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Farmakol Toksikol ; 50(1): 71-4, 1987.
Article in Russian | MEDLINE | ID: mdl-3556555

ABSTRACT

Toxic and pharmacological properties of promedol, droperidol and dimedrol were studied during burn shock and combined radiation and thermal injury (CRTI). Acute toxicity and analgesic effect of promedol were shown to increase in the given period Droperidol analgesic effect enhanced in burn and CRTI, cataleptic action enhanced only in CRTI. A decrease of antihistaminic activity of dimedrol was more pronounced in CRTI.


Subject(s)
Burns/drug therapy , Diphenhydramine/pharmacology , Droperidol/pharmacology , Meperidine/analogs & derivatives , Promedol/pharmacology , Radiation Injuries, Experimental/drug therapy , Shock, Traumatic/drug therapy , Animals , Diphenhydramine/toxicity , Droperidol/toxicity , Drug Evaluation, Preclinical , Guinea Pigs , Male , Mice , Promedol/toxicity , Rats , Rats, Inbred Strains , Time Factors
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