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2.
Colorectal Dis ; 26(5): 932-939, 2024 May.
Article in English | MEDLINE | ID: mdl-38519847

ABSTRACT

AIM: Pelvic radiotherapy is limited by dose-dependent toxicity to surrounding organs. The aim of this prospective study was to evaluate the efficacy and safety of intrarectal formalin treatment for radiotherapy-induced haemorrhagic proctopathy (RHP) at the Royal Marsden Hospital. METHOD: Adult patients were enrolled. Haemoglobin was evaluated before and after formalin treatment. Antiplatelet and/or anticoagulation treatment and administration of transfusion were recorded. The interval between completion of radiotherapy and the first intrarectal 5% formalin treatment was assessed and the dose of radiotherapy was evaluated. Clinical assessment of the frequency and amount of rectal bleeding (rectal bleeding score 1-6) and endoscopic appearance (grade 0-3) were classified. Complications were recorded. RESULTS: Nineteen patients were enrolled, comprising 13 men (68%) and 6 women. The mean age was 75 ± 9 years. The median time between completion of radiotherapy and the first treatment was 20 months [interquartile range (IQR) 15 months] and the median dose of radiotherapy was 68 Gy (IQR 14 Gy). Thirty-two procedures were performed (average 1.7 per patient). In total, 9/19 (47%) patients were receiving anticoagulation and/or antiplatelet medication and 5/19 (26%) received transfusion prior to treatment. The mean value of serum haemoglobin before the first treatment was 110 ± 18 g/L and afterwards it was 123 ± 16 g/L (p = 0.022). The median rectal bleeding score before the first treatment was 6 (IQR 0) and afterwards 2 (IQR 1-4; p < 0.001), while the median endoscopy score on the day of first treatment was 3 (IQR 0) compared with 1 (IQR 1-2) on the day of the last treatment 1 (p < 0.001). One female patient with a persistent rectal ulcer that eventually healed (18 months of healing) subsequently developed rectovaginal fistula (complication rate 1/19, 5%). CONCLUSIONS: Treatment with intrarectal formalin in RHP is effective and safe.


Subject(s)
Formaldehyde , Gastrointestinal Hemorrhage , Radiation Injuries , Rectal Diseases , Humans , Male , Female , Aged , Prospective Studies , Radiation Injuries/etiology , Radiation Injuries/drug therapy , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/therapy , Rectal Diseases/etiology , Rectal Diseases/therapy , Aged, 80 and over , Treatment Outcome , Administration, Rectal , Middle Aged , Rectum/radiation effects , Radiotherapy/adverse effects
3.
Photobiomodul Photomed Laser Surg ; 42(2): 182-185, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38301213

ABSTRACT

Objective: To investigate the efficacy of Photobiomodulation therapy (PBMT) for the treatment of solitary rectal ulcer syndrome (SRUS). Background: SRUS is a benign disease, diagnosed by symptoms, clinical, and histological findings. PBMT has been reported for the treatment of various inflammation-based diseases including aphthous ulcer, but still no such study on the treatment of SRUS is published. Materials and methods: A 29-year Asian women, diagnosed for SRUS of 0.57 cm diameter, was treated by a laser at 635 nm through seven sessions. Laser fluence of 85 J/cm2 was delivered to ulcer lesion during each session for 10 min. Clinical results were valued by physician with sigmoid probe throughout PBMT sessions and no medicines were prescribed to the patient. Results: After seven sessions, the lesion was completely healed with 100% clinical response. In follow-up, patient did not respond to any additional/recurring abnormality, and no side effects were observed. Conclusions: In conclusion, PBMT by using laser at 635 nm is an effective treatment for SRUS without any side effects and patient remained comfortable throughout treatment sessions. Patient registration No. H-744/23.


Subject(s)
Low-Level Light Therapy , Rectal Diseases , Female , Humans , Rectal Diseases/therapy , Rectal Diseases/diagnosis , Rectal Diseases/pathology , Syndrome , Treatment Outcome , Ulcer/radiotherapy , Ulcer/diagnosis , Adult
4.
Surg Clin North Am ; 103(6): 1153-1170, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37838461

ABSTRACT

Anorectal emergencies are rare presentations of common anorectal disorders, and surgeons are often called on to assist in their diagnosis and management. Although most patients presenting with anorectal emergencies can be managed nonoperatively or with a bedside procedure, surgeons must also be able to identify surgical anorectal emergencies, such as gangrenous rectal prolapse. This article provides a review of pertinent anatomy; examination techniques; and workup, diagnosis, and management of common anorectal emergencies including thrombosed hemorrhoids, incarcerated hemorrhoids, anal fissure, anorectal abscess, rectal prolapse, and pilonidal abscess and unique situations including rectal foreign body and anorectal sexually transmitted infections.


