetes types [RR 1.92 (T1DM); 1.37 (GDM); 1.63 (GDM progressing to T2DM)]. Risk of overall major congenital (RR ≥ 1.17), major congenital circulatory (RR ≥ 1.19) or major congenital heart (RR ≥ 1.18) complications was greater in newborns of mothers with diabetes versus without. Mothers with T2DM had significantly higher risk (RR ≥ 1.36) of anaemia, depression, hypertension, infection, migraine, or cardiac, obstetrical or respiratory complications than non-diabetes patients. Mean medical costs were higher with all diabetes types, particularly T1DM ($27 531), than non-diabetes ($14 355). CONCLUSIONS: Complications and costs of healthcare were greater with diabetes, highlighting the need to optimize diabetes management in pregnancy.


Subject(s)
Congenital Abnormalities/epidemiology , Diabetes Mellitus, Type 1/epidemiology , Diabetes Mellitus, Type 2/epidemiology , Diabetes, Gestational/epidemiology , Health Care Costs , Pregnancy Outcome/epidemiology , Pregnancy in Diabetics/epidemiology , Abortion, Spontaneous/economics , Abortion, Spontaneous/epidemiology , Adolescent , Adult , Anemia/economics , Anemia/epidemiology , Cesarean Section/economics , Cesarean Section/statistics & numerical data , Congenital Abnormalities/economics , Depression/economics , Depression/epidemiology , Diabetes Mellitus, Type 1/economics , Diabetes Mellitus, Type 2/economics , Diabetes, Gestational/economics , Female , Heart Defects, Congenital/economics , Heart Defects, Congenital/epidemiology , Humans , Incidence , Infant, Newborn , Middle Aged , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/epidemiology , Pregnancy Complications, Hematologic/economics , Pregnancy Complications, Hematologic/epidemiology , Pregnancy Complications, Infectious/economics , Pregnancy Complications, Infectious/epidemiology , Pregnancy Outcome/economics , Pregnancy in Diabetics/economics , Retrospective Studies , Stillbirth/economics , Stillbirth/epidemiology , United States , Young Adult
9.
Int J Cardiol ; 145(1): 93-4, 2010 Nov 05.
Article in English | MEDLINE | ID: mdl-19540008

ABSTRACT

Risk factors for peripartum cardiomyopathy (PPCM) are controversial. PPCM seems to be more prevalent in women of African descent, the highest observed incidence is in Haiti (1 per 300 live births). Our retrospective study conducted in Martinique showed an incidence of 1 per 5500 live births. This incidence is significantly lower than in Haiti. Women from Martinique and Haiti do not differ for most classical risk factors: African descent, age, pregnancy-associated hypertension, multiple pregnancy and pre-eclampsia. However, the parity rate and the socioeconomic level are different. Thus, African descent could be confounded by high parity rate and socioeconomic status.


Subject(s)
Black People/ethnology , Cardiomyopathies/ethnology , Puerperal Disorders/ethnology , Adolescent , Adult , Black People/genetics , Cardiomyopathies/economics , Cardiomyopathies/genetics , Cohort Studies , Female , Haiti/ethnology , Humans , Martinique/ethnology , Middle Aged , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/ethnology , Pregnancy Complications, Cardiovascular/genetics , Puerperal Disorders/economics , Puerperal Disorders/genetics , Retrospective Studies , Risk Factors , Socioeconomic Factors , Young Adult
11.
Am J Med ; 118(5): 503-14, 2005 May.
Article in English | MEDLINE | ID: mdl-15866253

