Subject(s)
Chemical and Drug Induced Liver Injury/prevention & control , Cytoprotection , Hepatocytes/drug effects , Liver/drug effects , Protective Agents/administration & dosage , Protective Agents/classification , Amino Acids/administration & dosage , Amino Acids/chemistry , Amino Acids/classification , Chemical and Drug Induced Liver Injury/drug therapy , Drug Combinations , Flavonoids/administration & dosage , Flavonoids/chemistry , Flavonoids/classification , Humans , Phosphatidylcholines/administration & dosage , Phosphatidylcholines/chemistry , Phosphatidylcholines/classification , Protective Agents/chemistry , Pyridoxine/administration & dosage , Pyridoxine/chemistry , Pyridoxine/classification , Pyrrolidonecarboxylic Acid/administration & dosage , Pyrrolidonecarboxylic Acid/chemistry , Pyrrolidonecarboxylic Acid/classification , Ursodeoxycholic Acid/administration & dosage , Ursodeoxycholic Acid/analogs & derivativesABSTRACT
Se presenta el caso de un lactante, con crísis clónicas inicialmente y luego tónicoclónicas que lo llevan finalmente a status epiléptico, secundarias a déficit de piridoxina. El caso debe alertar sobre la posibilidad de procesos infrecuentes, como el de este ejemplo, como causa de cuadros convulsivos de difícil manejo.
Subject(s)
Humans , Infant , Seizures/classification , Seizures/diagnosis , Seizures/drug therapy , Seizures/etiology , Seizures/nursing , Pyridoxine/administration & dosage , Pyridoxine/adverse effects , Pyridoxine/classification , Pyridoxine/metabolism , Pyridoxine/pharmacokinetics , Pyridoxine/therapeutic useABSTRACT
A previously developed high performance chromatographic method has been modified slightly and used to determine the forms of vitamin B6 in human milk. The chromatographic traces are free of compounds that would interfere with the two principal forms found, pyridoxal and pyridoxal phosphate. The method is fast and reliable; it yields recoveries of from 90 to 106% for the vitamers and agrees with results obtained on the same samples with the standard microbiological assay.
