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2.
Biomed Phys Eng Express ; 10(4)2024 May 14.
Article in English | MEDLINE | ID: mdl-38697045

ABSTRACT

Whole-body counters (WBC) are used in internal dosimetry forin vivomonitoring in radiation protection. The calibration processes of a WBC set-up include the measurement of a physical phantom filled with a certificate radioactive source that usually is referred to a standard set of individuals determined by the International Commission on Radiological Protection (ICRP). The aim of this study was to develop an anthropomorphic and anthropometric female physical phantom for the calibration of the WBC systems. The reference female computational phantom of the ICRP, now called RFPID (Reference Female Phantom for Internal Dosimetry) was printed using PLA filament and with an empty interior. The goal is to use the RFPID to reduce the uncertainties associated within vivomonitoring system. The images which generated the phantom were manipulated using ImageJ®, Amide®, GIMP®and the 3D Slicer®software. RFPID was split into several parts and printed using a 3D printer in order to print the whole-body phantom. The newly printed physical phantom RFPID was successfully fabricated, and it is suitable to mimic human tissue, anatomically similar to a human body i.e., size, shape, material composition, and density.


Subject(s)
Phantoms, Imaging , Printing, Three-Dimensional , Whole-Body Counting , Humans , Female , Whole-Body Counting/methods , Calibration , Radiation Protection/methods , Radiation Protection/instrumentation , Radiometry/methods , Radiometry/instrumentation , Anthropometry
3.
Sci Rep ; 14(1): 10719, 2024 05 10.
Article in English | MEDLINE | ID: mdl-38729975

ABSTRACT

The shielding parameters can vary depending on the geometrical structure of the linear accelerators (LINAC), treatment techniques, and beam energies. Recently, the introduction of O-ring type linear accelerators is increasing. The objective of this study is to evaluate the shielding parameters of new type of linac using a dedicated program developed by us named ORSE (O-ring type Radiation therapy equipment Shielding Evaluation). The shielding evaluation was conducted for a total of four treatment rooms including Elekta Unity, Varian Halcyon, and Accuray Tomotherapy. The developed program possesses the capability to calculate transmitted dose, maximum treatable patient capacity, and shielding wall thickness based on patient data. The doses were measured for five days using glass dosimeters to compare with the results of program. The IMRT factors and use factors obtained from patient data showed differences of up to 65.0% and 33.8%, respectively, compared to safety management report. The shielding evaluation conducted in each treatment room showed that the transmitted dose at every location was below 1% of the dose limit. The results of program and measurements showed a maximum difference of 0.003 mSv/week in transmitted dose. The ORSE program allows for the shielding evaluation results to the clinical environment of each institution based on patient data.


Subject(s)
Particle Accelerators , Radiation Protection , Particle Accelerators/instrumentation , Radiation Protection/instrumentation , Radiation Protection/methods , Humans , Radiotherapy, Intensity-Modulated/methods , Radiation Dosage
4.
Radiat Prot Dosimetry ; 200(8): 745-754, 2024 Jun 03.
Article in English | MEDLINE | ID: mdl-38702838

ABSTRACT

This study analysed the occupational dose in Korean pressurized heavy-water reactors (PHWRs) and identified tasks involving high radiation exposure. The average individual dose was sufficiently low to be below the annual effective dose limit for radiation workers and is even lower than the dose limit for the general public. However, some workers received relatively higher doses than others. Furthermore, most PHWR workers are exposed to radiation during planned maintenance periods. In this study, the radiation dose was normalized (radiation dose per unit time) to determine the high-radiation-exposure tasks in Korean PHWRs. Consequently, end-fitting lapping, delayed neutron tube work and fuel channel fixed-end change tasks were identified as high-radiation-exposure tasks in Korean PHWRs. If appropriate radiation protection measures are prioritized for the identified high-dose exposure tasks, optimization of radiological protection will be effectively achieved by reducing the dose that is relatively higher than the average.


