Localization of the mineralocorticoid receptor in rat cochlear tissue.

Distribution of the mineralocorticoid receptor within rat cochlear tissue was studied by immunohistochemistry. Intense immunoreactions of mineralocorticoid receptor antibodies were observed in outer and inner hair cells of the organ of Corti, stria vascularis, spiral ligament and spiral ganglion cells. Moderate to weak immunostaining was observed in the spiral limbus and cochlear nerve. Results of this study suggest that cochlear tissue is a mineralocorticoid hormone target tissue.