Empleo de Yttrium 90 coloidal en el tratamiento de craneofaringiomas quísticos. Presentación de técnicas y casos clínicos. Evaluación de resultados / Use of Yttrium 90 in the treatment of cystic craniopharyngiomas. Presentation of technichs and clinical cases. Evaluation of results

El craneofaringioma representa el 9

Estudo comparativo sobre radiaçöes e hipertermia em um grupo de neoplasmas / Comparative study on radiations and hyperthermia in a group of neoplasms

Trinta e cinco pacientes portadores de tumores avançados de mama, pulmäo, útero, esôfago, cabeça e pescoço, submetidos à radioterapia exclusiva, foram comparados com outros trinta e cinco pacientes com as mesmas patologías nos quais, além da radioterapia, associou-se hipertemia. Os resultados foram significativos na avaliaçäo do grau de respostas, principalmente no que se refere aos casos em que se observou regressäo completa dos tumores, em que a proporçäo foi de 20% a favor da hipertermia, contra 5,7% com radioterapia exclusiva e na ausência de resposta em que se registraram 40% de casos com radioterapia exclusiva contra 2,8% nos casos aos quais se associou hipertermia. Foram selecionados cinco casos de recidivas tumorais em plasträo costal e se utilizou, como fonte calórica, raios infravermelhos na seqüência da radioterapia, mais radiaçäo infravermelha. Todos os casos responderam com remissäo clínica completa à dose de 3.600 rads apenas

Helium ion therapy for choroidal melanoma.

Eighty-two patients with choroidal melanomas were treated with helium ion charged particle irradiation. Seventy-eight of 82 patients have either remained stable or demonstrated tumor shrinkage. Forty-five of 46 patients followed for at least 1 year after therapy have demonstrated tumor regression with a mean tumor shrinkage of approximately 31%. No tumor-related mortality has been observed. The most effective method of choroidal melanoma management is unclear. Charged particle external beam irradiation may be more applicable and have less ocular morbidity than either radioactive plaques or photocoagulation.

[The use of high-energy electrons in the treatment of malignant orbital tumors (author's transl)]. / Die Anwendung von hochenergetischen Elektronen bei der Behandlung von malignen Orbitatumoren.

Tumors of the anterior part of the orbita can be irradiated with high-energy electrons using a special eye tube with a central plexiglass stick to protect the eye. In eight patients suffering from lymphatic orbital tumors, complete remission was achieved after a dose of 3000 rad.

Cytotoxic activity, tumor accumulation, and tissue distribution of ruthenium-103-labeled bleomycin.

Bleomycin (BLM) was labeled with gamma-emitting 103Ru. Yields of 103Ru-labeled BLM as high as 50.6% were attained. 103Ru-labeled BLM was stable in vitro and the 103ru label was not displaced by large excesses of Cu (II) and Co (II) or Fe (III). Chromatography of the urine following 103Ru-labeled BLM injection indicated no in vivo decomposition. Pharmacokinetic studies in healthy inbred SD and tumor-bearing inbred BUF rats demonstrated tumor accumulations, tissue distributions, and clearance nearly identical with those reported for 3H-labeled BLM. Cytotoxicity studies on a WI-L2 human B-cell line showed that BLM labeled with nonradioactive Ru retained 100% of the activity demonstrated by native BLM. Thus BLM may be labeled with isotopes of Ru to form stable complexes by a simple, rapid reaction without loss of its chemotherapeutic properties or variations in its in vivo distribution. BLM labeled with the proper Ru isotope should prove useful as a gamma-emitting tracer for BLM or a beta-emitting compound capable of providing combination chemotherapy and radiotherapy of tumors.