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Brain Res ; 915(1): 25-31, 2001 Oct 05.
Article in English | MEDLINE | ID: mdl-11578617

ABSTRACT

The Long-Evans Cinnamon rat, an animal model of Wilson's disease, is an inbred mutant strain with spontaneous hepatitis isolated from Long-Evans rats. The copper concentration in the brains of Long-Evans Cinnamon rats at 4 weeks of age was lower than that of controls, but higher than that of controls at 20 weeks of age. We investigated the tyrosine hydroxylase and 5-hydroxytryptamine immunoreactive fiber densities in the brains of Long-Evans Cinnamon rats aged 4, 10, and 20 weeks by immunohistochemistry, comparing them with Long-Evans Agouti rats used as controls. Tyrosine hydroxylase immunoreactive fiber densities in the cingulate cortex, hippocampus and cerebellum in Long-Evans Cinnamon rats were significantly lower than those of Long-Evans Agouti rats at 4 and 10 weeks of age. On the other hand, 5-hydroxytryptamine immunoreactive fiber densities in the cingulate cortex, caudate-putamen, hypothalamus, and hippocampus in Long-Evans Cinnamon rats were significantly higher than those of controls at 4, 10 and 20 weeks of age. In the cingulate cortex and caudate-putamen, 5-hydroxytryptamine immunoreactive fiber densities became gradually higher with age. The number of aberrant 5-hydroxytryptamine immunoreactive fibers in the cingulate cortex, caudate-putamen, hypothalamus and hippocampus in LEC rats was significantly higher than that of controls. The number of another type of aberrant 5-hydroxytryptamine immunoreactive fibers, which were detected only at 20 weeks of age in the caudate-putamen in LEC rats was significantly higher than that of controls. These results suggest that age-dependent changes in copper concentrations of Long-Evans Cinnamon rats were related to changes in monoaminergic neuron systems.


Subject(s)
Axons/pathology , Biogenic Monoamines/metabolism , Brain/pathology , Copper/metabolism , Hepatolenticular Degeneration/pathology , Animals , Axons/metabolism , Brain/metabolism , Brain/physiopathology , Cerebellum/metabolism , Cerebellum/pathology , Cerebellum/physiopathology , Disease Models, Animal , Gyrus Cinguli/metabolism , Gyrus Cinguli/pathology , Gyrus Cinguli/physiopathology , Hepatolenticular Degeneration/metabolism , Hepatolenticular Degeneration/physiopathology , Hypothalamus/metabolism , Hypothalamus/pathology , Hypothalamus/physiopathology , Immunohistochemistry , Male , Neostriatum/metabolism , Neostriatum/pathology , Neostriatum/physiopathology , Rats , Rats, Inbred LEC/abnormalities , Rats, Inbred LEC/metabolism , Serotonin/metabolism , Tyrosine 3-Monooxygenase/metabolism
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