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1.
Nutrients ; 11(7)2019 Jun 29.
Article in English | MEDLINE | ID: mdl-31261904

ABSTRACT

Oral rehydration solutions (ORS) are specifically formulated with an osmolality to optimize fluid absorption. However, it is unclear how many ORS products comply with current World Health Organization (WHO) osmolality guidelines and the osmotic shelf-life stability is not known. Therefore, the purpose of this investigation was to examine the within and between ORS product osmolality variation in both pre-mixed and reconstituted powders. Additionally, the osmotic stability was examined over time. The osmolality of five different pre-mixed solutions and six powdered ORS products were measured. Pre-mixed solutions were stored at room temperatures and elevated temperatures (31 °C) for two months to examine osmotic shelf stability. Results demonstrated that only one pre-mixed ORS product was in compliance with the current guidelines both before and after the prolonged storage. Five of the six powdered ORS products were in compliance with minimal inter-packet variation observed within the given formulations. This investigation demonstrates that many commercially available pre-mixed ORS products do not currently adhere to the WHO recommended osmolality guidelines. Additionally, due to the presence of particular sugars and possibly other ingredients, the shelf-life stability of osmolality for certain ORS products may be questioned. These findings should be carefully considered in the design of future ORS products.


Subject(s)
Commerce , Drug Storage , Rehydration Solutions/chemistry , Temperature , Administration, Oral , Commerce/standards , Drug Stability , Drug Storage/standards , Guideline Adherence , Guidelines as Topic , Osmolar Concentration , Quality Control , Rehydration Solutions/administration & dosage , Rehydration Solutions/standards , Time Factors
3.
Top Companion Anim Med ; 30(1): 35-8, 2015 Mar.
Article in English | MEDLINE | ID: mdl-26041597

ABSTRACT

The objective of this study was to determine whether healthy dogs undergoing elective surgery will accept and prefer an oral recuperation fluid (ORF) to water during the perioperative time period and if the consumption of an ORF would lead to increased caloric intake during the final preoperative and first postoperative periods. This prospective, observational study was performed in the setting of a University Veterinary Teaching Hospital. A total of 67 healthy dogs were presented for routine ovariectomy (n = 30) or castration (n = 37). Before surgical intervention, dogs were offered an ORF to assess their voluntary acceptance of the fluid. After 2 hours, the ORF was offered alongside water to assess fluid preference. Routine castration or ovariectomy was then performed. During the immediate postoperative period, dogs were reassessed as to their acceptance and preference of the ORF. A high percentage of dogs accepted the ORF in both the preoperative (55/67, 82%) and postoperative (42/67, 63%) periods (P < .01 and P = .04, respectively). Of dogs that demonstrated a preference between the ORF and water, 87% (95% CI: 77%-93%) chose the ORF preoperatively, whereas 98% (95% CI: 87%-99.5%) chose the ORF postoperatively (P < .01 and P < .01, respectively). Dogs that consumed the ORF in each measurement period ingested a higher amount of food (measured as percentage of kilocalories offered) when compared with those that did not consume the ORF (preoperatively 83% vs. 49%, P < .01; postoperatively 51% vs. 27%, P = .01). A commercially manufactured veterinary ORF was found to be palatable, as determined by acceptance and preference testing, in healthy dogs during the preoperative and postoperative phases of routine sterilization. Further studies in dogs undergoing more intensive surgical procedures or recovering from nonsurgical illness or both are warranted.