Subject(s)
Anus Diseases , Fissure in Ano , Hemorrhoids , Rectal Diseases , Rectal Prolapse , Humans , Hemorrhoids/therapy , Hemorrhoids/surgery , Rectal Prolapse/diagnosis , Rectal Prolapse/therapy , Abscess/diagnosis , Abscess/therapy , Emergencies , Rectal Diseases/diagnosis , Rectal Diseases/therapy , Anus Diseases/diagnosis , Anus Diseases/therapy , Fissure in Ano/diagnosis , Fissure in Ano/therapy
5.
Clin Gastroenterol Hepatol ; 21(11): 2727-2739.e1, 2023 10.
Article in English | MEDLINE | ID: mdl-37302444

ABSTRACT

BACKGROUND & AIMS: Anorectal manometry (ARM) is a comprehensive diagnostic tool for evaluating patients with constipation, fecal incontinence, or anorectal pain; however, it is not widely utilized for reasons that remain unclear. The aim of this roundtable discussion was to critically examine the current clinical practices of ARM and biofeedback therapy by physicians and surgeons in both academic and community settings. METHODS: Leaders in medical and surgical gastroenterology and physical therapy with interest in anorectal disorders were surveyed regarding practice patterns and utilization of these technologies. Subsequently, a roundtable was held to discuss survey results, explore current diagnostic and therapeutic challenges with these technologies, review the literature, and generate consensus-based recommendations. RESULTS: ARM identifies key pathophysiological abnormalities such as dyssynergic defecation, anal sphincter weakness, or rectal sensory dysfunction, and is a critical component of biofeedback therapy, an evidence-based treatment for patients with dyssynergic defecation and fecal incontinence. Additionally, ARM has the potential to enhance health-related quality of life and reduce healthcare costs. However, it has significant barriers that include a lack of education and training of healthcare providers regarding the utility and availability of ARM and biofeedback procedures, as well as challenges with condition-specific testing protocols and interpretation. Additional barriers include understanding when to perform, where to refer, and how to use these technologies, and confusion over billing practices. CONCLUSIONS: Overcoming these challenges with appropriate education, training, collaborative research, and evidence-based guidelines for ARM testing and biofeedback therapy could significantly enhance patient care of anorectal disorders.


Subject(s)
Fecal Incontinence , Rectal Diseases , Humans , Fecal Incontinence/diagnosis , Fecal Incontinence/therapy , Defecation/physiology , Quality of Life , Manometry/methods , Constipation/diagnosis , Constipation/therapy , Rectum/physiology , Rectal Diseases/diagnosis , Rectal Diseases/therapy , Anal Canal , Biofeedback, Psychology/methods
6.
Medicine (Baltimore) ; 102(13): e33411, 2023 Mar 31.
Article in English | MEDLINE | ID: mdl-37000072

ABSTRACT

RATIONALE: Acute hemorrhagic rectal ulcer (AHRU) is a relatively rare condition characterized by sudden onset, painlessness, and massive hematochezia in patients with severe underlying conditions. When AHRU is encountered, they can often be successfully controlled endoscopically, though recurrent bleeding is common and an alternative treatment must be sought if initial endoscopic treatment fails. We report 2 cases of AHRU which were successfully treated with Vaseline gauze packing after the failure of endoscopic hemostasis. PATIENT CONCERNS: The first patient was an 88-year-old female that visited our emergency department with hematochezia. She was immobilized because of a left pelvic bone fracture resulting from a slip-down. The initial endoscopy showed fresh blood in her rectum with diffuse ulceration near the dentate line but no active bleeding. However, Massive hematochezia has recurred during conservation. A second patient, an 86-year-old female, debilitated because of schizophrenia, dementia, and past subdural hemorrhage, visited our emergency department, also with massive hematochezia. Her initial endoscopy showed deep ulceration near the dentate line. After admission, she experienced massive hematochezia from an AHRU with an exposed vessel but endoscopic hemostasis failed to control bleeding. DIAGNOSES: Both patients were diagnosed as AHRU based on the endoscopic findings. INTERVENTIONS: In both cases, Vaseline gauze packing was performed for bleeding control. OUTCOMES: After Vaseline gauze packing, no further bleeding occurred and follow-up endoscopy showed definitive improvement of ulcers. LESSONS: Based on these cases, we suggest that Vaseline gauze packing may be the alternative treatment for the AHRU which is located near the dentate line when endoscopic hemostasis is difficult or failed. Although further research is needed, Vaseline gauze packing has several potential advantages for the treatment of AHRU, especially in cases involving critically ill elderly patients.


