Subject(s)
Mental Disorders/therapy , Mind-Body Relations, Metaphysical , Psychiatry , Religion and Psychology , Child , Ethics, Medical , Humans , Mental Disorders/psychology , Mind-Body Relations, Metaphysical/ethics , Mind-Body Relations, Metaphysical/physiology , Neurosciences/ethics , Neurosciences/methods , Neurosciences/trends , Psychiatry/ethics , Psychiatry/methods , Psychiatry/trends , Psychopathology/ethics , Psychopathology/methods , Psychopathology/trends , Religion and Medicine , Therapies, Investigational/ethics , Therapies, Investigational/methods , Therapies, Investigational/trendsABSTRACT
Objectives: MicroRNA-200 family (miR-200f) has been consistently reported to be deregulated and modulate the metastatic process in multiple cancers. In the present study, we detected the expression of miR-200f in breast cancer (BC) tissue and explored its relationships with clinicopathological characteristics, especially with lymph node metastasis. Methods: Expression levels of miR-200a, miR-200b, miR-200c, miR-141, and miR-429 in 99 pairs of BC tissues and adjacent normal tissues were measured by real-time quantitative PCR. The correlation between miR-200f level and multiple clinicopathological factors was then examined by Mann Whitney test, ANOVA, and operating characteristic (ROC) analysis. Results: All members of the miR-200f were down-regulated in BC tissue compared with that in normal adjacent tissue; miR-200a, miR-200b, and miR-200c were highly decreased (p< 0.05), while the differences of miR-141 and miR-429 between patients and the control group were not statistically significant. Furthermore, all five members were found to be distinctly decreased with the incidence of lymph node metastasis (p < 0.05); When the patients were divided into three groups according to the number of lymph node metastasis (0; 1-3; ≥ 4), a gradual decrease of miR-200f expression was observed with the increasing number of lymph node metastasis; ROC revealed that miR-200b can differentiate patients with lymph node metastasis from those without lymph node metastasis. Conclusion: These observations imply that the down regulation of miR-200f in human BC is associated with an invasive phenotype, and miR-200b may be useful to estimate the likelihood of the presence of pathologically positive lymph nodes (AU)
No disponible
Subject(s)
Humans , Male , Female , Lymph Nodes/metabolism , Thorax/metabolism , MicroRNAs/genetics , Breast Neoplasms/pathology , Psychopathology/education , Carcinoma, Ductal/drug therapy , Lymphatic Metastasis/genetics , Pharmaceutical Preparations/administration & dosage , Therapeutics/methods , Therapeutics , Therapeutics/instrumentation , Therapeutics/standards , MicroRNAs/administration & dosage , Lymph Nodes/abnormalities , Thorax/abnormalities , Breast Neoplasms/drug therapy , Psychopathology/ethics , Carcinoma, Ductal/radiotherapy , Lymphatic Metastasis/pathology , Pharmaceutical Preparations/metabolismABSTRACT
No disponible
Subject(s)
Female , Humans , Male , Psychopathology/education , Psychopathology/ethics , Prisons/organization & administration , Criminal Liability , Mentally Ill Persons/classification , Mentally Ill Persons/psychology , Security Measures/trends , Psychopathology , Psychopathology/methods , Prisons/legislation & jurisprudence , Mentally Ill Persons/legislation & jurisprudence , Mentally Ill Persons/statistics & numerical data , Security MeasuresABSTRACT
La responsabilidad profesional médica (RPM) es la obligación de reparar las consecuencias de los actos profesionales y las omisiones que hayan causado un daño o perjuicio, ya sea por no haber puesto los medios necesarios o el cuidado adecuado en la asistencia a un paciente, ya sea por negligencia en su conducta o por incumplimiento de la lexartis. Actualmente, la lexartis ad hoc constituye el criterio para valorar la corrección de un acto médico concreto ejecutado por el médico. El interés y preocupación por la RPM son a la vez una problemática antigua y actual y en respuesta a dicha preocupación, desde hace años se dedican grandes esfuerzos a la denominada Seguridad Clínica. La Psiquiatría posee una serie de características específicas que deben tenerse en cuenta a la hora de valorar dicha RPM. La Psiquiatría tiene un riesgo muy bajo de reclamación y el porcentaje de casos en los que se considera probada la existencia de responsabilidad resulta igualmente bajo, pero existen ciertas actuaciones específicas que deben abordarse para la mejora de la seguridad clínica