Subject(s)
Dogs/surgery , Rehydration Solutions/administration & dosage , Rehydration Solutions/standards , Animals , Castration/veterinary , Elective Surgical Procedures/veterinary , Energy Intake , Feeding Behavior , Female , Fluid Therapy/veterinary , Male , Ovariectomy/veterinary , Perioperative Period/veterinary , Prospective Studies , Taste
4.
São Paulo; Secretaria da Saúde Pública e da Assistência Social do Estado de são Paulo; 1966. 14 p.
Monography in Portuguese | Sec. Est. Saúde SP, SESSP-ISPROD, Sec. Est. Saúde SP, SESSP-ISACERVO | ID: biblio-1081382
6.
J Dairy Sci ; 96(1): 1-8, 2013 Jan.
Article in English | MEDLINE | ID: mdl-23141821

ABSTRACT

A total of 90 samples comprising powdered infant formulas (n=51), follow-up formulas (n=21), and infant foods (n=18) from 15 domestic and imported brands were purchased from various retailers in Klang Valley, Malaysia and evaluated in terms of microbiological quality and the similarity of rehydration instructions on the product label to guidelines set by the World Health Organization. Microbiological analysis included the determination of aerobic plate count (APC) and the presence of Enterobacteriaceae and Cronobacter spp. Isolates of interest were identified using ID 32E (bioMérieux France, Craponne, France). In this study, 87% of powdered infant formulas, follow-up formulas, and infant foods analyzed had an APC below the permitted level of <10(4) cfu/g. These acceptable APC ranged between <10(2) to 7.2×10(3) cfu/g. The most frequently isolated Enterobacteriaceae was Enterobacter cloacae, which was present in 3 infant formulas and 1 infant food tested. Other Enterobacteriaceae detected from powdered infant and follow-up formulas were Citrobacter spp., Klebsiella spp., and other Enterobacter spp. No Cronobacter species were found in any samples. Rehydration instructions from the product labels were collated and it was observed that none directed the use of water with a temperature >70°C for formula preparation, as specified by the 2008 revised World Health Organization guidelines. Six brands instructed the use of water at 40 to 55°C, a temperature range that would support the survival and even growth of Enterobacteriaceae.


Subject(s)
Food Labeling/standards , Food Microbiology/standards , Infant Food/microbiology , Infant Formula/standards , Bacterial Load/standards , Enterobacteriaceae , Guidelines as Topic , Humans , Infant , Infant Food/standards , Malaysia , Rehydration Solutions/standards
7.
Acta Paediatr ; 101(10): e458-64, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22860693

ABSTRACT

AIM: To assess the efficacy and safety of a new oral rehydration solution (ORS) with improved flavour in the management of children with acute gastroenteritis (AGE). METHODS: Children 4 to 48 months of age with AGE (≥3 loose or watery stools per day for >1 but <5 days) with mild-to-moderate dehydration (3% to 9% loss of body weight) according to the World Health Organization criteria randomly received regular hypotonic ORS (Na 60 mmol/L, glucose 78 mmol/L) or the same hypotonic ORS with an apple taste. RESULTS: Of the 147 children randomized, 130 (88.4%) were available for intention-to-treat analysis. The proportion of children with the resolution of signs of dehydration in the experimental group compared with the control group was similar at 24 h (49/63 vs. 57/67, respectively, p = 0.28). There were also no significant differences in adequate weight gain (p = 0.48) and urine production at 24 h (p = 0.95) between groups. There were no differences between groups in any of the secondary outcome measures, including ORS intake. No adverse events were observed in the study groups. CONCLUSIONS: In an outpatient setting, there was no difference in efficacy between the study products. Both ORSs were equally effective and may be used interchangeably.


Subject(s)
Dehydration/therapy , Diarrhea/therapy , Flavoring Agents/standards , Gastroenteritis/therapy , Rehydration Solutions/standards , Acute Disease , Administration, Oral , Child, Preschool , Dehydration/etiology , Dehydration/prevention & control , Diarrhea/complications , Female , Gastroenteritis/complications , Humans , Infant , Male , Medication Adherence , Poland , Rehydration Solutions/administration & dosage , Taste
8.
Article in English | MEDLINE | ID: mdl-24779697