Subject(s)
Colonic Diseases , Rectal Diseases , Humans , Female , Aged , Aged, 80 and over , Rectum , Ulcer/therapy , Rectal Diseases/complications , Rectal Diseases/therapy , Rectal Diseases/diagnosis , Retrospective Studies , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/therapy , Gastrointestinal Hemorrhage/diagnosis , Acute Disease , Colonic Diseases/complications
7.
Rev Esp Enferm Dig ; 115(5): 284, 2023 05.
Article in English | MEDLINE | ID: mdl-36695767

ABSTRACT

A 50-year-old male, with a medical history of Lynch syndrome and transurethral-resection (TUR) secondary to multifocal bladder tumour (pT1-high grade) with normal subsequent follow-ups, consulted for anal pain, rectal tenesmus and fever for 3 weeks. On examination, he presented perianal oedema and, on digital rectal examination, a right lateral orifice was palpable at 6cm from the anal margin. CT scan revealed a defect-in-continuity in the right rectal wall which communicated with bilateral perirectal collections extending towards the puborectalis-levator ani. On the right side, it extended towards the ischiorectal fossa and, on the left side it continued with another collection that displaced the corpus cavernosum. Urgent transanal debridement of abscess with biopsy and cultures was performed. Subsequent evolution was torpid. The clinical history was reviewed, as the patient had undergone repeated bladder catheterizations after TUR and BCG therapy one year before. Abdominal tomography with urethral contrast and cystourethrography were performed, which confirmed the presence of a fistula in the bulbomembranous urethra that communicated with the perirectal abscesses. Cultures and biopsies were negative for mycobacteria and malignancy was ruled out. A new surgical exploration was carried out, enlarging the transanal drainage orifice, making a temporary intestinal stoma and bladder catheterization. After eighteen weeks, the healing of the fistula was verified through of a new cystourethrography. Reconstruction of the intestinal transit has now been scheduled, after radiologically and endoscopically verifying the closure of the rectal orifice.


Subject(s)
Fistula , Rectal Diseases , Male , Humans , Middle Aged , Abscess/diagnostic imaging , Abscess/etiology , Abscess/therapy , Urethra , Rectal Diseases/etiology , Rectal Diseases/therapy , Rectum , Fistula/complications
8.
Mymensingh Med J ; 31(4): 1206-1211, 2022 Oct.
Article in English | MEDLINE | ID: mdl-36189574

ABSTRACT

Solitary rectal ulcer syndrome (SRUS) is an uncommon benign rectal disorder. Typically, young adults are affected and it is rare in children. Straining during defecation, self-induced trauma and paradoxical contraction of puborectalis muscle are the major contributing factors of this condition. Clinical features of SRUS are rectal bleeding, mucorrhoea, excessive straining during defecation, tenesmus, feeling of incomplete defecation and constipation. A complete and thorough history is most important for diagnosis of SRUS. Rectal bleeding may be misinterpreted as originating from an anal fissure caused by constipation or as other causes of rectal bleeding such as a juvenile polyp. The best and most accurate diagnostic method of SRUS is rectal biopsy. The major histological feature of SRUS is fibromuscular obliteration of the lamina propria. Avoiding straining, regular toilet habit, use of bulk laxatives, steroid and sucralfate enemas are the mainstay of treatment. Biofeedback mechanism is another treatment option. Because the clinical presentation varies, the diagnosis requires a high index of suspicion for both the clinician and the pathologist.


Subject(s)
Rectal Diseases , Ulcer , Child , Constipation/etiology , Diagnostic Errors/adverse effects , Gastrointestinal Hemorrhage/diagnosis , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/therapy , Humans , Laxatives/therapeutic use , Rectal Diseases/diagnosis , Rectal Diseases/etiology , Rectal Diseases/therapy , Steroids/therapeutic use , Sucralfate/therapeutic use , Ulcer/diagnosis , Ulcer/etiology , Ulcer/therapy , Young Adult
9.
Medicine (Baltimore) ; 101(41): e30016, 2022 Oct 14.
Article in English | MEDLINE | ID: mdl-36254007

