[Metabolism, residue and excretion of the anthelmintic 131 I-rafoxanide in blood, milk, meat and urine of lactating cows]. / Metabolismus, Rückstände und Ausscheidung des Anthelminithikums 131J-Rafoxanid in Blut, Milch, Fleisch und Urin am laktierenden Rind.

Rafoxanide, labelled by 131J, was applied orally in the formulation "Ursovermit" to 2 lactating cows, 5 mg/kg bodymass, resp. Residues and halflifes in blood, milk and meat and the excretion in urine are given, related to 131J in the chloroform extract. 3,5-diiodosalicyclic acid was found as metabolite in amounts of 1-2,5%, relative to rafoxanide, resp.

[Degradation and elimination of the anthelminitic 131I-rafoxanid in cattle and sheep]. / Untersuchungen zum Abbau und zur Ausscheidung des Anthelminthikums 131J-Rafoxanid an Rind und Schaf

Rafoxanide, labelled by 131J, was applied orally in oily solution to cattle and sheep, 12 and 17 mg/kg bodymass, resp. The half time of 131J in blood in 12,5 and 10,5 d for sheep and cattle, resp., the compound is adsorbed to proteins in blood. In the milk a maximal level of 3-3,5 ppm (calculated as total 131J) after 4-6 d was measured. More detailed results regarding the metabolism of rafoxanide are hitherto not possible.