Subject(s)
Occupational Exposure , Radiation Dosage , Radiation Monitoring , Occupational Exposure/analysis , Occupational Exposure/prevention & control , Humans , Republic of Korea , Radiation Monitoring/methods , Radiation Monitoring/instrumentation , Radiation Protection/instrumentation , Radiation Exposure/analysis , Nuclear Reactors , Water
5.
Med Phys ; 51(6): 4423-4433, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38695760

ABSTRACT

BACKGROUND: The newly available ZAP-X stereotactic radiosurgical system is designed for the treatment of intracranial lesions, with several unique features that include a self-shielding, gyroscopic gantry, wheel collimation, non-orthogonal kV imaging, short source-axis distance, and low-energy megavoltage beam. Systematic characterization of its radiation as well as other properties is imperative to ensure its safe and effective clinical application. PURPOSE: To accurately determine the radiation output of the ZAP-X with a special focus on the smaller diameter cones and an aim to provide useful recommendations on quantification of small field dosimetry. METHODS: Six different types of detectors were used to measure relative output factors at field sizes ranging from 4 to 25 mm, including the PTW microSilicon and microdiamond diodes, Exradin W2 plastic scintillator, Exradin A16 and A1SL ionization chambers, and the alanine dosimeter. The 25 mm cone served as the reference field size. Absolute dose was determined with both TG-51-based dosimetry using a calibrated PTW Semiflex ion chamber and measurements using alanine dosimeters. RESULTS: The average radiation output factors (maximum deviation from the average) measured with the microDiamond, microSilicon, and W2 detectors were: for the 4 mm cone, 0.741 (1.0%); for the 5 mm cone: 0.817 (1.0%); for the 7.5 mm cone: 0.908 (1.0%); for the 10 mm cone: 0.946 (0.4%); for the 12.5 mm cone: 0.964 (0.2%); for the 15 mm cone: 0.976 (0.1%); for the 20 mm cone: 0.990 (0.1%). For field sizes larger than 10 mm, the A1SL and A16 micro-chambers also yielded consistent output factors within 1.5% of those obtained using the microSilicon, microdiamond, and W2 detectors. The absolute dose measurement obtained with alanine was within 1.2%, consistent with combined uncertainties, compared to the PTW Semiflex chamber for the 25 mm reference cone. CONCLUSION: For field sizes less than 10 mm, the microSilicon diode, microDiamond detector, and W2 scintillator are suitable devices for accurate small field dosimetry of the ZAP-X system. For larger fields, the A1SL and A16 micro-chambers can also be used. Furthermore, alanine dosimetry can be an accurate verification of reference and absolute dose typically measured with ion chambers. Use of multiple suitable detectors and uncertainty analyses were recommended for reliable determination of small field radiation outputs.


Subject(s)
Radiometry , Radiosurgery , Radiosurgery/instrumentation , Radiometry/instrumentation , Radiation Protection/instrumentation , Reference Standards
6.
Life Sci Space Res (Amst) ; 41: 119-126, 2024 May.
Article in English | MEDLINE | ID: mdl-38670638

ABSTRACT

The risk posed by prolonged exposure to space radiation represents a significant obstacle to long-duration human space exploration. Of the ion species present in the galactic cosmic ray spectrum, relativistic protons are the most abundant and as such are a relevant point of interest with regard to the radiation protection of space crews involved in future long-term missions to the Moon, Mars, and beyond. This work compared the shielding effectiveness of a number of standard and composite materials relevant to the design and development of future spacecraft or planetary surface habitats. Absorbed dose was measured using Al2O3:C optically stimulated luminescence dosimeters behind shielding targets of varying composition and depth using the 1 GeV nominal energy proton beam available at the NASA Space Radiation Laboratory at the Brookhaven National Laboratory in New York. Absorbed dose scored from computer simulations performed using the multi-purpose Monte Carlo radiation transport code FLUKA agrees well with measurements obtained via the shielding experiments. All shielding materials tested and modeled in this study were unable to reduce absorbed dose below that measured by the (unshielded) front detector, even after depths as large as 30 g/cm2. These results could be noteworthy given the broad range of proton energies present in the galactic cosmic ray spectrum, and the potential health and safety hazard such space radiation could represent to future human space exploration.


