1.
J Gen Virol
; 39(2): 381-5, 1978 May.
Article
in English
| MEDLINE
| ID: mdl-77308
ABSTRACT
Post-exposure protection of rabies-infected mice was observed by proximal application of axonal flow inhibitors, particularly vinblastine, to the local nerve(s). These observations indicate that rabies virus is transported by the axonal flow of the peripheral nerves to the central nervous system. Both a fixed virus (CVS) and a street (sylvatic) virus were used. This model in mice could be used to develop an additional post-exposure local treatment of rabies infection in man, by infiltrating local nerves or ganglions with axonal flow inhibitors, with the advantage that it would not interfere with subsequent vaccination as is the case with the administration of hyperimmune serum or immunoglobulin.
Subject(s)
Colchicine/administration & dosage , Rabies/prevention & control , Vinblastine/administration & dosage , Animals , Antibodies, Viral/biosynthesis , Axonal Transport/drug effects , Disease Models, Animal , Mice , Rabies/immunology , Rabies/surgery , Rabies/transmission , Rabies virus/immunology , Sciatic Nerve/drug effects , Sciatic Nerve/surgery
2.
Rev Inst Med Trop Sao Paulo
; 17(2): 103-10, 1975.
Article
in English
| MEDLINE
| ID: mdl-1153910
Subject(s)
Anti-Bacterial Agents/therapeutic use , Rabies/therapy , Ascorbic Acid/therapeutic use , Critical Care , Evaluation Studies as Topic , Immunization, Passive , Immunotherapy , Rabies/drug therapy , Rabies/surgery , Rabies Vaccines/therapeutic use , Respiration , Respiratory Function Tests , Tracheotomy , Water-Electrolyte Balance
3.
Zentralbl Chir
; 94(8): 264-8, 1969 Feb 22.
Article
in German
| MEDLINE
| ID: mdl-5371290