ABSTRACT

Total mercury (Hg) was measured in 150 infant formula products (as sold) and oral electrolyte solutions purchased in Canada in 2003. Results less than the limit of detection (LOD) were reported as the numeric value of the LOD. Electrolytes contained the lowest concentrations, averaging 0.026 ng/g. Average levels in milk-based ready-to-use, concentrated liquid and powdered concentrate were 0.028, 0.069 and 0.212 ng/g, respectively. In soy-based formulae, the respective mean concentrations were 0.049, 0.101 and 0.237 ng/g. These concentrations cannot be considered on an absolute basis because 76% of sample concentrations fell below the limit of detection. Despite the inability to measure many of the actual background concentrations, the method was sufficiently sensitive to identify clear cases of low-level Hg contamination (up to 1.5 ng/g) of individual lots of powdered formula. Also, all the different lots of one brand of concentrated liquid infant formulae had significantly higher concentrations of Hg than those of all other concentrated liquid products. After dilution with preparation water, the Hg concentrations in all products would be lower than the Canadian Drinking Water Guideline for Hg of 1 ng/mL and too low to impact on health.


Subject(s)
Drug Contamination , Electrolytes/chemistry , Food Contamination , Infant Formula/chemistry , Mercury/analysis , Poisons/analysis , Rehydration Solutions/chemistry , Administration, Oral , Electrolytes/administration & dosage , Electrolytes/economics , Electrolytes/standards , Food Handling , Food Inspection , Guideline Adherence , Health Policy , Health Promotion , Humans , Infant , Infant Formula/standards , Limit of Detection , Ontario , Quebec , Rehydration Solutions/administration & dosage , Rehydration Solutions/economics , Rehydration Solutions/standards , Reproducibility of Results , Soy Foods/analysis , Soy Foods/economics
9.
An. pediatr. (2003, Ed. impr.) ; 72(2): 111-115, feb. 2010. tab, ilus
Article in Spanish | IBECS | ID: ibc-77177

ABSTRACT

Introducción: La adherencia al tratamiento es esencial para el éxito terapéutico. En los niños, la palatabilidad de las medicaciones orales condiciona su aceptación y cumplimentación terapéutica. El objetivo fue estimar los sabores de las soluciones de rehidratación oral (SRO) que más gustan a los niños y analizar la relación entre los gustos del niño y la elección de un determinado sabor de SRO. Material y métodos: Ensayo clínico multicéntrico, aleatorizado y simple ciego. Ciento dieciséis niños cataron 4 sueros, 2 a 2, y puntuaron el sabor de cada uno de ellos como muy bueno, bueno, malo o muy malo, y en cada cata eligieron el preferido. Previamente se había encuestado sobre los gustos del niño. Resultados: Los sabores que más gustaron a los niños fueron el sabor a cola (puntuado como bueno o muy bueno por el 87,9%) y el sabor a fresa (62,1%). En 97 de las catas el sabor preferido fue el de cola y en 62 fue el de fresa, en 26 fue el de frutas y en 39 fue el sabor neutro. Hubo asociación entre los niños a los que les gustan los refrescos de cola y la preferencia de la SRO de cola (odds ratio ajustada: 10,3; intervalo de confianza del 95%: 3,1-34,6), y no se encontró relación entre la SRO de fresa y otros gustos. De los 7 niños a los que no les gustaban ni los refrescos de cola ni los caramelos de fresa, 5 prefirieron la solución neutra. Conclusiones: Existen grandes variaciones en la aceptación de los distintos sabores de las SRO. Preguntar a los niños por sus gustos puede orientar hacia la aceptación de los sueros (AU)


Introduction: Patient adherence to therapeutic regimens is extremely important to successful treatment. Among paediatric patients medication palatability of oral solutions is essential for patient acceptance, therapeutic compliance and successful outcome. The objective was to assess the palatability of different oral rehydration solutions (ORS), which flavour the children preferred and the relationship between the tastes of the child and the flavour chosen. They had been asked previously about their likings. Material and methods: Randomised, multicentre, single blind clinical trial. A total of 116 children tasted four solutions, two at a time, and scored each flavour as really good, good, bad or really bad, and in each of the two tastings chose their preferred choice. Results: The flavours that children preferred were cola (rated as good or really good by 87.9%) and strawberry (62.1%). In 97 of tastings, the flavour of choice was cola and in 62 strawberry, fruit in 26 and in 39 the neutral taste. There was an association between children who liked cola drinks and preferred the ORS cola flavoured (aOR: 10.3; 95%CI: 3.1-34.6). No relationship was found between children who preferred the strawberry flavoured ORS and their likings. Of the 7 children who did not like either cola drinks or strawberry sweets, 5 preferred the neutral solution. Conclusions: There are large variations in the acceptance of different flavours of ORS. Asking for children's tastes can lead towards the acceptance of the solutions (AU)