Subject(s)
Cosmic Radiation , Monte Carlo Method , Protons , Radiation Protection , Space Flight , Radiation Protection/instrumentation , Radiation Protection/methods , Humans , Cosmic Radiation/adverse effects , Radiation Dosage , Spacecraft , Computer Simulation
7.
Radiat Res ; 201(5): 499-503, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38471522

ABSTRACT

Despite the large variety of high-voltage semiconductor components for medium and high voltage switching and pulse-forming applications as well as for high-power high-frequency generation, the use of vacuum electron tubes still prevails to a considerable degree. Due to the common design incorporating a high energy electron beam which finally is dumped into an anode or a resonator cavity, these tubes are also considered as sources of X rays produced as bremsstrahlung and characteristic radiation, which are referred to as parasitic X rays. Here three types of vacuum-electron tubes, diode, tetrode, and thyratron, with glass housings are investigated. They are predominantly operated in the high voltage range below 30 kV and are not subject to licensing laws. The measurements of the dose rate and X-ray-spectra were performed in the laboratory without complex electrical circuitry usually used in making practical measurements for occupational radiation protection. For the diode tube, where a parasitic X-ray emission is observed only in the reverse operation as a blocking diode, a broad distribution of dose rates of electrically equivalent specimens was observed. This is attributed to field emission from the electrodes. For the tetrode and the thyratron tubes, field emission from the electrodes is identified as the dominant mechanism for the generation of parasitic X rays. Thus, technical radiation protection must focus on shielding of the glass tube rather than optimization of the electrical circuitry.


Subject(s)
Electrons , Glass , Occupational Exposure , X-Rays , Vacuum , Glass/chemistry , Occupational Exposure/analysis , Radiation Dosage , Radiation Protection/instrumentation
8.
Magn Reson Med ; 92(1): 406-415, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38411281

ABSTRACT

PURPOSE: To utilize the transmit radiofrequency (RF) field in MRI as a power source, near or within the field of view but without affecting image quality or safety. METHODS: Power harvesting is performed by RF induction in a resonant coil. Resulting RF field distortion in the subject is canceled by a selective shield that couples to the harvester while being transparent to the RF transmitter. Such shielding is designed with the help of electromagnetic simulation. A shielded harvester of 3 cm diameter is implemented, assessed on the bench, and tested in a 3T MRI system, recording power yield during typical scans. RESULTS: The concept of selective shielding is confirmed by simulation. Bench tests show effective power harvesting in the presence of the shield. In the MRI system, it is confirmed that selective shielding virtually eliminates RF perturbation. In scans with the harvester immediately adjacent to a phantom, up to 100 mW of average power are harvested without affecting image quality. CONCLUSION: Selective shielding enables stealthy RF harvesting which can be used to supply wireless power to on-body devices during MRI.


Subject(s)
Equipment Design , Magnetic Resonance Imaging , Phantoms, Imaging , Radio Waves , Magnetic Resonance Imaging/instrumentation , Radiation Protection/instrumentation , Humans , Equipment Failure Analysis
9.
Ir J Med Sci ; 193(3): 1461-1466, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38349509

