ABSTRACT
En esta segunda entrega revisamos extensamente la historia de los glucocorticoides, inmunosupresores, macrólidos como la ciclosporina, inhibidores como la prolactina, dehidroepiandrosterona, análogos de las gonado-tropinas y terapias experimentales en pacientes con lupus eritematoso sistémico. Hacemos énfasis en los estudios que de alguna manera abrieron camino en la investigación hacia la consecuci6n de una mejor terapéutica para estos pacientes.
Subject(s)
Cyclosporine/therapeutic use , Dehydroepiandrosterone Sulfate/therapeutic use , Glucocorticoids/therapeutic use , Immunosuppressive Agents/therapeutic use , Lupus Erythematosus, Systemic/history , Lupus Erythematosus, Systemic/pathology , Lupus Erythematosus, Systemic/drug therapy , Prolactin Release-Inhibiting Factors/therapeutic useSubject(s)
Amenorrhea/drug therapy , Adolescent , Adult , Amenorrhea/etiology , Bromocriptine/therapeutic use , Endocrine System Diseases/complications , Endocrine System Diseases/drug therapy , Estrogens/adverse effects , Estrogens/therapeutic use , Female , Humans , Prolactin Release-Inhibiting Factors/therapeutic useABSTRACT
Reported in this paper is the effectiveness of antiprolactinaemic treatment of 40 infertile women. All case histories revealed previous unsuccessful attempts to induce ovulation. Antiprolactinaemic treatment was in all cases preced by RIA determination of prolactin and gonadotrophin. Prolactin levels were found to be somewhat increase in 19 cases, while 21 women were normal. The gonadotrophin plasma levels usually were closer to the lower limits of normal values. The presence of hypophyseal adenoma had been ruled out beforehand. Long-time treatment was based on the administration of 5 mg Parlodel/die. The effect was excellent in all cases of hyperprolactinaemia, but response was recorded, as well, from a group of patients with normal prolactin levels. Galactorrhoea ceased to exist in all cases. Clomiphen was applied again to induce ovulation in those patients who had not responded at all or developed only bleeding without ovulation. That treatment proved to be effective in several cases.