ABSTRACT

RATIONALE: Rectum ulcer is a disease of the digestive system, the main symptoms of which includes bloody diarrhea, abdominal pain, hematochezia, etc. At present, drug therapy and surgery are the most common treatments. Platelet-rich plasma (PRP) contains high concentrations of platelets and has been used to promote wound healing. However, the utilization of PRP in rectal ulcers has rarely been reported. PATIENT CONCERNS: The patient had reported a complaint of blood dripping from the stool for more than 4 months. She had a history of surgery for rectal cancer with postoperative chemotherapy and radiotherapy 19 years prior. Mesalazine suppository was given to her for about 4 months, and glutamine capsules for 2 months, but the rectal ulcer remained unhealed. DIAGNOSIS: A rectal ulcer was observed on colonoscopy, and the biopsy result was tubular adenoma. INTERVENTIONS: Autologous PRP treatment was performed for the patient under an anorectal scope together with basic supportive care. OUTCOMES: The ulcer nearly healed within 9 days after twice PRP treatments. LESSONS: PRP treatment may bring about novel treatment options for rectal ulcers.


Subject(s)
Colonic Diseases , Platelet-Rich Plasma , Rectal Diseases , Skin Diseases , Stomach Ulcer , Capsules , Female , Glutamine , Humans , Mesalamine , Rectal Diseases/therapy , Rectum , Ulcer/therapy
10.
Zhonghua Er Ke Za Zhi ; 60(9): 920-924, 2022 Sep 02.
Article in Chinese | MEDLINE | ID: mdl-36038302

ABSTRACT

Objective: To analyze the clinical features, treatment and prognosis of solitary rectal ulcer syndrome (SRUS) in children. Methods: The clinical data of 7 children who were diagnosed with SRUS in Department of Gastroenterology in Guangzhou Women and Children' Medical Center from January 2019 to December 2021 were retrospectively analyzed. The clinical data including general demographics, clinical presentations, endoscopic and histologic features, treatment and outcome were extracted from hospital medical records. Results: The 7 patients were all males, and the age of onset was 6-12 years. The course before diagnosis was 2-36 months. The most common symptom was rectal bleeding (6 cases) and most common findings at initial colonoscopy were ulcer in 3 cases and protuberance in 4 cases, both located only in rectum. The intestinal histopathology of 5 cases showed characteristic fibromuscular obliteration of lamina propria. Five children were treated with mesalamine granules or suppositories, and 2 cases underwent local excision. The follow-up lasted for 5-24 months and found symptoms relieved in 5 cases, improved in 1 case, and no remission in 1 case. Colonoscopy after the treatment was performed in 5 children, among whom 2 cases achieved mucosal healing. Conclusions: SRUS in children is mainly presented with rectal bleeding, and has characteristic histological change of ulcer and protuberance in endoscopy. Pathology is crucial for diagnosis and differential diagnosis. Both the medical and surgical treatment are effective for SRUS.


Subject(s)
Rectal Diseases , Ulcer , Child , Colonoscopy , Female , Gastrointestinal Hemorrhage/diagnosis , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/therapy , Humans , Male , Rectal Diseases/diagnosis , Rectal Diseases/pathology , Rectal Diseases/therapy , Rectum/pathology , Rectum/surgery , Retrospective Studies , Ulcer/diagnosis , Ulcer/pathology , Ulcer/therapy
11.
Arch Pediatr ; 29(3): 171-176, 2022 Apr.
Article in English | MEDLINE | ID: mdl-35249800

ABSTRACT

Benign anorectal disease refers to a diverse group of frequent anorectal complaints that cause considerable discomfort, disability, and often constitute a significant problem for the child and his or her family. Hemorrhoids, fissures, rectal prolapse, and perianal abscess and fistulas are the most common anorectal disorders in pediatric population and their appearance may be age-specific. Although they generally follow a benign course, a careful examination must be performed in order to exclude other serious and complicated underlying pathology. Their diagnosis is based on the patient's medical history, physical examination, endoscopy, and imaging. Moreover, the management of these disorders includes medical and surgical treatment options, and if they are treated promptly and properly may be limited and short lived. This review presents the currently available data in the literature on the diverse aspects of these disorders, including the definition, epidemiology, clinical presentation, pathogenesis, diagnosis, indications for surgery, and long-term outcomes.