ABSTRACT

PURPOSE: Women with a history of prior venous thromboembolism have an increased risk for recurrence during pregnancy. Although thromboprophylaxis reduces this risk, recent evidence suggests that, in many cases, prophylaxis can be safely withheld because the estimated recurrence risk is very low. The balance of risks and benefits in women with different recurrence risks has not been examined. METHODS: We developed a Markov state transition decision analytic model to compare prophylactic low molecular weight heparin to expectant management for pregnant women with a single prior venous thromboembolism. A lifetime time horizon and societal perspective were assumed. Input data were obtained by literature review. Outcomes were expressed as U.S. dollars per quality-adjusted life-year (QALY). RESULTS: For "low-risk" women with a prior venous thromboembolism associated with a transient risk factor and no known thrombophilic condition (recurrence risk 0.5%), expectant management was both more effective and less costly than prophylaxis. For "high-risk" women with prior idiopathic venous thromboembolism or known thrombophilic condition (recurrence risk 5.9%), prophylaxis was associated with a reasonable cost-effectiveness ratio (USD 38,700 per QALY) given a risk of bleeding complications <1.0% (base case 0.5%). CONCLUSION: For low-risk women with prior venous thromboembolism, expectant management during pregnancy leads to better outcomes than administration of prophylactic low molecular weight heparin. For high-risk women, antepartum thromboprophylaxis is a cost-effective use of resources.


Subject(s)
Anticoagulants/economics , Drug Costs , Heparin, Low-Molecular-Weight/economics , Pregnancy Complications, Cardiovascular/prevention & control , Thromboembolism/prevention & control , Venous Thrombosis/prevention & control , Anticoagulants/therapeutic use , Cost-Benefit Analysis , Decision Support Techniques , Female , Heparin, Low-Molecular-Weight/therapeutic use , Humans , Markov Chains , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Quality-Adjusted Life Years , Secondary Prevention
12.
BJOG ; 111(8): 765-70, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15270921

ABSTRACT

OBJECTIVE: To determine the impact of a national strategy to promote implementation of a guideline on the management of mild, non-proteinuric hypertension in pregnancy. DESIGN: Simple, interrupted time series analysis. SETTING: Four maternity units in Scotland. POPULATION: Women delivering a live or stillborn baby. METHODS: Dissemination of the guideline under the auspices of a national clinical effectiveness programme, supported by a national launch meeting and feedback from a survey of obstetricians highlighting aspects of care that could be improved. MAIN OUTCOME MEASURES: Appropriateness of initial investigation and subsequent clinical management, and costs of guideline development and implementation activities. DATA COLLECTION: Twenty-four months pre-intervention and 12 months post-intervention data were abstracted from a random sample of case notes. RESULTS: Initial investigation was consistent with recommendations for 59.9% out of 1263 women and subsequent clinical management for 67.6% out of 1081 in whom a diagnosis could be made from available data. There were no significant changes in the appropriateness of initial investigation (10.6%; 95% confidence interval [CI] -0.1% to 19.3%; decreasing by 1.2% per month post-implementation, 95% CI -2.5% to 0.1%) or clinical management (-0.3%; 95% CI -8.7% to 11.2%). Guideline development and implementation cost an estimated pound 2784 per maternity unit in Scotland. CONCLUSIONS: Clinical care of mild hypertension in pregnancy remains highly inconsistent. The lack of the intervention effect may be related to the complexity of the guideline recommendations and the nature of the implementation strategy.


Subject(s)
Hypertension/therapy , Practice Guidelines as Topic , Pregnancy Complications, Cardiovascular/therapy , Adult , Female , Hospitals, Maternity/economics , Humans , Hypertension/economics , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Scotland
13.
Aust N Z J Obstet Gynaecol ; 43(3): 207-12, 2003 Jun.
Article in English | MEDLINE | ID: mdl-14712986

ABSTRACT

OBJECTIVE: To quantify the cost-effectiveness of, and evaluate patient satisfaction with, day care for management of hypertensive disorders of pregnancy. DESIGN: Retrospective descriptive study. SETTING: Pregnancy Day Care Centre, Royal Women's Hospital, Melbourne. SAMPLE: A total of 1200 consecutive women attending with a hypertensive disorder of pregnancy. METHODS: Sociodemographic details and perinatal outcome were entered in a purpose designed computer program. A satisfaction questionnaire was administered to 130 women. Clinical costing data were calculated by casemix analysts to compare traditional inpatient and day care models of care. RESULTS: An admission to the Pregnancy Day Care Centre cost an average of 684.85 dollars less than a traditional inpatient admission. Women had an overwhelming preference for day care. CONCLUSION: Pregnancy day care is a cost-effective method of providing care for women with hypertensive disorders of pregnancy. Women prefer day care to inpatient care.


