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Croat Med J ; 49(5): 669-73, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18925701

ABSTRACT

Pseudomyxoma peritonei is a clinical syndrome characterized by peritoneal dissemination of a mucinous tumor with mucinous ascites. The vast majority of the pseudomyxoma peritonei are associated with mucinous neoplasms of the appendix. We describe a case of pseudomyxoma peritonei associated with mucinous adenocarcinoma of the cervix in a 60-year-old woman. The patient developed low grade mucinous peritoneal carcinomatosis 8 years after hysterectomy for cervical adenocarcinoma. No other primary mucinous tumor was identified and peritoneal carcinomatosis tested positive for high-risk human papilloma virus (HPV), showing both integrated and episomal pattern. HPV has been previously associated with development of cervical carcinomas (both squamous and mucinous) but neither has cervical adenocarcinoma nor HPV been implicated in development of pseudomyxoma peritonei. To the best of our knowledge, this is the first description of HPV-associated malignancy presenting as pseudomyxoma peritonei.


Subject(s)
Adenocarcinoma, Mucinous/diagnosis , Papillomavirus Infections/complications , Peritoneal Neoplasms/diagnosis , Pseudomyxoma Peritonei/diagnosis , Pseudomyxoma Peritonei/etiology , Tumor Virus Infections/complications , Adenocarcinoma/surgery , Adenocarcinoma, Mucinous/complications , Adenocarcinoma, Mucinous/pathology , Adenocarcinoma, Mucinous/surgery , Adenocarcinoma, Mucinous/virology , Female , Human papillomavirus 11 , Human papillomavirus 16 , Human papillomavirus 6 , Humans , Middle Aged , Papillomavirus Infections/virology , Peritoneal Neoplasms/complications , Peritoneal Neoplasms/pathology , Peritoneal Neoplasms/surgery , Peritoneal Neoplasms/virology , Pseudomyxoma Peritonei/pathology , Pseudomyxoma Peritonei/surgery , Pseudomyxoma Peritonei/virology , Tumor Virus Infections/virology , Uterine Cervical Neoplasms/surgery
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