Subject(s)
Anus Diseases , Hemorrhoids , Rectal Diseases , Rectal Fistula , Rectal Prolapse , Abscess/diagnosis , Abscess/therapy , Anus Diseases/diagnosis , Anus Diseases/epidemiology , Anus Diseases/therapy , Child , Endoscopy , Female , Hemorrhoids/diagnosis , Hemorrhoids/epidemiology , Hemorrhoids/therapy , Humans , Male , Rectal Diseases/diagnosis , Rectal Diseases/epidemiology , Rectal Diseases/therapy , Rectal Fistula/diagnosis , Rectal Fistula/therapy , Rectal Prolapse/diagnosis , Rectal Prolapse/etiology , Rectal Prolapse/therapy
12.
Sci Rep ; 12(1): 2137, 2022 02 08.
Article in English | MEDLINE | ID: mdl-35136100

ABSTRACT

Pre-clinical studies have shown that spinal cord epidural stimulation (scES) at the level of pelvic and pudendal nerve inputs/outputs (L5-S1) alters storage and/or emptying functions of both the bladder and bowel. The current mapping experiments were conducted to investigate scES efficacy at the level of hypogastric nerve inputs/outputs (T13-L2) in male and female rats under urethane anesthesia. As found with L5-S1 scES, T13-L2 scES at select frequencies and intensities of stimulation produced an increase in inter-contraction interval (ICI) in non-injured female rats but a short-latency void in chronic T9 transected rats, as well as reduced rectal activity in all groups. However, the detrusor pressure during the lengthened ICI (i.e., urinary hold) remained at a low pressure and was not elevated as seen with L5-S1 scES, an effect that's critical for translation to the clinic as high fill pressures can damage the kidneys. Furthermore, T13-L2 scES was shown to stimulate voiding post-transection by increasing bladder activity while also directly inhibiting the external urethral sphincter, a pattern necessary to overcome detrusor-sphincter dyssynergia. Additionally, select scES parameters at T13-L2 also increased distal colon activity in all groups. Together, the current findings suggest that optimization of scES for bladder and bowel will likely require multiple electrode cohorts at different locations that target circuitries coordinating sympathetic, parasympathetic and somatic outputs.


Subject(s)
Electric Stimulation Therapy/methods , Rectal Diseases/therapy , Spinal Cord Injuries/complications , Urination Disorders/therapy , Animals , Electromyography , Female , Male , Rats , Rats, Wistar , Rectal Diseases/etiology , Urination Disorders/etiology
13.
Dis Colon Rectum ; 65(3): 413-420, 2022 03 01.
Article in English | MEDLINE | ID: mdl-33872283