ABSTRACT

BACKGROUND: Implantable central venous port systems are widely used in oncology. We upgraded our fluoroscopy machines, and all anesthetists completed two training courses focusing on the risks of ionizing radiation for patients and health workers. AIMS: This study aimed to evaluate the impact of upgrading the machines and the radiation-protection training on ionizing radiation exposure during venous port system implantation. METHODS: We retrospectively analyzed consecutive venous port implantations between 2019 and 2022. The older fluoroscopy machines were replaced by two new machines. A first training session about health worker radioprotection was organized. The medical staff completed a second training course focused on protecting patients from ionizing radiation. We defined four distinct time intervals (TI): venous port implantations performed with the old equipment, the new fluoroscopy machines, after the first training course, and after the second training course. The air kerma-area product (KAP) was compared between these four TI and fluoroscopy times and the number of exposures only with the new machines. RESULTS: We analyzed 2587 procedures. A 93% decrease in the median KAP between the first and last TI was noted (median KAP = 323.0 mGy.cm2 vs. 24.0 mGy.cm2, p < 0.0001). A decrease in the KAP was observed for each of the 11 anesthetists. We also noted a significant decrease in the time of fluoroscopy and the number of exposures. CONCLUSIONS: Upgrading the fluoroscopy equipment and completing two dedicated training courses allowed for a drastic decrease patient exposure to ionizing radiation during venous access port implantation by non-radiologist practitioners.


Subject(s)
Radiation Dosage , Radiation Protection , Humans , Retrospective Studies , Fluoroscopy , Radiation Protection/instrumentation , Radiation Protection/methods , Catheterization, Central Venous/methods , Catheterization, Central Venous/instrumentation , Female , Male , Occupational Exposure/prevention & control , Radiation Exposure/prevention & control , Middle Aged
10.
Odovtos (En línea) ; 24(2)ago. 2022.
Article in Spanish | LILACS, SaludCR | ID: biblio-1386591

ABSTRACT

Resumen En las últimas dos décadas ha aumentado el uso de equipos portátiles de rayos X intraorales, los cuales son estabilizados por el operador. Si bien todos los equipos radiográficos presentan un riesgo inherente por el uso de radiación ionizante, el uso indebido de los equipos portátiles puede aumentar la exposición del operador. Se recomienda el uso de los equipos portátiles en un trípode o activados desde un área protegida. Sin embargo, en casos altamente justificados para su uso sin estos aditamentos, se debe seguir recomendaciones para disminuir la exposición del operador. Debido a que la radioprotección es fundamental al trabajar con rayos X, se debe favorecer el uso de equipos radiográficos dentales fijos sobre los equipos portátiles, ya que estos proporcionan una menor dosis de radiación al operador.


Abstract In the last two decades, the use of portable intraoral X-ray devices, stabilized by the operator, has increased. While all radiographic devices present an inherent risk from ionizing radiation, improper use of portable devices can increase operator exposure. Use of portable devices on a tripod or powered from a protected area is recommended. However, in highly justified cases, for using without these accessories, recommendations should be followed to reduce operator exposure. Because radioprotection is essential when using X-rays, fixed dental radiographic devices should be favored over portable equipment since the first provides a lower radiation dose to the operator.


Subject(s)
Radiation Protection/instrumentation , Radiography, Dental , Mobile Applications
11.
Sci Rep ; 12(1): 8749, 2022 05 24.
Article in English | MEDLINE | ID: mdl-35610243

ABSTRACT

Pineapples are an important agricultural economic crop in Taiwan. Considerable human resources are required to protect pineapples from excessive solar radiation, which could otherwise lead to overheating and subsequent deterioration. Note that simple covering all of the fruit with a paper bag is not a viable solution, due to the fact that it makes it impossible to determine whether the fruit is ripe. This paper proposes a system by which to automate the detection of ripe pineapples. The proposed deep learning architecture enables detection regardless of lighting conditions, achieving accuracy of more than 99.27% with error of less than 2% at distances of 300 ~ 800 mm. This proposed system using an Nvidia TX2 is capable of 15 frames per second, thereby making it possible to mount the device on machines that move at walking speed.


