1.
Food Chem Toxicol
; 45 Suppl 1: S78-81, 2007.
Article
in English
| MEDLINE
| ID: mdl-18037206
ABSTRACT
A toxicologic and dermatologic review of cinnamyl isovalerate when used as a fragrance ingredient is presented.
Subject(s)
Cinnamates/toxicity , Perfume/toxicity , Propionates/toxicity , Animals , Cinnamates/classification , Cinnamates/pharmacokinetics , Consumer Product Safety , Humans , Perfume/classification , Perfume/pharmacokinetics , Propionates/classification , Propionates/pharmacokinetics , Risk Assessment , Skin/drug effects , Skin/metabolism , Skin/pathology , Skin Absorption , Skin Irritancy Tests , Skin Tests , Toxicity Tests
2.
Bioorg Med Chem Lett
; 17(23): 6579-83, 2007 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-17931864
ABSTRACT
A new series of non-peptidic, mono-acid protein tyrosine phosphatase 1B (PTP1B) inhibitors has been identified by structure-based design. Compounds with 2-(indol-3-yl)- and 2-phenyl-3,3,3-trifluoro-2-hydroxypropionic acid core units targeted at the enzyme's primary site and a hydrophobic chlorophenylthiazole extension in its 2 degrees site exhibit 3-60microM IC(50)s for PTP1B inhibition in an Sf9 cell-based assay.