Subject(s)
Day Care, Medical/economics , Hypertension/therapy , Patient Satisfaction , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Cardiovascular/therapy , Adult , Female , Humans , Pregnancy
14.
Thorac Cardiovasc Surg ; 49(1): 21-6, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11243517

ABSTRACT

A new medical community, the grown-up congenital heart patients--GUCH--has resulted from successes of cardiac surgery over 30-40 years. Many survivors have complicated problems, medical and surgical, demanding experience and expertise neither provided nor organised in most countries. Islands of good care exist with difficulty. The experience of one specialist GUCH unit established for 25 years shows that 55-60% admissions are for complex lesions, particularly after complicated surgery. The patients' overall costs are at least twice those of other cardiac patients. GUCH admissions are about 5-8% of the total, varying according to the population/region served. Supervised medical care for GUCH is equally important in outpatient services, involving 3 times the secretarial time of other cardiac patients, an accessible database and a "helpline" for doctors and patients. This may be life-saving in patients with complex conditions. The GUCH population is ageing, with increasing numbers of complex patients. 30% of admissions now are over 40 years old, and 5% are over 60, confirming that this is an adult medical speciality, not paediatric. Invasive investigations and arrhythmias provide the most frequent reasons for admissions--atrial flutter is the commonest arrhythmia, needing experts when it occurs in Fontan, transposition, etc. Routine coronary arteriography is also important. In cardiac surgery, one in five admissions presents organisational problems. Reoperation, now as many as 9 or 10 times, has to be optimised. Reoperation on left and right outflow tracts-for changing valves and conduits--is more common than first operations. GUCH patients represent a relatively small portion of the whole population. Such patients in a population of 7-8 million need to be concentrated in 1-2 centres, depending on culture, religion, geography, language etc., to provide necessary experience, expertise and education.


Subject(s)
Cardiac Care Facilities/statistics & numerical data , Heart Defects, Congenital/surgery , Heart Defects, Congenital/therapy , Patient Care Planning , Postoperative Complications/therapy , Adolescent , Adult , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/therapy , Cardiac Catheterization/statistics & numerical data , Child , Chronic Disease , Endocarditis/etiology , Endocarditis/prevention & control , Female , Health Care Costs , Heart Defects, Congenital/economics , Heart Failure/etiology , Heart Failure/therapy , Hospital Units/statistics & numerical data , Humans , London/epidemiology , Middle Aged , Patient Admission/statistics & numerical data , Postoperative Complications/economics , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Registries , Reoperation/statistics & numerical data
15.
J Reprod Med ; 42(4): 223-8, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9131495

ABSTRACT

OBJECTIVE: To determine the utility of evaluating coagulation function in patients with chronic hypertension, transient hypertension, preeclampsia, eclampsia and the HELLP syndrome. STUDY DESIGN: We retrospectively reviewed the charts of 244 patients who delivered between March 1992 and March 1994 at the University of New Mexico with a discharge diagnosis of either hypertension, preeclampsia or eclampsia. RESULTS: Nine patients were thrombocytopenic on admission, as defined by a platelet count of < 100,000/mm3. Three of the 244 patients had mild prolongation of the partial thromboplastin time, and none had prolongation of the prothrombin time. Two of the patients with prolongation of the partial thromboplastin time were thrombocytopenic on admission, and the last had elevation of liver enzymes. No patient had clinical evidence of coagulopathy. CONCLUSION: Measurement of the partial thromboplastin time and prothrombin time in the evaluation of preeclampsia/eclampsia can be avoided if the platelet count and liver enzymes are normal. This results in a decrease in hospital charges and no compromise in patient safety.