Subject(s)
Humans , Male , Female , Child , Rehydration Solutions/therapeutic use , Fluid Therapy/instrumentation , Fluid Therapy/methods , Rehydration Solutions/standards , Fluid Therapy/statistics & numerical data , Fluid Therapy/trends , Logistic Models
11.
JPEN J Parenter Enteral Nutr ; 30(5): 433-9, 2006.
Article in English | MEDLINE | ID: mdl-16931613

ABSTRACT

BACKGROUND: Pedialyte and Gatorade are advocated for the treatment of dehydration in viral gastroenteritis, but there is limited evidence to support their use. We examine the efficacy, safety, and palatability of Pedialyte, Gatorade, and a New Oral Rehydration Solution (N-ORS). This was a randomized double-blind trial conducted in an inpatient, community hospital. Seventy-five consecutive adult patients (male, 42; female, 33) admitted with viral gastroenteritis were randomized to receive Gatorade, Pedialyte, or N-ORS for 48 hours. A yogurt/rice diet was allowed ad libitum. Stool and urine output, electrolytes, fluid intake, body weight, hematocrit, and palatability of solutions were measured. RESULTS: Sixty completed the study. Stool frequency, consistency, and body weight improved (p < .001) in all 3 groups, but there was no difference between groups. Likewise, urine output, hematocrit, and correlations between fluid ingested, stool weight, or urine output were similar. At admission and 24 and 48 hours later, hypokalemia was observed in 7, 10, and 8 patients with Gatorade; 3, 2, and 1 with N-ORS; and 2, 2, and 1 with Pedialyte, respectively. Similarly, hyponatremia was observed in 6, 9, and 3 patients with Gatorade; 5, 3, and 4 with N-ORS; and 4, 5, and 4 with Pedialyte. Tastewise, Gatorade and N-ORS were rated higher (p < .05) than Pedialyte. Limitations were a smaller sample size and higher dropout (20%). CONCLUSIONS: Gatorade and N-ORS seem to be as effective as Pedialyte in correcting dehydration and in improving bowel symptoms. All 3 solutions were safe. Unlike other groups, hypokalemia persisted in the Gatorade group. Gatorade and N-ORS may be effective in the treatment of dehydration associated with mild viral gastroenteritis.


Subject(s)
Fluid Therapy , Gastroenteritis/therapy , Hypokalemia/epidemiology , Hyponatremia/epidemiology , Rehydration Solutions/standards , Adolescent , Adult , Aged , Aged, 80 and over , Consumer Product Safety , Double-Blind Method , Female , Fluid Therapy/adverse effects , Gastroenteritis/virology , Humans , Male , Middle Aged , Patient Satisfaction , Taste , Treatment Outcome
12.
J Pediatr Gastroenterol Nutr ; 39(5): 545-8, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15572897

ABSTRACT

OBJECTIVE: As a number of mild to moderately dehydrated children refuse to drink oral rehydration solution (ORS) because of its strong salty taste, many parents and health workers flavor ORS with the childs favorite juice. The effects of flavoring ORS on electrolyte content and osmolality were assessed and the palatability of various solutions were compared with commercially flavored ORS. METHODS: Osmolality, sodium, potassium, chloride and glucose content after flavoring with varying concentrations of apple juice, orange juice or orangeade was determined. Two of the solutions were offered to 30 children and adults to assess palatability. RESULTS: All additions to ORS (apple juice, orange juice or orangeade) caused a decrease of sodium (-30 to -53 mmol/L) and chloride (-27 to -47 mmol/L) content, whereas osmolality increased to greater than 311 mOsm/kg. These homemade oral rehydration solutions did not fulfill ESPGAN criteria for ORS, and rehydration will therefore be less effective. The majority of subjects also preferred the commercially flavored ORS. CONCLUSION: Only very small amounts of apple juice or orange juice can be added to the ORS without significantly altering electrolyte composition and osmolality. Palatability, however, does not improve compared with commercially flavored ORS. We therefore recommend using commercially flavored ORS, the composition of which fulfills ESPGAN criteria.