Subject(s)
Ananas , Deep Learning , Ananas/growth & development , Ananas/physiology , Ananas/radiation effects , Fruit/growth & development , Fruit/physiology , Fruit/radiation effects , Humans , Radiation Protection/instrumentation , Radiation Protection/methods , Sunlight/adverse effects , Taiwan
12.
Medicine (Baltimore) ; 101(4): e28744, 2022 Jan 28.
Article in English | MEDLINE | ID: mdl-35089250

ABSTRACT

ABSTRACT: Transarterial chemoembolization is the standard treatment option for intermediate-stage hepatocellular carcinoma (HCC). However, during the interventional procedure, occupational radiation protection is compromised. The use of real-time radiation dosimetry could provide instantaneous radiation doses. This study aimed to evaluate the occupational dose of the medical staff using a real-time radiation dosimeter during transarterial chemoembolization (TACE) for HCC, and to investigate factors affecting the radiation exposure dose.This retrospective observational study included 70 patients (mean age: 66 years; age range: 38-88 years; male: female = 59: 11) who underwent TACE using real-time radiation dosimetry systems between August 2018 and February 2019. Radiation exposure doses of operators, assistants, and technicians were evaluated. Patients' clinical, imaging, and procedural information was analyzed.The mean dose-area product (DAP) and fluoroscopy time during TACE were 66.72 ±â€Š55.14 Gycm2 and 12.03 ±â€Š5.95 minutes, respectively. The mean radiation exposure doses were 24.8 ±â€Š19.5, 2.0 ±â€Š2.2, and 1.65 ±â€Š2.0 µSv for operators, assistants, and technicians, respectively. The radiation exposure of the operators was significantly higher than that of the assistants or technicians (P < .001). The perpendicular position of the adjustable upper-body lead protector (AULP) on the table was one factor reducing in the radiation exposure of the assistants (P < .001) and technicians (P = .040). The DAP was a risk factor for the radiation exposure of the operators (P = .003) and technicians (P < .001).Occupational doses during TACE are affected by DAP and AULP positioning. Placing the AULP in the perpendicular position during fluoroscopy could be a simple and effective way to reduce the radiation exposure of the staff. As the occupational dose influencing factors vary by region or institution, further study is needed.


Subject(s)
Carcinoma, Hepatocellular/therapy , Chemoembolization, Therapeutic , Fluoroscopy/adverse effects , Liver Neoplasms/therapy , Occupational Exposure , Radiation Exposure , Adult , Aged , Aged, 80 and over , Female , Health Personnel , Humans , Liver/radiation effects , Male , Middle Aged , Occupational Exposure/adverse effects , Occupational Exposure/prevention & control , Radiation Dosage , Radiation Exposure/adverse effects , Radiation Exposure/prevention & control , Radiation Injuries/prevention & control , Radiation Protection/instrumentation , Radiometry
13.
Biomed Res Int ; 2021: 9985714, 2021.
Article in English | MEDLINE | ID: mdl-34671681

ABSTRACT

BACKGROUND: Radiation using conventional X-ray is associated with exposure of radiosensitive organs and typically requires the use of protection. This study is aimed at evaluating the use of bismuth shielding for radiation protection in pediatric pelvic radiography. The effects of the anteroposterior and lateral bismuth shielding were verified by direct measurements at the anatomical position of the gonads. METHODS: Radiation doses were measured using optically stimulated luminescence dosimeters (OSLD) and CIRS ATOM Dosimetry Verification Phantoms. Gonad radiographs were acquired using different shields of varying material (lead, bismuth) and thickness and were compared with radiographs obtained without shielding to examine the effects on image quality and optimal reduction of radiation dose. All images were evaluated separately by three pediatric orthopedic practitioners. RESULTS: Results showed that conventional lead gonadal shielding reduces radiation doses by 67.45%, whereas dose reduction using one layer of bismuth shielding is 76.38%. The use of two layers of bismuth shielding reduces the dose by 84.01%. Using three and four layers of bismuth shielding reduces dose by 97.33% and 99.34%, respectively. Progressively lower radiation doses can be achieved by increasing the number of bismuth layers. Images obtained using both one and two layers of bismuth shielding provided adequate diagnostic information, but those obtained using three or four layers of bismuth shielding were inadequate for diagnosis. CONCLUSIONS: Bismuth shielding reduces radiation dose exposure providing appropriate protection for children undergoing pelvic radiography. The bismuth shielding material is lighter than lead, making pediatric patients more comfortable and less apt to move, thereby avoiding repeat radiography.