ABSTRACT

BACKGROUND: Low anterior resection syndrome has a negative impact on quality of life. Intestinal irrigation is a method of lavage consisting of a scheduled evacuation. OBJECTIVE: This study aims to evaluate functional and quality-of-life outcomes in patients with low anterior resection syndrome after transanal irrigation using a colostomy irrigation system. DESIGN: This was a prospective case series. SETTINGS: This study presents a single-center experience at a tertiary oncological center in an upper-middle-income country. PATIENTS: Patients classified as having minor or major low anterior resection syndrome 12 months after their operation were selected. INTERVENTIONS: Transanal irrigation was performed using an ostomy irrigation kit. Questionnaires assessing patients' bowel function (low anterior resection syndrome and Wexner score) and quality of life (Short Form-36 questionnaire) were applied before and after treatment. MAIN OUTCOME MEASURES: The primary outcomes were low anterior resection syndrome score and quality-of-life improvement after a 12-month treatment. RESULTS: Of the 22 patients included, 20 had major and 2 had minor low anterior resection syndrome, with a median score of 39, especially high rates of incontinence for liquid stool (21; 95.5%), clustering (21; 95.5%), and urgency (17; 77.3%). All patients successfully completed the 3-day training, and there were no complications during the treatment. After the 12-month period, the median score was 8, with 90% of the patients classified as having "no syndrome" and great improvement in all domains of this score. The most improved quality-of-life sections were patient vitality (p = 0.025) and physical (p = 0.002), social (p = 0.001), and emotional aspects (p = 0.001). LIMITATIONS: The study was limited by its small sample size and the limited follow-up period. CONCLUSIONS: This study presents a safe implementation protocol of an ostomy irrigation device for transanal irrigation. It also adds to the literature that transanal irrigation is a safe, effective, and easily implemented procedure for patients with low anterior resection syndrome with a significant improvement in quality of life. See Video Abstract at http://links.lww.com/DCR/B563.ESTUDIO DE FACTIBILIDAD DE LA IRRIGACIÓN TRANSANAL UTILIZANDO EL SISTEMA DE IRRIGACIÓN PARA COLOSTOMÍA EN PACIENTES CON SÍNDROME DE RESECCIÓN ANTERIOR BAJAANTECEDENTES:El síndrome de resección anterior baja tiene un impacto negativo en la calidad de vida de los pacientes. La irrigación intestinal es un método de lavado que consiste en evacuaciones programadas.OBJETIVOS:Evaluar los resultados de la funcionalidad e impacto en la calidad de vida de los pacientes con síndrome de resección anterior y baja posterior a la irrigación transanal utilizando un sistema de irrigación de colostomía.DISEÑO:Es estudio prospectivo de una serie de casos.ESCENARIO:En este estudio se muestra la experiencia de un centro oncológico de tercer nivel en un país en vías de desarrollo.PACIENTES:Aquellos clasificados como síndrome con afección en menor o mayor grado doce meses después de la cirugía.METODO:Se efectuó irrigación transanal utilizando un equipo de irrigación de estomas. Se aplicaron cuestionarios para valorar la función intestinal de los pacientes (síndrome de resección anterior baja y la escala de Wexner) y para calidad de vida (Cuestionario Corto-36) antes y después del tratamiento.EVALUACION DE LOS RESULTADOS PRINCIPALES:Los principales resultados se obtuvieron de la escala del síndrome de resección baja y la mejoría en la calidad vida doce meses después de tratamiento.RESULTADOS:De los veintidós pacientes incluidos, veinte presentaron manifestaciones mayores del síndrome de resección baja y dos, manifestaciones menores. Con una media de treinta y nueve, se encontraron, especialmente, altos índices de incontinencia a líquidos (21; 95'5%) hiperdefecación "clustering" (21; 95'5%) y urgencia (17; 77'3%). Todos los pacientes completaron en forma satisfactoria el entrenamiento de tres días sin presentarse complicaciones durante el tratamiento. Al término del mes doce la media fue de ocho, con el 90% de los pacientes clasificados como "sin síndrome" y se observó una mejoría substancial en todos los puntos de la evaluación. Las secciones de calidad de vida que mostraron una mejoría significativa fueron: la vitalidad del paciente (p = 0'025), física (p = 0'002), social (p = 0'001) y emocional (p = 0'001).LIMITACIONES:El tamaño de la muestra es pequeño y el tiempo de seguimiento corto.CONCLUSIONES:Este estudio muestra la implementación de un protocolo seguro para la irrigación de estomas mediante un dispositivo transanal. Además contribuye con el concepto en la literatura de que la seguridad de la irrigación transanal es seguro, efectivo y facilmente reproducible para pacientes con síndrome de resección anterior baja con una mejoría significativa en la calidad de vida. Consulte Video Resumen en http://links.lww.com/DCR/B563. (Traducción-Dr. Miguel Esquivel-Herrera).


Subject(s)
Catheters , Intestine, Large/physiopathology , Postoperative Complications , Proctectomy/adverse effects , Quality of Life , Rectal Diseases , Rectal Neoplasms/surgery , Therapeutic Irrigation , Anastomosis, Surgical/adverse effects , Anastomosis, Surgical/methods , Equipment Design , Female , Humans , Male , Middle Aged , Neoadjuvant Therapy/methods , Neoadjuvant Therapy/statistics & numerical data , Postoperative Complications/etiology , Postoperative Complications/physiopathology , Postoperative Complications/psychology , Postoperative Complications/therapy , Proctectomy/methods , Rectal Diseases/etiology , Rectal Diseases/physiopathology , Rectal Diseases/psychology , Rectal Diseases/therapy , Rectal Neoplasms/drug therapy , Rectal Neoplasms/radiotherapy , Retrospective Studies , Therapeutic Irrigation/instrumentation , Therapeutic Irrigation/methods , Treatment Outcome
14.
J Visc Surg ; 159(6): 463-470, 2022 12.
Article in English | MEDLINE | ID: mdl-34736877

ABSTRACT

INTRODUCTION: Sacral neuromodulation (SNM) aims to improve anorectal function in patients with disorders of anal continence and rectal emptying. The mechanism of action of SNM is not well known, and its indications are still under evaluation. We report the functional results and morbidity of a prospective cohort treated between 2002 and 2019. RESULTS: A total of 284 patients (of 423 tested) had implantation of a SNM. Five patients (1.8%) were lost to follow-up. Among those who had implantation, the indications for SNM were anal incontinence (n=376), refractory constipation (n=17), anterior resection syndrome (n=13), solitary rectal ulcer syndrome (n=7), and chronic inflammatory bowel disease (IBD) (n=10). The morbidity rate was 2.7% (Dindo-Clavien>2), 33 patients (11%) required explantation for infection (n=5), pain (n=2), inefficacy (n=24) or other reasons (rectal cancer) (n=3). It was necessary to change the stimulator in 68 patients (24%) during the follow-up period. Regarding the group of patients with anal incontinence, functional results showed improvement of the incontinence score in 40% and of quality of life in 25% after a mean follow-up of 55months. CONCLUSION: SNM constitutes a mini-invasive treatment associated with low morbidity. Its' efficacy in anal incontinence makes it a priority approach. Other indications are still under evaluation; while results are promising, they are highly variable.