Subject(s)
Eclampsia , Hypertension , Pregnancy Complications, Cardiovascular , Cost Savings , Eclampsia/diagnosis , Eclampsia/economics , Female , HELLP Syndrome/diagnosis , Hemolysis , Hospital Charges , Humans , Hypertension/diagnosis , Hypertension/economics , Liver Function Tests , Partial Thromboplastin Time , Platelet Count , Pre-Eclampsia/diagnosis , Pre-Eclampsia/economics , Pregnancy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/economics , Pregnancy Complications, Hematologic/diagnosis , Pregnancy Complications, Hematologic/economics , Prothrombin Time , Retrospective Studies
16.
Acta Obstet Gynecol Scand ; 75(5): 443-8, 1996 May.
Article in English | MEDLINE | ID: mdl-8677768

ABSTRACT

BACKGROUND: Hypertension in pregnancy is associated with increased maternal and fetal morbidity and mortality. The aim of this prospective study was to evaluate the obstetric outcome of patients with pregnancy induced hypertension (PIH) that delivered at the Maternity Hospital Kuwait within a period of six months and evaluate the economic implications of present management strategies. METHODS: This was a comparative study with age and parity, as matching variables, in 224 pregnant hypertensive women and 224 normotensive controls. RESULTS: During the study period, the incidence of PIH was 4.9 percent. They were more associated with diabetes mellitus and multiple pregnancy than controls (p < 0.02). About 43 percent of the hypertensive parturients used antihypertensive therapy. More of them had induction of labor (p < 0.001), preterm delivery (p < 0.0002) and cesarean section (p < 0.001), and babies with low birthweight (p < 0.01). In the linear regression analysis, hypertension in pregnancy gave rise to more hospitalisation, intrauterine growth retardation and operative deliveries than the normotensive controls. The perinatal mortality was higher (p < 0.001). CONCLUSION: Despite the economic expenditure of about five times more for hypertensive women in pregnancy than in controls, both obstetric and neonatal outcome, are still significantly worse in the former. This study therefore advocates more research into the prevention, prediction and management, including neonatal care, of hypertensive disorders of pregnancy.


Subject(s)
Hypertension/economics , Pregnancy Complications, Cardiovascular/economics , Adult , Analysis of Variance , Asia/epidemiology , Female , Humans , Hypertension/epidemiology , Kuwait/epidemiology , Pregnancy , Pregnancy Complications, Cardiovascular/epidemiology , Pregnancy Outcome
17.
Br J Obstet Gynaecol ; 99(6): 459-63, 1992 Jun.
Article in English | MEDLINE | ID: mdl-1637759

ABSTRACT

OBJECTIVE: To evaluate the efficiency of daycare in the management of hypertension in pregnancy compared with inpatient management with prior domiciliary visits. DESIGN: Comparative study. SETTING: Two maternity teaching hospitals, Glasgow Royal Maternity Hospital which has an established daycare unit and Aberdeen Maternity Hospital with no daycare unit. MAIN OUTCOME MEASURES: Pregnancy outcomes in terms of maternal hypertensive complications, gestation at delivery, mode of delivery, birthweight, Apgar scores, admission rates and length of admission to special care baby unit. RESULTS: There was no significant difference in any of the measured pregnancy outcomes between the two hospitals. The average cost of treating a women with mild hypertension was 154.91 pounds in Glasgow and 136.59 pounds in Aberdeen. The average cost of treating women with a single episode of hypertension and women with a past history of hypertension was 88.65 pounds and 214.12 pounds in Glasgow and 31.18 pounds and 28.28 pounds in Aberdeen, respectively. If these two groups are excluded, the average cost of treating women with mild hypertension was 172.32 pounds in Glasgow and 201.13 pounds in Aberdeen. The majority of women were willing to attend daycare five times per week to avoid admission. CONCLUSION: Daycare management of hypertension in pregnancy is more efficient than inpatient care with prior domiciliary visits for most women, but less efficient for women with transient or previous hypertension. It is very acceptable to women. Domiciliary checking of women with hypertension found at outpatient clinics would reduce resource use.


Subject(s)
Day Care, Medical/economics , Hospitals, Maternity/economics , Hypertension/therapy , Pregnancy Complications, Cardiovascular/therapy , Adult , Attitude to Health , Birth Weight , Day Care, Medical/psychology , Delivery, Obstetric , Female , Health Care Costs , Home Care Services/economics , Hospitals, Maternity/organization & administration , Humans , Hypertension/economics , Pregnancy , Pregnancy Complications, Cardiovascular/economics , Prenatal Care/economics , Scotland
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