Subject(s)
Bismuth/chemistry , Pelvis/radiation effects , Radiation Protection/methods , Child , Humans , Phantoms, Imaging , Radiation Dosage , Radiation Exposure/prevention & control , Radiation Protection/instrumentation , Tomography, X-Ray Computed , X-Rays
14.
PLoS One ; 16(9): e0257638, 2021.
Article in English | MEDLINE | ID: mdl-34534258

ABSTRACT

Some concepts in nuclear radiation physics are abstract and intellectually demanding. In the present paper, an "MCHP platform" (MCHP was an acronym for Monte Carlo simulations + Human Phantoms) was proposed to provide assistance to the students through visualization. The platform involved Monte Carlo simulations of interactions between ionizing radiations and the Oak Ridge National Laboratory (ORNL) adult male human phantom. As an example to demonstrate the benefits of the proposed MCHP platform, the present paper investigated the variation of the absorbed photon dose per photon from a 137Cs source in three selected organs, namely, brain, spine and thyroid of an adult male for concrete and lead shields with varying thicknesses. The results were interesting but not readily comprehensible without direct visualization. Graphical visualization snapshots as well as video clips of real time interactions between the photons and the human phantom were presented for the involved cases, and the results were explained with the help of such snapshots and video clips. It is envisaged that, if the platform is found useful and effective by the readers, the readers can also propose examples to be gradually added onto this platform in future, with the ultimate goal of enhancing students' understanding and learning the concepts in an undergraduate nuclear radiation physics course or a related course.


Subject(s)
Monte Carlo Method , Nuclear Physics/education , Radiation Protection/methods , Brain/radiation effects , Cesium Radioisotopes/chemistry , Human Body , Humans , Photons , Radiation Protection/instrumentation , Radiation, Ionizing , Radiometry , Students
15.
Br J Radiol ; 94(1126): 20210701, 2021 Oct 01.
Article in English | MEDLINE | ID: mdl-34347543

ABSTRACT

The practice of placing radiation protective shielding on patients ('in contact') in order to reduce the dose to certain radiosensitive organs for diagnostic X-ray examination, has been employed for decades. However, there has been a growing body of evidence that this practice is often ineffective or even counterproductive and the use of such shielding can also overemphasise the hazards of ionising radiation in the public mind. This has led to a growing disparity in the application of patient contact shielding and culminated in several professional bodies issuing guidance and statements to provide a consistent approach to patient contact shielding. This, in turn, has led to a healthy discussion and re-evaluation of when and why patient contact shielding should be used, where the main issue centres around the criteria used to arrive at the recommendations. The decision process involves considering, among others, the reported effectiveness of the shielding and a subjective assessment of the subsequent risks from their use. In order to improve the transparency of these recommendations, it is therefore suggested that a threshold for dose and/or risk should be clearly stated, below which no protection is required. A suggested starting point for defining this threshold is discussed. This would enhance uniformity of application and provide clarity for staff, patients and the public. It would also ensure that any future research in this area could be easily incorporated into the general guidance.


Subject(s)
Radiation Protection/instrumentation , Decision Making , Humans , Radiation Dosage , Radiation, Ionizing , Radiography , Risk Factors
16.
J Radiat Res ; 62(5): 918-925, 2021 Sep 13.
Article in English | MEDLINE | ID: mdl-34350969