Medical professional liability (MPL) is the duty to repair the consequences of professional acts and omissions that caused injury or prejudice either for failing means necessary or proper care in assisting a patient, whether they performed a negligent conduct or breached the lex artis. Currently, the lexartis ad hoc is the criterion for assessing the correctness of a particular medical procedure performed by the physician. The interest and concerns for the MPL are both ancient and current problems and in response to this concern, great efforts have been made regarding Clinical Safety. Psychiatry has a number of specific characteristics that must be taken into account when assessing this MPL. Psychiatry has a very low risk of claim and the percentage of cases in which responsibility is considered proven is equally low, but there are some specific actions to be taken to improve clinical safety in Psychiatry
Subject(s)
Female , Humans , Male , Malpractice/statistics & numerical data , Social Work, Psychiatric , Social Work, Psychiatric/methods , Psychology, Clinical/education , Psychology, Clinical/methods , Forensic Medicine/legislation & jurisprudence , Forensic Medicine/methods , Psychopathology/ethics , Malpractice/classification , Social Work, Psychiatric/standards , Social Work, Psychiatric/trends , Psychology, Clinical , Psychology, Clinical/standards , Forensic Medicine/organization & administration , Forensic Medicine/standards , Psychopathology/methodsABSTRACT
BACKGROUND: The aim of this study was to adapt and obtain validity evidence of the Spanish Green Paranoid Thought Scales (S-GPTS). METHOD: 191 Spanish people responded to S-GPTS, Peters Delusions Inventory (PDI), and measures of psychopathology. RESULTS: Principal Component Analyses on the polychoric correlation matrix identified two factors accounting for 71.0% of the cumulative variance. Cronbach alphas for S-GPTS total and its subscales were above .90 in clinical and non-clinical group. The value of the area under the receiver operating characteristic curve was higher for the S-GPTS (.898), than for the PDI (.859). The best S-GPTS threshold to discriminate between cases and non-cases was 92 (sensitivity, 97.35%; specificity, 65%). S-GPTS scores positively correlated with PDI and measures of anxiety and depression. CONCLUSION: The S-GPTS has adequate psychometric properties to provide valid measures of delusional ideation in a Spanish population
ANTECEDENTES: el objetivo del presente estudio fue adaptar y obtener evidencias de validez de la versión española de las escalas de pensamiento paranoide de Green (S-GPTS). MÉTODO: 191 participantes españoles respondieron al S-GPTS, al Inventario de Delirios de Peters (PDI) y a medidas de psicopatología.RESULTADOS: el Análisis de Componentes Principales a partir de la matriz de correlaciones policóricas identificó dos factores que explicaban el 71% de la varianza acumulada. El coeficiente α de Cronbach para el S-GPTS y sus subescalas fue superior a .90 en ambos grupos. El valor del área bajo la curva ROC fue más alto para el S-GPTS (.898) que para el PDI (.859). El punto de corte que mejor discriminaba entre el grupo clínico y el no clínico fue 92 (97,35% de sensibilidad, 65% de especificidad). Las puntuaciones del S-GPTS correlacionaron positivamente con el PDI y con medidas de ansiedad y depresión. CONCLUSIONES: el S-GPTS posee propiedades psicométricas adecuadas para proporcionar una medida válida de la ideación delirante en población española
Subject(s)
Humans , Male , Female , Paranoid Behavior/complications , Paranoid Behavior/diagnosis , Paranoid Behavior/psychology , Psychopathology/education , Psychopathology/ethics , Paranoid Behavior/classification , Paranoid Behavior/prevention & control , Psychopathology/history , Psychopathology , Spain/ethnologyABSTRACT
La pérdida visual no orgánica es la presencia de sintomatología ocular sin una base orgánica que la justifique y que puede presentarse hasta en el 5% de los ninos que acuden a la consulta de oftalmología ambulatoria. La sospecha y el manejo de esta situación son fundamentales para un diagnóstico adecuado, evitando no solo derivaciones innecesarias a otras especialidades, sino para evitar también el gasto sanitario, además de disminuir la angustia paterna por la posible presencia de enfermedad ocular en sus hijos
Non-organic visual loss is the presence of ocular symptoms without an organic base that justifies it, and can occur in up to 5% of the children attending Ophthalmology Outpatients. A suspicion and the management of this situation are essential for a proper diagnosis, not only to avoid unnecessary referrals to other specialties, but also to avoid health spending, in addition to reducing parental distress by the possible presence of eye disease in their children
