[Effect of pyridoxylate on the intensity of changes in the internal organs and skeletal musculature of rats under considerable physical loading]. / Vliianie piridoksilata na vyrazhennost' izmenenii vnutrennoi organov i skeletnoi muskulatury krys pri znachitel'noi fizicheskoi nagruzke.

Under considerable physical load, marked enzymopathy, increased permeability of cellular membranes with the involvement of cellular and subcellular structures develop in the myocardium, skeletal musculature and viscera of rats. Administration of pyridozylate decreases the intensity of damage reactions and normalizes to a certain degree the structure of cellular and subcellular elements of tissues. This indicates the advisability of the employment of the cell respiration regulators under conditions of general and tissue hypoxy and metabolic shifts.

[Use of pyridoxylate for treating chronic coronary insufficiency]. / Primenenie piridoksilata dlia lecheniia bol'nykh s khronicheskoi koronarnoi nedostatochnost'iu

A total of 49 patients with chronic ischaemic heart disease (38 of whom had previously survived myoca dial infarction) were treated with Piridoxylate administered intramuscularly and orally. The treatment resulted in an improvement of the state of 2/3 of the patients, positive ECG shifts, improvements of cardio- and haemodynamics at rest and under physical exercises. In half of the patients an increased tolerance of physical exercises was noted. No side-effects of Piridoxylate therapy were observed.