ABSTRACT

Total body irradiation (TBI) with ovarian shielding is expected to preserve fertility among hematopoietic stem cell transplant (HSCT) patients with myeloablative TBI-based regimens. However, the radiation dose to the ovaries that preserves ovarian function in TBI remains poorly understood. Furthermore, it is uncertain whether the dose to the shielded organs is associated with relapse risk. Here, we retrospectively evaluated the relationship between fertility and the dose to the ovaries, and between relapse risk and the dose to the pelvic bones. A total of 20 patients (median age, 23 years) with standard-risk hematologic diseases were included. Median follow-up duration was 31.9 months. The TBI prescribed dose was 12 Gy in six fractions for three days. Patients' ovaries were shielded with cylinder-type lead blocks. The dose-volume parameters (D98% and Dmean) in the ovaries and the pelvic bones were extracted from the dose-volume histogram (DVH). The mean ovary Dmean for all patients was 2.4 Gy, and 18 patients recovered menstruation (90%). The mean ovary Dmean for patients with menstrual recovery and without recovery were 2.4 Gy and 2.4 Gy, respectively, with no significant difference (P = 0.998). Hematological relapse was observed in five patients. The mean pelvis Dmean and pelvis D98% for relapse and non-relapse patients were 11.6 Gy and 11.7 Gy and 5.6 Gy and 5.3 Gy, respectively. Both parameters showed no significant difference (P = 0.827, 0.807). In conclusion, TBI with ovarian shielding reduced the radiation dose to the ovaries to 2.4 Gy, and preserved fertility without increasing the risk of relapse.


Subject(s)
Fertility Preservation/methods , Organs at Risk/radiation effects , Ovary/radiation effects , Pelvic Bones/radiation effects , Radiation Injuries/etiology , Radiation Protection/methods , Transplantation Conditioning/adverse effects , Whole-Body Irradiation/adverse effects , Adolescent , Adult , Anemia, Aplastic/therapy , Female , Fertility Preservation/instrumentation , Follow-Up Studies , Hematopoietic Stem Cell Transplantation , Humans , Leukemia/therapy , Menstruation/radiation effects , Myeloablative Agonists/administration & dosage , Myelodysplastic Syndromes/therapy , Radiation Injuries/prevention & control , Radiation Protection/instrumentation , Recovery of Function , Recurrence , Retrospective Studies , Treatment Outcome , Young Adult
17.
Sci Rep ; 11(1): 14559, 2021 07 15.
Article in English | MEDLINE | ID: mdl-34267293

ABSTRACT

We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.


Subject(s)
Neoplasms, Experimental/radiotherapy , Radiation Protection/instrumentation , Radiation Protection/methods , Animals , Equipment Design , Female , Film Dosimetry/methods , Gamma Rays , Lead , Mice, Inbred BALB C , Radiotherapy Dosage
18.
J Bone Joint Surg Am ; 103(17): 1646-1651, 2021 09 01.
Article in English | MEDLINE | ID: mdl-34255759

ABSTRACT

BACKGROUND: Standard lead aprons and vests do not adequately shield the most common breast cancer site, the upper outer quadrant (UOQ), from intraoperative radiation. The purpose of the present study was to determine if lead sleeves, wings, and/or axillary supplements decreased intraoperative radiation exposure of the UOQ of the breast. METHODS: An anthropomorphic torso phantom (simulating the female surgeon) was placed adjacent to a standard operating room table. Dosimeters were placed bilaterally over the UOQ of the breast. Scatter radiation dose equivalent rates (mrem/hr) were measured during continuous fluoroscopy of a pelvic phantom (simulating the patient). Five protection configurations (no lead; lead vest; and vest with sleeves, wings, and axillary supplements), 2 surgeon positions (facing the table and perpendicular to the table), and 2 C-arm positions (anteroposterior and cross-table lateral projection) were tested. The t test was utilized with a Bonferroni correction for multiple t tests. RESULTS: Lead sleeves and axillary supplements decreased intraoperative radiation exposure to the UOQ of the breast when compared with a well-fitted standard lead vest alone (p < 0.01) across all surgeon and C-arm positions. The addition of wings decreased radiation exposure to a lesser extent than sleeves or axillary supplements, and the difference when compared with the lead vest alone did not reach significance (p = 0.29). Breast radiation exposure in the C-arm cross-table lateral projection was highest across all testing. CONCLUSIONS: The UOQ of the breast is not adequately protected by standard lead vests alone or vests with the addition of wings. Axillary supplements and sleeves improved protection of the breast. CLINICAL RELEVANCE: Modifications of lead protective vests may improve intraoperative breast radiation protection.


