Primary Pyomyositis Caused by Kingella kingae in a 21-Month-old Infant: A Case Report.

The authors report a rare case of an unusual primary pyomyositis of the biceps cruralis assigned to Kingella kingae in a 21-month-old girl. The reported case demonstrated that primary pyomyositis may be encountered during invasive infection due to K. kingae even if this manifestation remains rare. This bacterial etiology must, therefore, be evoked when a primary pyomyositis is observed, and this is in particular in children under 4 years of age.

63-year-old man with right biceps and right pectoralis major abscesses: an unusual case of pyomyositis.

Pyomyositis is considered a great mimicker and masquerader. This case is of a 63-year-old man with diabetes who initially presented to the outpatient clinic afebrile with right shoulder pain. His work-up was negative, and he was discharged home. He subsequently presented to the emergency room (ER) two times for worsening right shoulder pain. During his first visit to the ER, his work-up was unremarkable, and he was discharged home. On his return to the ER, he was now febrile with inflammation involving his right upper extremity and right chest wall. Imaging studies of his right upper extremity and his right chest wall were consistent with multiple abscesses. Methicillin resistant Staphylococcus aureus was cultured from the abscess, and from blood and urine cultures. The diagnosis of pyomyositis was confirmed. This case illustrates the difficulty of diagnosing pyomyositis and the importance of including it in the differential diagnosis, especially in an immunocompromised patient.

Toxic shock syndrome and pyomyositis: about an unusual case.

Pyomyositis is a pyogenic infection of skeletal muscle with abscess formation. It is a rare disease with nonspecific symptoms which requires a rapid diagnosis and treatment. Magnetic resonance imaging is considered the gold standard for early diagnosis and to rule out other etiologies. This article reports an atypical presentation of pyomyositis revealed by a toxic staphylococcal shock syndrome in an 8-year-old boy.

An unusual case of tropical pyomyositis: cryptococcal pyomyositis.

The more common manifestations of cryptococcal infections are restricted to the central nervous system and lungs. A young man, suffering from idiopathic dilated cardiomyopathy with a left ventricular ejection fraction of 20%, presented with subacute, painful tender swelling in both legs initially attributed to congestive cardiac failure. No response to diuretics was achieved. Metabolically active lesions in the muscles of both lower limbs suggestive of muscle abscesses were found. A diagnosis of tropical pyomyositis was therefore made, but aspiration surprisingly revealed gram-positive yeast cells, staining of which on India ink and culture confirmed Cryptococcus. A good response to a combination of liposomal amphotericin B and flucytosine was obtained, but nevertheless the patient died from heart failure after induction of antifungal therapy.

Tropical pyomyositis: an update.

Tropical pyomyositis (TP) is a life-threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non-specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin-susceptible S. aureus, is responsible for most TP cases. However, other bacteria (i.e. streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) have been reported. This narrative review provides an update on the epidemiology and clinical course of TP. A special focus is laid on the role of toxins (i.e. Panton-Valentine Leucocidin and α-toxin) in the pathogenesis of TP and their implication for the clinical management of infection.

La pyomyosite tropicale (TP) est une infection bactérienne potentiellement mortelle du muscle squelettique qui survient particulièrement chez les enfants, les jeunes adultes et les personnes immunodéprimées. Le diagnostic et le traitement appropriés sont souvent retardés en raison de ses signes non spécifiques, entraînant des conséquences fatales. Staphylococcus aureus, en particulier S. aureus sensible à la méthicilline, est responsable de la plupart des cas de TP. Cependant, d'autres bactéries (ex: streptocoques, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) ont été rapportées. Cette revue narrative fournit une mise à jour sur l'épidémiologie et l'évolution clinique du TP. Un accent particulier est mis sur le rôle des toxines (la Leukocidine de Panton-Valentine et l'α-toxine) dans la pathogenèse du TP et leur implication pour la prise en charge clinique de l'infection.

Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS.