Subject(s)
Electric Stimulation Therapy , Fecal Incontinence , Rectal Diseases , Humans , Prospective Studies , Quality of Life , Treatment Outcome , Fecal Incontinence/therapy , Rectal Diseases/therapy , Sacrum
16.
Cell Mol Biol (Noisy-le-grand) ; 67(3): 163-167, 2021 Nov 25.
Article in English | MEDLINE | ID: mdl-34933715

ABSTRACT

Constipation of anorectal outlet obstruction may be caused by mechanical or functional causes. This complication is a debilitating disease that needs proper and timely treatment. Many studies have shown that there is a direct link between constipation and intestinal cancer. One of the most effective ways to prevent or diagnose intestinal cancer is through genetic studies. Evaluation of people's polymorphism shows how much they are at risk for cancer. Therefore, in this study, the GSTM1 gene polymorphism was evaluated in patients with constipation of anorectal outlet obstruction to assess better and manage this disease and investigate the possibility of anorectal cancer in these people. In this regard, 40 people with constipation of anorectal outlet obstruction were compared with 40 healthy people. In the case group (patients), in addition to demographic and clinical evaluations, the anorectal manometric test was used to diagnose the pathology of the disease. Results showed that out of 40 patients with constipation of anorectal outlet obstruction, 5 cases (12.5%) had megarectum, 7 cases (17.5%) had anismus, 10 cases (25%) had Hirschsprung's disease, 5 cases (12.5%) had descending perineum syndrome, 6 cases (15%) had rectal prolapse, 4 cases (10%) had enterocele, and 3 cases (7.5%) were with rectocele. Also, the results of GSTM1 gene deletion polymorphism showed that patients with constipation of anorectal outlet obstruction were almost two times more exposed to the null genotype than the control group (P <0.04). Therefore, in people with both constipation of anorectal outlet obstruction and null genotype (i.e., deletion in the GSTM1 gene), because they do not have glutathione-S transferase, they appear to be at higher risk for anorectal cancer than healthy people with the same genotype.


Subject(s)
Anus Diseases/genetics , Constipation/genetics , Glutathione Transferase/genetics , Intestinal Obstruction/genetics , Polymorphism, Genetic , Rectal Diseases/genetics , Adult , Anus Diseases/physiopathology , Anus Diseases/therapy , Anus Neoplasms/genetics , Anus Neoplasms/physiopathology , Constipation/physiopathology , Constipation/therapy , Female , Gene Frequency , Genotype , Humans , Intestinal Obstruction/physiopathology , Intestinal Obstruction/therapy , Male , Rectal Diseases/physiopathology , Rectal Diseases/therapy , Rectal Neoplasms/genetics , Rectal Neoplasms/physiopathology , Risk Factors
17.
Am J Gastroenterol ; 116(10): 1987-2008, 2021 10 01.
Article in English | MEDLINE | ID: mdl-34618700

ABSTRACT

Benign anorectal disorders of structure and function are common in clinical practice. These guidelines summarize the preferred approach to the evaluation and management of defecation disorders, proctalgia syndromes, hemorrhoids, anal fissures, and fecal incontinence in adults and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was assessed using the Grading of Recommendations Assessment, Development and Evaluation process. When the evidence was not appropriate for Grading of Recommendations Assessment, Development and Evaluation, we used expert consensus to develop key concept statements. These guidelines should be considered as preferred but are not the only approaches to these conditions.


Subject(s)
Rectal Diseases/therapy , Defecation , Humans , Rectal Diseases/diagnosis , Rectal Diseases/etiology
18.
World J Emerg Surg ; 16(1): 48, 2021 09 16.
Article in English | MEDLINE | ID: mdl-34530908