Subject(s)
Humans , Male , Female , Child , Vision Disorders/complications , Vision Disorders/diagnosis , Vision Disorders/metabolism , Intraocular Pressure/genetics , Ocular Hypertension/diagnosis , Vision Disorders/genetics , Vision Disorders/prevention & control , Ocular Hypertension/complications , Ocular Hypertension/prevention & control , Photophobia/diagnosis , Psychopathology/ethicsABSTRACT
La diabetes mellitus tipo 1 (DM1) es una enfermedad crónica ampliamente extendida entre la población infantojuvenil. Suele suponer una sobrecarga significativa en el niño y su familia, modificando aspectos en su estilo de vida, necesarios para cumplimentar las exigencias del tratamiento. Nuestro objetivo es estudiar las principales características psicológicas, familiares y de ajuste a la enfermedad de los niños y adolescentes diagnosticados de DM1, haciendo especial hincapié en los factores psicopatológicos asociados. La metodología empleada ha consistido en una búsqueda bibliográfica sistemática en las principales bases de datos científicas. Debido al impacto biopsicosocial que la DM1 suele suponer en la vida del niño y su familia, pudiendo comprometer la calidad de vida y bienestar emocional de ambos, se ha señalado la importancia de identificar el conjunto de factores psicológicos asociados con un buen ajuste a la DM1 infantojuvenil
Type 1 Diabetes Mellitus (T1DM) is a widespread chronic disease among children and adolescents. Diagnosis and evolution usually involves a significant burden on the patient, and their families must change various aspects of their lifestyle to fulfill the demands of treatment. This study aims to identify the main psychological, family, and adjustment to illness features of children and adolescents diagnosed with DM1 and, in particular to highlight the associated psychopathological factors. The methodology involved a systematic literature search in the main scientific databases. Due to the biopsychosocial impact of DM1 usually assumed in the life of the child and family, and how it may compromise the quality of life and emotional well-being of both, different studies have agreed on the importance of identifying the set of psychological factors involved in healthy adjustment to illness in the child and adolescent with DM1
Subject(s)
Humans , Male , Female , Child , Diabetes Mellitus, Type 1/congenital , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/metabolism , Psychopathology/ethics , Psychopathology/methods , Depression/diagnosis , Glycemic Index/genetics , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/genetics , Diabetes Mellitus, Type 1/prevention & control , Psychopathology/instrumentation , Depression/complicationsSubject(s)
Diagnostic and Statistical Manual of Mental Disorders , Dyssomnias/diagnosis , Grief , Mental Disorders/diagnosis , Rage , Adult , Child , Diagnosis, Differential , Drug Industry/ethics , Dyssomnias/drug therapy , Dyssomnias/psychology , Ethics, Pharmacy , Female , Germany , Humans , International Classification of Diseases/ethics , Male , Mental Disorders/classification , Mental Disorders/psychology , Psychopathology/ethics , Rage/drug effects , Rage/ethics , United StatesABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Psychopathology/instrumentation , Psychopathology/methods , Psychopathology/standards , Depressive Disorder/psychology , Schizophrenia/prevention & control , Schizophrenia/physiopathology , Schizophrenic Psychology , Psychopathology/education , Psychopathology/ethics , Psychopathology/trendsABSTRACT
The rapidly changing demographic landscape of the United States, brought about by immigration, has resulted in an increasingly multiracial and multicultural population. These changes have become accentuated by the phenomenon of globalization, which occurs when there is an acceleration of movement of people, ideas, and products between nations, which also brings about an increase in the complexity of everyday problems. This article discusses the concept of identity formation and how the stresses of immigration and acculturation and the factors of resiliency and risk affect immigrant children, adolescents, and their families, so that clinicians treating these populations can be prepared to understand divergent, and often well-hidden, world views, which may cause intrafamilial conflicts and interfere with the child's developmental process.