Pyomyositis is a severe bacterial infection of skeletal muscle, commonly affecting children in tropical regions, predominantly caused by Staphylococcus aureus. To understand the contribution of bacterial genomic factors to pyomyositis, we conducted a genome-wide association study of S. aureus cultured from 101 children with pyomyositis and 417 children with asymptomatic nasal carriage attending the Angkor Hospital for Children, Cambodia. We found a strong relationship between bacterial genetic variation and pyomyositis, with estimated heritability 63.8% (95% CI 49.2-78.4%). The presence of the Panton-Valentine leucocidin (PVL) locus increased the odds of pyomyositis 130-fold (p=10-17.9). The signal of association mapped both to the PVL-coding sequence and to the sequence immediately upstream. Together these regions explained over 99.9% of heritability (95% CI 93.5-100%). Our results establish staphylococcal pyomyositis, like tetanus and diphtheria, as critically dependent on a single toxin and demonstrate the potential for association studies to identify specific bacterial genes promoting severe human disease.

Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report.

BACKGROUND: Fusobacterium necrophorum is a common agent of disease in humans, but the occurrence of primary infections outside the head and neck area is extremely rare. While infection with Fusobacterium necrophorum has a rather benign course above the thorax, the organism is capable of producing very severe disease when located in unusual sites, including various forms of septic thrombophlebitis. No infections of the leg have been documented before; thus, antibiotic coverage for Fusobacterium is currently not recommended in this area. CASE PRESENTATION: A 50-year-old homeless African-American man presented complaining of severe pain in his right lower extremity. A clinical workup was consistent with emphysematous pyomyositis and compartment syndrome; he received limb-saving surgical intervention. The offending organism was identified as Fusobacterium necrophorum, and the antibiotic coverage was adjusted accordingly. CONCLUSIONS: Bacteria typically involved in necrotizing infections of the lower extremity include Group A ß-hemolytic Streptococcus, Clostridium perfringens, and common anaerobic bacteria (Bacteroides, Peptococcus, and Peptostreptococcus). This case report presents a case of gas gangrene of the leg caused by Fusobacterium necrophorum, the first such case reported. Fusobacterium should now be included in the differential diagnosis of necrotizing fasciitis of the extremities.

Pyomyositis Causing Temporary Quadriparesis During Induction Therapy for Acute Lymphoblastic Leukemia: Case Report and Review of the Literature.

Pyomyositis (PM) is a purulent infection of skeletal muscle. It is often associated with immunosuppression in temperate climates. Herein, we report a case of PM causing temporary quadriparesis in a 14-year-old girl undergoing induction therapy for acute lymphoblastic leukemia and we review the reported pediatric cases associated with induction therapy for hematologic malignancies. Early symptoms of PM can be mistaken for the side effects of chemotherapeutic agents. Greater awareness of the clinical picture of PM will aid in early diagnosis and treatment. With appropriate medical therapy and timely abscess drainage, morbidity and mortality is greatly reduced.

Electromyographic diagnosis of multifocal pyomyositis.

INTRODUCTION: Multifocal pyomyositis is a rare inflammatory myopathy caused by bacterial infection and abscess formation in multiple skeletal muscles. To date, electromyography (EMG) of pyomyositis has not been reported. METHODS: We describe the EMG findings of a patient with pathologically proven multifocal pyomyositis. RESULTS AND CONCLUSIONS: Muscles affected by pyomyositis demonstrate EMG features similar to those of other inflammatory myopathies. Other features such as acute entrapment neuropathy may exist concomitantly due to nerve compression from muscle abscess formation.

