ABSTRACT
Adequate nutritional status may influence progression to frailty. The purpose of this study is to determine the prevalence of frailty and examine the relationship between dietary protein intake and the transition between frailty states and mortality in advanced age. We used data from a longitudinal cohort study of Maori (80-90 years) and non-Maori (85 years). Dietary assessments (24-h multiple pass dietary recalls) were completed at the second year of follow-up (wave 2 and forms the baseline in this study). Frailty was defined using the Fried Frailty criteria. Multi-state modelling examined the association of protein intake and transitions between frailty states and death over four years. Over three quarters of participants were pre-frail or frail at baseline (62% and 16%, respectively). Those who were frail had a higher co-morbidity (p < 0.05), where frailty state changed, 44% showed a worsening of frailty status (robust â pre-frail or pre-frail â frail). Those with higher protein intake (g/kg body weight/day) were less likely to transition from robust to pre-frail [Hazard Ratio (95% Confidence Interval): 0.28 (0.08-0.91)] but also from pre-frail to robust [0.24 (0.06-0.93)]. Increased protein intake was associated with lower risk of transitioning from pre-frailty to death [0.19 (0.04-0.80)], and this association was moderated by energy intake [0.22 (0.03-1.71)]. Higher protein intake in this sample of octogenarians was associated with both better and worse outcomes.
Subject(s)
Aging , Dietary Proteins/administration & dosage , Frail Elderly , Frailty/physiopathology , Nutritional Status , Protein Deficiency/physiopathology , Age Factors , Aged, 80 and over , Aging/ethnology , Comorbidity , Female , Frailty/diagnosis , Frailty/ethnology , Geriatric Assessment , Humans , Male , Native Hawaiian or Other Pacific Islander , New Zealand/epidemiology , Nutrition Assessment , Nutritional Status/ethnology , Prevalence , Protein Deficiency/diagnosis , Protein Deficiency/ethnology , Recommended Dietary Allowances , Risk Assessment , Risk FactorsABSTRACT
In an examination of Navajo elderly inpatients and outpatients, high rates of protein undernutrition (despite normal caloric stores) were found to be prevalent. The protein malnutrition was present in each of several measures used, covering structural as well as visceral protein. It was more common in males, inpatients, and the aged elderly, but excess rates of undernutrition were found in all groups examined. These rates were higher than those in any comparable group reported to date. With multiple regression analysis, length of stay in the hospital is shown to be related to this undernutrition among inpatients studied.