ABSTRACT

Anorectal emergencies comprise a wide variety of diseases that share common symptoms, i.e., anorectal pain or bleeding and might require immediate management. While most of the underlying conditions do not need inpatient management, some of them could be life-threatening and need prompt recognition and treatment. It is well known that an incorrect diagnosis is frequent for anorectal diseases and that a delayed diagnosis is related to an impaired outcome. This paper aims to improve the knowledge and the awareness on this specific topic and to provide a useful tool for every physician dealing with anorectal emergencies.The present guidelines have been developed according to the GRADE methodology. To create these guidelines, a panel of experts was designed and charged by the boards of the World Society of Emergency Surgery (WSES) and American Association for the Surgery of Trauma (AAST) to perform a systematic review of the available literature and to provide evidence-based statements with immediate practical application. All the statements were presented and discussed during the WSES-AAST-WJES Consensus Conference on Anorectal Emergencies, and for each statement, a consensus among the WSES-AAST panel of experts was reached. We structured our work into seven main topics to cover the entire management of patients with anorectal emergencies and to provide an up-to-date, easy-to-use tool that can help physicians and surgeons during the decision-making process.


Subject(s)
Emergencies , Rectal Diseases , Humans , Rectal Diseases/diagnosis , Rectal Diseases/therapy , United States
19.
Cir. Esp. (Ed. impr.) ; 99(5): 361-367, mayo 2021. tab
Article in Spanish | IBECS | ID: ibc-192544

ABSTRACT

INTRODUCCIÓN: Durante el estado de alarma sanitaria establecido a causa de la pandemia de la COVID-19 se anularon la mayor parte de las consultas externas presenciales y se estableció una consulta telefónica para el seguimiento de pacientes coloproctológicos. El objetivo de este estudio fue analizar la eficacia de la consulta telefónica (teleconsulta) en el seguimiento de los pacientes de una unidad de coloproctología, en el contexto de la pandemia de COVID-19. MÉTODO: Estudio descriptivo prospectivo de pacientes consecutivos en un solo centro. Se clasificó el resultado de la teleconsulta como alta, visita resuelta o reprogramación y se analizó por diferentes grupos diagnósticos. RESULTADOS: Del 19 de marzo al 17 de abril de 2020 se realizó la teleconsulta de 190 pacientes. La tasa de respuesta fue del 94,2% (179). Las categorías diagnósticas de los pacientes atendidos fueron: 51 (26,9%) neoplasia colorrectal, 48 (25,3%) enfermedad proctológica, 72 (37,9%) disfunciones del suelo pélvico y 19 (10%) otras enfermedades benignas. Se pudo volver a citar a 105 (55,26%) como si hubieran venido de forma presencial. Se dio el alta a 11 (5,8%) pacientes. No se encontraron diferencias significativas entre las distintas categorías diagnósticas y la resolución de la teleconsulta. Los motivos de reprogramación se analizan en el estudio. CONCLUSIÓN: En el contexto de pandemia, la teleconsulta ha permitido resolver de forma definitiva el 61% de las visitas de seguimiento y ha evitado la reprogramación de 116 pacientes. El nuevo paradigma social y sanitario tras la pandemia requerirá un replanteamiento de nuestro modelo de atención sanitaria y, en muchos aspectos, la telemedicina puede ofrecer herramientas para ello


INTRODUCTION: During the state of alarm established in Spain due to the COVID-19 pandemic, most of the face-to-face outpatient consultations were cancelled and a telephone consultation was established to follow up coloproctological patients. The objective of this study was to analyse the efficacy of telemedicine (by telephone) in monitoring patients in a coloproctology unit, in the context of the COVID-19 pandemic. METHOD: Prospective descriptive study of consecutive patients in a single centre. The result of the teleconsultation was classified as discharge, resolved visit or reprogramming and was analysed by different diagnostic groups. RESULTS: From March 19th to April 17th, 2020, the teleconsultation of 190 patients was carried out. The response rate was 94.2% (179). The diagnostic categories of the patients attended were: 51 (26.9%) colorectal neoplasia, 48 (25.3%) proctological pathology, 72 (37.9%) pelvic floor dysfunctions and 19 (10%) other benign pathologies. 105 (55.26%) could be recited as if they had come in person. Eleven (5.8%) patients were discharged. No significant differences were found between the different diagnostic categories and the resolution of the teleconsultation. The reasons for reprogramming are analyzed in the study. CONCLUSION: In the context of a pandemic, teleconsultation has allowed 61% of follow-up visits to be definitively solved, avoiding the reprogramming of 116 patients. The new social and health paradigm after the pandemic will require a rethinking of our healthcare model, and in many aspects, telemedicine can offer tools for this


Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Middle Aged , Aged , Aged, 80 and over , Telemedicine , Pandemics , Coronavirus Infections/epidemiology , Pneumonia, Viral/epidemiology , Colorectal Neoplasms/therapy , Colonic Diseases/therapy , Rectal Diseases/therapy , Prospective Studies
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