Piomiosistis como complicación de la varicela. A propósito de un caso / Pyomiositis as a complication of varicella. A case report

La varicela es la enfermedad exantemática más frecuente en la infancia. Generalmente es benigna y autolimitada. Están descritas complicaciones que requieren tratamiento hospitalario y que están asociadas a una alta morbimortalidad. La piomiositis o infección aguda del músculo estriado es, aunque infrecuente, una de las posibles complicaciones musculoesqueléticas de la varicela. Presentamos el caso de un niño que durante la convalecencia de dicha enfermedad presentó como complicación una celulitis del miembro inferior y, posteriormente, una piomiositis del músculo gastrocnemio (AU)

Varicella is the most common exanthematic disease in childhood. It is usually benign and self-limited. Some complications that require hospital treatment and are associated with high morbidity and mortality are reported. Pyomyositis or acute infection of the striated muscle is, although rare, one of the musculoskeletal possible complications of varicella. We present the case of a child that, while convalescing from that disease, presented lower limb cellulites, and later a pyomyositis of the gastrocnemius muscle (AU)

Piomiositis del músculo piriforme / Pyomyositis of the piriformis muscle

Las infecciones profundas de músculos pélvicos son difíciles de diagnosticar por ocasionar signos físicos inespecíficos que sugieren otras patologías más comunes. Comunicamos el caso de un paciente de 12 años, sexo masculino, sano, con el antecedente de practicar danza. Consultó por dolor en región lumbar y glútea derecha, irradiado por cara posterior del muslo, de siete días de evolución. Recibió tratamiento sintomático sin respuesta. Presentó diarrea, fiebre y compromiso del estado general, evolucionando con shock séptico durante su estadía hospitalaria. La resonancia nuclear magnética pélvica fue compatible con piomiositis de músculo piriforme. Se aisló en sangre Staphylococcus aureus multisensible. Recibió apoyo multisistémico y tratamiento antibiótico, evolucionando satisfactoriamente. La piomiositis del músculo piriforme es una entidad poco frecuente, que requiere un elevado índice de sospecha, para un adecuado diagnóstico y tratamiento, siendo la terapia antibiótica y drenaje en caso de abscesos los pilares de éste último. Este tratamiento debe instaurarse en forma precoz, ya que su evolución puede ser potencialmente letal (AU)

Unfortunately, diagnosis of deep pelvic muscle infection is often delayed since they usually present with non-specific physical signs suggesting other more common diseases. The authors communicate a case of a previously healthy 12-year-old male whot practiced dancing regularly and suffered acute pain in the lumbar and right gluteal regions irradiated to the posterior side of the thigh for 1 week. He initially received symptomatic treatment with no success. He continued with diarrhea, fever and malaise. When he was admitted to hospital he suffered severe septic shock and multi-organ failure. Pelvis magnetic resonance imaging showed pyomyositis of the piriformis muscle. Multi-sensitive Staphylococcus aureus was isolated in blood cultures. Antibacterial treatment and multi systemic support were administered, resulting in a good outcome. Pyomyositis of the piriformis muscle is a rare condition that demands a high index of suspicion to make an adequate diagnosis and prompt treatment, including antibacterial treatment and drainage, particularly in case of abscess formation. This treatment should be established promptly since its outcome may be potentially lethal (AU)

Pyomyositis.

Poorly controlled diabetes is associated with an increased risk of infectious complications. With the increasing prevalence of diabetes, many more people are being looked after in primary care. We describe a case of pyomyositis, a potentially severe but uncommon complication of poorly controlled diabetes that was not recognised in the community. Clinicians looking after people with diabetes need to be aware that prolonged, unexplained symptoms need specialist assessment.

Piomiositis primaria: un reto diagnóstico en la UCI / No disponible

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Infection and musculoskeletal conditions: Infectious myositis.

Infectious myositis, an infection of the skeletal muscle(s), is uncommon. This clinical entity may be caused by viral, bacterial, fungal, and parasitic pathogens. Viral etiologies typically cause diffuse myalgias and/or myositis, whereas bacteria and fungi usually lead to a local myositis which may be associated with sites compromised by trauma or surgery and are more common among immunocompromised patients. Localized collections within the muscles are referred to as pyomyositis. Other pyogenic causes of myositis include gas gangrene, group A streptococcal myonecrosis, and other types of non-clostridial myonecrosis. Early recognition and treatment of these conditions are necessary as they may rapidly become life-threatening.