Subject(s)
Electrolytes/analysis , Flavoring Agents/adverse effects , Fluid Therapy/methods , Rehydration Solutions/chemistry , Taste , Beverages , Dehydration/therapy , Flavoring Agents/administration & dosage , Fruit , Humans , Osmolar Concentration , Rehydration Solutions/administration & dosage , Rehydration Solutions/standards , Treatment Outcome
13.
J UOEH ; 25(1): 1-11, 2003 Mar 01.
Article in English | MEDLINE | ID: mdl-12669623

ABSTRACT

Eight skilled workers engaged in heat-exposed work in front of a blast furnace in a steel factory were asked to drink a sports drink or one of its dilutions of x 2, x 3, or x 5 during a regular daytime shift in the summer of 1999. A regular lunch was taken and the examined beverage was iced and was allowed to be consumed ad libitum. The beverage was changed each day during four days of the experiment without informing the dilution ratio. The non-diluted beverage contained 21 mEq/l of Na+, 5 mEq/l of K+, 6.7 g/dl of carbohydrate. In average, the body temperature measured in the ear canal was elevated by 0.34 degree C, the loss of body weight was 1.77 kg, total beverage intake was 1,875 g, total amount of urine was 291 g, and the total water loss was 3,732 g (1,350-5,810 g) during a single shift. Twenty out of 24 cases experienced more than 1.5% of weight reduction during morning work without noticing any subjective symptoms of dehydration. The amount of weight loss during morning work was significantly smaller when x 2 or x 3 dilution was taken compared to a non-diluted beverage. The mean value of urinary Na+ concentration was decreased after 8 hours of work; however, the difference was not significant. The urinary K+ concentration was significantly increased. When the total amount of urinary sodium excretion in stored urine was calculated, the x 3 dilution recorded the largest amount. Regarding palatability, the x 2 dilution received the best evaluation, whereas all subjects felt the original beverage as too condensed. We did not observe any adverse effect from diluting the sports drink for x 2 or x 3, when supplying them as water and electrolyte replacements for dehydrated steel workers.


Subject(s)
Beverages , Drinking Behavior/physiology , Hot Temperature/adverse effects , Occupational Exposure/adverse effects , Occupational Health , Rehydration Solutions/standards , Water-Electrolyte Balance , Adult , Body Temperature Regulation , Humans , Indicator Dilution Techniques , Male , Middle Aged
16.
Blood Purif ; 20(3): 239-42, 2002.
Article in English | MEDLINE | ID: mdl-11867870

ABSTRACT

The administration of intravenous fluids is perhaps the most common treatment given in the intensive care unit. According to biologic rationale, ongoing fluid losses should be replaced to maintain fluid homeostasis and relative or absolute deficiencies in circulating blood volume should be prevented or rapidly corrected. There is agreement that insensible fluid losses and isotonic fluid losses should be replaced with a judicious mixture of water and crystalloid solutions. There is, however, a great deal of controversy on which fluids should be used during the acute resuscitation phase to deal with acute relative or absolute hypovolemia. In particular, there is much controversy on whether colloidal or crystalloid solutions should be used. The controversy remains despite multiple meta-analyses. There are suggestions that albumin might increase mortality but the data supporting these concerns are weak. Starch solutions might adversely affect renal function. Crystalloids might be favored in trauma patients. These views remain inadequately supported by evidence. A randomized controlled trial now under way should increase the evidence base for practice in this area.