Subject(s)
Acculturation , Adaptation, Psychological , Child Development , Emigration and Immigration , Adaptation, Psychological/ethics , Adolescent , Child , Emigrants and Immigrants/psychology , Ethnopsychology , Family Characteristics , Humans , Internationality , Life Change Events , Multilingualism , Psychopathology/ethics , Self Concept , Social Identification , United StatesABSTRACT
In this article the authors discuss first why it is crucial, from a clinical and public health perspective, to better understand the development as well as risk and protection processes for the mental health of immigrant children. The authors then shift focus to the main tenet of this article, namely, that specific aspects of the dual language development of immigrant children are highly relevant to their mental health and adaptation. This argument is illustrated with empirical studies on Latino immigrant children, as they represent the majority of immigrant children in America and as a way of exemplifying the risks and circumstances that are potentially shared by other immigrant groups. Finally, the authors conceptually differentiate dual language development and its mental health impact from the dual-culture (bicultural) development and circumstance of immigrant children and their mental health impact.
Subject(s)
Adaptation, Psychological , Child Development , Cultural Diversity , Hispanic or Latino , Multilingualism , Adaptation, Psychological/ethics , Child , Child Guidance/ethics , Child Guidance/methods , Emigrants and Immigrants/education , Emigrants and Immigrants/psychology , Emigration and Immigration , Ethnopsychology , Hispanic or Latino/education , Hispanic or Latino/psychology , Humans , Mental Disorders/ethnology , Mental Disorders/prevention & control , Psychopathology/education , Psychopathology/ethics , Risk Factors , United StatesABSTRACT
Partiendo de estudios de una línea de investigación sobre el duelo se hacen observaciones sobre la implicación de éste en la evolución de las diferentes etapas biográficas y en la psicopatología (AU)
From studies of a line of research on bereavement, made comments on his involvement in the evolution of different stages in the biographical and psychopathology (AU)
Subject(s)
Humans , Male , Female , Grief , Psychopathology/methods , Psychopathology/trends , Death , Affective Symptoms/psychology , Psychopathology/ethics , Life Cycle Stages , Emotions/physiology , Social Support , Psychosocial ImpactABSTRACT
El estudio de los trastornos del límite revela que la neurosis y la psicosis sólo cubren un reducido campo de la psicopatología (AU)
Studies regarding disorders of borderline point out that neurosis and psychosis only cover a small field within psychopathology (AU)
Subject(s)
Humans , Male , Female , Borderline Personality Disorder/epidemiology , Borderline Personality Disorder/psychology , Neurotic Disorders/complications , Neurotic Disorders/psychology , Psychopathology/ethics , Psychopathology/methods , Narcissism , Denial, Psychological , Borderline Personality Disorder/history , Borderline Personality Disorder/physiopathology , Psychopathology/trendsABSTRACT
Se analizan los trastornos psicológicos de la infancia y adolescencia bajo el marco teórico de la psicopatología del desarrollo, y se hacen algunas sugerencias para entender la relación entre las grandes dimensiones psicopatológicas y los síndromes clínicos desde una perspectiva etiológica. Se formulan algunas hipótesis sobre el rol del contexto en la aparición de la psicopatología y, finalmente, se analiza el riesgo y la vulnerabilidad para algunos trastornos específicos (AU)
Psychological disorders in childhood and adolescence are analyzed according to the theoretical framework of the developmental psychopathology, and some suggestions are made to understand the relationship between dimensions of abnormal psychology and clinical syndromes in an etiologic perspective. Some hypotheses are presented on the role of context in the onset of psychopathology and, finally, the risk and vulnerability factors for some specific disorders are analyzed (AU)