Subject(s)
Breast/radiation effects , Occupational Exposure/prevention & control , Orthopedic Surgeons , Protective Clothing , Radiation Exposure/prevention & control , Radiation Protection/instrumentation , Female , Fluoroscopy , Humans , Intraoperative Period , Phantoms, Imaging , Physicians, Women , Radiation Protection/methods
19.
Adv Sci (Weinh) ; 8(12): 2100510, 2021 06.
Article in English | MEDLINE | ID: mdl-34194950

ABSTRACT

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D-printed GI radioprotective devices composed of high-Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost-effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.


Subject(s)
Gastrointestinal Tract/radiation effects , Mouth Neoplasms/radiotherapy , Printing, Three-Dimensional , Radiation Injuries/prevention & control , Radiation Protection/instrumentation , Radiation Protection/methods , Animals , Disease Models, Animal , Gastrointestinal Tract/diagnostic imaging , Humans , Mucous Membrane/diagnostic imaging , Mucous Membrane/radiation effects , Organs at Risk , Rats , Rats, Sprague-Dawley , Swine , Tomography, X-Ray Computed
20.
Radiat Oncol ; 16(1): 109, 2021 Jun 13.
Article in English | MEDLINE | ID: mdl-34120633

ABSTRACT

BACKGROUND: The present study aimed to propose a new foetal shielding device for pregnant cancer patients to reduce the foetal dose associated with treatment techniques using multiple gantry angles, such as intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT). METHODS: Three shielding structures were designed to minimise the scattered and leaked radiation from various gantry angles and radiation scattering within the patient. The base-plate part that can be placed on the treatment couch was designed to reduce the scattered and leaked radiation generated at gantry angles located near 180°. A body shielding part that can cover the lower chest and abdomen was designed, and a neck-shielding structure was added to reduce the internal and external radiation scattering from the treatment area. Evaluation plans were generated to assess the foetal dose reduction by the foetal shielding device in terms of the shielding material thickness, distance from the field edge, and shielding component using the flattened 6 MV photon beam (6MV) and flattening filter-free 6 MV photon beam (6MV-FFF). In addition, the effectiveness of the foetal shielding device was evaluated in a pregnant brain tumour patient. RESULTS: The shielding material consisting of three parts was placed on frames composed of four arch shapes with a vertical curved structure, connection bar at the top position, and base plate. Each shielding part resulted in reductions in the radiation dose according to the treatment technique, as the thickness of the shielding material increased and the foetal dose decreased. In addition, a foetal dose reduction of approximately 50% was confirmed at 50 cm from the field edge by using the designed shielding device in most delivery techniques. In patients, the newly designed shielding structures can effectively eliminate up to about 49% of the foetal dose generated from various gantry angles used in VMAT or IMRT. CONCLUSIONS: We designed a foetal shielding device consisting of three parts to effectively reduce the dose delivered to the foetus, and evaluated the device with various treatment techniques for a pregnant patient with brain tumour. The foetal shielding device shielded the scattered/leaked radiation from the treatment machine, and also effectively reduced internal scattering from the treatment area in the patient.


Subject(s)
Brain Neoplasms/radiotherapy , Fetus/radiation effects , Phantoms, Imaging , Pregnancy Complications, Neoplastic/prevention & control , Radiation Injuries/prevention & control , Radiation Protection/instrumentation , Radiotherapy Planning, Computer-Assisted/methods , Equipment Design , Female , Humans , Image Processing, Computer-Assisted/methods , Organs at Risk/radiation effects , Pregnancy , Radiotherapy Dosage , Radiotherapy, Intensity-Modulated/methods , Scattering, Radiation , Tomography, X-Ray Computed/methods
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