Subject(s)
Fluid Therapy/methods , Albumins/adverse effects , Albumins/therapeutic use , Colloids/therapeutic use , Crystalloid Solutions , Fluid Therapy/standards , Humans , Isotonic Solutions , Plasma Substitutes/therapeutic use , Rehydration Solutions/standards
18.
Pediatr Rev ; 22(11): 380-7, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11691948

ABSTRACT

Parenteral fluid therapy is a basic component of the care of hospitalized infants and children. Clinicians who care for inpatients must be able to assess the need for parenteral fluid therapy and to specify the composition of fluid and rate of administration. Fluid and electrolyte problems can be challenging but generally can be "tamed" by an organized approach, application of a few principles of physiology, and careful monitoring of the patient. It can be useful to consider separately the amount of fluid needed and the electrolyte composition for maintenance needs, deficit, and ongoing losses. Because maintenance is not as directly related to weight as deficit or as directly measureable as ongoing losses, it tends to cause the most confusion. It will, therefore, be discussed first and in more detail than deficit or ongoing losses.


Subject(s)
Fluid Therapy/methods , Rehydration Solutions/therapeutic use , Water-Electrolyte Imbalance/therapy , Algorithms , Basal Metabolism , Body Weight , Child , Child, Hospitalized , Child, Preschool , Dehydration/diagnosis , Dehydration/metabolism , Electrolytes/metabolism , Electrolytes/therapeutic use , Humans , Infant , Rehydration Solutions/standards , Water-Electrolyte Imbalance/diagnosis , Water-Electrolyte Imbalance/metabolism
20.
Indian Pediatr ; 37(9): 952-60, 2000 Sep.
Article in English | MEDLINE | ID: mdl-10992331

ABSTRACT

OBJECTIVE: To compare the safety and efficacy of a hyposmolar oral rehydration solution (H-ORS) (245 mmol/liter) with the World Health Organization oral rehydration solution (WHO ORS) in cholera and acute non-cholera diarrhea. DESIGN: Controlled clinical trial. SETTING: Diarrhea training and treatment unit. METHODS: Thirty-five culture proven cholera and 135 acute non-cholera diarrheal patients randomly received H-ORS or WHO-ORS. Intake and output were measured every 4 hours. RESULTS: Analysis of the total cases revealed rehydration phase (p=0.048, 95% CI 0.64-0.99) and overall (p=0.046, 95% CI 0.70-0.99) frequency of stools to be significantly less in the H-ORS group. In the severely malnourished, the rehydration phase (p=0.032, 95% CI 0.55-97), maintenance phase (p=0.035, 95% CI 0.51-0.97) and overall (p=0.011; 0.95% CI 0.55-0.93) stool frequency were significantly decreased in the H-ORS group. The amount of ORS consumed in the maintenance phase of the cholera cases was significantly (p=0.04, 95% CI 0.44-0.98) less in the H-ORS group. All other parameters, despite showing a decreasing trend, were statistically comparable in the cholera, non-cholera and total cases. The amount of intravenous fluid needed was significantly more in the noncholera and total cases on H-ORS. In the non-breastfed cases, under two years of age, the total duration of diarrhea was significantly decreased (p=0.03; 95% CI 11.07-11.45) but the need for intravenous fluids significantly increased (p=0.02; 95% CI 109.8-112.1) in the H-ORS group. The proportion of children vomiting, the weight gain, urine passed in 24 hours, serum sodium, caloric intake and failure rate were comparable. CONCLUSIONS: H-ORS is as safe and effective as the WHO-ORS and may have some additional benefits in malnourished children.


Subject(s)
Cholera/therapy , Diarrhea/microbiology , Diarrhea/therapy , Rehydration Solutions/administration & dosage , Rehydration Solutions/standards , Administration, Oral , Child, Preschool , Cholera/diagnosis , Confidence Intervals , Female , Fluid Therapy/methods , Follow-Up Studies , Humans , Hypotonic Solutions , India , Infant , Male , Osmolar Concentration , Probability , Treatment Outcome , World Health Organization
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